PubMed:21515908
Annnotations
Glycan-Motif
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 67-75 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparins |
| T2 | 67-75 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparins |
| T3 | 164-172 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparins |
| T4 | 164-172 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparins |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 67-75 | Glycan_Motif | denotes | heparins | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
| T3 | 164-172 | Glycan_Motif | denotes | heparins | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-117 | Sentence | denotes | Bioactivity screening of partially desulfated low-molecular-weight heparins: a structure/activity relationship study. |
| TextSentencer_T2 | 118-284 | Sentence | denotes | A series of size-defined low-molecular-weight heparins were generated by regioselective chemical modifications and profiled for their in vitro and in vivo activities. |
| TextSentencer_T3 | 285-673 | Sentence | denotes | The compounds displayed reduced anti-coagulant activity, demonstrated varying affinities toward angiogenic growth factors (fibroblast growth factor-2, vascular endothelial growth factor and stromal cell-derived factor-1α), inhibited the P-selectin/P-selectin glycoprotein ligand-1 interaction and, notably, exhibited anti-tumor efficacy in a murine melanoma experimental metastasis model. |
| TextSentencer_T4 | 674-908 | Sentence | denotes | Our results demonstrate that modulating specific sequences, especially the N-domains (-NS or -NH(2) or -NHCOCH(3)) in these polysaccharide sequences, has a major impact on the participation in a diverse range of biological activities. |
| TextSentencer_T5 | 909-1154 | Sentence | denotes | These results also suggest that the 6-O-sulfates, but not the 2-O-sulfates, critically affect the binding of a desulfated derivative to certain angiogenic proteins as well as its ability to inhibit P-selectin-mediated B16F10 melanoma metastases. |
| TextSentencer_T6 | 1155-1327 | Sentence | denotes | Furthermore, N-desulfation followed by N-acetylation regenerates the affinity/inhibition properties to different extents in all the compounds tested in the in vitro assays. |
| TextSentencer_T7 | 1328-1549 | Sentence | denotes | This systematic study lays a conceptual foundation for detailed structure function elucidation and will facilitate the rational design of targeted heparan sulfate proteoglycan-based anti-metastatic therapeutic candidates. |
| T1 | 0-117 | Sentence | denotes | Bioactivity screening of partially desulfated low-molecular-weight heparins: a structure/activity relationship study. |
| T2 | 118-284 | Sentence | denotes | A series of size-defined low-molecular-weight heparins were generated by regioselective chemical modifications and profiled for their in vitro and in vivo activities. |
| T3 | 285-673 | Sentence | denotes | The compounds displayed reduced anti-coagulant activity, demonstrated varying affinities toward angiogenic growth factors (fibroblast growth factor-2, vascular endothelial growth factor and stromal cell-derived factor-1α), inhibited the P-selectin/P-selectin glycoprotein ligand-1 interaction and, notably, exhibited anti-tumor efficacy in a murine melanoma experimental metastasis model. |
| T4 | 674-908 | Sentence | denotes | Our results demonstrate that modulating specific sequences, especially the N-domains (-NS or -NH(2) or -NHCOCH(3)) in these polysaccharide sequences, has a major impact on the participation in a diverse range of biological activities. |
| T5 | 909-1154 | Sentence | denotes | These results also suggest that the 6-O-sulfates, but not the 2-O-sulfates, critically affect the binding of a desulfated derivative to certain angiogenic proteins as well as its ability to inhibit P-selectin-mediated B16F10 melanoma metastases. |
| T6 | 1155-1327 | Sentence | denotes | Furthermore, N-desulfation followed by N-acetylation regenerates the affinity/inhibition properties to different extents in all the compounds tested in the in vitro assays. |
