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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-138 Sentence denotes Markers of inflammation are heritable and associated with subcutaneous and ectopic skeletal muscle adiposity in African ancestry families.
T2 139-150 Sentence denotes UNLABELLED:
T3 151-171 Sentence denotes Abstract Background:
T4 172-442 Sentence denotes Skeletal muscle adipose tissue (AT) infiltration, or myosteatosis, appears to be greater in African compared with European ancestry individuals and may play a role in type 2 diabetes mellitus (T2DM), a disease that disproportionally affects African ancestry populations.
T5 443-615 Sentence denotes Inflammation is one mechanism that may link myosteatosis with increased T2DM risk, but studies examining the relationship between inflammation and myosteatosis are lacking.
T6 616-624 Sentence denotes METHODS:
T7 625-968 Sentence denotes To examine these associations, we measured skeletal muscle subcutaneous AT, intermuscular AT, and skeletal muscle density using quantitative computed tomography and serum markers of inflammation in 471 individuals from 8 Afro-Caribbean multigenerational families [mean family size 67; mean age 43 years; mean body mass index (BMI) 28 kg/m(2)].
T8 969-977 Sentence denotes RESULTS:
T9 978-1220 Sentence denotes After removing the variation attributable to significant covariates, heritabilities of inflammation markers [C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)] ranged from 33% (TNFα) to 40% (CRP); all P<0.01.
T10 1221-1342 Sentence denotes Higher CRP, IL-6, and TNF-α were associated with lower subcutaneous AT around skeletal muscle (r=-0.13 to -0.19, P<0.05).
T11 1343-1603 Sentence denotes Higher CRP was additionally associated with lower skeletal muscle density, indicative of greater intramuscular AT (r=-0.10, P<0.05), hyperinsulinemia (r=0.12, P<0.05), and increased homeostasis model assessment of insulin resistance (HOMA-IR) (r=0.17, P<0.01).
T12 1604-1616 Sentence denotes CONCLUSIONS:
T13 1617-1768 Sentence denotes Our findings suggest that heredity may play a significant role in the determination of several markers of inflammation in African ancestry individuals.
T14 1769-1932 Sentence denotes Higher concentrations of CRP appear to be associated with greater skeletal muscle AT infiltration, lower subcutaneous AT, hyperinsulinemia, and insulin resistance.
T15 1933-2108 Sentence denotes Longitudinal studies are needed to further evaluate the relationship between inflammation with changes in skeletal muscle AT distribution with aging and the incidence of T2DM.
T1 0-138 Sentence denotes Markers of inflammation are heritable and associated with subcutaneous and ectopic skeletal muscle adiposity in African ancestry families.
T2 139-150 Sentence denotes UNLABELLED:
T3 151-171 Sentence denotes Abstract Background:
T4 172-442 Sentence denotes Skeletal muscle adipose tissue (AT) infiltration, or myosteatosis, appears to be greater in African compared with European ancestry individuals and may play a role in type 2 diabetes mellitus (T2DM), a disease that disproportionally affects African ancestry populations.
T5 443-615 Sentence denotes Inflammation is one mechanism that may link myosteatosis with increased T2DM risk, but studies examining the relationship between inflammation and myosteatosis are lacking.
T6 616-624 Sentence denotes METHODS:
T7 625-968 Sentence denotes To examine these associations, we measured skeletal muscle subcutaneous AT, intermuscular AT, and skeletal muscle density using quantitative computed tomography and serum markers of inflammation in 471 individuals from 8 Afro-Caribbean multigenerational families [mean family size 67; mean age 43 years; mean body mass index (BMI) 28 kg/m(2)].
T8 969-977 Sentence denotes RESULTS:
T9 978-1220 Sentence denotes After removing the variation attributable to significant covariates, heritabilities of inflammation markers [C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α)] ranged from 33% (TNFα) to 40% (CRP); all P<0.01.
T10 1221-1342 Sentence denotes Higher CRP, IL-6, and TNF-α were associated with lower subcutaneous AT around skeletal muscle (r=-0.13 to -0.19, P<0.05).
T11 1343-1603 Sentence denotes Higher CRP was additionally associated with lower skeletal muscle density, indicative of greater intramuscular AT (r=-0.10, P<0.05), hyperinsulinemia (r=0.12, P<0.05), and increased homeostasis model assessment of insulin resistance (HOMA-IR) (r=0.17, P<0.01).
T12 1604-1616 Sentence denotes CONCLUSIONS:
T13 1617-1768 Sentence denotes Our findings suggest that heredity may play a significant role in the determination of several markers of inflammation in African ancestry individuals.
T14 1769-1932 Sentence denotes Higher concentrations of CRP appear to be associated with greater skeletal muscle AT infiltration, lower subcutaneous AT, hyperinsulinemia, and insulin resistance.
T15 1933-2108 Sentence denotes Longitudinal studies are needed to further evaluate the relationship between inflammation with changes in skeletal muscle AT distribution with aging and the incidence of T2DM.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1794-1797 gene:1401 denotes CRP
T1 1891-1907 disease:C0020459 denotes hyperinsulinemia
R1 T0 T1 associated_with CRP,hyperinsulinemia

