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PubMed:21238926 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 103-244 DRI_Background denotes Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors.
T2 245-396 DRI_Approach denotes Upon division, Dpp signaling is extinguished, and Nos is downregulated in one daughter cell, causing it to switch to a differentiating cystoblast (CB).
T3 397-510 DRI_Challenge denotes However, downstream effectors of Pum-Nos remain unknown, and how CBs lose their responsiveness to Dpp is unclear.
T4 511-616 DRI_Approach denotes Here, we identify Brain Tumor (Brat) as a potent differentiation factor and target of Pum-Nos regulation.
T5 617-763 DRI_Approach denotes Brat is excluded from GSCs by Pum-Nos but functions with Pum in CBs to translationally repress distinct targets, including the Mad and dMyc mRNAs.
T6 764-920 DRI_Approach denotes Regulation of both targets simultaneously lowers cellular responsiveness to Dpp signaling, forcing the cell to become refractory to the self-renewal signal.
T7 921-1141 DRI_Background denotes Mathematical modeling elucidates bistability of cell fate in the Brat-mediated system, revealing how autoregulation of GSC number can arise from Brat coupling extracellular Dpp regulation to intracellular interpretation.

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-102 Sentence denotes Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling.
T2 103-244 Sentence denotes Drosophila ovarian germline stem cells (GSCs) are maintained by Dpp signaling and the Pumilio (Pum) and Nanos (Nos) translational repressors.
T3 245-396 Sentence denotes Upon division, Dpp signaling is extinguished, and Nos is downregulated in one daughter cell, causing it to switch to a differentiating cystoblast (CB).
T4 397-510 Sentence denotes However, downstream effectors of Pum-Nos remain unknown, and how CBs lose their responsiveness to Dpp is unclear.
T5 511-616 Sentence denotes Here, we identify Brain Tumor (Brat) as a potent differentiation factor and target of Pum-Nos regulation.
T6 617-763 Sentence denotes Brat is excluded from GSCs by Pum-Nos but functions with Pum in CBs to translationally repress distinct targets, including the Mad and dMyc mRNAs.
T7 764-920 Sentence denotes Regulation of both targets simultaneously lowers cellular responsiveness to Dpp signaling, forcing the cell to become refractory to the self-renewal signal.
T8 921-1141 Sentence denotes Mathematical modeling elucidates bistability of cell fate in the Brat-mediated system, revealing how autoregulation of GSC number can arise from Brat coupling extracellular Dpp regulation to intracellular interpretation.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 103-113 OrganismTaxon denotes Drosophila NCBItxid:7215|NCBItxid:32281|NCBItxid:2081351
T4 207-212 OrganismTaxon denotes Nanos NCBItxid:490857|NCBItxid:2605937
T6 214-217 OrganismTaxon denotes Nos NCBItxid:490857
T7 295-298 OrganismTaxon denotes Nos NCBItxid:490857
T8 434-437 OrganismTaxon denotes Nos NCBItxid:490857
T9 601-604 OrganismTaxon denotes Nos NCBItxid:490857
T10 651-654 OrganismTaxon denotes Nos NCBItxid:490857

