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PubMed:21389771 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 573-588 HP_0100280 denotes Crohn's disease

disease_gene_microbe_small

Id Subject Object Predicate Lexical cue
T0 574-589 DOID:8778 denotes rohn's disease,
T1 594-620 DOID:0050589 denotes nflammatory bowel disease.
T2 256-278 taxonomy:6239 denotes aenorhabditis elegans
T3 352-360 taxonomy:6231 denotes ematode

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-88 Sentence denotes Quantitative proteomics identifies ferritin in the innate immune response of C. elegans.
T2 89-222 Sentence denotes When encountering a pathogen, all organisms evoke a protective response by inducing defense mechanisms to help fight off the invader.
T3 223-428 Sentence denotes The invertebrate model organism Caenorhabditis elegans has proven to be valuable for studies of the host response and the small nematode mounts a substantial transcriptional response to numerous pathogens.
T4 429-620 Sentence denotes Here, we use global quantitative proteomics to profile the response to infection with E. coli strain LF82 isolated from patients suffering from Crohn's disease, an inflammatory bowel disease.
T5 621-688 Sentence denotes We show that LF82 infection induces more than one hundred proteins.
T6 689-841 Sentence denotes The response share many functional categories with other innate immunity studies in C. elegans, but also identifies novel host immune effector proteins.
T7 842-951 Sentence denotes We demonstrate functional relevance for four LF82 induced proteins, including a lysozyme and a C-type lectin.
T8 952-1122 Sentence denotes The ferritin homolog FTN-2 was shown to be necessary for the full protective response against the Gram-negative LF82 and the Gram-positive pathogen Staphylococcus aureus.
T9 1123-1392 Sentence denotes This study is the first to demonstrate a role for ferritin in the innate immune response of C. elegans, and our results suggests that quantitative proteomics is an attractive approach for identifying additional components in the complex immune response of the nematode.
T1 0-88 Sentence denotes Quantitative proteomics identifies ferritin in the innate immune response of C. elegans.
T2 89-222 Sentence denotes When encountering a pathogen, all organisms evoke a protective response by inducing defense mechanisms to help fight off the invader.
T3 223-428 Sentence denotes The invertebrate model organism Caenorhabditis elegans has proven to be valuable for studies of the host response and the small nematode mounts a substantial transcriptional response to numerous pathogens.
T4 429-620 Sentence denotes Here, we use global quantitative proteomics to profile the response to infection with E. coli strain LF82 isolated from patients suffering from Crohn's disease, an inflammatory bowel disease.
T5 621-688 Sentence denotes We show that LF82 infection induces more than one hundred proteins.
T6 689-841 Sentence denotes The response share many functional categories with other innate immunity studies in C. elegans, but also identifies novel host immune effector proteins.
T7 842-951 Sentence denotes We demonstrate functional relevance for four LF82 induced proteins, including a lysozyme and a C-type lectin.
T8 952-1122 Sentence denotes The ferritin homolog FTN-2 was shown to be necessary for the full protective response against the Gram-negative LF82 and the Gram-positive pathogen Staphylococcus aureus.
T9 1123-1392 Sentence denotes This study is the first to demonstrate a role for ferritin in the innate immune response of C. elegans, and our results suggests that quantitative proteomics is an attractive approach for identifying additional components in the complex immune response of the nematode.