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PubMed:21280006 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-88 Sentence denotes Alterations in Wnt pathway activity in mouse serum and kidneys during lupus development.
TextSentencer_T2 89-99 Sentence denotes OBJECTIVE:
TextSentencer_T3 100-218 Sentence denotes The canonical Wnt/β-catenin pathway was recently identified as a factor in the pathogenesis of several renal diseases.
TextSentencer_T4 219-344 Sentence denotes The aim of this study was to evaluate Wnt signaling activity during disease development in a murine model of lupus nephritis.
TextSentencer_T5 345-353 Sentence denotes METHODS:
TextSentencer_T6 354-497 Sentence denotes Wnt activity and Dkk-1 expression were serially assayed in the serum and kidneys of (NZB × NZW)F(1) mice during progression of lupus nephritis.
TextSentencer_T7 498-636 Sentence denotes The effects of serum obtained from mice with lupus and serum-equivalent concentrations of Dkk-1 on mesangial cells were assessed in vitro.
TextSentencer_T8 637-645 Sentence denotes RESULTS:
TextSentencer_T9 646-850 Sentence denotes Gene expression analyses revealed increased canonical Wnt pathway activity in kidneys during development of lupus nephritis, paralleled by an increase in renal and serum levels of the Wnt inhibitor Dkk-1.
TextSentencer_T10 851-955 Sentence denotes Sera obtained from proteinuric-stage (NZB × NZW)F(1) mice showed strong Wnt-inhibitory effects in vitro.
TextSentencer_T11 956-1208 Sentence denotes Dkk-1 concentrations comparable to those observed in lupus-prone mice induced apoptosis in tubular and mesangial cells in vitro, whereas no such effect was seen for the range of concentrations observed in young prediseased mice and control BALB/c mice.
TextSentencer_T12 1209-1220 Sentence denotes CONCLUSION:
TextSentencer_T13 1221-1369 Sentence denotes These data demonstrate that renal Wnt signaling activity is increased in lupus and is accompanied by an increase in renal and serum levels of Dkk-1.
TextSentencer_T14 1370-1583 Sentence denotes The Wnt pathway is involved in the turnover of extracellular matrix constituents and represents a potential mediator of the morphologic changes that occur within the glomerulus during the development of nephritis.
TextSentencer_T15 1584-1845 Sentence denotes Furthermore, increased levels of Dkk-1 serve as a potential proapoptotic stimulus in vitro and possibly in vivo and could be an important element in the initiation and progression of systemic and end-organ disease manifestations in systemic lupus erythematosus.
T1 0-88 Sentence denotes Alterations in Wnt pathway activity in mouse serum and kidneys during lupus development.
T2 89-99 Sentence denotes OBJECTIVE:
T3 100-218 Sentence denotes The canonical Wnt/β-catenin pathway was recently identified as a factor in the pathogenesis of several renal diseases.
T4 219-344 Sentence denotes The aim of this study was to evaluate Wnt signaling activity during disease development in a murine model of lupus nephritis.
T5 345-353 Sentence denotes METHODS:
T6 354-497 Sentence denotes Wnt activity and Dkk-1 expression were serially assayed in the serum and kidneys of (NZB × NZW)F(1) mice during progression of lupus nephritis.
T7 498-636 Sentence denotes The effects of serum obtained from mice with lupus and serum-equivalent concentrations of Dkk-1 on mesangial cells were assessed in vitro.
T8 637-645 Sentence denotes RESULTS:
T9 646-850 Sentence denotes Gene expression analyses revealed increased canonical Wnt pathway activity in kidneys during development of lupus nephritis, paralleled by an increase in renal and serum levels of the Wnt inhibitor Dkk-1.
T10 851-955 Sentence denotes Sera obtained from proteinuric-stage (NZB × NZW)F(1) mice showed strong Wnt-inhibitory effects in vitro.
T11 956-1208 Sentence denotes Dkk-1 concentrations comparable to those observed in lupus-prone mice induced apoptosis in tubular and mesangial cells in vitro, whereas no such effect was seen for the range of concentrations observed in young prediseased mice and control BALB/c mice.
T12 1209-1220 Sentence denotes CONCLUSION:
T13 1221-1369 Sentence denotes These data demonstrate that renal Wnt signaling activity is increased in lupus and is accompanied by an increase in renal and serum levels of Dkk-1.
T14 1370-1583 Sentence denotes The Wnt pathway is involved in the turnover of extracellular matrix constituents and represents a potential mediator of the morphologic changes that occur within the glomerulus during the development of nephritis.
T15 1584-1845 Sentence denotes Furthermore, increased levels of Dkk-1 serve as a potential proapoptotic stimulus in vitro and possibly in vivo and could be an important element in the initiation and progression of systemic and end-organ disease manifestations in systemic lupus erythematosus.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1617-1622 gene:22943 denotes Dkk-1
T1 1816-1844 disease:C0024141 denotes systemic lupus erythematosus
R1 T0 T1 associated_with Dkk-1,systemic lupus erythematosus

