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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 45-58 cell_type denotes T lymphocytes
T2 104-116 protein denotes immunophilin
T3 190-203 cell_type denotes T lymphocytes
T4 238-254 protein denotes antigen receptor
T5 369-382 protein denotes interleukin 2
T6 384-388 protein denotes IL-2
T7 566-578 protein denotes immunophilin
T8 580-613 protein denotes immunosuppressant binding protein
T9 675-696 protein denotes FK506 binding protein
T10 697-701 protein denotes FKBP
T11 766-770 protein denotes FKBP
T12 925-929 protein denotes IL-2
T13 987-992 protein denotes NF-AT
T14 996-1032 protein denotes T-cell-specific transcription factor
T15 1047-1056 DNA denotes IL-2 gene
T16 1152-1156 protein denotes IL-2
T17 1316-1328 protein denotes immunophilin
T18 1329-1333 protein denotes FKBP
T19 1335-1339 protein denotes FKBP
T20 1425-1451 protein denotes peptidyl-prolyl amide bond
T21 1566-1570 protein denotes FKBP
T22 1594-1598 protein denotes FKBP
T23 1646-1650 protein denotes FKBP
T24 1755-1767 protein denotes immunophilin
T25 1799-1815 protein denotes antigen receptor
T26 1862-1874 protein denotes immunophilin
T27 1891-1895 protein denotes IL-2

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-147 Sentence denotes Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.
S2 148-349 Sentence denotes Proliferation and immunologic function of T lymphocytes are initiated by signals from the antigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural analog, rapamycin.
S3 350-448 Sentence denotes On the other hand, interleukin 2 (IL-2)-induced signals are blocked by rapamycin but not by FK506.
S4 449-615 Sentence denotes Remarkably, these two drugs inhibit each other's actions, raising the possibility that both act by means of a common immunophilin (immunosuppressant binding protein).
S5 616-843 Sentence denotes We find that the dissociation constant of rapamycin to the FK506 binding protein FKBP (Kd = 0.2 nM) is close to the dissociation constant of FK506 to FKBP (Kd = 0.4 nM) and to their effective biologic inhibitory concentrations.
S6 844-1068 Sentence denotes However, an excess of rapamycin is needed to revert FK506-mediated inhibition of IL-2 production, apoptosis, and transcriptional activation of NF-AT, a T-cell-specific transcription factor necessary for IL-2 gene activation.
S7 1069-1179 Sentence denotes Similarly, an excess of FK506 is needed to revert rapamycin-mediated inhibition of IL-2-induced proliferation.
S8 1180-1334 Sentence denotes The drug concentrations required for antagonism may be explained by the relative affinity of the drugs to, and by the abundance of, the immunophilin FKBP.
S9 1335-1585 Sentence denotes FKBP has been shown to catalyze the interconversion of the cis- and trans-rotamers of the peptidyl-prolyl amide bond of peptide substrates; here we show that rapamycin, like FK506, is a potent inhibitor of the rotamase activity of FKBP (Ki = 0.2 nM).
S10 1586-1718 Sentence denotes Neither FKBP binding nor inhibition of rotamase activity of FKBP alone is sufficient to explain the biologic actions of these drugs.
S11 1719-1912 Sentence denotes Rather, these findings suggest that immunophilin bound to FK506 interferes with antigen receptor-induced signals, while rapamycin bound to the immunophilin interferes with IL-2-induced signals.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 45-58 NP denotes T lymphocytes
C2 101-116 NP denotes an immunophilin
C3 128-133 NP denotes FK506
C4 137-146 NP denotes rapamycin
C5 190-203 NP denotes T lymphocytes
C6 221-254 NP denotes signals from the antigen receptor
C7 255-259 NP denotes that
C8 277-304 NP denotes the immunosuppressant FK506
C10 316-319 NP denotes its
C9 316-337 NP denotes its structural analog
C11 339-348 NP denotes rapamycin
C12 369-405 NP denotes interleukin 2 (IL-2)-induced signals
C14 421-430 NP denotes rapamycin
C15 442-447 NP denotes FK506
C13 421-447 NP denotes rapamycin but not by FK506
C16 461-476 NP denotes these two drugs
C17 515-530 NP denotes the possibility
C18 531-535 NP denotes that
C19 536-540 NP denotes both
C20 557-614 NP denotes a common immunophilin (immunosuppressant binding protein)
C21 658-667 NP denotes rapamycin
C22 671-701 NP denotes the FK506 binding protein FKBP
C23 757-762 NP denotes FK506
C24 766-770 NP denotes FKBP
C25 792-797 NP denotes their
C26 987-992 NP denotes NF-AT
C27 994-1067 NP denotes a T-cell-specific transcription factor necessary for IL-2 gene activation
C28 1093-1098 NP denotes FK506
C29 1273-1282 NP denotes the drugs
C30 1312-1333 NP denotes the immunophilin FKBP
C31 1335-1339 NP denotes FKBP
C32 1493-1502 NP denotes rapamycin
C33 1509-1514 NP denotes FK506
C34 1566-1570 NP denotes FKBP