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 346-363 HP_0000819 denotes diabetes mellitus

Allie

Id Subject Object Predicate Lexical cue
SS1_21501070_2_0 188-202 expanded denotes adipose tissue
SS2_21501070_2_0 204-206 abbr denotes AT
SS1_21501070_2_1 339-363 expanded denotes type 2 diabetes mellitus
SS2_21501070_2_1 365-369 abbr denotes T2DM
SS1_21501070_5_0 934-949 expanded denotes body mass index
SS2_21501070_5_0 951-954 abbr denotes BMI
SS1_21501070_7_0 1087-1105 expanded denotes C-reactive protein
SS2_21501070_7_0 1107-1110 abbr denotes CRP
SS1_21501070_7_1 1113-1126 expanded denotes interleukin-6
SS2_21501070_7_1 1128-1132 abbr denotes IL-6
SS1_21501070_7_2 1139-1162 expanded denotes tumor necrosis factor-α
SS2_21501070_7_2 1164-1169 abbr denotes TNF-α
SS1_21501070_9_0 1525-1575 expanded denotes homeostasis model assessment of insulin resistance
SS2_21501070_9_0 1577-1584 abbr denotes HOMA-IR
AE1_21501070_2_0 SS1_21501070_2_0 SS2_21501070_2_0 abbreviatedTo adipose tissue,AT
AE1_21501070_2_1 SS1_21501070_2_1 SS2_21501070_2_1 abbreviatedTo type 2 diabetes mellitus,T2DM
AE1_21501070_5_0 SS1_21501070_5_0 SS2_21501070_5_0 abbreviatedTo body mass index,BMI
AE1_21501070_7_0 SS1_21501070_7_0 SS2_21501070_7_0 abbreviatedTo C-reactive protein,CRP
AE1_21501070_7_1 SS1_21501070_7_1 SS2_21501070_7_1 abbreviatedTo interleukin-6,IL-6
AE1_21501070_7_2 SS1_21501070_7_2 SS2_21501070_7_2 abbreviatedTo tumor necrosis factor-α,TNF-α
AE1_21501070_9_0 SS1_21501070_9_0 SS2_21501070_9_0 abbreviatedTo homeostasis model assessment of insulin resistance,HOMA-IR

Wangshuguang

Id Subject Object Predicate Lexical cue
T1 208-220 B-Variation denotes infiltration
T2 374-381 B-Variation denotes disease
T3 701-714 B-Variation denotes intermuscular
T4 1418-1428 B-Variation denotes indicative
T5 1537-1542 B-Cell_Physiological_Activity denotes model
T6 1543-1553 I-Cell_Physiological_Activity denotes assessment
T7 1891-1907 B-Variation denotes hyperinsulinemia
T8 1913-1920 B-Molecular_Activity denotes insulin
T9 1921-1931 I-Molecular_Activity denotes resistance
T10 2090-2099 B-Molecular_Activity denotes incidence

123123123

Id Subject Object Predicate Lexical cue
T1 208-220 B-Variation denotes infiltration
T2 374-381 B-Variation denotes disease
T3 701-714 B-Variation denotes intermuscular
T4 1418-1428 B-Variation denotes indicative
T5 1537-1542 B-Cell_Physiological_Activity denotes model
T6 1543-1553 I-Cell_Physiological_Activity denotes assessment
T7 1891-1907 B-Variation denotes hyperinsulinemia
T8 1913-1920 B-Molecular_Activity denotes insulin
T9 1921-1931 I-Molecular_Activity denotes resistance
T10 2090-2099 B-Molecular_Activity denotes incidence