PubMed:21454543
Annnotations
PubTator4TogoVar
| Id | Subject | Object | Predicate | Lexical cue | proteinmutation |
|---|---|---|---|---|---|
| 21454543_0 | 50-56 | ProteinMutation | denotes | G2019S | rs34637584 |
| 21454543_1 | 342-348 | ProteinMutation | denotes | G2019S | rs34637584 |
| 21454543_2 | 1377-1383 | ProteinMutation | denotes | G2019S | rs34637584 |
| 21454543_3 | 1388-1394 | ProteinMutation | denotes | R1441C | rs33939927 |
| 21454543_4 | 1546-1552 | ProteinMutation | denotes | G2019S | rs34637584 |
c_corpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 0-4 | PR:000013660 | denotes | Rac1 |
| T5 | 0-4 | PR:Q03206 | denotes | Rac1 |
| T6 | 0-4 | PR:Q38912 | denotes | Rac1 |
| T7 | 0-4 | PR:P63001 | denotes | Rac1 |
| T8 | 0-4 | PR:P40792 | denotes | Rac1 |
| T9 | 0-4 | PR:Q6RUV5 | denotes | Rac1 |
| T10 | 0-4 | PR:P63000 | denotes | Rac1 |
| T11 | 0-12 | D020830 | denotes | Rac1 protein |
| T16 | 5-12 | SO:0000104 | denotes | protein |
| T15 | 5-12 | PR:000000001 | denotes | protein |
| T12 | 5-12 | GO:0003675 | denotes | protein |
| T17 | 21-28 | GO:0043005 | denotes | neurite |
| T18 | 55-64 | CHEBI:15603 | denotes | S leucine |
| T20 | 57-64 | 6308 | denotes | leucine |
| T21 | 57-64 | SO:0001437 | denotes | leucine |
| T25 | 70-76 | SO:0001068 | denotes | repeat |
| T26 | 87-92 | PR:Q5S006 | denotes | LRRK2 |
| T27 | 87-92 | PR:000003033 | denotes | LRRK2 |
| T28 | 87-92 | PR:Q5S007 | denotes | LRRK2 |
| T30 | 108-115 | 6308 | denotes | leucine |
| T31 | 108-115 | SO:0001437 | denotes | leucine |
| T29 | 108-115 | CHEBI:15603 | denotes | leucine |
| T32 | 108-115 | D007930 | denotes | leucine |
| T33 | 108-115 | CHEBI:25017 | denotes | leucine |
| T34 | 108-115 | D007930 | denotes | leucine |
| T35 | 121-127 | SO:0001068 | denotes | repeat |
| T36 | 138-143 | PR:Q5S006 | denotes | LRRK2 |
| T37 | 138-143 | PR:000003033 | denotes | LRRK2 |
| T38 | 138-143 | PR:Q5S007 | denotes | LRRK2 |
| T39 | 201-211 | D000067562 | denotes | late-onset |
| T40 | 201-211 | D000067562 | denotes | late-onset |
| T43 | 212-229 | D010300 | denotes | Parkinson disease |
| T44 | 212-229 | D010300 | denotes | Parkinson disease |
| T47 | 285-292 | D004194 | denotes | disease |
| T48 | 285-292 | D004194 | denotes | disease |
| T49 | 323-331 | SO:0000109 | denotes | mutation |
| T50 | 335-340 | PR:Q5S006 | denotes | LRRK2 |
| T51 | 335-340 | PR:000003033 | denotes | LRRK2 |
| T52 | 335-340 | PR:Q5S007 | denotes | LRRK2 |
| T53 | 349-354 | PR:Q5S006 | denotes | LRRK2 |
| T54 | 349-354 | PR:000003033 | denotes | LRRK2 |
| T55 | 349-354 | PR:Q5S007 | denotes | LRRK2 |
| T56 | 374-381 | GO:0043005 | denotes | neurite |
| T57 | 435-445 | GO:0065007 | denotes | regulation |
| T58 | 449-456 | GO:0043005 | denotes | neurite |
| T59 | 467-472 | PR:Q5S006 | denotes | LRRK2 |
| T60 | 467-472 | PR:000003033 | denotes | LRRK2 |
| T61 | 467-472 | PR:Q5S007 | denotes | LRRK2 |
| T62 | 477-484 | 32644 | denotes | unknown |
| T63 | 535-540 | PR:Q5S006 | denotes | LRRK2 |
| T64 | 535-540 | PR:000003033 | denotes | LRRK2 |
| T65 | 535-540 | PR:Q5S007 | denotes | LRRK2 |
| T66 | 549-552 | PR:P51489 | denotes | Rho |
| T67 | 549-552 | PR:Q03222 | denotes | Rho |
| T68 | 549-552 | PR:P0AG30 | denotes | Rho |
| T69 | 549-552 | PR:P15409 | denotes | Rho |
| T70 | 549-552 | PR:P02699 | denotes | Rho |
| T71 | 549-552 | PR:000023742 | denotes | Rho |
| T73 | 549-552 | PR:P22328 | denotes | Rho |
| T74 | 549-552 | PR:000001245 | denotes | Rho |
| T75 | 549-552 | PR:P20350 | denotes | Rho |
| T76 | 549-552 | A0A059WLZ7 | denotes | Rho |
| T77 | 549-552 | PR:P08100 | denotes | Rho |
| T78 | 549-552 | PR:P35359 | denotes | Rho |
| T72 | 549-552 | CVCL_F405 | denotes | Rho |
| T79 | 553-559 | D020558 | denotes | GTPase |
| T83 | 561-565 | PR:000013660 | denotes | Rac1 |
| T84 | 561-565 | PR:Q03206 | denotes | Rac1 |
