PubMed:21325775
Annnotations
LitCoin-entities-OrganismTaxon-PD
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
T1 | 542-545 | OrganismTaxon | denotes | man | NCBItxid:9606 |
T2 | 1143-1148 | OrganismTaxon | denotes | codon | NCBItxid:79338 |
LitCoin-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 0-118 | Sentence | denotes | A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. |
T2 | 119-347 | Sentence | denotes | Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level. |
T3 | 348-424 | Sentence | denotes | Several gene mutations of apoE have been reported to be associated with LPG. |
T4 | 425-511 | Sentence | denotes | In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka. |
T5 | 512-593 | Sentence | denotes | The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome. |
T6 | 594-776 | Sentence | denotes | Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries. |
T7 | 777-891 | Sentence | denotes | His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis. |
T8 | 892-960 | Sentence | denotes | It is intriguing that the serum apoE level was within normal limits. |
T9 | 961-1077 | Sentence | denotes | We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products. |
T10 | 1078-1163 | Sentence | denotes | ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4. |
T11 | 1164-1281 | Sentence | denotes | This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE. |
T12 | 1282-1416 | Sentence | denotes | The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous. |
T13 | 1417-1630 | Sentence | denotes | It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries. |
T14 | 1631-1719 | Sentence | denotes | The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated. |
LitCoin-entities
Id | Subject | Object | Predicate | Lexical cue | db_id |
---|---|---|---|---|---|
8534 | 8-24 | GeneOrGeneProduct | denotes | apolipoprotein E | NCBIGene:348 |
8535 | 35-39 | GeneOrGeneProduct | denotes | ApoE | NCBIGene:348 |
8536 | 47-57 | SequenceVariant | denotes | Arg158 Pro | p|SUB|R|158|P |
8537 | 65-77 | DiseaseOrPhenotypicFeature | denotes | dyslipidemic | MESH:D050171 |
8538 | 78-85 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
8539 | 91-117 | DiseaseOrPhenotypicFeature | denotes | lipoprotein glomerulopathy | MESH:C567089 |
8540 | 119-145 | DiseaseOrPhenotypicFeature | denotes | Lipoprotein glomerulopathy | MESH:C567089 |
8541 | 147-150 | DiseaseOrPhenotypicFeature | denotes | LPG | MESH:C567089 |
8542 | 317-333 | GeneOrGeneProduct | denotes | apolipoprotein E | NCBIGene:348 |
8543 | 335-339 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8544 | 374-378 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8545 | 420-423 | DiseaseOrPhenotypicFeature | denotes | LPG | MESH:C567089 |
8546 | 460-463 | DiseaseOrPhenotypicFeature | denotes | LPG | MESH:C567089 |
8547 | 464-471 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
8548 | 485-489 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8549 | 500-504 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8550 | 516-523 | OrganismTaxon | denotes | patient | NCBITaxon:9606 |
8551 | 542-545 | OrganismTaxon | denotes | man | NCBITaxon:9606 |
8552 | 574-592 | DiseaseOrPhenotypicFeature | denotes | nephrotic syndrome | MESH:D009404 |
8553 | 696-699 | DiseaseOrPhenotypicFeature | denotes | LPG | MESH:C567089 |
8554 | 711-728 | DiseaseOrPhenotypicFeature | denotes | lamellate thrombi | MESH:D013927 |
8555 | 781-785 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8556 | 800-807 | GeneOrGeneProduct | denotes | apoE3/2 | NCBIGene:348 |
