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PubMed:21295812 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-144 Sentence denotes Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice.
TextSentencer_T2 145-156 Sentence denotes BACKGROUND:
TextSentencer_T3 157-343 Sentence denotes Adenoviral gene therapy has been applied widely for cancer therapy; however, transient gene expression as result of humoral immunoneutralization response to adenovirus limits its effect.
TextSentencer_T4 344-676 Sentence denotes The purpose of this study is to determine whether DOTAP:cholesterol liposome could shield adenovirus from neutralizing antibody and permit the use of multiple cycles of intravenous liposome encapsulated serotype 5 adenoviral rat insulin promoter directed thymidine kinase (L-A-5-RIP-TK) with ganciclovir (GCV) to enhance its effect.
TextSentencer_T5 677-685 Sentence denotes METHODS:
TextSentencer_T6 686-836 Sentence denotes The effect of multiple cycles of systemic L-A-5-RIP-TK/GCV therapy was evaluated in grouped PANC-1 SCID mice treated with different numbers of cycles.
TextSentencer_T7 837-981 Sentence denotes Humoral immune response to A-5-RIP-TK or L-A-5-RIP-TK was assessed using C57/B6J mice challenged with adenovirus or liposome adenovirus complex.
TextSentencer_T8 982-990 Sentence denotes RESULTS:
TextSentencer_T9 991-1163 Sentence denotes The minimal residual tumor burden (3.2 ± 0.6 mm(3)) and greatest survival time (153.0 ± 6 days) were obtained in the mice receiving 4 and 3 cycles of therapy, respectively.
TextSentencer_T10 1164-1251 Sentence denotes Toxicity to islet cells associated with RIP-TK/GCV therapy was observed after 4 cycles.
TextSentencer_T11 1252-1409 Sentence denotes DOTAP:chol-encapsulated adenovectors were able to protect adenovectors from the neutralization of high titer of anti-adenoviral antibodies induced by itself.
TextSentencer_T12 1410-1421 Sentence denotes CONCLUSION:
TextSentencer_T13 1422-1605 Sentence denotes Multiple treatment cycles of L-A-5-RIP-TK/GCV ablate human PANC-1 cells effectively in SCID mice; however, the mice become diabetic and have substantial mortality after the 4th cycle.
TextSentencer_T14 1606-1777 Sentence denotes Liposome-encapsulated adenovirus is functionally resistant to the neutralizing effects of anti-adenoviral antibodies, suggesting feasibility of multiple cycles of therapy.
TextSentencer_T15 1778-1905 Sentence denotes Liposome encapsulation of the adenovirus may be a promising strategy for repeated delivery of systemic adenoviral gene therapy.
T1 0-144 Sentence denotes Multiple treatment cycles of liposome-encapsulated adenoviral RIP-TK gene therapy effectively ablate human pancreatic cancer cells in SCID mice.
T2 145-156 Sentence denotes BACKGROUND:
T3 157-343 Sentence denotes Adenoviral gene therapy has been applied widely for cancer therapy; however, transient gene expression as result of humoral immunoneutralization response to adenovirus limits its effect.
T4 344-676 Sentence denotes The purpose of this study is to determine whether DOTAP:cholesterol liposome could shield adenovirus from neutralizing antibody and permit the use of multiple cycles of intravenous liposome encapsulated serotype 5 adenoviral rat insulin promoter directed thymidine kinase (L-A-5-RIP-TK) with ganciclovir (GCV) to enhance its effect.
T5 677-685 Sentence denotes METHODS:
T6 686-836 Sentence denotes The effect of multiple cycles of systemic L-A-5-RIP-TK/GCV therapy was evaluated in grouped PANC-1 SCID mice treated with different numbers of cycles.
T7 837-981 Sentence denotes Humoral immune response to A-5-RIP-TK or L-A-5-RIP-TK was assessed using C57/B6J mice challenged with adenovirus or liposome adenovirus complex.
T8 982-990 Sentence denotes RESULTS:
T9 991-1163 Sentence denotes The minimal residual tumor burden (3.2 ± 0.6 mm(3)) and greatest survival time (153.0 ± 6 days) were obtained in the mice receiving 4 and 3 cycles of therapy, respectively.
T10 1164-1251 Sentence denotes Toxicity to islet cells associated with RIP-TK/GCV therapy was observed after 4 cycles.
T11 1252-1409 Sentence denotes DOTAP:chol-encapsulated adenovectors were able to protect adenovectors from the neutralization of high titer of anti-adenoviral antibodies induced by itself.
T12 1410-1421 Sentence denotes CONCLUSION:
T13 1422-1605 Sentence denotes Multiple treatment cycles of L-A-5-RIP-TK/GCV ablate human PANC-1 cells effectively in SCID mice; however, the mice become diabetic and have substantial mortality after the 4th cycle.
T14 1606-1777 Sentence denotes Liposome-encapsulated adenovirus is functionally resistant to the neutralizing effects of anti-adenoviral antibodies, suggesting feasibility of multiple cycles of therapy.