| T85 | 561-565 | PR:Q38912 | denotes | Rac1 |
| T86 | 561-565 | PR:P63001 | denotes | Rac1 |
| T87 | 561-565 | PR:P40792 | denotes | Rac1 |
| T88 | 561-565 | PR:Q6RUV5 | denotes | Rac1 |
| T89 | 561-565 | PR:P63000 | denotes | Rac1 |
| T90 | 598-603 | P53491 | denotes | actin |
| T91 | 598-603 | P45520 | denotes | actin |
| T92 | 598-603 | O00937 | denotes | actin |
| T93 | 598-603 | Q05214 | denotes | actin |
| T94 | 598-603 | P13363 | denotes | actin |
| T95 | 598-603 | Q39596 | denotes | actin |
| T96 | 598-603 | P30161 | denotes | actin |
| T97 | 598-603 | P53476 | denotes | actin |
| T98 | 598-603 | P51775 | denotes | actin |
| T99 | 598-603 | P60011 | denotes | actin |
| T100 | 598-603 | Q9P4D1 | denotes | actin |
| T101 | 598-603 | P50138 | denotes | actin |
| T102 | 598-603 | O65314 | denotes | actin |
| T103 | 598-603 | P26183 | denotes | actin |
| T104 | 598-603 | Q75D00 | denotes | actin |
| T105 | 598-603 | P53502 | denotes | actin |
| T106 | 598-603 | P11426 | denotes | actin |
| T107 | 598-603 | P80709 | denotes | actin |
| T108 | 598-603 | Q8X119 | denotes | actin |
| T109 | 598-603 | Q6TCF2 | denotes | actin |
| T110 | 598-603 | Q99023 | denotes | actin |
| T111 | 598-603 | A5DQP9 | denotes | actin |
| T112 | 598-603 | P60009 | denotes | actin |
| T113 | 598-603 | O65315 | denotes | actin |
| T114 | 598-603 | P26182 | denotes | actin |
| T115 | 598-603 | Q9UVF3 | denotes | actin |
| T116 | 598-603 | Q2U7A3 | denotes | actin |
| T117 | 598-603 | Q92192 | denotes | actin |
| T118 | 598-603 | Q9UVZ8 | denotes | actin |
| T119 | 598-603 | P53689 | denotes | actin |
| T120 | 598-603 | P68555 | denotes | actin |
| T121 | 598-603 | P53455 | denotes | actin |
| T122 | 598-603 | O13419 | denotes | actin |
| T123 | 598-603 | P60010 | denotes | actin |
| T124 | 598-603 | Q39758 | denotes | actin |
| T125 | 598-603 | P81085 | denotes | actin |
| T126 | 598-603 | P48465 | denotes | actin |
| T127 | 598-603 | P78711 | denotes | actin |
| T128 | 598-603 | P17128 | denotes | actin |
| T129 | 598-603 | P91754 | denotes | actin |
| T130 | 598-603 | Q24733 | denotes | actin |
| T131 | 598-603 | P14235 | denotes | actin |
| T132 | 598-603 | Q92193 | denotes | actin |
| T133 | 598-603 | Q11212 | denotes | actin |
| T134 | 598-603 | P45521 | denotes | actin |
| T135 | 598-603 | P53477 | denotes | actin |
| T136 | 598-603 | P53499 | denotes | actin |
| T137 | 598-603 | P24902 | denotes | actin |
| T138 | 598-603 | Q8SWN8 | denotes | actin |
| T139 | 598-603 | O17320 | denotes | actin |
| T140 | 598-603 | P10365 | denotes | actin |
| T142 | 598-603 | O16808 | denotes | actin |
| T143 | 598-603 | P53498 | denotes | actin |
| T144 | 598-603 | Q9UVX4 | denotes | actin |
| T145 | 598-603 | O81221 | denotes | actin |
| T146 | 598-603 | P20904 | denotes | actin |
| T147 | 598-603 | O65316 | denotes | actin |
| T148 | 598-603 | O74258 | denotes | actin |
| T149 | 598-603 | P53500 | denotes | actin |
| T150 | 598-603 | P10989 | denotes | actin |
| T151 | 598-603 | P90689 | denotes | actin |
| T141 | 598-603 | D000199 | denotes | actin |
| T152 | 598-616 | GO:0015629 | denotes | actin cytoskeleton |
| T153 | 598-627 | GO:0031532 | denotes | actin cytoskeleton remodeling |
| T155 | 661-668 | GO:0043005 | denotes | neurite |
| T156 | 681-686 | PR:Q5S006 | denotes | LRRK2 |
| T157 | 681-686 | PR:000003033 | denotes | LRRK2 |
| T158 | 681-686 | PR:Q5S007 | denotes | LRRK2 |
| T162 | 729-733 | PR:000013660 | denotes | Rac1 |
| T163 | 729-733 | PR:Q03206 | denotes | Rac1 |
| T164 | 729-733 | PR:Q38912 | denotes | Rac1 |
| T165 | 729-733 | PR:P63001 | denotes | Rac1 |
| T166 | 729-733 | PR:P40792 | denotes | Rac1 |
| T167 | 729-733 | PR:Q6RUV5 | denotes | Rac1 |
| T168 | 729-733 | PR:P63000 | denotes | Rac1 |
| T169 | 754-761 | SO:0100018 | denotes | binding |
| T170 | 754-761 | SO:0001091 | denotes | binding |