| T7 | 1328-1549 | Sentence | denotes | This systematic study lays a conceptual foundation for detailed structure function elucidation and will facilitate the rational design of targeted heparan sulfate proteoglycan-based anti-metastatic therapeutic candidates. |
| T1 | 0-117 | Sentence | denotes | Bioactivity screening of partially desulfated low-molecular-weight heparins: a structure/activity relationship study. |
| T2 | 118-284 | Sentence | denotes | A series of size-defined low-molecular-weight heparins were generated by regioselective chemical modifications and profiled for their in vitro and in vivo activities. |
| T3 | 285-673 | Sentence | denotes | The compounds displayed reduced anti-coagulant activity, demonstrated varying affinities toward angiogenic growth factors (fibroblast growth factor-2, vascular endothelial growth factor and stromal cell-derived factor-1α), inhibited the P-selectin/P-selectin glycoprotein ligand-1 interaction and, notably, exhibited anti-tumor efficacy in a murine melanoma experimental metastasis model. |
| T4 | 674-908 | Sentence | denotes | Our results demonstrate that modulating specific sequences, especially the N-domains (-NS or -NH(2) or -NHCOCH(3)) in these polysaccharide sequences, has a major impact on the participation in a diverse range of biological activities. |
| T5 | 909-1154 | Sentence | denotes | These results also suggest that the 6-O-sulfates, but not the 2-O-sulfates, critically affect the binding of a desulfated derivative to certain angiogenic proteins as well as its ability to inhibit P-selectin-mediated B16F10 melanoma metastases. |
| T6 | 1155-1327 | Sentence | denotes | Furthermore, N-desulfation followed by N-acetylation regenerates the affinity/inhibition properties to different extents in all the compounds tested in the in vitro assays. |
| T7 | 1328-1549 | Sentence | denotes | This systematic study lays a conceptual foundation for detailed structure function elucidation and will facilitate the rational design of targeted heparan sulfate proteoglycan-based anti-metastatic therapeutic candidates. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 67-75 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparins |
| T2 | 67-75 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparins |
| T3 | 164-172 | https://glytoucan.org/Structures/Glycans/G00021MO | denotes | heparins |
| T4 | 164-172 | https://glytoucan.org/Structures/Glycans/G54161DR | denotes | heparins |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1475-1490 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 607-612 | HP_0002664 | denotes | tumor |
| T2 | 634-642 | HP_0002861 | denotes | melanoma |
| T3 | 1134-1142 | HP_0002861 | denotes | melanoma |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 67-75 | FMAID:167420 | denotes | heparins |
| _T2 | 67-75 | FMAID:82839 | denotes | heparins |
| _T3 | 164-172 | FMAID:167420 | denotes | heparins |
| _T4 | 164-172 | FMAID:82839 | denotes | heparins |
| _T5 | 289-298 | FMAID:67745 | denotes | compounds |
| _T6 | 289-298 | FMAID:165656 | denotes | compounds |
| _T7 | 408-418 | FMAID:63877 | denotes | fibroblast |
| _T8 | 408-418 | FMAID:162340 | denotes | fibroblast |
| _T9 | 445-456 | FMAID:162384 | denotes | endothelial |
| _T10 | 445-456 | FMAID:63916 | denotes | endothelial |
| _T11 | 475-487 | FMAID:83624 | denotes | stromal cell |
| _T12 | 475-487 | FMAID:197708 | denotes | stromal cell |
| _T13 | 522-532 | FMAID:167268 | denotes | P-selectin |
| _T14 | 522-532 | FMAID:62933 | denotes | P-selectin |
| _T15 | 522-532 | FMAID:167267 | denotes | P-selectin |
| _T16 | 522-532 | FMAID:62932 | denotes | P-selectin |
| _T17 | 522-532 | FMAID:62931 | denotes | P-selectin |
| _T18 | 522-532 | FMAID:167265 | denotes | P-selectin |
| _T19 | 524-532 | FMAID:61795 | denotes | selectin |
| _T20 | 524-532 | FMAID:165243 | denotes | selectin |
| _T21 | 533-543 | FMAID:62932 | denotes | P-selectin |
| _T22 | 533-543 | FMAID:62933 | denotes | P-selectin |
| _T23 | 533-543 | FMAID:167267 | denotes | P-selectin |
| _T24 | 533-543 | FMAID:62931 | denotes | P-selectin |
| _T25 | 533-543 | FMAID:167265 | denotes | P-selectin |
| _T26 | 533-543 | FMAID:167268 | denotes | P-selectin |
