PubMed:2139896 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/2139896","sourcedb":"PubMed","sourceid":"2139896","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/2139896","text":"Human immunodeficiency virus vpr product is a virion-associated regulatory protein.\nThe vpr product of the human immunodeficiency virus type 1 (HIV-1) acts in trans to accelerate virus replication and cytopathic effect in T cells. Here it is shown that the HIV-1 viral particle contains multiple copies of the vpr protein. The vpr product is the first regulatory protein of HIV-1 to be found in the virus particle. This observation raises the possibility that vpr acts to facilitate the early steps of infection before de novo viral protein synthesis 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