| T171 | 754-761 | GO:0005488 | denotes | binding |
| T172 | 765-768 | CL:0000990 | denotes | Cdc |
| T173 | 765-770 | PR:P19073 | denotes | Cdc42 |
| T174 | 765-770 | PR:P60953 | denotes | Cdc42 |
| T175 | 765-770 | PR:Q01112 | denotes | Cdc42 |
| T176 | 765-770 | PR:P60766 | denotes | Cdc42 |
| T177 | 765-770 | PR:P40793 | denotes | Cdc42 |
| T178 | 765-770 | PR:Q90694 | denotes | Cdc42 |
| T179 | 765-770 | PR:Q05062 | denotes | Cdc42 |
| T180 | 765-770 | PR:000005204 | denotes | Cdc42 |
| T181 | 765-770 | PR:Q8CFN2 | denotes | Cdc42 |
| T182 | 765-770 | PR:P0CY33 | denotes | Cdc42 |
| T183 | 775-785 | GO:0070026 | denotes | no binding |
| T184 | 778-785 | SO:0100018 | denotes | binding |
| T185 | 778-785 | SO:0001091 | denotes | binding |
| T187 | 789-793 | PR:Q22038 | denotes | RhoA |
| T188 | 789-793 | PR:000000176 | denotes | RhoA |
| T189 | 789-793 | PR:Q9QUI0 | denotes | RhoA |
| T190 | 789-793 | PR:P61589 | denotes | RhoA |
| T191 | 789-793 | PR:P61585 | denotes | RhoA |
| T192 | 789-793 | PR:P61586 | denotes | RhoA |
| T193 | 814-819 | PR:Q5S006 | denotes | LRRK2 |
| T194 | 814-819 | PR:000003033 | denotes | LRRK2 |
| T195 | 814-819 | PR:Q5S007 | denotes | LRRK2 |
| T199 | 830-834 | PR:000013660 | denotes | Rac1 |
| T200 | 830-834 | PR:Q03206 | denotes | Rac1 |
| T201 | 830-834 | PR:Q38912 | denotes | Rac1 |
| T202 | 830-834 | PR:P63001 | denotes | Rac1 |
| T203 | 830-834 | PR:P40792 | denotes | Rac1 |
| T204 | 830-834 | PR:Q6RUV5 | denotes | Rac1 |
| T205 | 830-834 | PR:P63000 | denotes | Rac1 |
| T206 | 867-874 | SO:0100018 | denotes | binding |
| T207 | 867-874 | SO:0001091 | denotes | binding |
| T208 | 867-874 | GO:0005488 | denotes | binding |
| T224 | 882-902 | G5EGQ3 | denotes | p21-activated kinase |
| T276 | 920-925 | D000199 | denotes | actin |
| T287 | 920-938 | P53463 | denotes | actin cytoskeletal |
| T288 | 920-938 | P53464 | denotes | actin cytoskeletal |
| T289 | 949-954 | PR:Q5S006 | denotes | LRRK2 |
| T290 | 949-954 | PR:000003033 | denotes | LRRK2 |
| T291 | 949-954 | PR:Q5S007 | denotes | LRRK2 |
| T292 | 1015-1021 | D020558 | denotes | GTPase |
| T296 | 1049-1053 | PR:000013660 | denotes | Rac1 |
| T297 | 1049-1053 | PR:Q03206 | denotes | Rac1 |
| T298 | 1049-1053 | PR:Q38912 | denotes | Rac1 |
| T299 | 1049-1053 | PR:P63001 | denotes | Rac1 |
| T300 | 1049-1053 | PR:P40792 | denotes | Rac1 |
| T301 | 1049-1053 | PR:Q6RUV5 | denotes | Rac1 |
| T302 | 1049-1053 | PR:P63000 | denotes | Rac1 |
| T303 | 1070-1075 | PR:Q5S006 | denotes | LRRK2 |
| T304 | 1070-1075 | PR:000003033 | denotes | LRRK2 |
| T305 | 1070-1075 | PR:Q5S007 | denotes | LRRK2 |
| T306 | 1104-1112 | UBERON:0000094 | denotes | membrane |
| T308 | 1104-1112 | UBERON:0000158 | denotes | membrane |
| T307 | 1104-1112 | GO:0016020 | denotes | membrane |
| T312 | 1119-1123 | PR:000013660 | denotes | Rac1 |
| T313 | 1119-1123 | PR:Q03206 | denotes | Rac1 |
| T314 | 1119-1123 | PR:Q38912 | denotes | Rac1 |
| T315 | 1119-1123 | PR:P63001 | denotes | Rac1 |
| T316 | 1119-1123 | PR:P40792 | denotes | Rac1 |
| T317 | 1119-1123 | PR:Q6RUV5 | denotes | Rac1 |
| T318 | 1119-1123 | PR:P63000 | denotes | Rac1 |
| T319 | 1153-1174 | GO:0051641 | denotes | cellular localization |
| T324 | 1178-1182 | PR:000013660 | denotes | Rac1 |
| T325 | 1178-1182 | PR:Q03206 | denotes | Rac1 |
| T326 | 1178-1182 | PR:Q38912 | denotes | Rac1 |
| T327 | 1178-1182 | PR:P63001 | denotes | Rac1 |
| T328 | 1178-1182 | PR:P40792 | denotes | Rac1 |
| T329 | 1178-1182 | PR:Q6RUV5 | denotes | Rac1 |
| T330 | 1178-1182 | PR:P63000 | denotes | Rac1 |
| T331 | 1238-1243 | PR:Q5S006 | denotes | LRRK2 |
| T332 | 1238-1243 | PR:000003033 | denotes | LRRK2 |
| T333 | 1238-1243 | PR:Q5S007 | denotes | LRRK2 |
| T337 | 1287-1291 | PR:000013660 | denotes | Rac1 |
| T338 | 1287-1291 | PR:Q03206 | denotes | Rac1 |
