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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1234-1248 Glycan_Motif denotes sialyl-Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T2 1241-1248 Glycan_Motif denotes Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO
T4 1490-1504 Glycan_Motif denotes sialyl-Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO
T5 1497-1504 Glycan_Motif denotes Lewis x https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1234-1248 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl-Lewis x
T2 1241-1248 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis x
T3 1241-1248 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis x
T4 1490-1504 https://glytoucan.org/Structures/Glycans/G00054MO denotes sialyl-Lewis x
T5 1497-1504 https://glytoucan.org/Structures/Glycans/G00051MO denotes Lewis x
T6 1497-1504 https://glytoucan.org/Structures/Glycans/G01187XC denotes Lewis x

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1234-1248 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl-Lewis x
T2 1241-1248 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis x
T3 1490-1504 http://www.glycoepitope.jp/epitopes/EP0012 denotes sialyl-Lewis x
T4 1497-1504 http://www.glycoepitope.jp/epitopes/EP0011 denotes Lewis x

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 130-137 http://purl.obolibrary.org/obo/MAT_0000051 denotes stomach
T2 1458-1468 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells.
T2 114-304 Sentence denotes Inflammation of stomach mucosa has been postulated as initiator of gastric carcinogenesis and the presence of pro-inflammatory cytokines can regulate specific genes involved in this process.
T3 305-455 Sentence denotes The cellular expression pattern of glycosyltransferases and Lewis antigens detected in the normal mucosa changed during the neoplassic transformation.
T4 456-639 Sentence denotes The aim of this work was to determine the regulation of specific fucosyltransferases and sialyltransferases by IL-1β and IL-6 pro-inflammatory cytokines in MKN45 gastric cancer cells.
T5 640-750 Sentence denotes IL-1β induced significant increases in the mRNA levels of FUT1, FUT2 and FUT4, and decreases of FUT3 and FUT5.
T6 751-839 Sentence denotes In IL-6 treatments, enhanced FUT1 and lower FUT3 and FUT5 mRNA expression were detected.
T7 840-917 Sentence denotes No substantial changes were observed in the levels of ST3GalIII and ST3GalIV.
T8 918-1158 Sentence denotes The activation of FUT1, FUT2 and FUT4 by IL-1β is through the NF-κB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively.
T9 1159-1432 Sentence denotes The levels of Lewis antigens after IL-1β or IL-6 stimulation decreased for sialyl-Lewis x, and no significant differences were found in the rest of the Lewis antigens analyzed, as it was also observed in subcutaneous mice tumors from MKN45 cells treated with IL-1β or IL-6.
T10 1433-1576 Sentence denotes In addition, in 61 human intestinal-type gastric tumors, sialyl-Lewis x was highly detected in samples from patients that developed metastasis.
T11 1577-1786 Sentence denotes These results indicate that the expression of the fucosyltransferases involved in the synthesis of Lewis antigens in gastric cancer cells can be specifically modulated by IL-1β and IL-6 inflammatory cytokines.
T1 0-113 Sentence denotes Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells.
T2 114-304 Sentence denotes Inflammation of stomach mucosa has been postulated as initiator of gastric carcinogenesis and the presence of pro-inflammatory cytokines can regulate specific genes involved in this process.
T3 305-455 Sentence denotes The cellular expression pattern of glycosyltransferases and Lewis antigens detected in the normal mucosa changed during the neoplassic transformation.
T4 456-639 Sentence denotes The aim of this work was to determine the regulation of specific fucosyltransferases and sialyltransferases by IL-1β and IL-6 pro-inflammatory cytokines in MKN45 gastric cancer cells.
T5 640-750 Sentence denotes IL-1β induced significant increases in the mRNA levels of FUT1, FUT2 and FUT4, and decreases of FUT3 and FUT5.
T6 751-839 Sentence denotes In IL-6 treatments, enhanced FUT1 and lower FUT3 and FUT5 mRNA expression were detected.
T7 840-917 Sentence denotes No substantial changes were observed in the levels of ST3GalIII and ST3GalIV.
T8 918-1158 Sentence denotes The activation of FUT1, FUT2 and FUT4 by IL-1β is through the NF-κB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively.
T9 1159-1432 Sentence denotes The levels of Lewis antigens after IL-1β or IL-6 stimulation decreased for sialyl-Lewis x, and no significant differences were found in the rest of the Lewis antigens analyzed, as it was also observed in subcutaneous mice tumors from MKN45 cells treated with IL-1β or IL-6.
T10 1433-1576 Sentence denotes In addition, in 61 human intestinal-type gastric tumors, sialyl-Lewis x was highly detected in samples from patients that developed metastasis.
T11 1577-1786 Sentence denotes These results indicate that the expression of the fucosyltransferases involved in the synthesis of Lewis antigens in gastric cancer cells can be specifically modulated by IL-1β and IL-6 inflammatory cytokines.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 78-82 gene:3569 denotes IL-6
T1 92-106 disease:C0699791 denotes gastric cancer
T2 78-82 gene:3569 denotes IL-6
T3 92-106 disease:C0024623 denotes gastric cancer
T4 68-73 gene:3553 denotes IL-1β
T5 92-106 disease:C0024623 denotes gastric cancer
T6 68-73 gene:3553 denotes IL-1β
T7 92-106 disease:C0699791 denotes gastric cancer
T8 1497-1504 gene:2526 denotes Lewis x
T9 1565-1575 disease:C2939420 denotes metastasis
T10 1497-1504 gene:2526 denotes Lewis x
T11 1565-1575 disease:C0027627 denotes metastasis
R1 T0 T1 associated_with IL-6,gastric cancer
R2 T2 T3 associated_with IL-6,gastric cancer
R3 T4 T5 associated_with IL-1β,gastric cancer
R4 T6 T7 associated_with IL-1β,gastric cancer
R5 T8 T9 associated_with Lewis x,metastasis
R6 T10 T11 associated_with Lewis x,metastasis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 618-632 HP_0012126 denotes gastric cancer
T2 626-632 HP_0002664 denotes cancer
T3 1381-1387 HP_0002664 denotes tumors
T4 1474-1488 HP_0012126 denotes gastric tumors
T5 1482-1488 HP_0002664 denotes tumors
T6 1694-1708 HP_0012126 denotes gastric cancer
T7 1702-1708 HP_0002664 denotes cancer