| _T27 | 535-543 | FMAID:165243 | denotes | selectin |
| _T28 | 535-543 | FMAID:61795 | denotes | selectin |
| _T29 | 544-556 | FMAID:167256 | denotes | glycoprotein |
| _T30 | 544-556 | FMAID:62925 | denotes | glycoprotein |
| _T31 | 798-812 | FMAID:82746 | denotes | polysaccharide |
| _T32 | 798-812 | FMAID:196735 | denotes | polysaccharide |
| _T33 | 798-812 | FMAID:196779 | denotes | polysaccharide |
| _T34 | 798-812 | FMAID:82785 | denotes | polysaccharide |
| _T35 | 1064-1072 | FMAID:165447 | denotes | proteins |
| _T36 | 1064-1072 | FMAID:67257 | denotes | proteins |
| _T37 | 1107-1117 | FMAID:167265 | denotes | P-selectin |
| _T38 | 1107-1117 | FMAID:62931 | denotes | P-selectin |
| _T39 | 1107-1117 | FMAID:62933 | denotes | P-selectin |
| _T40 | 1107-1117 | FMAID:167268 | denotes | P-selectin |
| _T41 | 1107-1117 | FMAID:62932 | denotes | P-selectin |
| _T42 | 1107-1117 | FMAID:167267 | denotes | P-selectin |
| _T43 | 1109-1117 | FMAID:165243 | denotes | selectin |
| _T44 | 1109-1117 | FMAID:61795 | denotes | selectin |
| _T45 | 1287-1296 | FMAID:165656 | denotes | compounds |
| _T46 | 1287-1296 | FMAID:67745 | denotes | compounds |
| _T47 | 1297-1303 | FMAID:178661 | denotes | tested |
| _T48 | 1475-1482 | FMAID:67110 | denotes | heparan |
| _T49 | 1475-1482 | FMAID:165191 | denotes | heparan |
| _T50 | 1475-1490 | FMAID:167405 | denotes | heparan sulfate |
| _T51 | 1475-1490 | FMAID:63023 | denotes | heparan sulfate |
| _T52 | 1475-1503 | FMAID:82834 | denotes | heparan sulfate proteoglycan |
| _T53 | 1475-1503 | FMAID:196834 | denotes | heparan sulfate proteoglycan |
| _T54 | 1491-1503 | FMAID:63015 | denotes | proteoglycan |
| _T55 | 1491-1503 | FMAID:167397 | denotes | proteoglycan |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 392-418 | http://www.uniprot.org/uniprot/P05230 | denotes | growth factors (fibroblast |
| T2 | 392-418 | http://www.uniprot.org/uniprot/P61328 | denotes | growth factors (fibroblast |
| T3 | 392-418 | http://www.uniprot.org/uniprot/Q92913 | denotes | growth factors (fibroblast |
| T4 | 392-418 | http://www.uniprot.org/uniprot/Q9NSA1 | denotes | growth factors (fibroblast |
| T5 | 392-418 | http://www.uniprot.org/uniprot/Q92915 | denotes | growth factors (fibroblast |
| T6 | 392-418 | http://www.uniprot.org/uniprot/O60258 | denotes | growth factors (fibroblast |
| T7 | 392-418 | http://www.uniprot.org/uniprot/O76093 | denotes | growth factors (fibroblast |
| T8 | 392-418 | http://www.uniprot.org/uniprot/P08620 | denotes | growth factors (fibroblast |
| T9 | 392-418 | http://www.uniprot.org/uniprot/Q9UC54 | denotes | growth factors (fibroblast |
| T10 | 419-434 | http://www.uniprot.org/uniprot/Q9UC54 | denotes | growth factor-2 |
| T11 | 419-434 | http://www.uniprot.org/uniprot/P20783 | denotes | growth factor-2 |
| T12 | 419-434 | http://www.uniprot.org/uniprot/Q9UK05 | denotes | growth factor-2 |
| T13 | 419-434 | http://www.uniprot.org/uniprot/O15520 | denotes | growth factor-2 |
| T14 | 433-456 | http://www.uniprot.org/uniprot/Q9NPG4 | denotes | 2, vascular endothelial |
| T15 | 433-456 | http://www.uniprot.org/uniprot/Q99944 | denotes | 2, vascular endothelial |
| T16 | 522-532 | http://www.uniprot.org/uniprot/P16109 | denotes | P-selectin |
| T17 | 533-543 | http://www.uniprot.org/uniprot/P16109 | denotes | P-selectin |
| T18 | 1107-1117 | http://www.uniprot.org/uniprot/P16109 | denotes | P-selectin |
| T19 | 761-763 | http://www.uniprot.org/uniprot/Q9BVP2 | denotes | NS |
| T20 | 1475-1503 | http://www.uniprot.org/uniprot/Q9UCB0 | denotes | heparan sulfate proteoglycan |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 522-532 | http://www.uniprot.org/uniprot/Q01102 | denotes | P-selectin |
| T2 | 533-543 | http://www.uniprot.org/uniprot/Q01102 | denotes | P-selectin |
| T3 | 1107-1117 | http://www.uniprot.org/uniprot/Q01102 | denotes | P-selectin |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 634-642 | http://purl.bioontology.org/ontology/NCBITAXON/1369386 | denotes | melanoma |
| T2 | 634-642 | http://purl.bioontology.org/ontology/NCBITAXON/45308 | denotes | melanoma |
| T3 | 1134-1142 | http://purl.bioontology.org/ontology/NCBITAXON/1369386 | denotes | melanoma |