| T339 | 1287-1291 | PR:Q38912 | denotes | Rac1 |
| T340 | 1287-1291 | PR:P63001 | denotes | Rac1 |
| T341 | 1287-1291 | PR:P40792 | denotes | Rac1 |
| T342 | 1287-1291 | PR:Q6RUV5 | denotes | Rac1 |
| T343 | 1287-1291 | PR:P63000 | denotes | Rac1 |
| T344 | 1308-1315 | D004194 | denotes | disease |
| T345 | 1308-1315 | D004194 | denotes | disease |
| T346 | 1337-1342 | PR:Q5S006 | denotes | LRRK2 |
| T347 | 1337-1342 | PR:000003033 | denotes | LRRK2 |
| T348 | 1337-1342 | PR:Q5S007 | denotes | LRRK2 |
| T349 | 1351-1358 | SO:0100018 | denotes | binding |
| T350 | 1351-1358 | SO:0001091 | denotes | binding |
| T351 | 1351-1358 | GO:0005488 | denotes | binding |
| T355 | 1362-1366 | PR:000013660 | denotes | Rac1 |
| T356 | 1362-1366 | PR:Q03206 | denotes | Rac1 |
| T357 | 1362-1366 | PR:Q38912 | denotes | Rac1 |
| T358 | 1362-1366 | PR:P63001 | denotes | Rac1 |
| T359 | 1362-1366 | PR:P40792 | denotes | Rac1 |
| T360 | 1362-1366 | PR:Q6RUV5 | denotes | Rac1 |
| T361 | 1362-1366 | PR:P63000 | denotes | Rac1 |
| T362 | 1395-1400 | PR:Q5S006 | denotes | LRRK2 |
| T363 | 1395-1400 | PR:000003033 | denotes | LRRK2 |
| T364 | 1395-1400 | PR:Q5S007 | denotes | LRRK2 |
| T368 | 1423-1427 | PR:000013660 | denotes | Rac1 |
| T369 | 1423-1427 | PR:Q03206 | denotes | Rac1 |
| T370 | 1423-1427 | PR:Q38912 | denotes | Rac1 |
| T371 | 1423-1427 | PR:P63001 | denotes | Rac1 |
| T372 | 1423-1427 | PR:P40792 | denotes | Rac1 |
| T373 | 1423-1427 | PR:Q6RUV5 | denotes | Rac1 |
| T374 | 1423-1427 | PR:P63000 | denotes | Rac1 |
| T375 | 1428-1435 | SO:0100018 | denotes | binding |
| T376 | 1428-1435 | SO:0001091 | denotes | binding |
| T377 | 1428-1435 | GO:0005488 | denotes | binding |
| T378 | 1462-1467 | PR:Q5S006 | denotes | LRRK2 |
| T379 | 1462-1467 | PR:000003033 | denotes | LRRK2 |
| T380 | 1462-1467 | PR:Q5S007 | denotes | LRRK2 |
| T381 | 1489-1496 | SO:0100018 | denotes | binding |
| T382 | 1489-1496 | SO:0001091 | denotes | binding |
| T383 | 1489-1496 | GO:0005488 | denotes | binding |
| T387 | 1512-1516 | PR:000013660 | denotes | Rac1 |
| T388 | 1512-1516 | PR:Q03206 | denotes | Rac1 |
| T389 | 1512-1516 | PR:Q38912 | denotes | Rac1 |
| T390 | 1512-1516 | PR:P63001 | denotes | Rac1 |
| T391 | 1512-1516 | PR:P40792 | denotes | Rac1 |
| T392 | 1512-1516 | PR:Q6RUV5 | denotes | Rac1 |
| T393 | 1512-1516 | PR:P63000 | denotes | Rac1 |
| T394 | 1520-1527 | CVCL_0019 | denotes | SH-SY5Y |
| T396 | 1573-1580 | GO:0043005 | denotes | neurite |
| T397 | 1639-1644 | PR:Q5S006 | denotes | LRRK2 |
| T398 | 1639-1644 | PR:000003033 | denotes | LRRK2 |
| T399 | 1639-1644 | PR:Q5S007 | denotes | LRRK2 |
| T403 | 1670-1674 | PR:000013660 | denotes | Rac1 |
| T404 | 1670-1674 | PR:Q03206 | denotes | Rac1 |
| T405 | 1670-1674 | PR:Q38912 | denotes | Rac1 |
| T406 | 1670-1674 | PR:P63001 | denotes | Rac1 |
| T407 | 1670-1674 | PR:P40792 | denotes | Rac1 |
| T408 | 1670-1674 | PR:Q6RUV5 | denotes | Rac1 |
| T409 | 1670-1674 | PR:P63000 | denotes | Rac1 |
| T410 | 1699-1704 | P53491 | denotes | actin |
| T411 | 1699-1704 | P45520 | denotes | actin |
| T412 | 1699-1704 | O00937 | denotes | actin |
| T413 | 1699-1704 | Q05214 | denotes | actin |
| T414 | 1699-1704 | P13363 | denotes | actin |
| T415 | 1699-1704 | Q39596 | denotes | actin |
| T416 | 1699-1704 | P30161 | denotes | actin |
| T417 | 1699-1704 | P53476 | denotes | actin |
| T418 | 1699-1704 | P51775 | denotes | actin |
| T419 | 1699-1704 | P60011 | denotes | actin |
| T420 | 1699-1704 | Q9P4D1 | denotes | actin |
| T421 | 1699-1704 | P50138 | denotes | actin |
| T422 | 1699-1704 | O65314 | denotes | actin |
| T423 | 1699-1704 | P26183 | denotes | actin |
| T424 | 1699-1704 | Q75D00 | denotes | actin |
| T425 | 1699-1704 | P53502 | denotes | actin |
| T426 | 1699-1704 | P11426 | denotes | actin |
| T427 | 1699-1704 | P80709 | denotes | actin |
| T428 | 1699-1704 | Q8X119 | denotes | actin |
