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PubMed:2136350 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 120-126 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 173-176 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T4 184-190 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T5 267-270 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 478-481 Glycan_Motif denotes GM4 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G77824XV|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G30207PZ
T9 490-496 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T10 550-557 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG
T11 582-591 Glycan_Motif denotes galactose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G68158BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G65889KE

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 478-481 http://www.glycoepitope.jp/epitopes/EP0055 denotes GM4

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 120-126 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T2 173-176 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T3 173-176 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T4 184-190 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T5 267-270 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 267-270 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 478-481 https://glytoucan.org/Structures/Glycans/G30207PZ denotes GM4
T8 478-481 https://glytoucan.org/Structures/Glycans/G77824XV denotes GM4
T9 490-496 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T10 550-557 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose
T11 582-591 https://glytoucan.org/Structures/Glycans/G65889KE denotes galactose
T12 582-591 https://glytoucan.org/Structures/Glycans/G68158BT denotes galactose

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-63 Sentence denotes New ganglioside analogs that inhibit influenza virus sialidase.
TextSentencer_T2 64-434 Sentence denotes Synthetic thioglycoside-analogs of gangliosides such as Neu5Ac alpha(2-S-6)Glc beta(1-1)Ceramide (1) and the GM3 analog Neu5Ac alpha(2-S-6)Gal beta(1-4)Glc beta(1-1)Ceramide (2), competitively inhibited GM3 hydrolysis by the sialidase of different subtypes of human and animal influenza viruses with an apparent Ki value of 2.8 x 10(-6) and 1.5 x 10(-5) M, respectively.
TextSentencer_T3 435-640 Sentence denotes The inhibitory activity of the ganglioside GM4 analog [Neu5Ac alpha(2-S-6)Gal beta(1-1)Ceramide (3)], in which the glucose of 1 was substituted by galactose, was lower than that of 1 (Ki = 1.0 x 10(-4) M).
TextSentencer_T4 641-760 Sentence denotes The thioglycoside-analogs (1, 2, 3) of the gangliosides were non-hydrolyzable substrates for influenza virus sialidase.
TextSentencer_T5 761-1186 Sentence denotes The inhibitory activity of 1 to bacterial sialidases from Clostridium perfringens and Arthrobacter ureafaciens was considerably lower than that to influenza virus sialidase, indicating that the structure of the active site in bacterial and influenza virus sialidase may be different and the analogs may be useful to determine the orientation of the substrate to the active site of sialidases, especially of influenza viruses.
T1 0-63 Sentence denotes New ganglioside analogs that inhibit influenza virus sialidase.
T2 64-434 Sentence denotes Synthetic thioglycoside-analogs of gangliosides such as Neu5Ac alpha(2-S-6)Glc beta(1-1)Ceramide (1) and the GM3 analog Neu5Ac alpha(2-S-6)Gal beta(1-4)Glc beta(1-1)Ceramide (2), competitively inhibited GM3 hydrolysis by the sialidase of different subtypes of human and animal influenza viruses with an apparent Ki value of 2.8 x 10(-6) and 1.5 x 10(-5) M, respectively.
T3 435-640 Sentence denotes The inhibitory activity of the ganglioside GM4 analog [Neu5Ac alpha(2-S-6)Gal beta(1-1)Ceramide (3)], in which the glucose of 1 was substituted by galactose, was lower than that of 1 (Ki = 1.0 x 10(-4) M).
T4 641-760 Sentence denotes The thioglycoside-analogs (1, 2, 3) of the gangliosides were non-hydrolyzable substrates for influenza virus sialidase.
T5 761-1186 Sentence denotes The inhibitory activity of 1 to bacterial sialidases from Clostridium perfringens and Arthrobacter ureafaciens was considerably lower than that to influenza virus sialidase, indicating that the structure of the active site in bacterial and influenza virus sialidase may be different and the analogs may be useful to determine the orientation of the substrate to the active site of sialidases, especially of influenza viruses.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 37-46 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T2 341-350 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T3 734-743 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T4 908-917 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T5 1001-1010 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T6 1168-1177 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 120-126 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 173-176 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 184-190 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 267-270 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 478-481 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T6 490-496 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 120-126 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 173-176 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 184-190 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 267-270 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 478-481 Glycan denotes GM4 https://api.glycosmos.org/wurcs2image/latest/png/binary/G30207PZ
T6 490-496 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 478-481 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 324-329 Organism denotes human 9606
T2 819-842 Organism denotes Clostridium perfringens 1502
T3 847-871 Organism denotes Arthrobacter ureafaciens 37931

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-63 Sentence denotes New ganglioside analogs that inhibit influenza virus sialidase.
T2 64-434 Sentence denotes Synthetic thioglycoside-analogs of gangliosides such as Neu5Ac alpha(2-S-6)Glc beta(1-1)Ceramide (1) and the GM3 analog Neu5Ac alpha(2-S-6)Gal beta(1-4)Glc beta(1-1)Ceramide (2), competitively inhibited GM3 hydrolysis by the sialidase of different subtypes of human and animal influenza viruses with an apparent Ki value of 2.8 x 10(-6) and 1.5 x 10(-5) M, respectively.
T3 435-640 Sentence denotes The inhibitory activity of the ganglioside GM4 analog [Neu5Ac alpha(2-S-6)Gal beta(1-1)Ceramide (3)], in which the glucose of 1 was substituted by galactose, was lower than that of 1 (Ki = 1.0 x 10(-4) M).
T4 641-760 Sentence denotes The thioglycoside-analogs (1, 2, 3) of the gangliosides were non-hydrolyzable substrates for influenza virus sialidase.
T5 761-1186 Sentence denotes The inhibitory activity of 1 to bacterial sialidases from Clostridium perfringens and Arthrobacter ureafaciens was considerably lower than that to influenza virus sialidase, indicating that the structure of the active site in bacterial and influenza virus sialidase may be different and the analogs may be useful to determine the orientation of the substrate to the active site of sialidases, especially of influenza viruses.

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 478-481 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM4 http://www.glycoepitope.jp/epitopes/EP0055

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 37-46 Disease denotes influenza MONDO:0005812
T2 341-350 Disease denotes influenza MONDO:0005812
T3 734-743 Disease denotes influenza MONDO:0005812
T4 908-917 Disease denotes influenza MONDO:0005812
T5 1001-1010 Disease denotes influenza MONDO:0005812
T6 1168-1177 Disease denotes influenza MONDO:0005812

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 324-329 OrganismTaxon denotes human 9606
T2 819-842 OrganismTaxon denotes Clostridium perfringens 1502
T3 847-871 OrganismTaxon denotes Arthrobacter ureafaciens 37931