| T4 | 1134-1142 | http://purl.bioontology.org/ontology/NCBITAXON/45308 | denotes | melanoma |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 322-331 | http://purl.obolibrary.org/obo/GO_0050817 | denotes | coagulant |
| T2 | 322-340 | http://purl.obolibrary.org/obo/GO_0050820 | denotes | coagulant activity |
| T3 | 392-398 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T4 | 419-425 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T5 | 457-463 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T6 | 392-418 | http://purl.obolibrary.org/obo/GO_0071774 | denotes | growth factors (fibroblast |
| T7 | 949-957 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfates |
| T8 | 975-983 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfates |
| T9 | 1483-1490 | http://purl.obolibrary.org/obo/GO_0051923 | denotes | sulfate |
| T10 | 1208-1219 | http://purl.obolibrary.org/obo/GO_0031099 | denotes | regenerates |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 399-425 | http://purl.obolibrary.org/obo/GO_0005104 | denotes | factors (fibroblast growth |
| T2 | 399-425 | http://purl.obolibrary.org/obo/GO_0017134 | denotes | factors (fibroblast growth |
| T3 | 524-532 | http://purl.obolibrary.org/obo/GO_0030246 | denotes | selectin |
| T4 | 535-543 | http://purl.obolibrary.org/obo/GO_0030246 | denotes | selectin |
| T5 | 1109-1117 | http://purl.obolibrary.org/obo/GO_0030246 | denotes | selectin |
| T6 | 557-563 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligand |
| T7 | 1007-1014 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T8 | 1007-1014 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T9 | 1007-1014 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T10 | 1007-1014 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
| T11 | 1475-1503 | http://purl.obolibrary.org/obo/GO_0043395 | denotes | heparan sulfate proteoglycan |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 483-487 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
GlyTouCan-IUPAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| GlycanIUPAC_T1 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G41652MJ" | denotes | all |
| GlycanIUPAC_T2 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G20761YC" | denotes | all |
| GlycanIUPAC_T3 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G19807HM" | denotes | all |
| GlycanIUPAC_T4 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G20351TE" | denotes | all |
| GlycanIUPAC_T5 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G71957MR" | denotes | all |
| GlycanIUPAC_T6 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G59040AE" | denotes | all |
| GlycanIUPAC_T7 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G14987PW" | denotes | all |
| GlycanIUPAC_T8 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G95064PC" | denotes | all |
| GlycanIUPAC_T9 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G39143AQ" | denotes | all |
| GlycanIUPAC_T10 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G65149OO" | denotes | all |
| GlycanIUPAC_T11 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G02766SY" | denotes | all |
| GlycanIUPAC_T12 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G26019KJ" | denotes | all |
| GlycanIUPAC_T13 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G36429CZ" | denotes | all |
| GlycanIUPAC_T14 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G89633TP" | denotes | all |
| GlycanIUPAC_T15 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G28494FO" | denotes | all |
| GlycanIUPAC_T16 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G06219CP" | denotes | all |
| GlycanIUPAC_T17 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G44237SM" | denotes | all |
| GlycanIUPAC_T18 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G57948RL" | denotes | all |
| GlycanIUPAC_T19 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G64016DN" | denotes | all |
| GlycanIUPAC_T20 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G14536PC" | denotes | all |
| GlycanIUPAC_T21 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G14356FW" | denotes | all |
