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PubMed:2144551 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 13-43 DNA denotes immediate early response genes
T2 47-83 protein denotes macrophage colony-stimulating factor
T3 87-109 cell_type denotes normal human monocytes
T4 143-157 DNA denotes protooncogenes
T5 159-203 DNA denotes cytoskeletal, and extracellular matrix genes
T6 221-251 DNA denotes immediate early response genes
T7 298-311 protein denotes growth factor
T8 396-410 protein denotes macrophage-CSF
T9 412-417 protein denotes M-CSF
T10 422-437 cell_type denotes human monocytes
T11 477-482 protein denotes M-CSF
T12 547-562 cell_type denotes human monocytes
T13 700-713 cell_type denotes resting cells
T14 735-740 protein denotes M-CSF
T15 815-828 cell_type denotes resting cells
T16 869-874 RNA denotes c-jun
T17 876-896 RNA denotes fibronectin receptor
T18 902-912 RNA denotes actin mRNA
T19 949-954 protein denotes M-CSF
T20 1027-1037 DNA denotes c-jun gene
T21 1107-1112 protein denotes M-CSF
T22 1154-1189 RNA denotes actin and fibronectin receptor mRNA
T23 1282-1287 protein denotes M-CSF
T24 1336-1384 DNA denotes myelomonocytic specific tyrosine kinase hck gene
T25 1415-1445 DNA denotes immediate early response genes
T26 1589-1594 DNA denotes c-jun
T27 1599-1602 DNA denotes hck
T28 1640-1645 DNA denotes c-jun
T29 1647-1650 DNA denotes hck
T30 1656-1667 DNA denotes actin genes
T31 1683-1705 cell_type denotes normal human monocytes
T32 1706-1711 protein denotes M-CSF
T33 1720-1750 DNA denotes immediate early response genes
T34 1884-1887 protein denotes CSF

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-110 Sentence denotes Induction of immediate early response genes by macrophage colony-stimulating factor in normal human monocytes.
S2 111-342 Sentence denotes A group of coordinately induced protooncogenes, cytoskeletal, and extracellular matrix genes have been termed immediate early response genes, and their induction has been associated with growth factor-stimulated cell proliferation.
S3 343-539 Sentence denotes We have investigated the induction of these genes by macrophage-CSF (M-CSF) in human monocytes that do not proliferate in response to M-CSF but require the factor for optimal cell differentiation.
S4 540-665 Sentence denotes Normal human monocytes were isolated, carefully washed, and incubated for 36 to 48 h in fetal bovine serum-containing medium.
S5 666-797 Sentence denotes At the end of this incubation the resting cells were stimulated with M-CSF, and RNA was isolated for analysis by Northern blotting.
S6 798-913 Sentence denotes RNA from control resting cells contained low to undetectable levels of c-jun, fibronectin receptor, and actin mRNA.
S7 914-1022 Sentence denotes Within 15 to 30 min of addition of M-CSF, however, there was a dramatic coordinate induction of these genes.
S8 1023-1122 Sentence denotes The c-jun gene expression was very transient and was not detectable by 60 min after M-CSF addition.
S9 1123-1297 Sentence denotes In contrast, the expression of actin and fibronectin receptor mRNA was more sustained, and the expression of these genes remained elevated at 24 to 48 h after M-CSF addition.
S10 1298-1446 Sentence denotes We also observed the induction of the myelomonocytic specific tyrosine kinase hck gene simultaneously with the other immediate early response genes.
S11 1447-1603 Sentence denotes The protein synthesis inhibitor cycloheximide did not block the induction of any of these genes, and in fact, super-induced the expression of c-jun and hck.
S12 1604-1668 Sentence denotes Nuclear run on transcription of the c-jun, hck, and actin genes.
S13 1669-1787 Sentence denotes Therefore, in normal human monocytes M-CSF induces immediate early response genes without inducing cell proliferation.
