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LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 542-545 OrganismTaxon denotes man NCBItxid:9606
T2 1143-1148 OrganismTaxon denotes codon NCBItxid:79338

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-118 Sentence denotes A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy.
T2 119-347 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level.
T3 348-424 Sentence denotes Several gene mutations of apoE have been reported to be associated with LPG.
T4 425-511 Sentence denotes In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka.
T5 512-593 Sentence denotes The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome.
T6 594-776 Sentence denotes Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries.
T7 777-891 Sentence denotes His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis.
T8 892-960 Sentence denotes It is intriguing that the serum apoE level was within normal limits.
T9 961-1077 Sentence denotes We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products.
T10 1078-1163 Sentence denotes ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4.
T11 1164-1281 Sentence denotes This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE.
T12 1282-1416 Sentence denotes The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous.
T13 1417-1630 Sentence denotes It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries.
T14 1631-1719 Sentence denotes The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
8534 8-24 GeneOrGeneProduct denotes apolipoprotein E NCBIGene:348
8535 35-39 GeneOrGeneProduct denotes ApoE NCBIGene:348
8536 47-57 SequenceVariant denotes Arg158 Pro p|SUB|R|158|P
8537 65-77 DiseaseOrPhenotypicFeature denotes dyslipidemic MESH:D050171
8538 78-85 OrganismTaxon denotes patient NCBITaxon:9606
8539 91-117 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy MESH:C567089
8540 119-145 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy MESH:C567089
8541 147-150 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
8542 317-333 GeneOrGeneProduct denotes apolipoprotein E NCBIGene:348
8543 335-339 GeneOrGeneProduct denotes apoE NCBIGene:348
8544 374-378 GeneOrGeneProduct denotes apoE NCBIGene:348
8545 420-423 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
8546 460-463 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
8547 464-471 OrganismTaxon denotes patient NCBITaxon:9606
8548 485-489 GeneOrGeneProduct denotes apoE NCBIGene:348
8549 500-504 GeneOrGeneProduct denotes apoE NCBIGene:348
8550 516-523 OrganismTaxon denotes patient NCBITaxon:9606
8551 542-545 OrganismTaxon denotes man NCBITaxon:9606
8552 574-592 DiseaseOrPhenotypicFeature denotes nephrotic syndrome MESH:D009404
8553 696-699 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
8554 711-728 DiseaseOrPhenotypicFeature denotes lamellate thrombi MESH:D013927
8555 781-785 GeneOrGeneProduct denotes apoE NCBIGene:348
8556 800-807 GeneOrGeneProduct denotes apoE3/2 NCBIGene:348
8557 824-836 DiseaseOrPhenotypicFeature denotes dyslipidemia MESH:D050171
8558 856-870 ChemicalEntity denotes polyacrylamide
8559 924-928 GeneOrGeneProduct denotes apoE NCBIGene:348
8560 995-999 GeneOrGeneProduct denotes apoE NCBIGene:348
8561 1078-1082 GeneOrGeneProduct denotes ApoE NCBIGene:348
8562 1133-1152 SequenceVariant denotes G to C at codon 158 c|SUB|G|CODON158|C
8563 1216-1272 SequenceVariant denotes arginine residue for the proline residue at position 158 p|SUB|R|158|P
8564 1276-1280 GeneOrGeneProduct denotes apoE NCBIGene:348
8565 1437-1441 GeneOrGeneProduct denotes apoE NCBIGene:348
8566 1491-1495 GeneOrGeneProduct denotes apoE NCBIGene:348
8567 1549-1553 GeneOrGeneProduct denotes apoE NCBIGene:348
8568 1656-1659 DiseaseOrPhenotypicFeature denotes LPG MESH:C567089
8569 1673-1677 GeneOrGeneProduct denotes apoE NCBIGene:348

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 91-117 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy 0012725
T2 119-145 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy 0012725
T3 157-161 DiseaseOrPhenotypicFeature denotes rare 0021136
T4 574-592 DiseaseOrPhenotypicFeature denotes nephrotic syndrome 0005377
T5 1586-1597 DiseaseOrPhenotypicFeature denotes endothelial 0015292

