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This resulted in 60% loss of aggrecan, after 7 days, without affecting cell viability. When TGFβ was injected to validate that the system can be used to study a repair response following injection of a bio-active substance, proteoglycan synthesis nearly doubled compared to baseline synthesis. Trypsin-treated bovine CEP discs therefore provide a model system for studying repair of the degenerate disc, as morphology, cell viability and responsiveness to bio-active substances were maintained."}

{"project":"PubMed_ArguminSci","denotations":[{"id":"T1","span":{"begin":146,"end":337},"obj":"DRI_Background"},{"id":"T2","span":{"begin":338,"end":484},"obj":"DRI_Approach"},{"id":"T3","span":{"begin":485,"end":563},"obj":"DRI_Background"},{"id":"T4","span":{"begin":564,"end":716},"obj":"DRI_Approach"},{"id":"T5","span":{"begin":717,"end":817},"obj":"DRI_Approach"},{"id":"T6","span":{"begin":818,"end":1050},"obj":"DRI_Approach"},{"id":"T7","span":{"begin":1051,"end":1179},"obj":"DRI_Outcome"},{"id":"T8","span":{"begin":1180,"end":1303},"obj":"DRI_Approach"},{"id":"T9","span":{"begin":1304,"end":1390},"obj":"DRI_Approach"},{"id":"T10","span":{"begin":1391,"end":1597},"obj":"DRI_Outcome"},{"id":"T11","span":{"begin":1598,"end":1798},"obj":"DRI_Background"}],"text":"Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential.\nThe present work describes a novel bovine disc organ culture system with long-term maintenance of cell viability, in which degenerative changes can be induced as a prelude to studying repair. Discs were isolated with three different techniques: without endplates (NEP), with bony endplates (BEP) and with intact cartilage endplates (CEP). Swelling, deformation, and cell viability were evaluated in unloaded cultures. Degeneration was induced by a single trypsin injection into the center of the disc and the effect on cell viability and matrix degradation was followed. Trypsin-treated discs were exposed to TGFβ to evaluate the potential to study repair in this system. NEP isolated discs showed \u003e75% maintained cell viability for up to 10 days but were severely deformed, BEP discs on the other hand maintained morphology but failed to retain cell viability having only 27% viable cells after 10 days. In CEP discs, both cell viability and morphology were maintained for at least 4 weeks where \u003e75% of the cells were still viable. To mimic proteoglycan loss during disc degeneration, a single trypsin injection was administered to the center of the disc. This resulted in 60% loss of aggrecan, after 7 days, without affecting cell viability. When TGFβ was injected to validate that the system can be used to study a repair response following injection of a bio-active substance, proteoglycan synthesis nearly doubled compared to baseline synthesis. Trypsin-treated bovine CEP discs therefore provide a model system for studying repair of the degenerate disc, as morphology, cell viability and responsiveness to bio-active substances were maintained."}