8557 | 824-836 | DiseaseOrPhenotypicFeature | denotes | dyslipidemia | MESH:D050171 |
8558 | 856-870 | ChemicalEntity | denotes | polyacrylamide | |
8559 | 924-928 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8560 | 995-999 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8561 | 1078-1082 | GeneOrGeneProduct | denotes | ApoE | NCBIGene:348 |
8562 | 1133-1152 | SequenceVariant | denotes | G to C at codon 158 | c|SUB|G|CODON158|C |
8563 | 1216-1272 | SequenceVariant | denotes | arginine residue for the proline residue at position 158 | p|SUB|R|158|P |
8564 | 1276-1280 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8565 | 1437-1441 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8566 | 1491-1495 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8567 | 1549-1553 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
8568 | 1656-1659 | DiseaseOrPhenotypicFeature | denotes | LPG | MESH:C567089 |
8569 | 1673-1677 | GeneOrGeneProduct | denotes | apoE | NCBIGene:348 |
LitCoin_Mondo
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 91-117 | DiseaseOrPhenotypicFeature | denotes | lipoprotein glomerulopathy | 0012725 |
T2 | 119-145 | DiseaseOrPhenotypicFeature | denotes | Lipoprotein glomerulopathy | 0012725 |
T3 | 157-161 | DiseaseOrPhenotypicFeature | denotes | rare | 0021136 |
T4 | 574-592 | DiseaseOrPhenotypicFeature | denotes | nephrotic syndrome | 0005377 |
T5 | 1586-1597 | DiseaseOrPhenotypicFeature | denotes | endothelial | 0015292 |
LitCoin-SeqVar
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 47-57 | SequenceVariant | denotes | Arg158 Pro |
LitCoin-GeneOrGeneProduct-v0
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 2-7 | GeneOrGeneProduct | denotes | novel |
T2 | 8-24 | GeneOrGeneProduct | denotes | apolipoprotein E |
T3 | 25-33 | GeneOrGeneProduct | denotes | mutation |
T4 | 35-39 | GeneOrGeneProduct | denotes | ApoE |
T16 | 490-498 | GeneOrGeneProduct | denotes | mutation |
T5 | 60-64 | GeneOrGeneProduct | denotes | in a |
T6 | 91-102 | GeneOrGeneProduct | denotes | lipoprotein |
T7 | 119-130 | GeneOrGeneProduct | denotes | Lipoprotein |
T8 | 157-161 | GeneOrGeneProduct | denotes | rare |
T9 | 230-238 | GeneOrGeneProduct | denotes | markedly |
T10 | 317-333 | GeneOrGeneProduct | denotes | apolipoprotein E |
T11 | 335-339 | GeneOrGeneProduct | denotes | apoE |
T12 | 361-370 | GeneOrGeneProduct | denotes | mutations |
T13 | 374-378 | GeneOrGeneProduct | denotes | apoE |
T14 | 479-484 | GeneOrGeneProduct | denotes | novel |
T15 | 485-489 | GeneOrGeneProduct | denotes | apoE |
T17 | 500-504 | GeneOrGeneProduct | denotes | apoE |
T18 | 533-537 | GeneOrGeneProduct | denotes | year |
T19 | 584-592 | GeneOrGeneProduct | denotes | syndrome |
T20 | 594-599 | GeneOrGeneProduct | denotes | Light |
T21 | 684-692 | GeneOrGeneProduct | denotes | findings |
T22 | 781-785 | GeneOrGeneProduct | denotes | apoE |
T23 | 806-811 | GeneOrGeneProduct | denotes | 2 and |
T24 | 842-847 | GeneOrGeneProduct | denotes | a mid |
T25 | 848-852 | GeneOrGeneProduct | denotes | band |
T26 | 871-874 | GeneOrGeneProduct | denotes | gel |
T27 | 924-928 | GeneOrGeneProduct | denotes | apoE |
T28 | 953-959 | GeneOrGeneProduct | denotes | limits |
T29 | 964-978 | GeneOrGeneProduct | denotes | determined the |
T30 | 995-999 | GeneOrGeneProduct | denotes | apoE |
T31 | 1036-1046 | GeneOrGeneProduct | denotes | polymerase |
T32 | 1047-1052 | GeneOrGeneProduct | denotes | chain |
T33 | 1068-1076 | GeneOrGeneProduct | denotes | products |
T34 | 1078-1082 | GeneOrGeneProduct | denotes | ApoE |
