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PubMed:2156561 JSONTXT

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Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 22-31 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T2 80-87 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T3 165-174 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T4 200-209 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T5 293-300 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T6 502-509 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T7 606-615 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T8 746-755 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T9 874-883 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T10 933-940 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T11 961-970 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T12 1004-1013 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T13 1147-1156 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T14 1546-1555 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T15 1656-1665 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T16 2005-2014 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 895-903 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-143 Sentence denotes Mechanism of enhanced melibiose transport rate catalyzed by an Escherichia coli lactose carrier mutant with leucine substituted for serine-306.
T2 144-182 Sentence denotes The pH-dependence of melibiose efflux.
T3 183-367 Sentence denotes The mechanism of melibiose transport was studied in cells containing plasmid pAA22 which expresses the mutant lactose carrier (serine-306 to leucine) cloned from Escherichia coli AA22.
T4 368-707 Sentence denotes These studies were of interest because several lines of evidence suggested that the AA22 mutation conferred novel properties upon the lactose carrier, decreasing turnover with several beta-galactoside substrates, increasing turnover with melibiose, and abolishing active accumulation even though equilibration occurred via symport with H+.
T5 708-949 Sentence denotes Although severely defective in active melibiose accumulation, the present study indicates that in cells poisoned with azide the AA22 carrier does in fact equilibrate melibiose across the membrane more rapidly than the normal lactose carrier.
T6 950-1097 Sentence denotes Similarly, melibiose efflux from cells preloaded with melibiose was more rapidly catalyzed by the AA22 carrier than by the normal carrier (pH 7.0).
T7 1098-1275 Sentence denotes Furthermore, although external H+ did reduce net melibiose efflux to a rate slower than seen in equilibrium exchange, a lower than normal pH was required to achieve this effect.
T8 1276-1476 Sentence denotes Therefore, at pH 7.0, the AA22 carrier (but not the normal carrier) catalyzed net efflux at a rate approaching that for the exchange process (which was pH-resistant in both the mutant and the parent).
T9 1477-1616 Sentence denotes At pH 8.0 both the AA22 carrier and the normal carrier catalyzed net melibiose efflux at a rate identical to the equilibrium exchange rate.
T10 1617-2153 Sentence denotes We suggest (i) that the sensitivity of melibiose efflux to external pH indicates that during efflux the AA22 carrier interacts with protons in a manner similar to the normal carrier (i.e., sugar is cotransported with H+) and hence the absence of accumulation is not explained by internal leak via a binary carrier-melibose complex; and (ii) that the modest increase in rate constants for melibiose exit reflect small changes in activation energy (1 kcal/mol) consistent with a steric mechanism possibly involving van der Waals contacts.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 22-31 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T2 80-87 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T3 165-174 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T4 200-209 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T5 293-300 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T6 502-509 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T7 606-615 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T8 746-755 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T9 874-883 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T10 933-940 Glycan denotes lactose https://api.glycosmos.org/wurcs2image/latest/png/binary/G15541SE
T11 961-970 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T12 1004-1013 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T13 1147-1156 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T14 1546-1555 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T15 1656-1665 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II
T16 2005-2014 Glycan denotes melibiose https://api.glycosmos.org/wurcs2image/latest/png/binary/G66481II

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 151-161 Disease denotes dependence MONDO:0004938

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 63-79 OrganismTaxon denotes Escherichia coli 562
T2 345-361 OrganismTaxon denotes Escherichia coli 562

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 63-79 OrganismTaxon denotes Escherichia coli 562
T2 345-361 OrganismTaxon denotes Escherichia coli 562

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 895-903 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158