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-113 Sentence denotes Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells.
TextSentencer_T2 114-304 Sentence denotes Inflammation of stomach mucosa has been postulated as initiator of gastric carcinogenesis and the presence of pro-inflammatory cytokines can regulate specific genes involved in this process.
TextSentencer_T3 305-455 Sentence denotes The cellular expression pattern of glycosyltransferases and Lewis antigens detected in the normal mucosa changed during the neoplassic transformation.
TextSentencer_T4 456-639 Sentence denotes The aim of this work was to determine the regulation of specific fucosyltransferases and sialyltransferases by IL-1β and IL-6 pro-inflammatory cytokines in MKN45 gastric cancer cells.
TextSentencer_T5 640-750 Sentence denotes IL-1β induced significant increases in the mRNA levels of FUT1, FUT2 and FUT4, and decreases of FUT3 and FUT5.
TextSentencer_T6 751-839 Sentence denotes In IL-6 treatments, enhanced FUT1 and lower FUT3 and FUT5 mRNA expression were detected.
TextSentencer_T7 840-917 Sentence denotes No substantial changes were observed in the levels of ST3GalIII and ST3GalIV.
TextSentencer_T8 918-1158 Sentence denotes The activation of FUT1, FUT2 and FUT4 by IL-1β is through the NF-κB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively.
TextSentencer_T9 1159-1432 Sentence denotes The levels of Lewis antigens after IL-1β or IL-6 stimulation decreased for sialyl-Lewis x, and no significant differences were found in the rest of the Lewis antigens analyzed, as it was also observed in subcutaneous mice tumors from MKN45 cells treated with IL-1β or IL-6.
TextSentencer_T10 1433-1576 Sentence denotes In addition, in 61 human intestinal-type gastric tumors, sialyl-Lewis x was highly detected in samples from patients that developed metastasis.
TextSentencer_T11 1577-1786 Sentence denotes These results indicate that the expression of the fucosyltransferases involved in the synthesis of Lewis antigens in gastric cancer cells can be specifically modulated by IL-1β and IL-6 inflammatory cytokines.
T1 0-113 Sentence denotes Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells.
T2 114-304 Sentence denotes Inflammation of stomach mucosa has been postulated as initiator of gastric carcinogenesis and the presence of pro-inflammatory cytokines can regulate specific genes involved in this process.
T3 305-455 Sentence denotes The cellular expression pattern of glycosyltransferases and Lewis antigens detected in the normal mucosa changed during the neoplassic transformation.
T4 456-639 Sentence denotes The aim of this work was to determine the regulation of specific fucosyltransferases and sialyltransferases by IL-1β and IL-6 pro-inflammatory cytokines in MKN45 gastric cancer cells.
T5 640-750 Sentence denotes IL-1β induced significant increases in the mRNA levels of FUT1, FUT2 and FUT4, and decreases of FUT3 and FUT5.
T6 751-839 Sentence denotes In IL-6 treatments, enhanced FUT1 and lower FUT3 and FUT5 mRNA expression were detected.
T7 840-917 Sentence denotes No substantial changes were observed in the levels of ST3GalIII and ST3GalIV.
T8 918-1158 Sentence denotes The activation of FUT1, FUT2 and FUT4 by IL-1β is through the NF-κB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively.
T9 1159-1432 Sentence denotes The levels of Lewis antigens after IL-1β or IL-6 stimulation decreased for sialyl-Lewis x, and no significant differences were found in the rest of the Lewis antigens analyzed, as it was also observed in subcutaneous mice tumors from MKN45 cells treated with IL-1β or IL-6.
T10 1433-1576 Sentence denotes In addition, in 61 human intestinal-type gastric tumors, sialyl-Lewis x was highly detected in samples from patients that developed metastasis.
T11 1577-1786 Sentence denotes These results indicate that the expression of the fucosyltransferases involved in the synthesis of Lewis antigens in gastric cancer cells can be specifically modulated by IL-1β and IL-6 inflammatory cytokines.