| T429 | 1699-1704 | Q6TCF2 | denotes | actin |
| T430 | 1699-1704 | Q99023 | denotes | actin |
| T431 | 1699-1704 | A5DQP9 | denotes | actin |
| T432 | 1699-1704 | P60009 | denotes | actin |
| T433 | 1699-1704 | O65315 | denotes | actin |
| T434 | 1699-1704 | P26182 | denotes | actin |
| T435 | 1699-1704 | Q9UVF3 | denotes | actin |
| T436 | 1699-1704 | Q2U7A3 | denotes | actin |
| T437 | 1699-1704 | Q92192 | denotes | actin |
| T438 | 1699-1704 | Q9UVZ8 | denotes | actin |
| T439 | 1699-1704 | P53689 | denotes | actin |
| T440 | 1699-1704 | P68555 | denotes | actin |
| T441 | 1699-1704 | P53455 | denotes | actin |
| T442 | 1699-1704 | O13419 | denotes | actin |
| T443 | 1699-1704 | P60010 | denotes | actin |
| T444 | 1699-1704 | Q39758 | denotes | actin |
| T445 | 1699-1704 | P81085 | denotes | actin |
| T446 | 1699-1704 | P48465 | denotes | actin |
| T447 | 1699-1704 | P78711 | denotes | actin |
| T448 | 1699-1704 | P17128 | denotes | actin |
| T449 | 1699-1704 | P91754 | denotes | actin |
| T450 | 1699-1704 | Q24733 | denotes | actin |
| T451 | 1699-1704 | P14235 | denotes | actin |
| T452 | 1699-1704 | Q92193 | denotes | actin |
| T453 | 1699-1704 | Q11212 | denotes | actin |
| T454 | 1699-1704 | P45521 | denotes | actin |
| T455 | 1699-1704 | P53477 | denotes | actin |
| T456 | 1699-1704 | P53499 | denotes | actin |
| T457 | 1699-1704 | P24902 | denotes | actin |
| T458 | 1699-1704 | Q8SWN8 | denotes | actin |
| T459 | 1699-1704 | O17320 | denotes | actin |
| T460 | 1699-1704 | P10365 | denotes | actin |
| T462 | 1699-1704 | O16808 | denotes | actin |
| T463 | 1699-1704 | P53498 | denotes | actin |
| T464 | 1699-1704 | Q9UVX4 | denotes | actin |
| T465 | 1699-1704 | O81221 | denotes | actin |
| T466 | 1699-1704 | P20904 | denotes | actin |
| T467 | 1699-1704 | O65316 | denotes | actin |
| T468 | 1699-1704 | O74258 | denotes | actin |
| T469 | 1699-1704 | P53500 | denotes | actin |
| T470 | 1699-1704 | P10989 | denotes | actin |
| T471 | 1699-1704 | P90689 | denotes | actin |
| T461 | 1699-1704 | D000199 | denotes | actin |
| T472 | 1727-1734 | GO:0043005 | denotes | neurite |
| T473 | 1772-1777 | PR:Q5S006 | denotes | LRRK2 |
| T474 | 1772-1777 | PR:000003033 | denotes | LRRK2 |
| T475 | 1772-1777 | PR:Q5S007 | denotes | LRRK2 |
| T476 | 1782-1785 | PR:P51489 | denotes | Rho |
| T477 | 1782-1785 | PR:Q03222 | denotes | Rho |
| T478 | 1782-1785 | PR:P0AG30 | denotes | Rho |
| T479 | 1782-1785 | PR:P15409 | denotes | Rho |
| T480 | 1782-1785 | PR:P02699 | denotes | Rho |
| T481 | 1782-1785 | PR:000023742 | denotes | Rho |
| T483 | 1782-1785 | PR:P22328 | denotes | Rho |
| T484 | 1782-1785 | PR:000001245 | denotes | Rho |
| T485 | 1782-1785 | PR:P20350 | denotes | Rho |
| T486 | 1782-1785 | A0A059WLZ7 | denotes | Rho |
| T487 | 1782-1785 | PR:P08100 | denotes | Rho |
| T488 | 1782-1785 | PR:P35359 | denotes | Rho |
| T482 | 1782-1785 | CVCL_F405 | denotes | Rho |
| T489 | 1782-1793 | D020741 | denotes | Rho GTPases |
| T491 | 1810-1817 | CHEBI:34922 | denotes | pathway |
| T492 | 1832-1837 | PR:Q5S006 | denotes | LRRK2 |
| T493 | 1832-1837 | PR:000003033 | denotes | LRRK2 |
| T494 | 1832-1837 | PR:Q5S007 | denotes | LRRK2 |
| T497 | 1912-1929 | D010300 | denotes | Parkinson disease |
| T498 | 1912-1929 | D010300 | denotes | Parkinson disease |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-94 | Sentence | denotes | Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). |
| T2 | 95-293 | Sentence | denotes | Mutations in leucine-rich repeat kinase 2 (LRRK2) are currently the most common genetic cause of familial late-onset Parkinson disease, which is clinically indistinguishable from idiopathic disease. |
| T3 | 294-393 | Sentence | denotes | The most common pathological mutation in LRRK2, G2019S LRRK2, is known to cause neurite retraction. |