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 47-57 SequenceVariant denotes Arg158 Pro

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 2-7 GeneOrGeneProduct denotes novel
T2 8-24 GeneOrGeneProduct denotes apolipoprotein E
T3 25-33 GeneOrGeneProduct denotes mutation
T4 35-39 GeneOrGeneProduct denotes ApoE
T16 490-498 GeneOrGeneProduct denotes mutation
T5 60-64 GeneOrGeneProduct denotes in a
T6 91-102 GeneOrGeneProduct denotes lipoprotein
T7 119-130 GeneOrGeneProduct denotes Lipoprotein
T8 157-161 GeneOrGeneProduct denotes rare
T9 230-238 GeneOrGeneProduct denotes markedly
T10 317-333 GeneOrGeneProduct denotes apolipoprotein E
T11 335-339 GeneOrGeneProduct denotes apoE
T12 361-370 GeneOrGeneProduct denotes mutations
T13 374-378 GeneOrGeneProduct denotes apoE
T14 479-484 GeneOrGeneProduct denotes novel
T15 485-489 GeneOrGeneProduct denotes apoE
T17 500-504 GeneOrGeneProduct denotes apoE
T18 533-537 GeneOrGeneProduct denotes year
T19 584-592 GeneOrGeneProduct denotes syndrome
T20 594-599 GeneOrGeneProduct denotes Light
T21 684-692 GeneOrGeneProduct denotes findings
T22 781-785 GeneOrGeneProduct denotes apoE
T23 806-811 GeneOrGeneProduct denotes 2 and
T24 842-847 GeneOrGeneProduct denotes a mid
T25 848-852 GeneOrGeneProduct denotes band
T26 871-874 GeneOrGeneProduct denotes gel
T27 924-928 GeneOrGeneProduct denotes apoE
T28 953-959 GeneOrGeneProduct denotes limits
T29 964-978 GeneOrGeneProduct denotes determined the
T30 995-999 GeneOrGeneProduct denotes apoE
T31 1036-1046 GeneOrGeneProduct denotes polymerase
T32 1047-1052 GeneOrGeneProduct denotes chain
T33 1068-1076 GeneOrGeneProduct denotes products
T34 1078-1082 GeneOrGeneProduct denotes ApoE
T35 1169-1177 GeneOrGeneProduct denotes mutation
T36 1189-1199 GeneOrGeneProduct denotes amino acid
T37 1276-1280 GeneOrGeneProduct denotes apoE
T38 1391-1399 GeneOrGeneProduct denotes mutation
T39 1437-1441 GeneOrGeneProduct denotes apoE
T40 1448-1456 GeneOrGeneProduct denotes mutation
T41 1491-1495 GeneOrGeneProduct denotes apoE
T42 1496-1503 GeneOrGeneProduct denotes protein
T43 1549-1553 GeneOrGeneProduct denotes apoE
T44 1565-1577 GeneOrGeneProduct denotes lipoproteins
T45 1586-1597 GeneOrGeneProduct denotes endothelial
T46 1598-1603 GeneOrGeneProduct denotes cells
T47 1673-1677 GeneOrGeneProduct denotes apoE