T35 | 1169-1177 | GeneOrGeneProduct | denotes | mutation |
T36 | 1189-1199 | GeneOrGeneProduct | denotes | amino acid |
T37 | 1276-1280 | GeneOrGeneProduct | denotes | apoE |
T38 | 1391-1399 | GeneOrGeneProduct | denotes | mutation |
T39 | 1437-1441 | GeneOrGeneProduct | denotes | apoE |
T40 | 1448-1456 | GeneOrGeneProduct | denotes | mutation |
T41 | 1491-1495 | GeneOrGeneProduct | denotes | apoE |
T42 | 1496-1503 | GeneOrGeneProduct | denotes | protein |
T43 | 1549-1553 | GeneOrGeneProduct | denotes | apoE |
T44 | 1565-1577 | GeneOrGeneProduct | denotes | lipoproteins |
T45 | 1586-1597 | GeneOrGeneProduct | denotes | endothelial |
T46 | 1598-1603 | GeneOrGeneProduct | denotes | cells |
T47 | 1673-1677 | GeneOrGeneProduct | denotes | apoE |
LitCoin-GeneOrGeneProduct-v2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 2-7 | GeneOrGeneProduct | denotes | novel |
T2 | 8-24 | GeneOrGeneProduct | denotes | apolipoprotein E |
T3 | 91-102 | GeneOrGeneProduct | denotes | lipoprotein |
T4 | 119-130 | GeneOrGeneProduct | denotes | Lipoprotein |
T5 | 157-161 | GeneOrGeneProduct | denotes | rare |
T6 | 317-333 | GeneOrGeneProduct | denotes | apolipoprotein E |
T7 | 335-339 | GeneOrGeneProduct | denotes | apoE |
T8 | 374-378 | GeneOrGeneProduct | denotes | apoE |
T9 | 479-484 | GeneOrGeneProduct | denotes | novel |
T10 | 485-489 | GeneOrGeneProduct | denotes | apoE |
T11 | 500-504 | GeneOrGeneProduct | denotes | apoE |
T12 | 584-592 | GeneOrGeneProduct | denotes | syndrome |
T13 | 594-599 | GeneOrGeneProduct | denotes | Light |
T14 | 781-785 | GeneOrGeneProduct | denotes | apoE |
T15 | 842-847 | GeneOrGeneProduct | denotes | a mid |
T16 | 848-852 | GeneOrGeneProduct | denotes | band |
T17 | 924-928 | GeneOrGeneProduct | denotes | apoE |
T18 | 995-999 | GeneOrGeneProduct | denotes | apoE |
T19 | 1036-1046 | GeneOrGeneProduct | denotes | polymerase |
T20 | 1047-1052 | GeneOrGeneProduct | denotes | chain |
T21 | 1189-1199 | GeneOrGeneProduct | denotes | amino acid |
T22 | 1276-1280 | GeneOrGeneProduct | denotes | apoE |
T23 | 1437-1441 | GeneOrGeneProduct | denotes | apoE |
T24 | 1491-1495 | GeneOrGeneProduct | denotes | apoE |
T25 | 1496-1503 | GeneOrGeneProduct | denotes | protein |
T26 | 1549-1553 | GeneOrGeneProduct | denotes | apoE |
T27 | 1565-1577 | GeneOrGeneProduct | denotes | lipoproteins |
T28 | 1586-1597 | GeneOrGeneProduct | denotes | endothelial |
T29 | 1673-1677 | GeneOrGeneProduct | denotes | apoE |
LitCoin-Disease-MeSH
Id | Subject | Object | Predicate | Lexical cue | originalLabel |
---|---|---|---|---|---|
T1 | 91-117 | DiseaseOrPhenotypicFeature | denotes | lipoprotein glomerulopathy | C567089 |
T2 | 119-145 | DiseaseOrPhenotypicFeature | denotes | Lipoprotein glomerulopathy | C567089 |
T3 | 147-150 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T4 | 157-169 | DiseaseOrPhenotypicFeature | denotes | rare disease | D035583 |
T5 | 420-423 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T6 | 460-463 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T7 | 574-592 | DiseaseOrPhenotypicFeature | denotes | nephrotic syndrome | D009404 |
T8 | 696-699 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T9 | 824-836 | DiseaseOrPhenotypicFeature | denotes | dyslipidemia | D050171 |
T10 | 1656-1659 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
LitCoin-GeneOrGeneProduct-v3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 8-24 | GeneOrGeneProduct | denotes | apolipoprotein E |
T2 | 91-102 | GeneOrGeneProduct | denotes | lipoprotein |
T3 | 119-130 | GeneOrGeneProduct | denotes | Lipoprotein |
T4 | 317-333 | GeneOrGeneProduct | denotes | apolipoprotein E |
T5 | 335-339 | GeneOrGeneProduct | denotes | apoE |
T6 | 374-378 | GeneOrGeneProduct | denotes | apoE |
T7 | 485-489 | GeneOrGeneProduct | denotes | apoE |
T8 | 500-504 | GeneOrGeneProduct | denotes | apoE |
T9 | 781-785 | GeneOrGeneProduct | denotes | apoE |
T10 | 842-847 | GeneOrGeneProduct | denotes | a mid |
T11 | 924-928 | GeneOrGeneProduct | denotes | apoE |
T12 | 995-999 | GeneOrGeneProduct | denotes | apoE |
T13 | 1276-1280 | GeneOrGeneProduct | denotes | apoE |
T14 | 1437-1441 | GeneOrGeneProduct | denotes | apoE |
T15 | 1491-1495 | GeneOrGeneProduct | denotes | apoE |
T16 | 1549-1553 | GeneOrGeneProduct | denotes | apoE |
T17 | 1673-1677 | GeneOrGeneProduct | denotes | apoE |
LitCoin_Mondo_095
Id | Subject | Object | Predicate | Lexical cue | mondo_id |
---|---|---|---|---|---|
T1 | 91-117 | DiseaseOrPhenotypicFeature | denotes | lipoprotein glomerulopathy | 0012725 |
T2 | 119-145 | DiseaseOrPhenotypicFeature | denotes | Lipoprotein glomerulopathy | 0012725 |
T3 | 147-150 | DiseaseOrPhenotypicFeature | denotes | LPG | 0012725 |
T4 | 420-423 | DiseaseOrPhenotypicFeature | denotes | LPG | 0012725 |
T5 | 460-463 | DiseaseOrPhenotypicFeature | denotes | LPG | 0012725 |
T6 | 574-592 | DiseaseOrPhenotypicFeature | denotes | nephrotic syndrome | 0005377 |
T7 | 696-699 | DiseaseOrPhenotypicFeature | denotes | LPG | 0012725 |
T8 | 812-814 | DiseaseOrPhenotypicFeature | denotes | he | 0017319 |
T9 | 824-836 | DiseaseOrPhenotypicFeature | denotes | dyslipidemia | 0002525 |
T10 | 1656-1659 | DiseaseOrPhenotypicFeature | denotes | LPG | 0012725 |
LitCoin-MeSH-Disease-2
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 65-77 | DiseaseOrPhenotypicFeature | denotes | dyslipidemic | DISEASE |
T2 | 91-117 | DiseaseOrPhenotypicFeature | denotes | lipoprotein glomerulopathy | C567089 |
T3 | 119-145 | DiseaseOrPhenotypicFeature | denotes | Lipoprotein glomerulopathy | C567089 |
T4 | 147-150 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T5 | 157-169 | DiseaseOrPhenotypicFeature | denotes | rare disease | D035583 |
T6 | 239-269 | DiseaseOrPhenotypicFeature | denotes | dilated glomerular capillaries | DISEASE |
T7 | 420-423 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T8 | 460-463 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T9 | 574-592 | DiseaseOrPhenotypicFeature | denotes | nephrotic syndrome | D009404 |
T10 | 696-699 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T11 | 711-728 | DiseaseOrPhenotypicFeature | denotes | lamellate thrombi | DISEASE |
T12 | 745-775 | DiseaseOrPhenotypicFeature | denotes | dilated glomerular capillaries | DISEASE |
T13 | 824-836 | DiseaseOrPhenotypicFeature | denotes | dyslipidemia | D050171 |
T14 | 1656-1659 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
LitCoin-MONDO_bioort2019
Id | Subject | Object | Predicate | Lexical cue | #label |
---|---|---|---|---|---|
T1 | 65-77 | DiseaseOrPhenotypicFeature | denotes | dyslipidemic | DISEASE |
T2 | 91-117 | DiseaseOrPhenotypicFeature | denotes | lipoprotein glomerulopathy | C567089 |
T3 | 119-145 | DiseaseOrPhenotypicFeature | denotes | Lipoprotein glomerulopathy | C567089 |
T4 | 147-150 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T5 | 420-423 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T6 | 460-463 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T7 | 574-592 | DiseaseOrPhenotypicFeature | denotes | nephrotic syndrome | D009404 |
T8 | 696-699 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
T9 | 711-728 | DiseaseOrPhenotypicFeature | denotes | lamellate thrombi | DISEASE |
T10 | 824-836 | DiseaseOrPhenotypicFeature | denotes | dyslipidemia | D050171 |
T11 | 1656-1659 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 |
LitCoin-Chemical-MeSH-CHEBI
Id | Subject | Object | Predicate | Lexical cue | ID: |
---|---|---|---|---|---|
T1 | 8-22 | ChemicalEntity | denotes | apolipoprotein | http://purl.obolibrary.org/obo/CHEBI_39015 |
T2 | 54-57 | ChemicalEntity | denotes | Pro | http://purl.obolibrary.org/obo/CHEBI_50342 |
T3 | 147-150 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 |
T4 | 317-331 | ChemicalEntity | denotes | apolipoprotein | http://purl.obolibrary.org/obo/CHEBI_39015 |
T5 | 420-423 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 |
T6 | 460-463 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 |
T7 | 696-699 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 |
T8 | 856-874 | ChemicalEntity | denotes | polyacrylamide gel | C016680 |
T9 | 1216-1232 | ChemicalEntity | denotes | arginine residue | http://purl.obolibrary.org/obo/CHEBI_32700 |
T10 | 1241-1256 | ChemicalEntity | denotes | proline residue | http://purl.obolibrary.org/obo/CHEBI_32874 |
T11 | 1656-1659 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 |
LitCoin-NCBITaxon-2
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 78-85 | OrganismTaxon | denotes | patient |
T2 | 464-471 | OrganismTaxon | denotes | patient |
T3 | 516-523 | OrganismTaxon | denotes | patient |
T4 | 542-545 | OrganismTaxon | denotes | man |
LitCoin-training-merged
Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
---|---|---|---|---|---|---|
T11 | 1656-1659 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 | |
T10 | 1241-1256 | ChemicalEntity | denotes | proline residue | http://purl.obolibrary.org/obo/CHEBI_32874 | |
T9 | 1216-1232 | ChemicalEntity | denotes | arginine residue | http://purl.obolibrary.org/obo/CHEBI_32700 | |
T8 | 856-874 | ChemicalEntity | denotes | polyacrylamide gel | C016680 | |
T7 | 696-699 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 | |
T6 | 460-463 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 | |
T5 | 420-423 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 | |
T4 | 317-331 | ChemicalEntity | denotes | apolipoprotein | http://purl.obolibrary.org/obo/CHEBI_39015 | |
T3 | 147-150 | ChemicalEntity | denotes | LPG | http://purl.obolibrary.org/obo/CHEBI_59681 | |
T2 | 54-57 | ChemicalEntity | denotes | Pro | http://purl.obolibrary.org/obo/CHEBI_50342 | |
T1 | 8-22 | ChemicalEntity | denotes | apolipoprotein | http://purl.obolibrary.org/obo/CHEBI_39015 | |
T17 | 1673-1677 | GeneOrGeneProduct | denotes | apoE | ||
T16 | 1549-1553 | GeneOrGeneProduct | denotes | apoE | ||
T15 | 1491-1495 | GeneOrGeneProduct | denotes | apoE | ||
T14 | 1437-1441 | GeneOrGeneProduct | denotes | apoE | ||
T13 | 1276-1280 | GeneOrGeneProduct | denotes | apoE | ||
T12 | 995-999 | GeneOrGeneProduct | denotes | apoE | ||
T40585 | 924-928 | GeneOrGeneProduct | denotes | apoE | ||
T78034 | 842-847 | GeneOrGeneProduct | denotes | a mid | ||
T99137 | 781-785 | GeneOrGeneProduct | denotes | apoE | ||
T10885 | 500-504 | GeneOrGeneProduct | denotes | apoE | ||
T36294 | 485-489 | GeneOrGeneProduct | denotes | apoE | ||
T48186 | 374-378 | GeneOrGeneProduct | denotes | apoE | ||
T30566 | 335-339 | GeneOrGeneProduct | denotes | apoE | ||
T53690 | 317-333 | GeneOrGeneProduct | denotes | apolipoprotein E | ||
T86738 | 119-130 | GeneOrGeneProduct | denotes | Lipoprotein | ||
T85608 | 91-102 | GeneOrGeneProduct | denotes | lipoprotein | ||
