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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 450-459 Glycan_Motif denotes T antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO
T2 557-566 Glycan_Motif denotes T antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00031MO

sentences

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma.
T2 165-300 Sentence denotes Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer.
T3 301-489 Sentence denotes Here we report cloning of the urothelium-specific promoter uroplakin-II (UPK II) and generation of transgenic mice in which expression of SV40 large T antigen is driven by UPK II promoter.
T4 490-647 Sentence denotes Inactivation of tumor suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma, resembling human high-grade carcinoma in situ.
T5 648-793 Sentence denotes Specific deletion of p53 in urothelial cells using the newly generated UPK II-Cre mice results in normal bladders without any evidence of cancer.
T6 794-1017 Sentence denotes The high-grade carcinoma in situ in the UPK II-SV40 mice is associated with significant activation of angiogenic signals consisting of hypoxia-inducible factor-1α (HIF-1α) and VEGF and a down-regulation of thrombospondin-1.
T7 1018-1117 Sentence denotes Interestingly, such pro-angiogenic activity was not associated with progression to invasive cancer.
T8 1118-1305 Sentence denotes Analysis of bladder-associated microRNAs in carcinoma in situ lesions reveals a pro-angiogenic profile, with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107.
T9 1306-1436 Sentence denotes A group of microRNAs (miRs) identified as associated with invasive human urothelial cancer remained unchanged in this mouse model.
T10 1437-1584 Sentence denotes Collectively, our results support the notion that activation of angiogenesis and loss of p53 are not sufficient for progression to invasive cancer.
T11 1585-1747 Sentence denotes Our studies identify a new mouse model for bladder cancer that can be used to study factors that determine progression to an invasive phenotype of bladder cancer.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 450-459 https://glytoucan.org/Structures/Glycans/G00031MO denotes T antigen
T2 557-566 https://glytoucan.org/Structures/Glycans/G00031MO denotes T antigen

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue glyco_epitope_db_id
T1 450-459 GlycoEpitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020
T2 557-566 GlycoEpitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 105-112 http://purl.obolibrary.org/obo/MAT_0000122 denotes bladder
T2 753-761 http://purl.obolibrary.org/obo/MAT_0000122 denotes bladders
T3 1130-1137 http://purl.obolibrary.org/obo/MAT_0000122 denotes bladder
T4 1628-1635 http://purl.obolibrary.org/obo/MAT_0000122 denotes bladder
T5 1732-1739 http://purl.obolibrary.org/obo/MAT_0000122 denotes bladder

DisGeNET

Id Subject Object Predicate Lexical cue
T0 8-11 gene:7157 denotes p53
T1 145-163 disease:C1334274 denotes invasive carcinoma
T2 8-11 gene:7157 denotes p53
T3 105-133 disease:C0279680 denotes bladder urothelial carcinoma
T4 506-526 gene:7157 denotes tumor suppressor p53
T5 629-646 disease:C0007099 denotes carcinoma in situ
T6 506-526 gene:7157 denotes tumor suppressor p53
T7 579-599 disease:C0007138 denotes urothelial carcinoma
T8 506-526 gene:7157 denotes tumor suppressor p53
T9 579-599 disease:C2145472 denotes urothelial carcinoma
T10 669-672 gene:7157 denotes p53
T11 786-792 disease:C0006826 denotes cancer
T12 669-672 gene:7157 denotes p53
T13 786-792 disease:C1306459 denotes cancer
T14 1000-1016 gene:7057 denotes thrombospondin-1
T15 809-826 disease:C0007099 denotes carcinoma in situ
T16 970-974 gene:7422 denotes VEGF
T17 809-826 disease:C0007099 denotes carcinoma in situ
T18 929-956 gene:3091 denotes hypoxia-inducible factor-1α
T19 809-826 disease:C0007099 denotes carcinoma in situ
T20 1266-1273 gene:406979 denotes miR-19a
T21 1162-1179 disease:C0007099 denotes carcinoma in situ
T22 1526-1529 gene:7157 denotes p53
T23 1568-1583 disease:C0677898 denotes invasive cancer
R1 T0 T1 associated_with p53,invasive carcinoma
R2 T2 T3 associated_with p53,bladder urothelial carcinoma
R3 T4 T5 associated_with tumor suppressor p53,carcinoma in situ
R4 T6 T7 associated_with tumor suppressor p53,urothelial carcinoma
R5 T8 T9 associated_with tumor suppressor p53,urothelial carcinoma
R6 T10 T11 associated_with p53,cancer
R7 T12 T13 associated_with p53,cancer
R8 T14 T15 associated_with thrombospondin-1,carcinoma in situ
R9 T16 T17 associated_with VEGF,carcinoma in situ
R10 T18 T19 associated_with hypoxia-inducible factor-1α,carcinoma in situ
R11 T20 T21 associated_with miR-19a,carcinoma in situ
R12 T22 T23 associated_with p53,invasive cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 208-213 HP_0002664 denotes tumor
T2 293-299 HP_0002664 denotes cancer
T3 506-511 HP_0002664 denotes tumor
T4 786-792 HP_0002664 denotes cancer
T5 1110-1116 HP_0002664 denotes cancer
T6 1390-1396 HP_0002664 denotes cancer
T7 1577-1583 HP_0002664 denotes cancer
T8 1628-1642 HP_0009725 denotes bladder cancer
T9 1636-1642 HP_0002664 denotes cancer
T10 1732-1746 HP_0009725 denotes bladder cancer
T11 1740-1746 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_21388952_2_0 331-372 expanded denotes urothelium-specific promoter uroplakin-II
SS2_21388952_2_0 374-380 abbr denotes UPK II
SS1_21388952_5_0 929-956 expanded denotes hypoxia-inducible factor-1α
SS2_21388952_5_0 958-964 abbr denotes HIF-1α
SS1_21388952_8_0 1317-1326 expanded denotes microRNAs
SS2_21388952_8_0 1328-1332 abbr denotes miRs
AE1_21388952_2_0 SS1_21388952_2_0 SS2_21388952_2_0 abbreviatedTo urothelium-specific promoter uroplakin-II,UPK II
AE1_21388952_5_0 SS1_21388952_5_0 SS2_21388952_5_0 abbreviatedTo hypoxia-inducible factor-1α,HIF-1α
AE1_21388952_8_0 SS1_21388952_8_0 SS2_21388952_8_0 abbreviatedTo microRNAs,miRs

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21388952-0#8#11#gene7157 8-11 gene7157 denotes p53
21388952-0#105#133#diseaseC0279680 105-133 diseaseC0279680 denotes bladder urothelial carcinoma
21388952-0#145#163#diseaseC1334274 145-163 diseaseC1334274 denotes invasive carcinoma
21388952-3#16#36#gene7157 506-526 gene7157 denotes tumor suppressor p53
21388952-3#89#109#diseaseC0007138 579-599 diseaseC0007138 denotes urothelial carcinoma
21388952-3#89#109#diseaseC2145472 579-599 diseaseC2145472 denotes urothelial carcinoma
21388952-9#89#92#gene7157 1526-1529 gene7157 denotes p53
21388952-9#131#146#diseaseC0677898 1568-1583 diseaseC0677898 denotes invasive cancer
8#11#gene7157105#133#diseaseC0279680 21388952-0#8#11#gene7157 21388952-0#105#133#diseaseC0279680 associated_with p53,bladder urothelial carcinoma
8#11#gene7157145#163#diseaseC1334274 21388952-0#8#11#gene7157 21388952-0#145#163#diseaseC1334274 associated_with p53,invasive carcinoma
16#36#gene715789#109#diseaseC0007138 21388952-3#16#36#gene7157 21388952-3#89#109#diseaseC0007138 associated_with tumor suppressor p53,urothelial carcinoma
16#36#gene715789#109#diseaseC2145472 21388952-3#16#36#gene7157 21388952-3#89#109#diseaseC2145472 associated_with tumor suppressor p53,urothelial carcinoma
89#92#gene7157131#146#diseaseC0677898 21388952-9#89#92#gene7157 21388952-9#131#146#diseaseC0677898 associated_with p53,invasive cancer

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 450-459 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T2 557-566 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 105-133 Disease denotes bladder urothelial carcinoma http://purl.obolibrary.org/obo/MONDO_0005611
T2 145-163 Disease denotes invasive carcinoma http://purl.obolibrary.org/obo/MONDO_0040677
T3 208-213 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T4 293-299 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T5 506-511 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 579-599 Disease denotes urothelial carcinoma http://purl.obolibrary.org/obo/MONDO_0040679
T7 629-646 Disease denotes carcinoma in situ http://purl.obolibrary.org/obo/MONDO_0004647
T8 786-792 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T9 809-826 Disease denotes carcinoma in situ http://purl.obolibrary.org/obo/MONDO_0004647
T10 1110-1116 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T11 1162-1179 Disease denotes carcinoma in situ http://purl.obolibrary.org/obo/MONDO_0004647
T12 1390-1396 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T13 1577-1583 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T14 1628-1642 Disease denotes bladder cancer http://purl.obolibrary.org/obo/MONDO_0001187|http://purl.obolibrary.org/obo/MONDO_0004986|http://purl.obolibrary.org/obo/MONDO_0022578
T17 1732-1746 Disease denotes bladder cancer http://purl.obolibrary.org/obo/MONDO_0001187|http://purl.obolibrary.org/obo/MONDO_0004986|http://purl.obolibrary.org/obo/MONDO_0022578

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 105-112 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122
T2 753-761 Body_part denotes bladders http://purl.obolibrary.org/obo/MAT_0000122
T3 1130-1137 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122
T4 1628-1635 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122
T5 1732-1739 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 450-459 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO
T2 557-566 Glycan denotes T antigen https://api.glycosmos.org/wurcs2image/latest/png/binary/G00031MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 450-459 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020
T2 557-566 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 124-133 Phenotype denotes carcinoma HP:0030731
T2 154-163 Phenotype denotes carcinoma HP:0030731
T3 208-213 Phenotype denotes tumor HP:0002664
T4 293-299 Phenotype denotes cancer HP:0002664
T5 506-511 Phenotype denotes tumor HP:0002664
T6 590-599 Phenotype denotes carcinoma HP:0030731
T7 629-638 Phenotype denotes carcinoma HP:0030731
T8 786-792 Phenotype denotes cancer HP:0002664
T9 809-818 Phenotype denotes carcinoma HP:0030731
T10 929-936 Phenotype denotes hypoxia HP:0012418
T11 1110-1116 Phenotype denotes cancer HP:0002664
T12 1162-1171 Phenotype denotes carcinoma HP:0030731
T13 1390-1396 Phenotype denotes cancer HP:0002664
T14 1577-1583 Phenotype denotes cancer HP:0002664
T15 1628-1642 Phenotype denotes bladder cancer HP:0009725
T16 1732-1746 Phenotype denotes bladder cancer HP:0009725

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 676-692 Cell denotes urothelial cells http://purl.obolibrary.org/obo/CL:0000731

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 105-133 Disease denotes bladder urothelial carcinoma MONDO:0005611
T2 145-163 Disease denotes invasive carcinoma MONDO:0040677
T3 208-213 Disease denotes tumor MONDO:0005070
T4 293-299 Disease denotes cancer MONDO:0004992
T5 506-511 Disease denotes tumor MONDO:0005070
T6 579-599 Disease denotes urothelial carcinoma MONDO:0040679
T7 629-646 Disease denotes carcinoma in situ MONDO:0004647
T8 786-792 Disease denotes cancer MONDO:0004992
T9 809-826 Disease denotes carcinoma in situ MONDO:0004647
T10 1110-1116 Disease denotes cancer MONDO:0004992
T11 1162-1179 Disease denotes carcinoma in situ MONDO:0004647
T12 1390-1396 Disease denotes cancer MONDO:0004992
T13 1577-1583 Disease denotes cancer MONDO:0004992
T14 1628-1642 Disease denotes bladder cancer MONDO:0004986|MONDO:0022578
T16 1732-1746 Disease denotes bladder cancer MONDO:0004986|MONDO:0022578

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 105-112 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707
T3 229-239 Body_part denotes urothelium http://purl.obolibrary.org/obo/UBERON_0000365|http://purl.obolibrary.org/obo/UBERON_0004645
T5 331-341 Body_part denotes urothelium http://purl.obolibrary.org/obo/UBERON_0000365|http://purl.obolibrary.org/obo/UBERON_0004645
T7 538-548 Body_part denotes urothelium http://purl.obolibrary.org/obo/UBERON_0000365|http://purl.obolibrary.org/obo/UBERON_0004645
T9 676-692 Body_part denotes urothelial cells http://purl.obolibrary.org/obo/CL_0000731
T10 1130-1137 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707
T12 1628-1635 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707
T14 1732-1739 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 411-415 Organism denotes mice 10088
T2 612-617 Organism denotes human 9606
T3 730-734 Organism denotes mice 10088
T4 846-850 Organism denotes mice 10088
T5 1373-1378 Organism denotes human 9606
T6 1424-1429 Organism denotes mouse 10088|10090
T8 1612-1617 Organism denotes mouse 10088|10090

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-164 Sentence denotes Loss of p53 and acquisition of angiogenic microRNA profile are insufficient to facilitate progression of bladder urothelial carcinoma in situ to invasive carcinoma.
T2 165-300 Sentence denotes Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer.
T3 301-489 Sentence denotes Here we report cloning of the urothelium-specific promoter uroplakin-II (UPK II) and generation of transgenic mice in which expression of SV40 large T antigen is driven by UPK II promoter.
T4 490-647 Sentence denotes Inactivation of tumor suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma, resembling human high-grade carcinoma in situ.
T5 648-793 Sentence denotes Specific deletion of p53 in urothelial cells using the newly generated UPK II-Cre mice results in normal bladders without any evidence of cancer.
T6 794-1017 Sentence denotes The high-grade carcinoma in situ in the UPK II-SV40 mice is associated with significant activation of angiogenic signals consisting of hypoxia-inducible factor-1α (HIF-1α) and VEGF and a down-regulation of thrombospondin-1.
T7 1018-1117 Sentence denotes Interestingly, such pro-angiogenic activity was not associated with progression to invasive cancer.
T8 1118-1305 Sentence denotes Analysis of bladder-associated microRNAs in carcinoma in situ lesions reveals a pro-angiogenic profile, with specific overexpression of miR-18a and miR-19a and down-regulation of miR-107.
T9 1306-1436 Sentence denotes A group of microRNAs (miRs) identified as associated with invasive human urothelial cancer remained unchanged in this mouse model.
T10 1437-1584 Sentence denotes Collectively, our results support the notion that activation of angiogenesis and loss of p53 are not sufficient for progression to invasive cancer.
T11 1585-1747 Sentence denotes Our studies identify a new mouse model for bladder cancer that can be used to study factors that determine progression to an invasive phenotype of bladder cancer.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 450-459 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020
T2 557-566 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes T antigen http://www.glycoepitope.jp/epitopes/EP0020

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 105-112 Body_part denotes bladder FMA:15900
T2 229-239 Body_part denotes urothelium FMA:67695
T3 331-341 Body_part denotes urothelium FMA:67695
T4 538-548 Body_part denotes urothelium FMA:67695
T5 676-692 Body_part denotes urothelial cells FMA:84127
T6 753-761 Body_part denotes bladders FMA:15900
T7 1130-1137 Body_part denotes bladder FMA:15900
T8 1628-1635 Body_part denotes bladder FMA:15900
T9 1732-1739 Body_part denotes bladder FMA:15900

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 105-112 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122
T2 753-761 Body_part denotes bladders http://purl.obolibrary.org/obo/MAT_0000122
T3 1130-1137 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122
T4 1628-1635 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122
T5 1732-1739 Body_part denotes bladder http://purl.obolibrary.org/obo/MAT_0000122

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 411-415 OrganismTaxon denotes mice 10088
T2 612-617 OrganismTaxon denotes human 9606
T3 730-734 OrganismTaxon denotes mice 10088
T4 846-850 OrganismTaxon denotes mice 10088
T5 1373-1378 OrganismTaxon denotes human 9606
T6 1424-1429 OrganismTaxon denotes mouse 10088|10090
T8 1612-1617 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 105-112 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707
T3 229-239 Body_part denotes urothelium http://purl.obolibrary.org/obo/UBERON_0000365|http://purl.obolibrary.org/obo/UBERON_0004645
T5 331-341 Body_part denotes urothelium http://purl.obolibrary.org/obo/UBERON_0000365|http://purl.obolibrary.org/obo/UBERON_0004645
T7 538-548 Body_part denotes urothelium http://purl.obolibrary.org/obo/UBERON_0000365|http://purl.obolibrary.org/obo/UBERON_0004645
T9 676-692 Body_part denotes urothelial cells http://purl.obolibrary.org/obo/CL_0000731
T10 1130-1137 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707
T12 1628-1635 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707
T14 1732-1739 Body_part denotes bladder http://purl.obolibrary.org/obo/UBERON_0001255|http://purl.obolibrary.org/obo/UBERON_0018707

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 124-133 Phenotype denotes carcinoma HP:0030731
T2 154-163 Phenotype denotes carcinoma HP:0030731
T3 208-213 Phenotype denotes tumor HP:0002664
T4 293-299 Phenotype denotes cancer HP:0002664
T5 506-511 Phenotype denotes tumor HP:0002664
T6 590-599 Phenotype denotes carcinoma HP:0030731
T7 629-638 Phenotype denotes carcinoma HP:0030731
T8 786-792 Phenotype denotes cancer HP:0002664
T9 809-818 Phenotype denotes carcinoma HP:0030731
T10 929-936 Phenotype denotes hypoxia HP:0012418
T11 1110-1116 Phenotype denotes cancer HP:0002664
T12 1162-1171 Phenotype denotes carcinoma HP:0030731
T13 1390-1396 Phenotype denotes cancer HP:0002664
T14 1577-1583 Phenotype denotes cancer HP:0002664
T15 1628-1642 Phenotype denotes bladder cancer HP:0009725
T16 1732-1746 Phenotype denotes bladder cancer HP:0009725

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 676-692 Cell denotes urothelial cells http://purl.obolibrary.org/obo/CL:0000731