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 334-343 HP_0000123 denotes nephritis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21280006-10#33#38#gene22943 1617-1622 gene22943 denotes Dkk-1
21280006-10#232#260#diseaseC0024141 1816-1844 diseaseC0024141 denotes systemic lupus erythematosus
21280006-3#17#22#gene22943 371-376 gene22943 denotes Dkk-1
21280006-3#127#142#diseaseC0024143 481-496 diseaseC0024143 denotes lupus nephritis
21280006-8#142#147#gene22943 1363-1368 gene22943 denotes Dkk-1
21280006-8#73#78#diseaseC0024131 1294-1299 diseaseC0024131 denotes lupus
21280006-8#73#78#diseaseC0024138 1294-1299 diseaseC0024138 denotes lupus
21280006-8#73#78#diseaseC0409974 1294-1299 diseaseC0409974 denotes lupus
33#38#gene22943232#260#diseaseC0024141 21280006-10#33#38#gene22943 21280006-10#232#260#diseaseC0024141 associated_with Dkk-1,systemic lupus erythematosus
17#22#gene22943127#142#diseaseC0024143 21280006-3#17#22#gene22943 21280006-3#127#142#diseaseC0024143 associated_with Dkk-1,lupus nephritis
142#147#gene2294373#78#diseaseC0024131 21280006-8#142#147#gene22943 21280006-8#73#78#diseaseC0024131 associated_with Dkk-1,lupus
142#147#gene2294373#78#diseaseC0024138 21280006-8#142#147#gene22943 21280006-8#73#78#diseaseC0024138 associated_with Dkk-1,lupus
142#147#gene2294373#78#diseaseC0409974 21280006-8#142#147#gene22943 21280006-8#73#78#diseaseC0409974 associated_with Dkk-1,lupus

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1441 1363-1368 gene:22943 denotes Dkk-1
T1442 1294-1299 disease:C0024131 denotes lupus
R1 T1441 T1442 associated_with Dkk-1,lupus
R2 T1441 T1442 associated_with Dkk-1,lupus
R3 T1441 T1442 associated_with Dkk-1,lupus

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 45-50 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 417-422 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 513-518 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 553-558 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T5 810-815 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T6 1347-1352 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T7 55-62 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
PD-UBERON-AE-B_T8 427-434 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
PD-UBERON-AE-B_T9 724-731 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
PD-UBERON-AE-B_T10 1784-1789 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 55-62 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
PD-UBERON-AE-B_T2 427-434 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
PD-UBERON-AE-B_T3 724-731 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
PD-UBERON-AE-B_T4 45-50 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T5 417-422 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T6 513-518 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T7 553-558 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T8 810-815 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T9 1347-1352 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T10 1784-1789 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organ