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 1234-1248 Glycan denotes sialyl-Lewis x https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T2 1490-1504 Glycan denotes sialyl-Lewis x https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 92-106 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056
T2 114-137 Disease denotes Inflammation of stomach http://purl.obolibrary.org/obo/MONDO_0004966
T3 618-632 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056
T4 1381-1387 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T5 1474-1488 Disease denotes gastric tumors http://purl.obolibrary.org/obo/MONDO_0021085
T6 1694-1708 Disease denotes gastric cancer http://purl.obolibrary.org/obo/MONDO_0001056

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 1234-1248 Glycan denotes sialyl-Lewis x https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO
T2 1490-1504 Glycan denotes sialyl-Lewis x https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1234-1248 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl-Lewis x http://www.glycoepitope.jp/epitopes/EP0012
T2 1490-1504 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl-Lewis x http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 92-106 Phenotype denotes gastric cancer HP:0012126
T2 618-632 Phenotype denotes gastric cancer HP:0012126
T3 1694-1708 Phenotype denotes gastric cancer HP:0012126

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 100-112 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 626-638 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T3 1702-1714 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 130-144 Body_part denotes stomach mucosa http://purl.obolibrary.org/obo/UBERON_0001199
T2 403-409 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 92-106 Disease denotes gastric cancer MONDO:0001056|MONDO:0004950
T3 114-137 Disease denotes Inflammation of stomach MONDO:0004966
T4 618-632 Disease denotes gastric cancer MONDO:0001056|MONDO:0004950
T6 1474-1488 Disease denotes gastric tumors MONDO:0021085
T7 1694-1708 Disease denotes gastric cancer MONDO:0001056|MONDO:0004950

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 86-91 Organism denotes human 9606
T2 1376-1380 Organism denotes mice 10088
T3 1452-1457 Organism denotes human 9606
T4 1541-1549 Organism denotes patients 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-113 Sentence denotes Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells.
T2 114-304 Sentence denotes Inflammation of stomach mucosa has been postulated as initiator of gastric carcinogenesis and the presence of pro-inflammatory cytokines can regulate specific genes involved in this process.
T3 305-455 Sentence denotes The cellular expression pattern of glycosyltransferases and Lewis antigens detected in the normal mucosa changed during the neoplassic transformation.
T4 456-639 Sentence denotes The aim of this work was to determine the regulation of specific fucosyltransferases and sialyltransferases by IL-1β and IL-6 pro-inflammatory cytokines in MKN45 gastric cancer cells.
T5 640-750 Sentence denotes IL-1β induced significant increases in the mRNA levels of FUT1, FUT2 and FUT4, and decreases of FUT3 and FUT5.
T6 751-839 Sentence denotes In IL-6 treatments, enhanced FUT1 and lower FUT3 and FUT5 mRNA expression were detected.
T7 840-917 Sentence denotes No substantial changes were observed in the levels of ST3GalIII and ST3GalIV.
T8 918-1158 Sentence denotes The activation of FUT1, FUT2 and FUT4 by IL-1β is through the NF-κB pathway and the down-regulation of FUT3 and FUT5 by IL-6 is through the gp130/STAT-3 pathway, since they are inhibited specifically by panepoxydone and AG490, respectively.
T9 1159-1432 Sentence denotes The levels of Lewis antigens after IL-1β or IL-6 stimulation decreased for sialyl-Lewis x, and no significant differences were found in the rest of the Lewis antigens analyzed, as it was also observed in subcutaneous mice tumors from MKN45 cells treated with IL-1β or IL-6.
T10 1433-1576 Sentence denotes In addition, in 61 human intestinal-type gastric tumors, sialyl-Lewis x was highly detected in samples from patients that developed metastasis.
T11 1577-1786 Sentence denotes These results indicate that the expression of the fucosyltransferases involved in the synthesis of Lewis antigens in gastric cancer cells can be specifically modulated by IL-1β and IL-6 inflammatory cytokines.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1234-1248 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl-Lewis x http://www.glycoepitope.jp/epitopes/EP0012
T2 1490-1504 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes sialyl-Lewis x http://www.glycoepitope.jp/epitopes/EP0012

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 130-137 Body_part denotes stomach FMA:7148
T2 138-144 Body_part denotes mucosa FMA:85355
T3 403-409 Body_part denotes mucosa FMA:85355
T4 1458-1468 Body_part denotes intestinal FMA:7199

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 130-137 Body_part denotes stomach http://purl.obolibrary.org/obo/MAT_0000051
T2 1458-1468 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 86-91 OrganismTaxon denotes human 9606
T2 1376-1380 OrganismTaxon denotes mice 10088
T3 1452-1457 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 130-137 Body_part denotes stomach http://purl.obolibrary.org/obo/MAT_0000051
T2 1458-1468 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 130-144 Body_part denotes stomach mucosa http://purl.obolibrary.org/obo/UBERON_0001199
T2 403-409 Body_part denotes mucosa http://purl.obolibrary.org/obo/UBERON_0000344

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 92-106 Phenotype denotes gastric cancer HP:0012126
T2 618-632 Phenotype denotes gastric cancer HP:0012126
T3 1694-1708 Phenotype denotes gastric cancer HP:0012126

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 100-112 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T2 626-638 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064
T3 1702-1714 Cell denotes cancer cells http://purl.obolibrary.org/obo/CL:0001064