T9920 | 8-24 | GeneOrGeneProduct | denotes | apolipoprotein E | ||
T5091 | 1656-1659 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 | |
T43643 | 824-836 | DiseaseOrPhenotypicFeature | denotes | dyslipidemia | D050171 | |
T46203 | 711-728 | DiseaseOrPhenotypicFeature | denotes | lamellate thrombi | DISEASE | |
T34156 | 696-699 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 | |
T46048 | 574-592 | DiseaseOrPhenotypicFeature | denotes | nephrotic syndrome | D009404 | |
T76709 | 460-463 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 | |
T2806 | 420-423 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 | |
T91188 | 147-150 | DiseaseOrPhenotypicFeature | denotes | LPG | C567089 | |
T65387 | 119-145 | DiseaseOrPhenotypicFeature | denotes | Lipoprotein glomerulopathy | C567089 | |
T19616 | 91-117 | DiseaseOrPhenotypicFeature | denotes | lipoprotein glomerulopathy | C567089 | |
T53256 | 65-77 | DiseaseOrPhenotypicFeature | denotes | dyslipidemic | DISEASE | |
T18478 | 542-545 | OrganismTaxon | denotes | man | ||
T55944 | 516-523 | OrganismTaxon | denotes | patient | ||
T8739 | 464-471 | OrganismTaxon | denotes | patient | ||
T69208 | 78-85 | OrganismTaxon | denotes | patient | ||
T38839 | 47-57 | SequenceVariant | denotes | Arg158 Pro |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
TextSentencer_T1 | 0-118 | Sentence | denotes | A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. |
TextSentencer_T2 | 119-347 | Sentence | denotes | Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level. |
TextSentencer_T3 | 348-424 | Sentence | denotes | Several gene mutations of apoE have been reported to be associated with LPG. |
TextSentencer_T4 | 425-511 | Sentence | denotes | In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka. |
TextSentencer_T5 | 512-593 | Sentence | denotes | The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome. |
TextSentencer_T6 | 594-776 | Sentence | denotes | Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries. |
TextSentencer_T7 | 777-891 | Sentence | denotes | His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis. |
TextSentencer_T8 | 892-960 | Sentence | denotes | It is intriguing that the serum apoE level was within normal limits. |
TextSentencer_T9 | 961-1077 | Sentence | denotes | We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products. |
TextSentencer_T10 | 1078-1163 | Sentence | denotes | ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4. |
TextSentencer_T11 | 1164-1281 | Sentence | denotes | This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE. |
TextSentencer_T12 | 1282-1416 | Sentence | denotes | The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous. |
TextSentencer_T13 | 1417-1630 | Sentence | denotes | It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries. |
TextSentencer_T14 | 1631-1719 | Sentence | denotes | The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated. |
T1 | 0-118 | Sentence | denotes | A novel apolipoprotein E mutation, ApoE Osaka (Arg158 Pro), in a dyslipidemic patient with lipoprotein glomerulopathy. |
T2 | 119-347 | Sentence | denotes | Lipoprotein glomerulopathy (LPG) is a rare disease characterized by the presence of thrombuslike deposition in markedly dilated glomerular capillaries and is often accompanied by an increased serum apolipoprotein E (apoE) level. |
T3 | 348-424 | Sentence | denotes | Several gene mutations of apoE have been reported to be associated with LPG. |
T4 | 425-511 | Sentence | denotes | In the current study, we report an LPG patient with a novel apoE mutation, apoE Osaka. |