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
8507 0-4 GeneOrGeneProduct denotes Brat NCBIGene:35197
8508 88-91 GeneOrGeneProduct denotes BMP NCBIGene:33432
8509 103-113 OrganismTaxon denotes Drosophila NCBITaxon:7227
8510 167-170 GeneOrGeneProduct denotes Dpp NCBIGene:33432
8511 189-196 GeneOrGeneProduct denotes Pumilio NCBIGene:41094
8512 198-201 GeneOrGeneProduct denotes Pum NCBIGene:41094
8513 207-212 GeneOrGeneProduct denotes Nanos NCBIGene:42297
8514 214-217 GeneOrGeneProduct denotes Nos NCBIGene:42297
8515 260-263 GeneOrGeneProduct denotes Dpp NCBIGene:33432
8516 295-298 GeneOrGeneProduct denotes Nos NCBIGene:42297
8517 430-433 GeneOrGeneProduct denotes Pum NCBIGene:41094
8518 434-437 GeneOrGeneProduct denotes Nos NCBIGene:42297
8519 495-498 GeneOrGeneProduct denotes Dpp NCBIGene:33432
8520 529-540 GeneOrGeneProduct denotes Brain Tumor NCBIGene:35197
8521 542-546 GeneOrGeneProduct denotes Brat NCBIGene:35197
8522 597-600 GeneOrGeneProduct denotes Pum NCBIGene:41094
8523 601-604 GeneOrGeneProduct denotes Nos NCBIGene:42297
8524 617-621 GeneOrGeneProduct denotes Brat NCBIGene:35197
8525 647-650 GeneOrGeneProduct denotes Pum NCBIGene:41094
8526 651-654 GeneOrGeneProduct denotes Nos NCBIGene:42297
8527 674-677 GeneOrGeneProduct denotes Pum NCBIGene:41094
8528 744-747 GeneOrGeneProduct denotes Mad NCBIGene:33529
8529 752-756 GeneOrGeneProduct denotes dMyc NCBIGene:31310
8530 840-843 GeneOrGeneProduct denotes Dpp NCBIGene:33432
8531 986-990 GeneOrGeneProduct denotes Brat NCBIGene:35197
8532 1066-1070 GeneOrGeneProduct denotes Brat NCBIGene:35197
8533 1094-1097 GeneOrGeneProduct denotes Dpp NCBIGene:33432

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T6 189-196 GeneOrGeneProduct denotes Pumilio
T1 0-4 GeneOrGeneProduct denotes Brat
T2 19-39 GeneOrGeneProduct denotes cell differentiation
T3 66-72 GeneOrGeneProduct denotes switch
T4 136-141 GeneOrGeneProduct denotes cells
T5 143-147 GeneOrGeneProduct denotes GSCs
T7 198-201 GeneOrGeneProduct denotes Pum
T8 207-212 GeneOrGeneProduct denotes Nanos
T9 214-217 GeneOrGeneProduct denotes Nos
T10 219-243 GeneOrGeneProduct denotes translational repressors
T11 295-298 GeneOrGeneProduct denotes Nos
T12 332-336 GeneOrGeneProduct denotes cell
T13 352-358 GeneOrGeneProduct denotes switch
T14 417-426 GeneOrGeneProduct denotes effectors
T15 430-433 GeneOrGeneProduct denotes Pum
T16 434-437 GeneOrGeneProduct denotes Nos
T17 445-452 GeneOrGeneProduct denotes unknown
T18 502-509 GeneOrGeneProduct denotes unclear
T19 529-540 GeneOrGeneProduct denotes Brain Tumor
T20 542-546 GeneOrGeneProduct denotes Brat
T21 576-582 GeneOrGeneProduct denotes factor
T22 597-600 GeneOrGeneProduct denotes Pum
T23 601-604 GeneOrGeneProduct denotes Nos
T24 605-615 GeneOrGeneProduct denotes regulation
T25 617-621 GeneOrGeneProduct denotes Brat
T26 639-643 GeneOrGeneProduct denotes GSCs
T27 647-650 GeneOrGeneProduct denotes Pum
T28 651-654 GeneOrGeneProduct denotes Nos
T29 674-677 GeneOrGeneProduct denotes Pum
T30 752-756 GeneOrGeneProduct denotes dMyc
T31 764-774 GeneOrGeneProduct denotes Regulation
T32 855-862 GeneOrGeneProduct denotes forcing
T33 867-871 GeneOrGeneProduct denotes cell
T34 969-973 GeneOrGeneProduct denotes cell
T35 974-978 GeneOrGeneProduct denotes fate
T36 986-990 GeneOrGeneProduct denotes Brat
T37 991-999 GeneOrGeneProduct denotes mediated
T38 1040-1043 GeneOrGeneProduct denotes GSC
T39 1066-1070 GeneOrGeneProduct denotes Brat
T40 1080-1093 GeneOrGeneProduct denotes extracellular
T41 1098-1111 GeneOrGeneProduct denotes regulation to

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-4 GeneOrGeneProduct denotes Brat
T2 19-39 GeneOrGeneProduct denotes cell differentiation
T3 66-72 GeneOrGeneProduct denotes switch
T4 189-196 GeneOrGeneProduct denotes Pumilio
T5 198-201 GeneOrGeneProduct denotes Pum
T6 207-212 GeneOrGeneProduct denotes Nanos
T7 214-217 GeneOrGeneProduct denotes Nos
T8 219-243 GeneOrGeneProduct denotes translational repressors
T9 295-298 GeneOrGeneProduct denotes Nos
T10 332-336 GeneOrGeneProduct denotes cell
T11 352-358 GeneOrGeneProduct denotes switch
T12 430-433 GeneOrGeneProduct denotes Pum
T13 434-437 GeneOrGeneProduct denotes Nos
T14 445-452 GeneOrGeneProduct denotes unknown
T15 502-509 GeneOrGeneProduct denotes unclear
T16 529-540 GeneOrGeneProduct denotes Brain Tumor
T17 542-546 GeneOrGeneProduct denotes Brat
T18 576-582 GeneOrGeneProduct denotes factor
T19 597-600 GeneOrGeneProduct denotes Pum
T20 601-604 GeneOrGeneProduct denotes Nos
T21 617-621 GeneOrGeneProduct denotes Brat
T22 647-650 GeneOrGeneProduct denotes Pum
T23 651-654 GeneOrGeneProduct denotes Nos
T24 674-677 GeneOrGeneProduct denotes Pum
T25 752-756 GeneOrGeneProduct denotes dMyc
T26 867-871 GeneOrGeneProduct denotes cell
T27 969-973 GeneOrGeneProduct denotes cell
T28 986-990 GeneOrGeneProduct denotes Brat
T29 1066-1070 GeneOrGeneProduct denotes Brat
T30 1080-1093 GeneOrGeneProduct denotes extracellular

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 0-4 DiseaseOrPhenotypicFeature denotes Brat D001932
T2 529-540 DiseaseOrPhenotypicFeature denotes Brain Tumor D001932
T3 542-546 DiseaseOrPhenotypicFeature denotes Brat D001932
T4 617-621 DiseaseOrPhenotypicFeature denotes Brat D001932
T5 986-990 DiseaseOrPhenotypicFeature denotes Brat D001932
T6 1066-1070 DiseaseOrPhenotypicFeature denotes Brat D001932

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-4 GeneOrGeneProduct denotes Brat
T2 189-196 GeneOrGeneProduct denotes Pumilio
T3 198-201 GeneOrGeneProduct denotes Pum
T4 207-212 GeneOrGeneProduct denotes Nanos
T5 214-217 GeneOrGeneProduct denotes Nos
T6 219-243 GeneOrGeneProduct denotes translational repressors
T7 295-298 GeneOrGeneProduct denotes Nos
T8 430-433 GeneOrGeneProduct denotes Pum
T9 434-437 GeneOrGeneProduct denotes Nos
T10 529-540 GeneOrGeneProduct denotes Brain Tumor
T11 542-546 GeneOrGeneProduct denotes Brat
T12 597-600 GeneOrGeneProduct denotes Pum
T13 601-604 GeneOrGeneProduct denotes Nos
T14 617-621 GeneOrGeneProduct denotes Brat
T15 647-650 GeneOrGeneProduct denotes Pum
T16 651-654 GeneOrGeneProduct denotes Nos
T17 674-677 GeneOrGeneProduct denotes Pum
T18 752-756 GeneOrGeneProduct denotes dMyc
T19 986-990 GeneOrGeneProduct denotes Brat
T20 1066-1070 GeneOrGeneProduct denotes Brat

