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PubMed:21523445 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer.
TextSentencer_T2 123-307 Sentence denotes The potential anti-senescence gene Klotho (KL) has been recently found to participate in the progression of several different human cancers including breast, lung, and cervical cancer.
TextSentencer_T3 308-455 Sentence denotes In this current study, we identified KL as a candidate tumor suppressor gene silenced through promoter hypermethylation in colorectal cancer (CRC).
TextSentencer_T4 456-677 Sentence denotes KL gene expression is found to be absent or reduced in colon cancer cell lines (5/6, 83.3%), which can be reversed by treatment with demethylation agent 5-aza-2'-deoxycytidine (Aza), but not HDAC inhibitor trichostatin A.
TextSentencer_T5 678-826 Sentence denotes In addition, KL expression is markedly downregulated in colorectal carcinoma tissues when compared to the adjacent nontumor tissues (n=25, p<0.001).
TextSentencer_T6 827-980 Sentence denotes The methylation of the KL gene promoter was frequently detected in primary tumor tissues (34/40, 85%) when compared with adjacent nontumor colon tissues.
TextSentencer_T7 981-1153 Sentence denotes Furthermore, ectopic expression of KL led to the cell proliferation inhibition of colon cancer cell lines via the induction of cell apoptosis and S-phase cell cycle arrest.
TextSentencer_T8 1154-1307 Sentence denotes Taken together, our results suggest that KL is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in CRC.
T1 0-122 Sentence denotes Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer.
T2 123-307 Sentence denotes The potential anti-senescence gene Klotho (KL) has been recently found to participate in the progression of several different human cancers including breast, lung, and cervical cancer.
T3 308-455 Sentence denotes In this current study, we identified KL as a candidate tumor suppressor gene silenced through promoter hypermethylation in colorectal cancer (CRC).
T4 456-677 Sentence denotes KL gene expression is found to be absent or reduced in colon cancer cell lines (5/6, 83.3%), which can be reversed by treatment with demethylation agent 5-aza-2'-deoxycytidine (Aza), but not HDAC inhibitor trichostatin A.
T5 678-826 Sentence denotes In addition, KL expression is markedly downregulated in colorectal carcinoma tissues when compared to the adjacent nontumor tissues (n=25, p<0.001).
T6 827-980 Sentence denotes The methylation of the KL gene promoter was frequently detected in primary tumor tissues (34/40, 85%) when compared with adjacent nontumor colon tissues.
T7 981-1153 Sentence denotes Furthermore, ectopic expression of KL led to the cell proliferation inhibition of colon cancer cell lines via the induction of cell apoptosis and S-phase cell cycle arrest.
T8 1154-1307 Sentence denotes Taken together, our results suggest that KL is inactivated through promoter hypermethylation and potentially functions as a tumor suppressor gene in CRC.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1195-1197 gene:9365 denotes KL
T1 1303-1306 disease:C0009402 denotes CRC
T2 1195-1197 gene:9365 denotes KL
T3 1303-1306 disease:C1527249 denotes CRC
R1 T0 T1 associated_with KL,CRC
R2 T2 T3 associated_with KL,CRC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 255-262 HP_0002664 denotes cancers
T2 291-306 HP_0030079 denotes cervical cancer
T3 300-306 HP_0002664 denotes cancer
T4 363-368 HP_0002664 denotes tumor
T5 442-448 HP_0002664 denotes cancer
T6 511-523 HP_0003003 denotes colon cancer
T7 511-523 HP_0100273 denotes colon cancer
T8 517-523 HP_0002664 denotes cancer
T9 902-907 HP_0002664 denotes tumor
T10 1063-1075 HP_0003003 denotes colon cancer
T11 1063-1075 HP_0100273 denotes colon cancer
T12 1069-1075 HP_0002664 denotes cancer
T13 1278-1283 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_21523445_1_0 158-164 expanded denotes Klotho
SS2_21523445_1_0 166-168 abbr denotes KL
SS1_21523445_2_0 431-448 expanded denotes colorectal cancer
SS2_21523445_2_0 450-453 abbr denotes CRC
SS1_21523445_3_0 609-631 expanded denotes 5-aza-2'-deoxycytidine
SS2_21523445_3_0 633-636 abbr denotes Aza
AE1_21523445_1_0 SS1_21523445_1_0 SS2_21523445_1_0 abbreviatedTo Klotho,KL
AE1_21523445_2_0 SS1_21523445_2_0 SS2_21523445_2_0 abbreviatedTo colorectal cancer,CRC
AE1_21523445_3_0 SS1_21523445_3_0 SS2_21523445_3_0 abbreviatedTo 5-aza-2'-deoxycytidine,Aza

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21523445-0#0#6#gene9365 0-6 gene9365 denotes Klotho
21523445-0#104#121#diseaseC0009402 104-121 diseaseC0009402 denotes colorectal cancer
21523445-0#104#121#diseaseC1527249 104-121 diseaseC1527249 denotes colorectal cancer
21523445-1#35#41#gene9365 158-164 gene9365 denotes Klotho
21523445-1#43#45#gene9365 166-168 gene9365 denotes KL
21523445-1#168#183#diseaseC0007847 291-306 diseaseC0007847 denotes cervical cancer
21523445-1#168#183#diseaseC0302592 291-306 diseaseC0302592 denotes cervical cancer
21523445-1#168#183#diseaseC4048328 291-306 diseaseC4048328 denotes cervical cancer
21523445-1#168#183#diseaseC0007847 291-306 diseaseC0007847 denotes cervical cancer
21523445-1#168#183#diseaseC0302592 291-306 diseaseC0302592 denotes cervical cancer