C35 1646-1650 NP denotes FKBP
C36 1706-1717 NP denotes these drugs
C37 1755-1767 NP denotes immunophilin
C38 1777-1782 NP denotes FK506
C39 1799-1831 NP denotes antigen receptor-induced signals
C40 1839-1848 NP denotes rapamycin
C41 1858-1874 NP denotes the immunophilin
C42 1891-1911 NP denotes IL-2-induced signals
R1 C5 C1 coref-ident T lymphocytes,T lymphocytes
R2 C7 C6 coref-relat that,signals from the antigen receptor
R3 C8 C3 coref-ident the immunosuppressant FK506,FK506
R4 C10 C6 coref-pron its,signals from the antigen receptor
R5 C9 C4 coref-ident its structural analog,rapamycin
R6 C11 C9 coref-appos rapamycin,its structural analog
R7 C15 C8 coref-ident FK506,the immunosuppressant FK506
R8 C13 C11 coref-ident rapamycin but not by FK506,rapamycin
R9 C16 C14 coref-ident these two drugs,rapamycin
R10 C18 C17 coref-ident that,the possibility
R11 C19 C16 coref-ident both,these two drugs
R12 C20 C2 coref-ident a common immunophilin (immunosuppressant binding protein),an immunophilin
R13 C21 C13 coref-ident rapamycin,rapamycin but not by FK506
R14 C23 C15 coref-ident FK506,FK506
R15 C24 C22 coref-ident FKBP,the FK506 binding protein FKBP
R16 C25 C24 coref-pron their,FKBP
R17 C27 C26 coref-appos a T-cell-specific transcription factor necessary for IL-2 gene activation,NF-AT
R18 C28 C23 coref-ident FK506,FK506
R19 C29 C16 coref-ident the drugs,these two drugs
R20 C30 C24 coref-ident the immunophilin FKBP,FKBP
R21 C31 C30 coref-ident FKBP,the immunophilin FKBP
R22 C32 C21 coref-ident rapamycin,rapamycin
R23 C33 C28 coref-ident FK506,FK506
R24 C34 C31 coref-ident FKBP,FKBP
R25 C35 C34 coref-ident FKBP,FKBP
R26 C36 C29 coref-ident these drugs,the drugs
R27 C37 C20 coref-ident immunophilin,a common immunophilin (immunosuppressant binding protein)
R28 C38 C33 coref-ident FK506,FK506
R29 C39 C6 coref-ident antigen receptor-induced signals,signals from the antigen receptor
R30 C40 C32 coref-ident rapamycin,rapamycin
R31 C41 C37 coref-ident the immunophilin,immunophilin
R32 C42 C12 coref-ident IL-2-induced signals,interleukin 2 (IL-2)-induced signals

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 13-41 other_name denotes signal transmission pathways
T2 45-58 cell_type denotes T lymphocytes
T3 104-116 protein_molecule denotes immunophilin
T4 128-133 other_organic_compound denotes FK506
T5 137-146 other_organic_compound denotes rapamycin
T6 166-186 other_name denotes immunologic function
T7 190-203 cell_type denotes T lymphocytes
T8 238-254 protein_family_or_group denotes antigen receptor
T9 281-298 other_name denotes immunosuppressant
T10 299-304 other_organic_compound denotes FK506
T11 339-348 other_organic_compound denotes rapamycin
T12 369-382 protein_molecule denotes interleukin 2
T13 384-388 protein_molecule denotes IL-2
T14 421-430 other_organic_compound denotes rapamycin
T15 442-447 other_organic_compound denotes FK506
T16 566-578 protein_molecule denotes immunophilin
T17 580-613 protein_family_or_group denotes immunosuppressant binding protein
T18 658-667 other_organic_compound denotes rapamycin
T19 675-680 other_organic_compound denotes FK506
T20 697-701 protein_molecule denotes FKBP
T21 757-762 other_organic_compound denotes FK506
T22 766-770 protein_molecule denotes FKBP
T23 808-842 other_name denotes biologic inhibitory concentrations
T24 866-875 other_organic_compound denotes rapamycin
T25 896-901 other_organic_compound denotes FK506
T26 925-929 protein_molecule denotes IL-2
T27 942-951 other_name denotes apoptosis
T28 957-983 other_name denotes transcriptional activation
T29 987-992 protein_molecule denotes NF-AT
T30 996-1032 protein_family_or_group denotes T-cell-specific transcription factor
T31 1047-1051 protein_molecule denotes IL-2
T32 1093-1098 other_organic_compound denotes FK506
T33 1119-1128 other_organic_compound denotes rapamycin
T34 1152-1156 protein_molecule denotes IL-2
T35 1316-1328 protein_molecule denotes immunophilin
T36 1329-1333 protein_molecule denotes FKBP
T37 1335-1339 protein_molecule denotes FKBP
T38 1455-1473 peptide denotes peptide substrates
T39 1493-1502 other_organic_compound denotes rapamycin
T40 1509-1514 other_organic_compound denotes FK506
T41 1545-1562 other_name denotes rotamase activity
T42 1566-1570 protein_molecule denotes FKBP
T43 1594-1598 protein_molecule denotes FKBP
T44 1625-1642 other_name denotes rotamase activity
T45 1646-1650 protein_molecule denotes FKBP
T46 1686-1702 other_name denotes biologic actions
T47 1755-1767 protein_molecule denotes immunophilin
T48 1777-1782 other_organic_compound denotes FK506
T49 1799-1815 protein_family_or_group denotes antigen receptor
T50 1839-1848 other_organic_compound denotes rapamycin
T51 1862-1874 protein_molecule denotes immunophilin
T52 1891-1895 protein_molecule denotes IL-2