T5 | 512-593 | Sentence | denotes | The patient was a 45-year-old man who was hospitalized due to nephrotic syndrome. |
T6 | 594-776 | Sentence | denotes | Light and electron microscopic observations of renal biopsy clearly showed characteristic findings of LPG, including lamellate thrombi in the lumen of dilated glomerular capillaries. |
T7 | 777-891 | Sentence | denotes | His apoE phenotype was apoE3/2 and he had mild dyslipidemia with a mid-band on polyacrylamide gel electrophoresis. |
T8 | 892-960 | Sentence | denotes | It is intriguing that the serum apoE level was within normal limits. |
T9 | 961-1077 | Sentence | denotes | We determined the sequence of the apoE gene using direct sequencing of the polymerase chain reaction (PCR) products. |
T10 | 1078-1163 | Sentence | denotes | ApoE gene analysis showed a nucleotide substitution of G to C at codon 158 of exon 4. |
T11 | 1164-1281 | Sentence | denotes | This mutation denoted an amino acid substitution of arginine residue for the proline residue at position 158 of apoE. |
T12 | 1282-1416 | Sentence | denotes | The result of PCR associated with restriction fragment length polymorphism analysis also suggested that this mutation is heterozygous. |
T13 | 1417-1630 | Sentence | denotes | It is possible that apoE Osaka mutation causes a conformational change of apoE protein and affects the interaction between abnormal apoE-containing lipoproteins and the endothelial cells of glomerular capillaries. |
T14 | 1631-1719 | Sentence | denotes | The precise mechanism of LPG related with apoE Osaka, however, remains to be elucidated. |
DisGeNET
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T0 | 8-24 | gene:348 | denotes | apolipoprotein E |
T1 | 91-117 | disease:C2673196 | denotes | lipoprotein glomerulopathy |
T2 | 335-339 | gene:348 | denotes | apoE |
T3 | 119-145 | disease:C2673196 | denotes | Lipoprotein glomerulopathy |
T4 | 317-333 | gene:348 | denotes | apolipoprotein E |
T5 | 157-169 | disease:C0678236 | denotes | rare disease |
T6 | 317-333 | gene:348 | denotes | apolipoprotein E |
T7 | 147-150 | disease:C2673196 | denotes | LPG |
T8 | 317-333 | gene:348 | denotes | apolipoprotein E |
T9 | 119-145 | disease:C2673196 | denotes | Lipoprotein glomerulopathy |
T10 | 335-339 | gene:348 | denotes | apoE |
T11 | 157-169 | disease:C0678236 | denotes | rare disease |
T12 | 335-339 | gene:348 | denotes | apoE |
T13 | 147-150 | disease:C2673196 | denotes | LPG |
T14 | 374-378 | gene:348 | denotes | apoE |
T15 | 420-423 | disease:C2673196 | denotes | LPG |
T16 | 485-489 | gene:348 | denotes | apoE |
T17 | 460-463 | disease:C2673196 | denotes | LPG |
R1 | T0 | T1 | associated_with | apolipoprotein E,lipoprotein glomerulopathy |
R2 | T2 | T3 | associated_with | apoE,Lipoprotein glomerulopathy |
R3 | T4 | T5 | associated_with | apolipoprotein E,rare disease |
R4 | T6 | T7 | associated_with | apolipoprotein E,LPG |
R5 | T8 | T9 | associated_with | apolipoprotein E,Lipoprotein glomerulopathy |
R6 | T10 | T11 | associated_with | apoE,rare disease |
R7 | T12 | T13 | associated_with | apoE,LPG |
R8 | T14 | T15 | associated_with | apoE,LPG |
R9 | T16 | T17 | associated_with | apoE,LPG |
PubmedHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 131-145 | HP_0100820 | denotes | glomerulopathy |
T2 | 574-592 | HP_0000100 | denotes | nephrotic syndrome |
Allie
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
SS1_21325775_1_0 | 119-145 | expanded | denotes | Lipoprotein glomerulopathy |
