PubMed:21281310 JSONTXT

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":176},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":177,"end":365},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":366,"end":482},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":483,"end":578},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":579,"end":640},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":641,"end":825},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":826,"end":1001},"obj":"Sentence"},{"id":"TextSentencer_T8","span":{"begin":1002,"end":1126},"obj":"Sentence"},{"id":"TextSentencer_T9","span":{"begin":1127,"end":1264},"obj":"Sentence"},{"id":"TextSentencer_T10","span":{"begin":1265,"end":1337},"obj":"Sentence"},{"id":"TextSentencer_T11","span":{"begin":1338,"end":1569},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":176},"obj":"Sentence"},{"id":"T2","span":{"begin":177,"end":365},"obj":"Sentence"},{"id":"T3","span":{"begin":366,"end":482},"obj":"Sentence"},{"id":"T4","span":{"begin":483,"end":578},"obj":"Sentence"},{"id":"T5","span":{"begin":579,"end":640},"obj":"Sentence"},{"id":"T6","span":{"begin":641,"end":825},"obj":"Sentence"},{"id":"T7","span":{"begin":826,"end":1001},"obj":"Sentence"},{"id":"T8","span":{"begin":1002,"end":1126},"obj":"Sentence"},{"id":"T9","span":{"begin":1127,"end":1264},"obj":"Sentence"},{"id":"T10","span":{"begin":1265,"end":1337},"obj":"Sentence"},{"id":"T11","span":{"begin":1338,"end":1569},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":587,"end":593},"obj":"gene:7076"},{"id":"T1","span":{"begin":627,"end":639},"obj":"disease:C0007682"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":183,"end":199},"obj":"HP_0002721"},{"id":"T2","span":{"begin":803,"end":812},"obj":"HP_0001300"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}

{"project":"Allie","denotations":[{"id":"SS1_21281310_1_0","span":{"begin":177,"end":205},"obj":"expanded"},{"id":"SS2_21281310_1_0","span":{"begin":207,"end":210},"obj":"abbr"},{"id":"SS1_21281310_1_1","span":{"begin":301,"end":323},"obj":"expanded"},{"id":"SS2_21281310_1_1","span":{"begin":325,"end":327},"obj":"abbr"},{"id":"SS1_21281310_3_0","span":{"begin":502,"end":539},"obj":"expanded"},{"id":"SS2_21281310_3_0","span":{"begin":541,"end":545},"obj":"abbr"}],"relations":[{"id":"AE1_21281310_1_0","pred":"abbreviatedTo","subj":"SS1_21281310_1_0","obj":"SS2_21281310_1_0"},{"id":"AE1_21281310_1_1","pred":"abbreviatedTo","subj":"SS1_21281310_1_1","obj":"SS2_21281310_1_1"},{"id":"AE1_21281310_3_0","pred":"abbreviatedTo","subj":"SS1_21281310_3_0","obj":"SS2_21281310_3_0"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"21281310-0#0#32#gene1051","span":{"begin":0,"end":32},"obj":"gene1051"},{"id":"21281310-0#77#80#diseaseC0019693","span":{"begin":77,"end":80},"obj":"diseaseC0019693"},{"id":"21281310-10#88#94#gene7076","span":{"begin":1426,"end":1432},"obj":"gene7076"},{"id":"21281310-10#113#116#diseaseC0019693","span":{"begin":1451,"end":1454},"obj":"diseaseC0019693"},{"id":"21281310-4#8#14#gene7076","span":{"begin":587,"end":593},"obj":"gene7076"},{"id":"21281310-4#48#60#diseaseC0007682","span":{"begin":627,"end":639},"obj":"diseaseC0007682"},{"id":"21281310-5#0#32#gene1051","span":{"begin":641,"end":673},"obj":"gene1051"},{"id":"21281310-5#179#183#diseaseC0029227","span":{"begin":820,"end":824},"obj":"diseaseC0029227"},{"id":"21281310-5#179#183#diseaseC4041080","span":{"begin":820,"end":824},"obj":"diseaseC4041080"}],"relations":[{"id":"0#32#gene105177#80#diseaseC0019693","pred":"associated_with","subj":"21281310-0#0#32#gene1051","obj":"21281310-0#77#80#diseaseC0019693"},{"id":"88#94#gene7076113#116#diseaseC0019693","pred":"associated_with","subj":"21281310-10#88#94#gene7076","obj":"21281310-10#113#116#diseaseC0019693"},{"id":"8#14#gene707648#60#diseaseC0007682","pred":"associated_with","subj":"21281310-4#8#14#gene7076","obj":"21281310-4#48#60#diseaseC0007682"},{"id":"0#32#gene1051179#183#diseaseC0029227","pred":"associated_with","subj":"21281310-5#0#32#gene1051","obj":"21281310-5#179#183#diseaseC0029227"},{"id":"0#32#gene1051179#183#diseaseC4041080","pred":"associated_with","subj":"21281310-5#0#32#gene1051","obj":"21281310-5#179#183#diseaseC4041080"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}

{"project":"DisGeNet-2017-sample","denotations":[{"id":"T1280","span":{"begin":641,"end":673},"obj":"gene:1051"},{"id":"T1281","span":{"begin":820,"end":824},"obj":"disease:C0029227"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T1280","obj":"T1281"},{"id":"R2","pred":"associated_with","subj":"T1280","obj":"T1281"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}

{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":64,"end":69},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":336,"end":341},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":930,"end":935},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":136,"end":142},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":502,"end":508},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":936,"end":942},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":136,"end":142},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":502,"end":508},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T3","span":{"begin":936,"end":942},"obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"PD-UBERON-AE-B_T4","span":{"begin":64,"end":69},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T5","span":{"begin":336,"end":341},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T6","span":{"begin":731,"end":737},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T7","span":{"begin":930,"end":935},"obj":"http://purl.obolibrary.org/obo/UBERON_0000955"},{"id":"PD-UBERON-AE-B_T8","span":{"begin":464,"end":472},"obj":"http://purl.obolibrary.org/obo/UBERON_2000602"}],"text":"CCAAT/enhancer binding protein β expression is increased in the brain during HIV-1-infection and contributes to regulation of astrocyte tissue inhibitor of metalloproteinase-1.\nHuman immunodeficiency virus (HIV)-1-associated neurocognitive disorders (HAND) associated with infection and activation of mononuclear phagocytes (MP) in the brain, occur late in disease. Infected/activated MP initiate neuroinflammation activating glial cells and ultimately disrupting neuronal function. Astrocytes secrete tissue inhibitor of metalloproteinase (TIMP)-1 in response to neural injury. Altered TIMP-1 levels are implicated in several CNS diseases. CCAAT enhancer-binding protein β (C/EBPβ), a transcription factor, is expressed in rodent brains in response to neuroinflammation, implicating it in Alzheimer's, Parkinson's, and HAND. Here, we report that C/EBPβ mRNA levels are elevated and its isoforms differentially expressed in total brain tissue lysates of HIV-1-infected and HIV-1 encephalitis patients. In vitro, HAND-relevant stimuli additively induce C/EBPβ nuclear expression in human astrocytes through 7 days of treatment. Over-expression of C/EBPβ increases TIMP-1 promoter activity, mRNA, and protein levels in human astrocytes activated with interleukin-1β. Knockdown of C/EBPβ with siRNA decreases TIMP-1 mRNA and protein levels. These data suggest that C/EBPβ isoforms are involved in complex regulation of astrocyte TIMP-1 production during HIV-1 infection; however, further studies are required to completely understand their role during disease progression."}