| T4 | 394-485 | Sentence | denotes | However, molecular mechanisms underlying regulation of neurite length by LRRK2 are unknown. |
| T5 | 486-680 | Sentence | denotes | Here, we demonstrate a novel interaction between LRRK2 and the Rho GTPase, Rac1, which plays a critical role in actin cytoskeleton remodeling necessary for the maintenance of neurite morphology. |
| T6 | 681-794 | Sentence | denotes | LRRK2 binds strongly to endogenous or expressed Rac1, while showing weak binding to Cdc42 and no binding to RhoA. |
| T7 | 795-948 | Sentence | denotes | Co-expression with LRRK2 increases Rac1 activity, as shown by increased binding to the p21-activated kinase, which modulates actin cytoskeletal dynamics. |
| T8 | 949-1054 | Sentence | denotes | LRRK2 constructs carrying mutations that inactivate the kinase or GTPase activities do not activate Rac1. |
| T9 | 1055-1292 | Sentence | denotes | Interestingly, LRRK2 does not increase levels of membrane-bound Rac1 but dramatically changes the cellular localization of Rac1, causing polarization, which is augmented further when LRRK2 is co-expressed with constitutively active Rac1. |
| T10 | 1293-1497 | Sentence | denotes | Four different disease-related mutations in LRRK2 altered binding to Rac1, with the G2019S and R1441C LRRK2 mutations attenuating Rac1 binding and the Y1699C and I2020T LRRK2 mutations increasing binding. |
| T11 | 1498-1592 | Sentence | denotes | Co-expressing Rac1 in SH-SY5Y cells rescues the G2019S mutant phenotype of neurite retraction. |
| T12 | 1593-1746 | Sentence | denotes | We hypothesize that pathological mutations in LRRK2 attenuates activation of Rac1, causing disassembly of actin filaments, leading to neurite retraction. |
| T13 | 1747-1930 | Sentence | denotes | The interactions between LRRK2 and Rho GTPases provide a novel pathway through which LRRK2 might modulate cellular dynamics and contribute to the pathophysiology of Parkinson disease. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 108-136 | gene:120892 | denotes | leucine-rich repeat kinase 2 |
| T1 | 201-229 | disease:C3160718 | denotes | late-onset Parkinson disease |
| T2 | 108-136 | gene:120892 | denotes | leucine-rich repeat kinase 2 |
| T3 | 274-292 | disease:C0277553 | denotes | idiopathic disease |
| T4 | 138-143 | gene:120892 | denotes | LRRK2 |
| T5 | 201-229 | disease:C3160718 | denotes | late-onset Parkinson disease |
| T6 | 138-143 | gene:120892 | denotes | LRRK2 |
| T7 | 274-292 | disease:C0277553 | denotes | idiopathic disease |
| R1 | T0 | T1 | associated_with | leucine-rich repeat kinase 2,late-onset Parkinson disease |
| R2 | T2 | T3 | associated_with | leucine-rich repeat kinase 2,idiopathic disease |
| R3 | T4 | T5 | associated_with | LRRK2,late-onset Parkinson disease |
| R4 | T6 | T7 | associated_with | LRRK2,idiopathic disease |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 212-221 | HP_0001300 | denotes | Parkinson |
| T2 | 1912-1921 | HP_0001300 | denotes | Parkinson |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_21454543_0_0 | 57-85 | expanded | denotes | leucine-rich repeat kinase 2 |
| SS2_21454543_0_0 | 87-92 | abbr | denotes | LRRK2 |
| SS1_21454543_1_0 | 108-136 | expanded | denotes | leucine-rich repeat kinase 2 |
| SS2_21454543_1_0 | 138-143 | abbr | denotes | LRRK2 |
| AE1_21454543_0_0 | SS1_21454543_0_0 | SS2_21454543_0_0 | abbreviatedTo | leucine-rich repeat kinase 2,LRRK2 |
| AE1_21454543_1_0 | SS1_21454543_1_0 | SS2_21454543_1_0 | abbreviatedTo | leucine-rich repeat kinase 2,LRRK2 |
UseCases_ArguminSci_Discourse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-94 | DRI_Approach | denotes | Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). |
| T2 | 95-293 | DRI_Background | denotes | Mutations in leucine-rich repeat kinase 2 (LRRK2) are currently the most common genetic cause of familial late-onset Parkinson disease, which is clinically indistinguishable from idiopathic disease. |