SS2_21325775_1_0 | 147-150 | abbr | denotes | LPG |
SS1_21325775_1_1 | 317-333 | expanded | denotes | apolipoprotein E |
SS2_21325775_1_1 | 335-339 | abbr | denotes | apoE |
SS1_21325775_8_0 | 1036-1061 | expanded | denotes | polymerase chain reaction |
SS2_21325775_8_0 | 1063-1066 | abbr | denotes | PCR |
AE1_21325775_1_0 | SS1_21325775_1_0 | SS2_21325775_1_0 | abbreviatedTo | Lipoprotein glomerulopathy,LPG |
AE1_21325775_1_1 | SS1_21325775_1_1 | SS2_21325775_1_1 | abbreviatedTo | apolipoprotein E,apoE |
AE1_21325775_8_0 | SS1_21325775_8_0 | SS2_21325775_8_0 | abbreviatedTo | polymerase chain reaction,PCR |
DisGeNET5_gene_disease
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
21325775-0#8#24#gene348 | 8-24 | gene348 | denotes | apolipoprotein E |
21325775-0#91#117#diseaseC2673196 | 91-117 | diseaseC2673196 | denotes | lipoprotein glomerulopathy |
8#24#gene34891#117#diseaseC2673196 | 21325775-0#8#24#gene348 | 21325775-0#91#117#diseaseC2673196 | associated_with | apolipoprotein E,lipoprotein glomerulopathy |
performance-test
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 311-316 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
PD-UBERON-AE-B_T2 | 918-923 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
PD-UBERON-AE-B_T3 | 247-269 | http://purl.obolibrary.org/obo/UBERON_0004212 | denotes | glomerular capillaries |
PD-UBERON-AE-B_T4 | 753-775 | http://purl.obolibrary.org/obo/UBERON_0004212 | denotes | glomerular capillaries |
PD-UBERON-AE-B_T5 | 1607-1629 | http://purl.obolibrary.org/obo/UBERON_0004212 | denotes | glomerular capillaries |
PD-UBERON-AE-B_T6 | 258-269 | http://purl.obolibrary.org/obo/UBERON_0001982 | denotes | capillaries |
PD-UBERON-AE-B_T7 | 764-775 | http://purl.obolibrary.org/obo/UBERON_0001982 | denotes | capillaries |
PD-UBERON-AE-B_T8 | 1618-1629 | http://purl.obolibrary.org/obo/UBERON_0001982 | denotes | capillaries |
UBERON-AE
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
PD-UBERON-AE-B_T1 | 247-269 | http://purl.obolibrary.org/obo/UBERON_0004212 | denotes | glomerular capillaries |
PD-UBERON-AE-B_T2 | 753-775 | http://purl.obolibrary.org/obo/UBERON_0004212 | denotes | glomerular capillaries |
PD-UBERON-AE-B_T3 | 1607-1629 | http://purl.obolibrary.org/obo/UBERON_0004212 | denotes | glomerular capillaries |
PD-UBERON-AE-B_T4 | 258-269 | http://purl.obolibrary.org/obo/UBERON_0001982 | denotes | capillaries |
PD-UBERON-AE-B_T5 | 764-775 | http://purl.obolibrary.org/obo/UBERON_0001982 | denotes | capillaries |
PD-UBERON-AE-B_T6 | 1618-1629 | http://purl.obolibrary.org/obo/UBERON_0001982 | denotes | capillaries |
PD-UBERON-AE-B_T7 | 311-316 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
PD-UBERON-AE-B_T8 | 918-923 | http://purl.obolibrary.org/obo/UBERON_0001977 | denotes | serum |
PubCasesHPO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
AB1 | 131-145 | HP:0100820 | denotes | glomerulopathy |
TI1 | 103-117 | HP:0100820 | denotes | glomerulopathy |
AB2 | 574-592 | HP:0000100 | denotes | nephrotic syndrome |
PubCasesORDO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
AB1 | 119-145 | ORDO:329481 | denotes | Lipoprotein glomerulopathy |
AB2 | 147-150 | ORDO:329481 | denotes | LPG |
TI1 | 91-117 | ORDO:329481 | denotes | lipoprotein glomerulopathy |
AB3 | 420-423 | ORDO:329481 | denotes | LPG |
AB4 | 460-463 | ORDO:329481 | denotes | LPG |
AB5 | 696-699 | ORDO:329481 | denotes | LPG |
AB6 | 1656-1659 | ORDO:329481 | denotes | LPG |
tmVarCorpus
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1 | 47-57 | ProteinMutation:p|SUB|R|158|P | denotes | Arg158 Pro |