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 2-7 GeneOrGeneProduct denotes novel
T2 8-24 GeneOrGeneProduct denotes apolipoprotein E
T3 91-102 GeneOrGeneProduct denotes lipoprotein
T4 119-130 GeneOrGeneProduct denotes Lipoprotein
T5 157-161 GeneOrGeneProduct denotes rare
T6 317-333 GeneOrGeneProduct denotes apolipoprotein E
T7 335-339 GeneOrGeneProduct denotes apoE
T8 374-378 GeneOrGeneProduct denotes apoE
T9 479-484 GeneOrGeneProduct denotes novel
T10 485-489 GeneOrGeneProduct denotes apoE
T11 500-504 GeneOrGeneProduct denotes apoE
T12 584-592 GeneOrGeneProduct denotes syndrome
T13 594-599 GeneOrGeneProduct denotes Light
T14 781-785 GeneOrGeneProduct denotes apoE
T15 842-847 GeneOrGeneProduct denotes a mid
T16 848-852 GeneOrGeneProduct denotes band
T17 924-928 GeneOrGeneProduct denotes apoE
T18 995-999 GeneOrGeneProduct denotes apoE
T19 1036-1046 GeneOrGeneProduct denotes polymerase
T20 1047-1052 GeneOrGeneProduct denotes chain
T21 1189-1199 GeneOrGeneProduct denotes amino acid
T22 1276-1280 GeneOrGeneProduct denotes apoE
T23 1437-1441 GeneOrGeneProduct denotes apoE
T24 1491-1495 GeneOrGeneProduct denotes apoE
T25 1496-1503 GeneOrGeneProduct denotes protein
T26 1549-1553 GeneOrGeneProduct denotes apoE
T27 1565-1577 GeneOrGeneProduct denotes lipoproteins
T28 1586-1597 GeneOrGeneProduct denotes endothelial
T29 1673-1677 GeneOrGeneProduct denotes apoE

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 91-117 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T2 119-145 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T3 147-150 DiseaseOrPhenotypicFeature denotes LPG C567089
T4 157-169 DiseaseOrPhenotypicFeature denotes rare disease D035583
T5 420-423 DiseaseOrPhenotypicFeature denotes LPG C567089
T6 460-463 DiseaseOrPhenotypicFeature denotes LPG C567089
T7 574-592 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T8 696-699 DiseaseOrPhenotypicFeature denotes LPG C567089
T9 824-836 DiseaseOrPhenotypicFeature denotes dyslipidemia D050171
T10 1656-1659 DiseaseOrPhenotypicFeature denotes LPG C567089

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 8-24 GeneOrGeneProduct denotes apolipoprotein E
T2 91-102 GeneOrGeneProduct denotes lipoprotein
T3 119-130 GeneOrGeneProduct denotes Lipoprotein
T4 317-333 GeneOrGeneProduct denotes apolipoprotein E
T5 335-339 GeneOrGeneProduct denotes apoE
T6 374-378 GeneOrGeneProduct denotes apoE
T7 485-489 GeneOrGeneProduct denotes apoE
T8 500-504 GeneOrGeneProduct denotes apoE
T9 781-785 GeneOrGeneProduct denotes apoE
T10 842-847 GeneOrGeneProduct denotes a mid
T11 924-928 GeneOrGeneProduct denotes apoE
T12 995-999 GeneOrGeneProduct denotes apoE
T13 1276-1280 GeneOrGeneProduct denotes apoE
T14 1437-1441 GeneOrGeneProduct denotes apoE
T15 1491-1495 GeneOrGeneProduct denotes apoE
T16 1549-1553 GeneOrGeneProduct denotes apoE
T17 1673-1677 GeneOrGeneProduct denotes apoE

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 91-117 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy 0012725
T2 119-145 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy 0012725
T3 147-150 DiseaseOrPhenotypicFeature denotes LPG 0012725
T4 420-423 DiseaseOrPhenotypicFeature denotes LPG 0012725
T5 460-463 DiseaseOrPhenotypicFeature denotes LPG 0012725
T6 574-592 DiseaseOrPhenotypicFeature denotes nephrotic syndrome 0005377
T7 696-699 DiseaseOrPhenotypicFeature denotes LPG 0012725
T8 812-814 DiseaseOrPhenotypicFeature denotes he 0017319
T9 824-836 DiseaseOrPhenotypicFeature denotes dyslipidemia 0002525
T10 1656-1659 DiseaseOrPhenotypicFeature denotes LPG 0012725