| GlycanIUPAC_T22 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G34565UO" | denotes | all |
| GlycanIUPAC_T23 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G67124MW" | denotes | all |
| GlycanIUPAC_T24 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G71457ZU" | denotes | all |
| GlycanIUPAC_T25 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G55228VZ" | denotes | all |
| GlycanIUPAC_T26 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G31034MJ" | denotes | all |
| GlycanIUPAC_T27 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G25776IP" | denotes | all |
| GlycanIUPAC_T28 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G64442BV" | denotes | all |
| GlycanIUPAC_T29 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G57018LE" | denotes | all |
| GlycanIUPAC_T30 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G61761GX" | denotes | all |
| GlycanIUPAC_T31 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G76318UX" | denotes | all |
| GlycanIUPAC_T32 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G61906ER" | denotes | all |
| GlycanIUPAC_T33 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G68723GR" | denotes | all |
| GlycanIUPAC_T34 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G19540LE" | denotes | all |
| GlycanIUPAC_T35 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G74944PO" | denotes | all |
| GlycanIUPAC_T36 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G89489ZJ" | denotes | all |
| GlycanIUPAC_T37 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G04434YU" | denotes | all |
| GlycanIUPAC_T38 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G21450PB" | denotes | all |
| GlycanIUPAC_T39 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G93629QY" | denotes | all |
| GlycanIUPAC_T40 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G02603TR" | denotes | all |
| GlycanIUPAC_T41 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G40280JP" | denotes | all |
| GlycanIUPAC_T42 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G95259IC" | denotes | all |
| GlycanIUPAC_T43 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G26900FE" | denotes | all |
| GlycanIUPAC_T44 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G21346KK" | denotes | all |
| GlycanIUPAC_T45 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G62509FF" | denotes | all |
| GlycanIUPAC_T46 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G83932AK" | denotes | all |
| GlycanIUPAC_T47 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G96978IB" | denotes | all |
| GlycanIUPAC_T48 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G34275DN" | denotes | all |
| GlycanIUPAC_T49 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G07071JF" | denotes | all |
| GlycanIUPAC_T50 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G80639QD" | denotes | all |
| GlycanIUPAC_T51 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G99460PJ" | denotes | all |
| GlycanIUPAC_T52 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G22024BZ" | denotes | all |
| GlycanIUPAC_T53 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G74097ZY" | denotes | all |
| GlycanIUPAC_T54 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G84439YP" | denotes | all |
| GlycanIUPAC_T55 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G52207WQ" | denotes | all |
| GlycanIUPAC_T56 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G90695MS" | denotes | all |
| GlycanIUPAC_T57 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G50398QX" | denotes | all |
| GlycanIUPAC_T58 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G12166ZT" | denotes | all |
| GlycanIUPAC_T59 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G48368BR" | denotes | all |
| GlycanIUPAC_T60 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G57407RW" | denotes | all |
| GlycanIUPAC_T61 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G00386TY" | denotes | all |
| GlycanIUPAC_T62 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G18723JK" | denotes | all |
| GlycanIUPAC_T63 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G93757OR" | denotes | all |
| GlycanIUPAC_T64 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G29006SI" | denotes | all |