{"project":"Goldhamster2_Cellosaurus","denotations":[{"id":"T1","span":{"begin":15,"end":17},"obj":"CVCL_8754|Cancer_cell_line|Homo sapiens"},{"id":"T2","span":{"begin":15,"end":17},"obj":"CVCL_H241|Cancer_cell_line|Homo sapiens"},{"id":"T3","span":{"begin":106,"end":107},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T4","span":{"begin":173,"end":174},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T5","span":{"begin":282,"end":289},"obj":"CVCL_0238|Cancer_cell_line|Homo sapiens"},{"id":"T6","span":{"begin":308,"end":309},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T7","span":{"begin":410,"end":413},"obj":"CVCL_IS66|Cancer_cell_line|Homo sapiens"},{"id":"T8","span":{"begin":592,"end":593},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T9","span":{"begin":628,"end":634},"obj":"CVCL_E031|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T10","span":{"begin":818,"end":821},"obj":"CVCL_IS66|Cancer_cell_line|Homo sapiens"},{"id":"T11","span":{"begin":1019,"end":1021},"obj":"CVCL_T366|Transformed_cell_line|Chlorocebus aethiops"},{"id":"T12","span":{"begin":1183,"end":1188},"obj":"CVCL_Z366|Spontaneously_immortalized_cell_line|Spodoptera frugiperda"},{"id":"T13","span":{"begin":1233,"end":1234},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T14","span":{"begin":1284,"end":1290},"obj":"CVCL_E031|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T15","span":{"begin":1321,"end":1323},"obj":"CVCL_C917|Induced_pluripotent_stem_cell|Homo sapiens"},{"id":"T16","span":{"begin":1463,"end":1464},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T17","span":{"begin":1504,"end":1505},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T18","span":{"begin":1510,"end":1516},"obj":"CVCL_C410|Hybridoma|Mus musculus"},{"id":"T19","span":{"begin":1649,"end":1650},"obj":"CVCL_6479|Finite_cell_line|Mus musculus"},{"id":"T20","span":{"begin":1764,"end":1770},"obj":"CVCL_C410|Hybridoma|Mus musculus"}],"text":"Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential.\nThe present work describes a novel bovine disc organ culture system with long-term maintenance of cell viability, in which degenerative changes can be induced as a prelude to studying repair. Discs were isolated with three different techniques: without endplates (NEP), with bony endplates (BEP) and with intact cartilage endplates (CEP). Swelling, deformation, and cell viability were evaluated in unloaded cultures. Degeneration was induced by a single trypsin injection into the center of the disc and the effect on cell viability and matrix degradation was followed. Trypsin-treated discs were exposed to TGFβ to evaluate the potential to study repair in this system. NEP isolated discs showed \u003e75% maintained cell viability for up to 10 days but were severely deformed, BEP discs on the other hand maintained morphology but failed to retain cell viability having only 27% viable cells after 10 days. In CEP discs, both cell viability and morphology were maintained for at least 4 weeks where \u003e75% of the cells were still viable. To mimic proteoglycan loss during disc degeneration, a single trypsin injection was administered to the center of the disc. This resulted in 60% loss of aggrecan, after 7 days, without affecting cell viability. When TGFβ was injected to validate that the system can be used to study a repair response following injection of a bio-active substance, proteoglycan synthesis nearly doubled compared to baseline synthesis. Trypsin-treated bovine CEP discs therefore provide a model system for studying repair of the degenerate disc, as morphology, cell viability and responsiveness to bio-active substances were maintained."}

{"project":"Allie","denotations":[{"id":"SS1_21336509_2_0","span":{"begin":421,"end":435},"obj":"expanded"},{"id":"SS2_21336509_2_0","span":{"begin":437,"end":440},"obj":"abbr"},{"id":"SS1_21336509_2_1","span":{"begin":458,"end":477},"obj":"expanded"},{"id":"SS2_21336509_2_1","span":{"begin":479,"end":482},"obj":"abbr"}],"relations":[{"id":"AE1_21336509_2_0","pred":"abbreviatedTo","subj":"SS1_21336509_2_0","obj":"SS2_21336509_2_0"},{"id":"AE1_21336509_2_1","pred":"abbreviatedTo","subj":"SS1_21336509_2_1","obj":"SS2_21336509_2_1"}],"text":"Development of an intact intervertebral disc organ culture system in which degeneration can be induced as a prelude to studying repair potential.\nThe present work describes a novel bovine disc organ culture system with long-term maintenance of cell viability, in which degenerative changes can be induced as a prelude to studying repair. Discs were isolated with three different techniques: without endplates (NEP), with bony endplates (BEP) and with intact cartilage endplates (CEP). Swelling, deformation, and cell viability were evaluated in unloaded cultures. Degeneration was induced by a single trypsin injection into the center of the disc and the effect on cell viability and matrix degradation was followed. Trypsin-treated discs were exposed to TGFβ to evaluate the potential to study repair in this system. NEP isolated discs showed \u003e75% maintained cell viability for up to 10 days but were severely deformed, BEP discs on the other hand maintained morphology but failed to retain cell viability having only 27% viable cells after 10 days. In CEP discs, both cell viability and morphology were maintained for at least 4 weeks where \u003e75% of the cells were still viable. To mimic proteoglycan loss during disc degeneration, a single trypsin injection was administered to the center of the disc. This resulted in 60% loss of aggrecan, after 7 days, without affecting cell viability. When TGFβ was injected to validate that the system can be used to study a repair response following injection of a bio-active substance, proteoglycan synthesis nearly doubled compared to baseline synthesis. Trypsin-treated bovine CEP discs therefore provide a model system for studying repair of the degenerate disc, as morphology, cell viability and responsiveness to bio-active substances were maintained."}