| T3 | 294-341 | DRI_Background | denotes | The most common pathological mutation in LRRK2, |
| T4 | 342-354 | Token_Label.OUTSIDE | denotes | G2019S LRRK2 |
| T5 | 354-393 | DRI_Background | denotes | , is known to cause neurite retraction. |
| T6 | 394-485 | DRI_Background | denotes | However, molecular mechanisms underlying regulation of neurite length by LRRK2 are unknown. |
| T7 | 486-680 | DRI_Outcome | denotes | Here, we demonstrate a novel interaction between LRRK2 and the Rho GTPase, Rac1, which plays a critical role in actin cytoskeleton remodeling necessary for the maintenance of neurite morphology. |
| T8 | 681-794 | DRI_Outcome | denotes | LRRK2 binds strongly to endogenous or expressed Rac1, while showing weak binding to Cdc42 and no binding to RhoA. |
| T9 | 795-948 | DRI_Outcome | denotes | Co-expression with LRRK2 increases Rac1 activity, as shown by increased binding to the p21-activated kinase, which modulates actin cytoskeletal dynamics. |
| T10 | 949-1054 | DRI_Approach | denotes | LRRK2 constructs carrying mutations that inactivate the kinase or GTPase activities do not activate Rac1. |
| T11 | 1055-1292 | DRI_Outcome | denotes | Interestingly, LRRK2 does not increase levels of membrane-bound Rac1 but dramatically changes the cellular localization of Rac1, causing polarization, which is augmented further when LRRK2 is co-expressed with constitutively active Rac1. |
| T12 | 1293-1387 | DRI_Approach | denotes | Four different disease-related mutations in LRRK2 altered binding to Rac1, with the G2019S and |
| T13 | 1388-1400 | Token_Label.OUTSIDE | denotes | R1441C LRRK2 |
| T14 | 1401-1454 | DRI_Approach | denotes | mutations attenuating Rac1 binding and the Y1699C and |
| T15 | 1455-1467 | Token_Label.OUTSIDE | denotes | I2020T LRRK2 |
| T16 | 1468-1497 | DRI_Approach | denotes | mutations increasing binding. |
| T17 | 1498-1592 | DRI_Background | denotes | Co-expressing Rac1 in SH-SY5Y cells rescues the G2019S mutant phenotype of neurite retraction. |
| T18 | 1593-1746 | DRI_Outcome | denotes | We hypothesize that pathological mutations in LRRK2 attenuates activation of Rac1, causing disassembly of actin filaments, leading to neurite retraction. |
| T19 | 1747-1930 | DRI_Challenge | denotes | The interactions between LRRK2 and Rho GTPases provide a novel pathway through which LRRK2 might modulate cellular dynamics and contribute to the pathophysiology of Parkinson disease. |
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 95-293 | DRI_Background | denotes | Mutations in leucine-rich repeat kinase 2 (LRRK2) are currently the most common genetic cause of familial late-onset Parkinson disease, which is clinically indistinguishable from idiopathic disease. |
| T2 | 294-341 | DRI_Background | denotes | The most common pathological mutation in LRRK2, |
| T3 | 354-393 | DRI_Background | denotes | , is known to cause neurite retraction. |
| T4 | 394-485 | DRI_Background | denotes | However, molecular mechanisms underlying regulation of neurite length by LRRK2 are unknown. |
| T5 | 486-680 | DRI_Outcome | denotes | Here, we demonstrate a novel interaction between LRRK2 and the Rho GTPase, Rac1, which plays a critical role in actin cytoskeleton remodeling necessary for the maintenance of neurite morphology. |
| T6 | 681-794 | DRI_Outcome | denotes | LRRK2 binds strongly to endogenous or expressed Rac1, while showing weak binding to Cdc42 and no binding to RhoA. |
| T7 | 795-948 | DRI_Outcome | denotes | Co-expression with LRRK2 increases Rac1 activity, as shown by increased binding to the p21-activated kinase, which modulates actin cytoskeletal dynamics. |
| T8 | 949-1054 | DRI_Approach | denotes | LRRK2 constructs carrying mutations that inactivate the kinase or GTPase activities do not activate Rac1. |