T15 1778-1905 Sentence denotes Liposome encapsulation of the adenovirus may be a promising strategy for repeated delivery of systemic adenoviral gene therapy.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 62-65 gene:84268 denotes RIP
T1 134-138 disease:C0085110 denotes SCID
T2 62-65 gene:3267 denotes RIP
T3 134-138 disease:C0085110 denotes SCID
T4 62-65 gene:9730 denotes RIP
T5 134-138 disease:C0085110 denotes SCID
T6 62-65 gene:10928 denotes RIP
T7 134-138 disease:C0085110 denotes SCID
T8 62-65 gene:8737 denotes RIP
T9 134-138 disease:C0085110 denotes SCID
T10 1457-1460 gene:84268 denotes RIP
T11 1509-1513 disease:C0085110 denotes SCID
T12 1457-1460 gene:3267 denotes RIP
T13 1509-1513 disease:C0085110 denotes SCID
T14 1457-1460 gene:9730 denotes RIP
T15 1509-1513 disease:C0085110 denotes SCID
T16 1457-1460 gene:10928 denotes RIP
T17 1509-1513 disease:C0085110 denotes SCID
T18 1457-1460 gene:8737 denotes RIP
T19 1509-1513 disease:C0085110 denotes SCID
R1 T0 T1 associated_with RIP,SCID
R2 T2 T3 associated_with RIP,SCID
R3 T4 T5 associated_with RIP,SCID
R4 T6 T7 associated_with RIP,SCID
R5 T8 T9 associated_with RIP,SCID
R6 T10 T11 associated_with RIP,SCID
R7 T12 T13 associated_with RIP,SCID
R8 T14 T15 associated_with RIP,SCID
R9 T16 T17 associated_with RIP,SCID
R10 T18 T19 associated_with RIP,SCID

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 209-215 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_21295812_3_0 636-647 expanded denotes ganciclovir
SS2_21295812_3_0 649-652 abbr denotes GCV
AE1_21295812_3_0 SS1_21295812_3_0 SS2_21295812_3_0 abbreviatedTo ganciclovir,GCV

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21295812-0#62#65#gene3267 62-65 gene3267 denotes RIP
21295812-0#62#65#gene9730 62-65 gene9730 denotes RIP
21295812-0#62#65#gene10928 62-65 gene10928 denotes RIP
21295812-0#62#65#gene8737 62-65 gene8737 denotes RIP
21295812-0#62#65#gene84268 62-65 gene84268 denotes RIP
21295812-0#107#124#diseaseC0235974 107-124 diseaseC0235974 denotes pancreatic cancer
21295812-0#107#124#diseaseC0346647 107-124 diseaseC0346647 denotes pancreatic cancer
21295812-0#107#124#diseaseC0235974 107-124 diseaseC0235974 denotes pancreatic cancer
21295812-0#107#124#diseaseC0346647 107-124 diseaseC0346647 denotes pancreatic cancer
21295812-0#107#124#diseaseC0235974 107-124 diseaseC0235974 denotes pancreatic cancer
21295812-0#107#124#diseaseC0346647 107-124 diseaseC0346647 denotes pancreatic cancer
21295812-0#107#124#diseaseC0235974 107-124 diseaseC0235974 denotes pancreatic cancer
21295812-0#107#124#diseaseC0346647 107-124 diseaseC0346647 denotes pancreatic cancer
21295812-0#107#124#diseaseC0235974 107-124 diseaseC0235974 denotes pancreatic cancer
21295812-0#107#124#diseaseC0346647 107-124 diseaseC0346647 denotes pancreatic cancer
62#65#gene3267107#124#diseaseC0235974 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0346647 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0235974 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0346647 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0235974 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0346647 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0235974 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0346647 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0235974 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene3267107#124#diseaseC0346647 21295812-0#62#65#gene3267 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0235974 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0346647 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0235974 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0346647 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0235974 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0346647 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0235974 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0346647 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0235974 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene9730107#124#diseaseC0346647 21295812-0#62#65#gene9730 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0235974 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0346647 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0235974 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0346647 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0235974 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0346647 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0235974 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0346647 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0235974 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene10928107#124#diseaseC0346647 21295812-0#62#65#gene10928 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0235974 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0346647 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0235974 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0346647 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0235974 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0346647 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0235974 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0346647 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0235974 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene8737107#124#diseaseC0346647 21295812-0#62#65#gene8737 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0235974 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0346647 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0235974 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0346647 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0235974 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0346647 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0235974 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0346647 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0235974 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0235974 associated_with RIP,pancreatic cancer
62#65#gene84268107#124#diseaseC0346647 21295812-0#62#65#gene84268 21295812-0#107#124#diseaseC0346647 associated_with RIP,pancreatic cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1429 62-65 gene:3267 denotes RIP
T1430 107-124 disease:C0235974 denotes pancreatic cancer
R1 T1429 T1430 associated_with RIP,pancreatic cancer
R2 T1429 T1430 associated_with RIP,pancreatic cancer
R3 T1429 T1430 associated_with RIP,pancreatic cancer
R4 T1429 T1430 associated_with RIP,pancreatic cancer
R5 T1429 T1430 associated_with RIP,pancreatic cancer
R6 T1429 T1430 associated_with RIP,pancreatic cancer
R7 T1429 T1430 associated_with RIP,pancreatic cancer
R8 T1429 T1430 associated_with RIP,pancreatic cancer
R9 T1429 T1430 associated_with RIP,pancreatic cancer
R10 T1429 T1430 associated_with RIP,pancreatic cancer