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 65-77 DiseaseOrPhenotypicFeature denotes dyslipidemic DISEASE
T2 91-117 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T3 119-145 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T4 147-150 DiseaseOrPhenotypicFeature denotes LPG C567089
T5 157-169 DiseaseOrPhenotypicFeature denotes rare disease D035583
T6 239-269 DiseaseOrPhenotypicFeature denotes dilated glomerular capillaries DISEASE
T7 420-423 DiseaseOrPhenotypicFeature denotes LPG C567089
T8 460-463 DiseaseOrPhenotypicFeature denotes LPG C567089
T9 574-592 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T10 696-699 DiseaseOrPhenotypicFeature denotes LPG C567089
T11 711-728 DiseaseOrPhenotypicFeature denotes lamellate thrombi DISEASE
T12 745-775 DiseaseOrPhenotypicFeature denotes dilated glomerular capillaries DISEASE
T13 824-836 DiseaseOrPhenotypicFeature denotes dyslipidemia D050171
T14 1656-1659 DiseaseOrPhenotypicFeature denotes LPG C567089

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 65-77 DiseaseOrPhenotypicFeature denotes dyslipidemic DISEASE
T2 91-117 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T3 119-145 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T4 147-150 DiseaseOrPhenotypicFeature denotes LPG C567089
T5 420-423 DiseaseOrPhenotypicFeature denotes LPG C567089
T6 460-463 DiseaseOrPhenotypicFeature denotes LPG C567089
T7 574-592 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T8 696-699 DiseaseOrPhenotypicFeature denotes LPG C567089
T9 711-728 DiseaseOrPhenotypicFeature denotes lamellate thrombi DISEASE
T10 824-836 DiseaseOrPhenotypicFeature denotes dyslipidemia D050171
T11 1656-1659 DiseaseOrPhenotypicFeature denotes LPG C567089

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 8-22 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T2 54-57 ChemicalEntity denotes Pro http://purl.obolibrary.org/obo/CHEBI_50342
T3 147-150 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T4 317-331 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T5 420-423 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T6 460-463 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T7 696-699 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T8 856-874 ChemicalEntity denotes polyacrylamide gel C016680
T9 1216-1232 ChemicalEntity denotes arginine residue http://purl.obolibrary.org/obo/CHEBI_32700
T10 1241-1256 ChemicalEntity denotes proline residue http://purl.obolibrary.org/obo/CHEBI_32874
T11 1656-1659 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 78-85 OrganismTaxon denotes patient
T2 464-471 OrganismTaxon denotes patient
T3 516-523 OrganismTaxon denotes patient
T4 542-545 OrganismTaxon denotes man

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T11 1656-1659 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T10 1241-1256 ChemicalEntity denotes proline residue http://purl.obolibrary.org/obo/CHEBI_32874
T9 1216-1232 ChemicalEntity denotes arginine residue http://purl.obolibrary.org/obo/CHEBI_32700
T8 856-874 ChemicalEntity denotes polyacrylamide gel C016680
T7 696-699 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T6 460-463 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T5 420-423 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T4 317-331 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T3 147-150 ChemicalEntity denotes LPG http://purl.obolibrary.org/obo/CHEBI_59681
T2 54-57 ChemicalEntity denotes Pro http://purl.obolibrary.org/obo/CHEBI_50342
T1 8-22 ChemicalEntity denotes apolipoprotein http://purl.obolibrary.org/obo/CHEBI_39015
T17 1673-1677 GeneOrGeneProduct denotes apoE
T16 1549-1553 GeneOrGeneProduct denotes apoE
T15 1491-1495 GeneOrGeneProduct denotes apoE
T14 1437-1441 GeneOrGeneProduct denotes apoE
T13 1276-1280 GeneOrGeneProduct denotes apoE
T12 995-999 GeneOrGeneProduct denotes apoE
T40585 924-928 GeneOrGeneProduct denotes apoE
T78034 842-847 GeneOrGeneProduct denotes a mid
T99137 781-785 GeneOrGeneProduct denotes apoE
T10885 500-504 GeneOrGeneProduct denotes apoE
T36294 485-489 GeneOrGeneProduct denotes apoE
T48186 374-378 GeneOrGeneProduct denotes apoE
T30566 335-339 GeneOrGeneProduct denotes apoE
T53690 317-333 GeneOrGeneProduct denotes apolipoprotein E
T86738 119-130 GeneOrGeneProduct denotes Lipoprotein
T85608 91-102 GeneOrGeneProduct denotes lipoprotein
T9920 8-24 GeneOrGeneProduct denotes apolipoprotein E
T5091 1656-1659 DiseaseOrPhenotypicFeature denotes LPG C567089
T43643 824-836 DiseaseOrPhenotypicFeature denotes dyslipidemia D050171
T46203 711-728 DiseaseOrPhenotypicFeature denotes lamellate thrombi DISEASE
T34156 696-699 DiseaseOrPhenotypicFeature denotes LPG C567089
T46048 574-592 DiseaseOrPhenotypicFeature denotes nephrotic syndrome D009404
T76709 460-463 DiseaseOrPhenotypicFeature denotes LPG C567089
T2806 420-423 DiseaseOrPhenotypicFeature denotes LPG C567089
T91188 147-150 DiseaseOrPhenotypicFeature denotes LPG C567089
T65387 119-145 DiseaseOrPhenotypicFeature denotes Lipoprotein glomerulopathy C567089
T19616 91-117 DiseaseOrPhenotypicFeature denotes lipoprotein glomerulopathy C567089
T53256 65-77 DiseaseOrPhenotypicFeature denotes dyslipidemic DISEASE
T18478 542-545 OrganismTaxon denotes man
T55944 516-523 OrganismTaxon denotes patient
T8739 464-471 OrganismTaxon denotes patient
T69208 78-85 OrganismTaxon denotes patient
T38839 47-57 SequenceVariant denotes Arg158 Pro