| GlycanIUPAC_T65 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G03099OQ" | denotes | all |
| GlycanIUPAC_T66 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G53739OW" | denotes | all |
| GlycanIUPAC_T67 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G70440ZO" | denotes | all |
| GlycanIUPAC_T68 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G29951RR" | denotes | all |
| GlycanIUPAC_T69 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G58402TI" | denotes | all |
| GlycanIUPAC_T70 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G39875TP" | denotes | all |
| GlycanIUPAC_T71 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G83439QV" | denotes | all |
| GlycanIUPAC_T72 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G41762RC" | denotes | all |
| GlycanIUPAC_T73 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G91604UI" | denotes | all |
| GlycanIUPAC_T74 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G88447WE" | denotes | all |
| GlycanIUPAC_T75 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G93634BS" | denotes | all |
| GlycanIUPAC_T76 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G02587BH" | denotes | all |
| GlycanIUPAC_T77 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G43511MX" | denotes | all |
| GlycanIUPAC_T78 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G64958DH" | denotes | all |
| GlycanIUPAC_T79 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G30384TR" | denotes | all |
| GlycanIUPAC_T80 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G15624EX" | denotes | all |
| GlycanIUPAC_T81 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G22706ST" | denotes | all |
| GlycanIUPAC_T82 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G57408PI" | denotes | all |
| GlycanIUPAC_T83 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G86403XX" | denotes | all |
| GlycanIUPAC_T84 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G78043YB" | denotes | all |
| GlycanIUPAC_T85 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G18952JK" | denotes | all |
| GlycanIUPAC_T86 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G49020ND" | denotes | all |
| GlycanIUPAC_T87 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G63590YW" | denotes | all |
| GlycanIUPAC_T88 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G22793KS" | denotes | all |
| GlycanIUPAC_T89 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G64134SS" | denotes | all |
| GlycanIUPAC_T90 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G17338HY" | denotes | all |
| GlycanIUPAC_T91 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G99745XF" | denotes | all |
| GlycanIUPAC_T92 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G27782HN" | denotes | all |
| GlycanIUPAC_T93 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G57496DC" | denotes | all |
| GlycanIUPAC_T94 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G93169WB" | denotes | all |
| GlycanIUPAC_T95 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G05518TD" | denotes | all |
| GlycanIUPAC_T96 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G62603DN" | denotes | all |
| GlycanIUPAC_T97 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G59574FS" | denotes | all |
| GlycanIUPAC_T98 | 1279-1282 | "http://rdf.glycoinfo.org/glycan/G47567WC" | denotes | all |
GlycoBiology-Motifs
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 67-75 | http://rdf.glycoinfo.org/glycan/G54161DR | denotes | heparins |
| T2 | 164-172 | http://rdf.glycoinfo.org/glycan/G54161DR | denotes | heparins |
Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| Lectin_T1 | 524-532 | https://acgg.asia/db/lfdb/LfDB0142 | denotes | selectin |
| Lectin_T2 | 535-543 | https://acgg.asia/db/lfdb/LfDB0142 | denotes | selectin |
| Lectin_T3 | 1109-1117 | https://acgg.asia/db/lfdb/LfDB0142 | denotes | selectin |
| Lectin_T4 | 522-532 | https://acgg.asia/db/lfdb/LfDB0013 | denotes | P-selectin |
| Lectin_T5 | 533-543 | https://acgg.asia/db/lfdb/LfDB0013 | denotes | P-selectin |
| Lectin_T6 | 1107-1117 | https://acgg.asia/db/lfdb/LfDB0013 | denotes | P-selectin |