| T9 | 1055-1292 | DRI_Outcome | denotes | Interestingly, LRRK2 does not increase levels of membrane-bound Rac1 but dramatically changes the cellular localization of Rac1, causing polarization, which is augmented further when LRRK2 is co-expressed with constitutively active Rac1. |
| T10 | 1293-1387 | DRI_Approach | denotes | Four different disease-related mutations in LRRK2 altered binding to Rac1, with the G2019S and |
| T11 | 1401-1454 | DRI_Approach | denotes | mutations attenuating Rac1 binding and the Y1699C and |
| T12 | 1468-1497 | DRI_Approach | denotes | mutations increasing binding. |
| T13 | 1498-1592 | DRI_Background | denotes | Co-expressing Rac1 in SH-SY5Y cells rescues the G2019S mutant phenotype of neurite retraction. |
| T14 | 1593-1746 | DRI_Outcome | denotes | We hypothesize that pathological mutations in LRRK2 attenuates activation of Rac1, causing disassembly of actin filaments, leading to neurite retraction. |
| T15 | 1747-1930 | DRI_Challenge | denotes | The interactions between LRRK2 and Rho GTPases provide a novel pathway through which LRRK2 might modulate cellular dynamics and contribute to the pathophysiology of Parkinson disease. |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 21454543-1#13#41#gene120892 | 108-136 | gene120892 | denotes | leucine-rich repeat kinase 2 |
| 21454543-1#43#48#gene120892 | 138-143 | gene120892 | denotes | LRRK2 |
| 21454543-1#106#134#diseaseC3160718 | 201-229 | diseaseC3160718 | denotes | late-onset Parkinson disease |
| 21454543-12#25#30#gene120892 | 1772-1777 | gene120892 | denotes | LRRK2 |
| 21454543-12#85#90#gene120892 | 1832-1837 | gene120892 | denotes | LRRK2 |
| 21454543-12#165#182#diseaseC0030567 | 1912-1929 | diseaseC0030567 | denotes | Parkinson disease |
| 13#41#gene120892106#134#diseaseC3160718 | 21454543-1#13#41#gene120892 | 21454543-1#106#134#diseaseC3160718 | associated_with | leucine-rich repeat kinase 2,late-onset Parkinson disease |
| 43#48#gene120892106#134#diseaseC3160718 | 21454543-1#43#48#gene120892 | 21454543-1#106#134#diseaseC3160718 | associated_with | LRRK2,late-onset Parkinson disease |
| 25#30#gene120892165#182#diseaseC0030567 | 21454543-12#25#30#gene120892 | 21454543-12#165#182#diseaseC0030567 | associated_with | LRRK2,Parkinson disease |
| 85#90#gene120892165#182#diseaseC0030567 | 21454543-12#85#90#gene120892 | 21454543-12#165#182#diseaseC0030567 | associated_with | LRRK2,Parkinson disease |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 201-229 | Disease | denotes | late-onset Parkinson disease | http://purl.obolibrary.org/obo/MONDO_0008199|http://purl.obolibrary.org/obo/MONDO_0018466 |
| T3 | 1912-1929 | Disease | denotes | Parkinson disease | http://purl.obolibrary.org/obo/MONDO_0005180 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 212-221 | Phenotype | denotes | Parkinson | HP:0001300 |
| T2 | 1912-1921 | Phenotype | denotes | Parkinson | HP:0001300 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 21-28 | Body_part | denotes | neurite | http://purl.obolibrary.org/obo/GO_0043005 |
| T2 | 374-381 | Body_part | denotes | neurite | http://purl.obolibrary.org/obo/GO_0043005 |
| T3 | 449-456 | Body_part | denotes | neurite | http://purl.obolibrary.org/obo/GO_0043005 |
| T4 | 598-616 | Body_part | denotes | actin cytoskeleton | http://purl.obolibrary.org/obo/GO_0015629 |
| T5 | 661-668 | Body_part | denotes | neurite | http://purl.obolibrary.org/obo/GO_0043005 |
| T6 | 1104-1112 | Body_part | denotes | membrane | http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158 |
| T9 | 1573-1580 | Body_part | denotes | neurite | http://purl.obolibrary.org/obo/GO_0043005 |
| T10 | 1699-1714 | Body_part | denotes | actin filaments | http://purl.obolibrary.org/obo/GO_0005884 |
| T11 | 1727-1734 | Body_part | denotes | neurite | http://purl.obolibrary.org/obo/GO_0043005 |