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-118 Sentence denotes A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy.
TextSentencer_T2 119-347 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level.
TextSentencer_T3 348-424 Sentence denotes Several gene mutations of apoE have been reported to be associated with LPG.
TextSentencer_T4 425-511 Sentence denotes In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka.
TextSentencer_T5 512-593 Sentence denotes The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome.
TextSentencer_T6 594-776 Sentence denotes Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries.
TextSentencer_T7 777-891 Sentence denotes His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis.
TextSentencer_T8 892-960 Sentence denotes It is intriguing that the serum apoE level was within normal limits.
TextSentencer_T9 961-1077 Sentence denotes We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products.
TextSentencer_T10 1078-1163 Sentence denotes ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4.
TextSentencer_T11 1164-1281 Sentence denotes This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE.
TextSentencer_T12 1282-1416 Sentence denotes The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous.
TextSentencer_T13 1417-1630 Sentence denotes It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries.
TextSentencer_T14 1631-1719 Sentence denotes The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated.
T1 0-118 Sentence denotes A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy.
T2 119-347 Sentence denotes Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level.
T3 348-424 Sentence denotes Several gene mutations of apoE have been reported to be associated with LPG.
T4 425-511 Sentence denotes In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka.
T5 512-593 Sentence denotes The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome.
T6 594-776 Sentence denotes Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries.
T7 777-891 Sentence denotes His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis.
T8 892-960 Sentence denotes It is intriguing that the serum apoE level was within normal limits.
T9 961-1077 Sentence denotes We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products.
T10 1078-1163 Sentence denotes ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4.
T11 1164-1281 Sentence denotes This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE.
T12 1282-1416 Sentence denotes The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous.
T13 1417-1630 Sentence denotes It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries.
T14 1631-1719 Sentence denotes The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 8-24 gene:348 denotes apolipoprotein E
T1 91-117 disease:C2673196 denotes lipoprotein glomerulopathy
T2 335-339 gene:348 denotes apoE
T3 119-145 disease:C2673196 denotes Lipoprotein glomerulopathy
T4 317-333 gene:348 denotes apolipoprotein E
T5 157-169 disease:C0678236 denotes rare disease
T6 317-333 gene:348 denotes apolipoprotein E
T7 147-150 disease:C2673196 denotes LPG
T8 317-333 gene:348 denotes apolipoprotein E
T9 119-145 disease:C2673196 denotes Lipoprotein glomerulopathy
T10 335-339 gene:348 denotes apoE
T11 157-169 disease:C0678236 denotes rare disease
T12 335-339 gene:348 denotes apoE
T13 147-150 disease:C2673196 denotes LPG
T14 374-378 gene:348 denotes apoE
T15 420-423 disease:C2673196 denotes LPG
T16 485-489 gene:348 denotes apoE
T17 460-463 disease:C2673196 denotes LPG
R1 T0 T1 associated_with apolipoprotein E,lipoprotein glomerulopathy
R2 T2 T3 associated_with apoE,Lipoprotein glomerulopathy
R3 T4 T5 associated_with apolipoprotein E,rare disease
R4 T6 T7 associated_with apolipoprotein E,LPG
R5 T8 T9 associated_with apolipoprotein E,Lipoprotein glomerulopathy
R6 T10 T11 associated_with apoE,rare disease
R7 T12 T13 associated_with apoE,LPG
R8 T14 T15 associated_with apoE,LPG
R9 T16 T17 associated_with apoE,LPG