S14 1788-1888 Sentence denotes These genes may then play a role in altering the physiologic status of the cells in response to CSF.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C2 13-43 NP denotes immediate early response genes
C1 0-43 NP denotes Induction of immediate early response genes
C3 47-83 NP denotes macrophage colony-stimulating factor
C4 87-109 NP denotes normal human monocytes
C5 111-203 NP denotes A group of coordinately induced protooncogenes, cytoskeletal, and extracellular matrix genes
C6 221-251 NP denotes immediate early response genes
C8 257-262 NP denotes their
C7 257-272 NP denotes their induction
C10 381-392 NP denotes these genes
C9 364-392 NP denotes the induction of these genes
C11 396-418 NP denotes macrophage-CSF (M-CSF)
C12 422-437 NP denotes human monocytes
C13 438-442 NP denotes that
C14 477-482 NP denotes M-CSF
C15 540-562 NP denotes Normal human monocytes
C16 696-713 NP denotes the resting cells
C17 735-740 NP denotes M-CSF
C18 746-749 NP denotes RNA
C19 798-801 NP denotes RNA
C20 869-912 NP denotes c-jun, fibronectin receptor, and actin mRNA
C21 949-954 NP denotes M-CSF
C22 1010-1021 NP denotes these genes
C23 1107-1112 NP denotes M-CSF
C25 1154-1189 NP denotes actin and fibronectin receptor mRNA
C24 1136-1189 NP denotes the expression of actin and fibronectin receptor mRNA
C27 1232-1243 NP denotes these genes
C26 1214-1243 NP denotes the expression of these genes
C28 1405-1445 NP denotes the other immediate early response genes
C29 1683-1705 NP denotes normal human monocytes
C30 1706-1711 NP denotes M-CSF
C31 1720-1750 NP denotes immediate early response genes
C32 1788-1799 NP denotes These genes
R1 C5 C2 coref-ident "A group of coordinately induced protooncogenes, cytoskeletal, and extracellular matrix genes",immediate early response genes
R2 C6 C5 coref-ident immediate early response genes,"A group of coordinately induced protooncogenes, cytoskeletal, and extracellular matrix genes"
R3 C8 C6 coref-pron their,immediate early response genes
R4 C7 C1 coref-ident their induction,Induction of immediate early response genes
R5 C10 C6 coref-ident these genes,immediate early response genes
R6 C9 C7 coref-ident the induction of these genes,their induction
R7 C11 C3 coref-ident macrophage-CSF (M-CSF),macrophage colony-stimulating factor
R8 C13 C12 coref-relat that,human monocytes
R9 C14 C11 coref-ident M-CSF,macrophage-CSF (M-CSF)
R10 C15 C4 coref-ident Normal human monocytes,normal human monocytes
R11 C16 C15 coref-ident the resting cells,Normal human monocytes
R12 C17 C14 coref-ident M-CSF,M-CSF
R13 C19 C18 coref-ident RNA,RNA
R14 C21 C17 coref-ident M-CSF,M-CSF
R15 C22 C20 coref-ident these genes,"c-jun, fibronectin receptor, and actin mRNA"
R16 C23 C21 coref-ident M-CSF,M-CSF
R17 C27 C25 coref-ident these genes,actin and fibronectin receptor mRNA
R18 C26 C24 coref-ident the expression of these genes,the expression of actin and fibronectin receptor mRNA
R19 C29 C15 coref-ident normal human monocytes,Normal human monocytes
R20 C30 C23 coref-ident M-CSF,M-CSF
R21 C31 C28 coref-ident immediate early response genes,the other immediate early response genes
R22 C32 C31 coref-ident These genes,immediate early response genes

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-43 DNA_family_or_group denotes immediate early response genes
T2 47-83 protein_molecule denotes macrophage colony-stimulating factor
T3 87-109 cell_type denotes normal human monocytes
T4 143-157 DNA_family_or_group denotes protooncogenes
T5 221-251 DNA_family_or_group denotes immediate early response genes
T6 298-311 protein_family_or_group denotes growth factor
T7 396-410 protein_molecule denotes macrophage-CSF
T8 412-417 protein_molecule denotes M-CSF
T9 422-437 cell_type denotes human monocytes
T10 477-482 protein_molecule denotes M-CSF
T11 518-538 other_name denotes cell differentiation
T12 547-562 cell_type denotes human monocytes
T13 628-664 other_organic_compound denotes fetal bovine serum-containing medium
T14 700-713 cell_type denotes resting cells
T15 735-740 protein_molecule denotes M-CSF
T16 779-796 other_name denotes Northern blotting
T17 815-828 cell_type denotes resting cells
T18 869-874 RNA_molecule denotes c-jun
T19 876-896 RNA_molecule denotes fibronectin receptor
T20 902-912 RNA_molecule denotes actin mRNA
T21 949-954 protein_molecule denotes M-CSF
T22 1027-1037 DNA_domain_or_region denotes c-jun gene
T23 1107-1112 protein_molecule denotes M-CSF
T24 1140-1150 other_name denotes expression
T25 1282-1287 protein_molecule denotes M-CSF
T26 1336-1375 protein_molecule denotes myelomonocytic specific tyrosine kinase
T27 1415-1445 DNA_family_or_group denotes immediate early response genes
T28 1451-1478 other_name denotes protein synthesis inhibitor
T29 1479-1492 other_organic_compound denotes cycloheximide
T30 1589-1594 DNA_domain_or_region denotes c-jun
T31 1599-1602 DNA_domain_or_region denotes hck
T32 1640-1645 DNA_domain_or_region denotes c-jun
T33 1647-1650 DNA_domain_or_region denotes hck
T34 1656-1667 DNA_domain_or_region denotes actin genes
T35 1683-1689 cell_type denotes normal
T36 1690-1705 cell_type denotes human monocytes
T37 1706-1711 protein_molecule denotes M-CSF
T38 1720-1750 DNA_family_or_group denotes immediate early response genes
T39 1884-1887 protein_family_or_group denotes CSF