| Lectin_T7 | 524-532 | https://acgg.asia/db/lfdb/LfDB0043 | denotes | selectin |
| Lectin_T8 | 535-543 | https://acgg.asia/db/lfdb/LfDB0043 | denotes | selectin |
| Lectin_T9 | 1109-1117 | https://acgg.asia/db/lfdb/LfDB0043 | denotes | selectin |
GlycoBiology-Epitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-GlycoEpitope-B_T1 | 1475-1490 | http://www.glycoepitope.jp/epitopes/EP0086 | denotes | heparan sulfate |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 607-612 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T2 | 634-642 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
| T3 | 1134-1142 | Disease | denotes | melanoma | http://purl.obolibrary.org/obo/MONDO_0005105 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 607-612 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 634-642 | Phenotype | denotes | melanoma | HP:0002861 |
| T3 | 1134-1142 | Phenotype | denotes | melanoma | HP:0002861 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 607-612 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 634-642 | Phenotype | denotes | melanoma | HP:0002861 |
| T3 | 1134-1142 | Phenotype | denotes | melanoma | HP:0002861 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-117 | Sentence | denotes | Bioactivity screening of partially desulfated low-molecular-weight heparins: a structure/activity relationship study. |
| T2 | 118-284 | Sentence | denotes | A series of size-defined low-molecular-weight heparins were generated by regioselective chemical modifications and profiled for their in vitro and in vivo activities. |
| T3 | 285-673 | Sentence | denotes | The compounds displayed reduced anti-coagulant activity, demonstrated varying affinities toward angiogenic growth factors (fibroblast growth factor-2, vascular endothelial growth factor and stromal cell-derived factor-1α), inhibited the P-selectin/P-selectin glycoprotein ligand-1 interaction and, notably, exhibited anti-tumor efficacy in a murine melanoma experimental metastasis model. |
| T4 | 674-908 | Sentence | denotes | Our results demonstrate that modulating specific sequences, especially the N-domains (-NS or -NH(2) or -NHCOCH(3)) in these polysaccharide sequences, has a major impact on the participation in a diverse range of biological activities. |
| T5 | 909-1154 | Sentence | denotes | These results also suggest that the 6-O-sulfates, but not the 2-O-sulfates, critically affect the binding of a desulfated derivative to certain angiogenic proteins as well as its ability to inhibit P-selectin-mediated B16F10 melanoma metastases. |
| T6 | 1155-1327 | Sentence | denotes | Furthermore, N-desulfation followed by N-acetylation regenerates the affinity/inhibition properties to different extents in all the compounds tested in the in vitro assays. |
| T7 | 1328-1549 | Sentence | denotes | This systematic study lays a conceptual foundation for detailed structure function elucidation and will facilitate the rational design of targeted heparan sulfate proteoglycan-based anti-metastatic therapeutic candidates. |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 607-612 | Disease | denotes | tumor | MONDO:0005070 |
| T2 | 634-642 | Disease | denotes | melanoma | MONDO:0005105 |
| T3 | 1134-1142 | Disease | denotes | melanoma | MONDO:0005105 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 1475-1490 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | heparan sulfate | http://www.glycoepitope.jp/epitopes/EP0086 |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 408-418 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
| T2 | 475-487 | Body_part | denotes | stromal cell | http://purl.obolibrary.org/obo/CL_0000499 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 408-418 | Body_part | denotes | fibroblast | FMA:63877 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 408-418 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
| T2 | 475-487 | Body_part | denotes | stromal cell | http://purl.obolibrary.org/obo/CL_0000499 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 408-418 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |
| T2 | 475-487 | Cell | denotes | stromal cell | http://purl.obolibrary.org/obo/CL:0000499 |