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 131-145 HP_0100820 denotes glomerulopathy
T2 574-592 HP_0000100 denotes nephrotic syndrome

Allie

Id Subject Object Predicate Lexical cue
SS1_21325775_1_0 119-145 expanded denotes Lipoprotein glomerulopathy
SS2_21325775_1_0 147-150 abbr denotes LPG
SS1_21325775_1_1 317-333 expanded denotes apolipoprotein E
SS2_21325775_1_1 335-339 abbr denotes apoE
SS1_21325775_8_0 1036-1061 expanded denotes polymerase chain reaction
SS2_21325775_8_0 1063-1066 abbr denotes PCR
AE1_21325775_1_0 SS1_21325775_1_0 SS2_21325775_1_0 abbreviatedTo Lipoprotein glomerulopathy,LPG
AE1_21325775_1_1 SS1_21325775_1_1 SS2_21325775_1_1 abbreviatedTo apolipoprotein E,apoE
AE1_21325775_8_0 SS1_21325775_8_0 SS2_21325775_8_0 abbreviatedTo polymerase chain reaction,PCR

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21325775-0#8#24#gene348 8-24 gene348 denotes apolipoprotein E
21325775-0#91#117#diseaseC2673196 91-117 diseaseC2673196 denotes lipoprotein glomerulopathy
8#24#gene34891#117#diseaseC2673196 21325775-0#8#24#gene348 21325775-0#91#117#diseaseC2673196 associated_with apolipoprotein E,lipoprotein glomerulopathy

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 311-316 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 918-923 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 247-269 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T4 753-775 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T5 1607-1629 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T6 258-269 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries
PD-UBERON-AE-B_T7 764-775 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries
PD-UBERON-AE-B_T8 1618-1629 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 247-269 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T2 753-775 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T3 1607-1629 http://purl.obolibrary.org/obo/UBERON_0004212 denotes glomerular capillaries
PD-UBERON-AE-B_T4 258-269 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries
PD-UBERON-AE-B_T5 764-775 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries
PD-UBERON-AE-B_T6 1618-1629 http://purl.obolibrary.org/obo/UBERON_0001982 denotes capillaries
PD-UBERON-AE-B_T7 311-316 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T8 918-923 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 131-145 HP:0100820 denotes glomerulopathy
TI1 103-117 HP:0100820 denotes glomerulopathy
AB2 574-592 HP:0000100 denotes nephrotic syndrome

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 119-145 ORDO:329481 denotes Lipoprotein glomerulopathy
AB2 147-150 ORDO:329481 denotes LPG
TI1 91-117 ORDO:329481 denotes lipoprotein glomerulopathy
AB3 420-423 ORDO:329481 denotes LPG
AB4 460-463 ORDO:329481 denotes LPG
AB5 696-699 ORDO:329481 denotes LPG
AB6 1656-1659 ORDO:329481 denotes LPG

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 47-57 ProteinMutation:p|SUB|R|158|P denotes Arg158 Pro