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PubMed:21357691 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 476-487 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

sentences

Id Subject Object Predicate Lexical cue
T1 0-92 Sentence denotes Vipirinin, a coumarin-based HIV-1 Vpr inhibitor, interacts with a hydrophobic region of VPR.
T2 93-247 Sentence denotes The human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) is an accessory protein that has been shown to have multiple roles in HIV-1 pathogenesis.
T3 248-488 Sentence denotes By screening chemical libraries in the RIKEN Natural Products Depository, we identified a 3-phenyl coumarin-based compound that inhibited the cell cycle arrest activity of Vpr in yeast and Vpr-dependent viral infection of human macrophages.
T4 489-614 Sentence denotes We determined its minimal pharmacophore through a structure-activity relationship study and produced more potent derivatives.
T5 615-807 Sentence denotes We detected direct binding, and by assaying a panel of Vpr mutants, we found the hydrophobic region about residues Glu-25 and Gln-65 to be potentially involved in the binding of the inhibitor.
T6 808-983 Sentence denotes Our findings exposed a targeting site on Vpr and delineated a convenient approach to explore other targeting sites on the protein using small molecule inhibitors as bioprobes.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 103-119 HP_0002721 denotes immunodeficiency

Allie

Id Subject Object Predicate Lexical cue
SS1_21357691_1_0 97-127 expanded denotes human immunodeficiency virus 1
SS2_21357691_1_0 129-134 abbr denotes HIV-1
SS1_21357691_1_1 136-151 expanded denotes viral protein R
SS2_21357691_1_1 153-156 abbr denotes Vpr
AE1_21357691_1_0 SS1_21357691_1_0 SS2_21357691_1_0 abbreviatedTo human immunodeficiency virus 1,HIV-1
AE1_21357691_1_1 SS1_21357691_1_1 SS2_21357691_1_1 abbreviatedTo viral protein R,Vpr

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 103-119 Disease denotes immunodeficiency http://purl.obolibrary.org/obo/MONDO_0021094
T2 451-466 Disease denotes viral infection http://purl.obolibrary.org/obo/MONDO_0005108

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 103-119 Phenotype denotes immunodeficiency HP:0002721

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 97-127 OrganismTaxon denotes human immunodeficiency virus 1 11676
T2 470-475 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 390-400 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T2 476-487 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235