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 1051-1054 DiseaseOrPhenotypicFeature denotes can 0012833

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 0-4 DiseaseOrPhenotypicFeature denotes Brat D001932
T2 529-540 DiseaseOrPhenotypicFeature denotes Brain Tumor D001932
T3 542-546 DiseaseOrPhenotypicFeature denotes Brat D001932
T4 617-621 DiseaseOrPhenotypicFeature denotes Brat D001932
T5 986-990 DiseaseOrPhenotypicFeature denotes Brat D001932
T6 1066-1070 DiseaseOrPhenotypicFeature denotes Brat D001932

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 535-540 DiseaseOrPhenotypicFeature denotes Tumor D009369

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 103-113 OrganismTaxon denotes Drosophila
T2 207-212 OrganismTaxon denotes Nanos

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label
T20 1066-1070 GeneOrGeneProduct denotes Brat
T19 986-990 GeneOrGeneProduct denotes Brat
T18 752-756 GeneOrGeneProduct denotes dMyc
T17 674-677 GeneOrGeneProduct denotes Pum
T16 651-654 GeneOrGeneProduct denotes Nos
T15 647-650 GeneOrGeneProduct denotes Pum
T14 617-621 GeneOrGeneProduct denotes Brat
T13 601-604 GeneOrGeneProduct denotes Nos
T12 597-600 GeneOrGeneProduct denotes Pum
T11 542-546 GeneOrGeneProduct denotes Brat
T10 529-540 GeneOrGeneProduct denotes Brain Tumor
T9 434-437 GeneOrGeneProduct denotes Nos
T8 430-433 GeneOrGeneProduct denotes Pum
T7 295-298 GeneOrGeneProduct denotes Nos
T6 219-243 GeneOrGeneProduct denotes translational repressors
T5 214-217 GeneOrGeneProduct denotes Nos
T4 207-212 GeneOrGeneProduct denotes Nanos
T3 198-201 GeneOrGeneProduct denotes Pum
T2 189-196 GeneOrGeneProduct denotes Pumilio
T1 0-4 GeneOrGeneProduct denotes Brat
T87333 535-540 DiseaseOrPhenotypicFeature denotes Tumor D009369
T74012 207-212 OrganismTaxon denotes Nanos
T48846 103-113 OrganismTaxon denotes Drosophila

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 535-540 HP_0002664 denotes Tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_21238926_1_0 122-141 expanded denotes germline stem cells
SS2_21238926_1_0 143-147 abbr denotes GSCs
SS1_21238926_1_1 189-196 expanded denotes Pumilio
SS2_21238926_1_1 198-201 abbr denotes Pum
SS1_21238926_1_2 207-212 expanded denotes Nanos
SS2_21238926_1_2 214-217 abbr denotes Nos
SS1_21238926_2_0 380-390 expanded denotes cystoblast
SS2_21238926_2_0 392-394 abbr denotes CB
SS1_21238926_4_0 529-540 expanded denotes Brain Tumor
SS2_21238926_4_0 542-546 abbr denotes Brat
AE1_21238926_1_0 SS1_21238926_1_0 SS2_21238926_1_0 abbreviatedTo germline stem cells,GSCs
AE1_21238926_1_1 SS1_21238926_1_1 SS2_21238926_1_1 abbreviatedTo Pumilio,Pum
AE1_21238926_1_2 SS1_21238926_1_2 SS2_21238926_1_2 abbreviatedTo Nanos,Nos
AE1_21238926_2_0 SS1_21238926_2_0 SS2_21238926_2_0 abbreviatedTo cystoblast,CB
AE1_21238926_4_0 SS1_21238926_4_0 SS2_21238926_4_0 abbreviatedTo Brain Tumor,Brat