21523445-1#168#183#diseaseC4048328 291-306 diseaseC4048328 denotes cervical cancer
21523445-3#191#195#gene9734 647-651 gene9734 denotes HDAC
21523445-3#55#67#diseaseC0007102 511-523 diseaseC0007102 denotes colon cancer
21523445-3#55#67#diseaseC0699790 511-523 diseaseC0699790 denotes colon cancer
21523445-6#35#37#gene9365 1016-1018 gene9365 denotes KL
21523445-6#82#94#diseaseC0007102 1063-1075 diseaseC0007102 denotes colon cancer
21523445-6#82#94#diseaseC0699790 1063-1075 diseaseC0699790 denotes colon cancer
0#6#gene9365104#121#diseaseC0009402 21523445-0#0#6#gene9365 21523445-0#104#121#diseaseC0009402 associated_with Klotho,colorectal cancer
0#6#gene9365104#121#diseaseC1527249 21523445-0#0#6#gene9365 21523445-0#104#121#diseaseC1527249 associated_with Klotho,colorectal cancer
35#41#gene9365168#183#diseaseC0007847 21523445-1#35#41#gene9365 21523445-1#168#183#diseaseC0007847 associated_with Klotho,cervical cancer
35#41#gene9365168#183#diseaseC0302592 21523445-1#35#41#gene9365 21523445-1#168#183#diseaseC0302592 associated_with Klotho,cervical cancer
35#41#gene9365168#183#diseaseC4048328 21523445-1#35#41#gene9365 21523445-1#168#183#diseaseC4048328 associated_with Klotho,cervical cancer
35#41#gene9365168#183#diseaseC0007847 21523445-1#35#41#gene9365 21523445-1#168#183#diseaseC0007847 associated_with Klotho,cervical cancer
35#41#gene9365168#183#diseaseC0302592 21523445-1#35#41#gene9365 21523445-1#168#183#diseaseC0302592 associated_with Klotho,cervical cancer
35#41#gene9365168#183#diseaseC4048328 21523445-1#35#41#gene9365 21523445-1#168#183#diseaseC4048328 associated_with Klotho,cervical cancer
43#45#gene9365168#183#diseaseC0007847 21523445-1#43#45#gene9365 21523445-1#168#183#diseaseC0007847 associated_with KL,cervical cancer
43#45#gene9365168#183#diseaseC0302592 21523445-1#43#45#gene9365 21523445-1#168#183#diseaseC0302592 associated_with KL,cervical cancer
43#45#gene9365168#183#diseaseC4048328 21523445-1#43#45#gene9365 21523445-1#168#183#diseaseC4048328 associated_with KL,cervical cancer
43#45#gene9365168#183#diseaseC0007847 21523445-1#43#45#gene9365 21523445-1#168#183#diseaseC0007847 associated_with KL,cervical cancer
43#45#gene9365168#183#diseaseC0302592 21523445-1#43#45#gene9365 21523445-1#168#183#diseaseC0302592 associated_with KL,cervical cancer
43#45#gene9365168#183#diseaseC4048328 21523445-1#43#45#gene9365 21523445-1#168#183#diseaseC4048328 associated_with KL,cervical cancer
191#195#gene973455#67#diseaseC0007102 21523445-3#191#195#gene9734 21523445-3#55#67#diseaseC0007102 associated_with HDAC,colon cancer
191#195#gene973455#67#diseaseC0699790 21523445-3#191#195#gene9734 21523445-3#55#67#diseaseC0699790 associated_with HDAC,colon cancer
35#37#gene936582#94#diseaseC0007102 21523445-6#35#37#gene9365 21523445-6#82#94#diseaseC0007102 associated_with KL,colon cancer
35#37#gene936582#94#diseaseC0699790 21523445-6#35#37#gene9365 21523445-6#82#94#diseaseC0699790 associated_with KL,colon cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T327 0-6 gene:9365 denotes Klotho
T328 104-121 disease:C0009402 denotes colorectal cancer
T329 158-164 gene:9365 denotes Klotho
T330 291-306 disease:C0007847 denotes cervical cancer
T331 166-168 gene:9365 denotes KL
T332 647-651 gene:9734 denotes HDAC
T333 511-523 disease:C0007102 denotes colon cancer
T334 1016-1018 gene:9365 denotes KL
T335 1063-1075 disease:C0007102 denotes colon cancer
R1 T327 T328 associated_with Klotho,colorectal cancer
R2 T327 T328 associated_with Klotho,colorectal cancer
R3 T329 T330 associated_with Klotho,cervical cancer
R4 T329 T330 associated_with Klotho,cervical cancer
R5 T329 T330 associated_with Klotho,cervical cancer
R6 T331 T330 associated_with KL,cervical cancer
R7 T331 T330 associated_with KL,cervical cancer
R8 T331 T330 associated_with KL,cervical cancer
R9 T332 T333 associated_with HDAC,colon cancer
R10 T332 T333 associated_with HDAC,colon cancer
R11 T334 T335 associated_with KL,colon cancer
R12 T334 T335 associated_with KL,colon cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 273-279 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
PD-UBERON-AE-B_T2 281-285 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T3 511-516 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T4 966-971 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T5 1063-1068 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T6 755-762 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T7 802-809 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T8 908-915 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T9 972-979 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 511-516 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T2 966-971 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T3 1063-1068 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T4 281-285 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T5 755-762 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T6 802-809 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T7 908-915 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T8 972-979 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T9 273-279 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast