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PubMed:21383697 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.
TextSentencer_T2 112-262 Sentence denotes The tyrosine kinase c-Src is upregulated in various human cancers, but the molecular mechanisms underlying c-Src-mediated tumor growth remain unclear.
TextSentencer_T3 263-344 Sentence denotes Here we examined the involvement of microRNAs in the c-Src-mediated tumor growth.
TextSentencer_T4 345-567 Sentence denotes Microarray profiling revealed that c-Src activation downregulates a limited set of microRNAs, including miR-99a, which targets oncogenic mammalian target of rapamycin (mTOR) and fibroblast growth factor receptor 3 (FGFR3).
TextSentencer_T5 568-704 Sentence denotes Re-expression of miR-99a suppressed tumor growth of c-Src-transformed cells, and this effect was restored by the overexpression of mTOR.
TextSentencer_T6 705-896 Sentence denotes The downregulation of miR-99a was also observed in epidermal growth factor- and Ras-transformed cells, and it was suppressed by inhibiting the mitogen-activated protein kinase (MAPK) pathway.
TextSentencer_T7 897-1019 Sentence denotes Furthermore, miR-99a downregulation is associated with mTOR/FGFR3 upregulation in various human lung cancer cells/tissues.
TextSentencer_T8 1020-1100 Sentence denotes The tumorigenicity of these cells was suppressed by the introduction of miR-99a.
TextSentencer_T9 1101-1296 Sentence denotes These findings suggest that the miR-99a-mTOR/FGFR3 pathway is crucial for controlling tumor growth in a wide range of human cancers that harbor upregulation of the Src-related oncogenic pathways.
T1 0-111 Sentence denotes MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.
T2 112-262 Sentence denotes The tyrosine kinase c-Src is upregulated in various human cancers, but the molecular mechanisms underlying c-Src-mediated tumor growth remain unclear.
T3 263-344 Sentence denotes Here we examined the involvement of microRNAs in the c-Src-mediated tumor growth.
T4 345-567 Sentence denotes Microarray profiling revealed that c-Src activation downregulates a limited set of microRNAs, including miR-99a, which targets oncogenic mammalian target of rapamycin (mTOR) and fibroblast growth factor receptor 3 (FGFR3).
T5 568-704 Sentence denotes Re-expression of miR-99a suppressed tumor growth of c-Src-transformed cells, and this effect was restored by the overexpression of mTOR.
T6 705-896 Sentence denotes The downregulation of miR-99a was also observed in epidermal growth factor- and Ras-transformed cells, and it was suppressed by inhibiting the mitogen-activated protein kinase (MAPK) pathway.
T7 897-1019 Sentence denotes Furthermore, miR-99a downregulation is associated with mTOR/FGFR3 upregulation in various human lung cancer cells/tissues.
T8 1020-1100 Sentence denotes The tumorigenicity of these cells was suppressed by the introduction of miR-99a.
T9 1101-1296 Sentence denotes These findings suggest that the miR-99a-mTOR/FGFR3 pathway is crucial for controlling tumor growth in a wide range of human cancers that harbor upregulation of the Src-related oncogenic pathways.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 957-962 gene:2261 denotes FGFR3
T1 993-1004 disease:C0242379 denotes lung cancer
T2 957-962 gene:2261 denotes FGFR3
T3 993-1004 disease:C0684249 denotes lung cancer
R1 T0 T1 associated_with FGFR3,lung cancer
R2 T2 T3 associated_with FGFR3,lung cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 170-177 HP_0002664 denotes cancers
T2 234-239 HP_0002664 denotes tumor
T3 331-336 HP_0002664 denotes tumor
T4 604-609 HP_0002664 denotes tumor
T5 993-1004 HP_0100526 denotes lung cancer
T6 998-1004 HP_0002664 denotes cancer
T7 1187-1192 HP_0002664 denotes tumor
T8 1225-1232 HP_0002664 denotes cancers

Allie

Id Subject Object Predicate Lexical cue
SS1_21383697_3_0 482-511 expanded denotes mammalian target of rapamycin
SS2_21383697_3_0 513-517 abbr denotes mTOR
SS1_21383697_3_1 523-558 expanded denotes fibroblast growth factor receptor 3
SS2_21383697_3_1 560-565 abbr denotes FGFR3
SS1_21383697_5_0 848-880 expanded denotes mitogen-activated protein kinase
SS2_21383697_5_0 882-886 abbr denotes MAPK
AE1_21383697_3_0 SS1_21383697_3_0 SS2_21383697_3_0 abbreviatedTo mammalian target of rapamycin,mTOR
AE1_21383697_3_1 SS1_21383697_3_1 SS2_21383697_3_1 abbreviatedTo fibroblast growth factor receptor 3,FGFR3
AE1_21383697_5_0 SS1_21383697_5_0 SS2_21383697_5_0 abbreviatedTo mitogen-activated protein kinase,MAPK

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21383697-6#13#20#gene407055 910-917 gene407055 denotes miR-99a
21383697-6#60#65#gene2261 957-962 gene2261 denotes FGFR3
21383697-6#96#107#diseaseC0242379 993-1004 diseaseC0242379 denotes lung cancer
21383697-6#96#107#diseaseC0684249 993-1004 diseaseC0684249 denotes lung cancer
21383697-6#96#107#diseaseC1306460 993-1004 diseaseC1306460 denotes lung cancer
21383697-6#96#107#diseaseC0242379 993-1004 diseaseC0242379 denotes lung cancer
21383697-6#96#107#diseaseC0684249 993-1004 diseaseC0684249 denotes lung cancer
21383697-6#96#107#diseaseC1306460 993-1004 diseaseC1306460 denotes lung cancer
13#20#gene40705596#107#diseaseC0242379 21383697-6#13#20#gene407055 21383697-6#96#107#diseaseC0242379 associated_with miR-99a,lung cancer
13#20#gene40705596#107#diseaseC0684249 21383697-6#13#20#gene407055 21383697-6#96#107#diseaseC0684249 associated_with miR-99a,lung cancer
13#20#gene40705596#107#diseaseC1306460 21383697-6#13#20#gene407055 21383697-6#96#107#diseaseC1306460 associated_with miR-99a,lung cancer
13#20#gene40705596#107#diseaseC0242379 21383697-6#13#20#gene407055 21383697-6#96#107#diseaseC0242379 associated_with miR-99a,lung cancer
13#20#gene40705596#107#diseaseC0684249 21383697-6#13#20#gene407055 21383697-6#96#107#diseaseC0684249 associated_with miR-99a,lung cancer
13#20#gene40705596#107#diseaseC1306460 21383697-6#13#20#gene407055 21383697-6#96#107#diseaseC1306460 associated_with miR-99a,lung cancer
60#65#gene226196#107#diseaseC0242379 21383697-6#60#65#gene2261 21383697-6#96#107#diseaseC0242379 associated_with FGFR3,lung cancer
60#65#gene226196#107#diseaseC0684249 21383697-6#60#65#gene2261 21383697-6#96#107#diseaseC0684249 associated_with FGFR3,lung cancer
60#65#gene226196#107#diseaseC1306460 21383697-6#60#65#gene2261 21383697-6#96#107#diseaseC1306460 associated_with FGFR3,lung cancer
60#65#gene226196#107#diseaseC0242379 21383697-6#60#65#gene2261 21383697-6#96#107#diseaseC0242379 associated_with FGFR3,lung cancer
60#65#gene226196#107#diseaseC0684249 21383697-6#60#65#gene2261 21383697-6#96#107#diseaseC0684249 associated_with FGFR3,lung cancer
60#65#gene226196#107#diseaseC1306460 21383697-6#60#65#gene2261 21383697-6#96#107#diseaseC1306460 associated_with FGFR3,lung cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T350 910-917 gene:407055 denotes miR-99a
T351 993-1004 disease:C0242379 denotes lung cancer
T352 957-962 gene:2261 denotes FGFR3
R1 T350 T351 associated_with miR-99a,lung cancer
R2 T350 T351 associated_with miR-99a,lung cancer
R3 T350 T351 associated_with miR-99a,lung cancer
R4 T352 T351 associated_with FGFR3,lung cancer
R5 T352 T351 associated_with FGFR3,lung cancer
R6 T352 T351 associated_with FGFR3,lung cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 993-997 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 1011-1018 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1011-1018 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T2 993-997 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung