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PubMed:21362567 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T1 0-5 PR:Q5S006 denotes LRRK2
T2 0-5 PR:000003033 denotes LRRK2
T3 0-5 PR:Q5S007 denotes LRRK2
T4 59-73 D004198 denotes susceptibility
T5 59-73 D004198 denotes susceptibility
T10 106-125 D010300 denotes Parkinson's disease
T11 106-125 D010300 denotes Parkinson's disease
T14 153-157 PR:Q9V853 denotes lack
T15 180-185 D006801 denotes human
T16 298-306 SO:0000109 denotes mutation
T18 329-336 6308 denotes Leucine
T17 329-336 CHEBI:15603 denotes Leucine
T20 329-336 D007930 denotes Leucine
T21 329-336 CHEBI:25017 denotes Leucine
T22 329-336 D007930 denotes Leucine
T19 329-336 SO:0001437 denotes Leucine
T23 337-341 PR:Q9V3C5 denotes Rich
T24 349-355 D010770 denotes Kinase
T25 359-364 PR:Q5S006 denotes LRRK2
T26 359-364 PR:000003033 denotes LRRK2
T27 359-364 PR:Q5S007 denotes LRRK2
T28 366-370 SO:0000704 denotes gene
T29 399-407 SO:0000109 denotes mutation
T30 479-484 PR:Q5S006 denotes LRRK2
T31 479-484 PR:000003033 denotes LRRK2
T32 479-484 PR:Q5S007 denotes LRRK2
T33 485-493 SO:0000109 denotes mutation
T34 601-608 D004194 denotes disease
T35 601-608 D004194 denotes disease
T36 622-626 CHEBI:23888 denotes drug
T38 764-773 P37379 denotes synuclein
T37 764-773 D051843 denotes synuclein
T42 774-781 PR:000000001 denotes protein
T39 774-781 GO:0003675 denotes protein
T43 774-781 SO:0000104 denotes protein
T40 774-781 CHEBI:36080 denotes protein
T41 774-781 CHEBI:11122 denotes protein
T46 830-839 P55866 denotes caspase-3
T47 830-839 Q8MJC3 denotes caspase-3
T48 830-839 Q2PFV2 denotes caspase-3
T49 830-839 Q08DY9 denotes caspase-3
T50 830-839 Q5IS54 denotes caspase-3
T51 830-839 Q8MKI5 denotes caspase-3
T52 830-839 PR:000002312 denotes caspase-3
T53 830-839 Q8MJU1 denotes caspase-3
T54 830-839 Q60431 denotes caspase-3
T55 830-839 P42574 denotes caspase-3
T56 830-839 Q5IS99 denotes caspase-3
T57 830-839 Q95ND5 denotes caspase-3
T58 830-839 P70677 denotes caspase-3
T59 830-839 P55213 denotes caspase-3
T45 830-839 D053148 denotes caspase-3
T60 855-865 GO:0008219 denotes cell death
T63 911-928 5499 denotes hydrogen peroxide
T64 911-928 D006861 denotes hydrogen peroxide
T65 911-928 CHEBI:16240 denotes hydrogen peroxide
T66 911-928 D006861 denotes hydrogen peroxide
T68 930-936 C072553 denotes MG-132
T69 930-936 CHEBI:75142 denotes MG-132
T70 930-936 C072553 denotes MG-132
T72 942-959 D016627 denotes 6-hydroxydopamine
T73 942-959 D016627 denotes 6-hydroxydopamine
T74 942-959 CHEBI:78741 denotes 6-hydroxydopamine

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-5 gene:120892 denotes LRRK2
T1 87-93 disease:C3825627 denotes stress
R1 T0 T1 associated_with LRRK2,stress

Allie

Id Subject Object Predicate Lexical cue
SS1_21362567_1_0 106-125 expanded denotes Parkinson's disease
SS2_21362567_1_0 127-129 abbr denotes PD
SS1_21362567_1_1 186-198 expanded denotes dopaminergic
SS2_21362567_1_1 200-202 abbr denotes DA
SS1_21362567_2_0 329-357 expanded denotes Leucine-Rich Repeat Kinase-2
SS2_21362567_2_0 359-364 abbr denotes LRRK2
AE1_21362567_1_0 SS1_21362567_1_0 SS2_21362567_1_0 abbreviatedTo Parkinson's disease,PD
AE1_21362567_1_1 SS1_21362567_1_1 SS2_21362567_1_1 abbreviatedTo dopaminergic,DA
AE1_21362567_2_0 SS1_21362567_2_0 SS2_21362567_2_0 abbreviatedTo Leucine-Rich Repeat Kinase-2,LRRK2

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-94 DRI_Background denotes LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.
T2 95-212 DRI_Background denotes Studies of Parkinson's disease (PD) have been hindered by lack of access to affected human dopaminergic (DA) neurons.
T3 213-451 DRI_Approach denotes Here, we report generation of induced pluripotent stem cells that carry the p.G2019S mutation (G2019S-iPSCs) in the Leucine-Rich Repeat Kinase-2 (LRRK2) gene, the most common PD-related mutation, and their differentiation into DA neurons.
T4 452-639 DRI_Challenge denotes The high penetrance of the LRRK2 mutation and its clinical resemblance to sporadic PD suggest that these cells could provide a valuable platform for disease analysis and drug development.
T5 640-782 DRI_Outcome denotes We found that DA neurons derived from G2019S-iPSCs showed increased expression of key oxidative stress-response genes and α-synuclein protein.
T6 783-985 DRI_Background denotes The mutant neurons were also more sensitive to caspase-3 activation and cell death caused by exposure to stress agents, such as hydrogen peroxide, MG-132, and 6-hydroxydopamine, than control DA neurons.
T7 986-1130 DRI_Challenge denotes This enhanced stress sensitivity is consistent with existing understanding of early PD phenotypes and represents a potential therapeutic target.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 95-212 DRI_Background denotes Studies of Parkinson's disease (PD) have been hindered by lack of access to affected human dopaminergic (DA) neurons.
T2 213-451 DRI_Approach denotes Here, we report generation of induced pluripotent stem cells that carry the p.G2019S mutation (G2019S-iPSCs) in the Leucine-Rich Repeat Kinase-2 (LRRK2) gene, the most common PD-related mutation, and their differentiation into DA neurons.
T3 452-639 DRI_Challenge denotes The high penetrance of the LRRK2 mutation and its clinical resemblance to sporadic PD suggest that these cells could provide a valuable platform for disease analysis and drug development.
T4 640-782 DRI_Outcome denotes We found that DA neurons derived from G2019S-iPSCs showed increased expression of key oxidative stress-response genes and α-synuclein protein.
T5 783-985 DRI_Background denotes The mutant neurons were also more sensitive to caspase-3 activation and cell death caused by exposure to stress agents, such as hydrogen peroxide, MG-132, and 6-hydroxydopamine, than control DA neurons.
T6 986-1130 DRI_Challenge denotes This enhanced stress sensitivity is consistent with existing understanding of early PD phenotypes and represents a potential therapeutic target.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 106-115 HP_0001300 denotes Parkinson

DisGeNET5_variant_disease

Id Subject Object Predicate Lexical cue
21362567-2#95#101#geners34637584 308-314 geners34637584 denotes G2019S
21362567-2#76#84#geners34637584 289-297 geners34637584 denotes p.G2019S
21362567-2#175#177#diseaseC0030567 388-390 diseaseC0030567 denotes PD
95#101#geners34637584175#177#diseaseC0030567 21362567-2#95#101#geners34637584 21362567-2#175#177#diseaseC0030567 associated_with G2019S,PD
76#84#geners34637584175#177#diseaseC0030567 21362567-2#76#84#geners34637584 21362567-2#175#177#diseaseC0030567 associated_with p.G2019S,PD

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21362567-3#27#32#gene120892 479-484 gene120892 denotes LRRK2
21362567-3#83#85#diseaseC0030567 535-537 diseaseC0030567 denotes PD
27#32#gene12089283#85#diseaseC0030567 21362567-3#27#32#gene120892 21362567-3#83#85#diseaseC0030567 associated_with LRRK2,PD