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PubMed:21209915 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-124 Sentence denotes Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
TextSentencer_T2 125-136 Sentence denotes BACKGROUND:
TextSentencer_T3 137-299 Sentence denotes Germline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé syndrome.
TextSentencer_T4 300-548 Sentence denotes TFE3 is a member of the MiTF/TFE transcription factor family and Xp11.2 translocations found in sporadic RCC involving TFE3 result in gene fusions and overexpression of chimeric fusion proteins that retain the C-terminal DNA binding domain of TFE3.
TextSentencer_T5 549-710 Sentence denotes We found that GPNMB expression, which is regulated by MiTF, was greatly elevated in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
TextSentencer_T6 711-866 Sentence denotes Since TFE3 is implicated in RCC, we hypothesized that elevated GPNMB expression was due to increased TFE3 activity resulting from the inactivation of FLCN.
TextSentencer_T7 867-1019 Sentence denotes METHODOLOGY/PRINCIPAL FINDINGS: TFE3 knockdown reduced GPNMB expression in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
TextSentencer_T8 1020-1106 Sentence denotes Moreover, FLCN knockdown induced GPNMB expression in FLCN-restored renal cancer cells.
TextSentencer_T9 1107-1180 Sentence denotes Conversely, wildtype FLCN suppressed GPNMB expression in FLCN-null cells.
TextSentencer_T10 1181-1508 Sentence denotes FLCN inactivation was correlated with increased TFE3 transcriptional activity accompanied by its nuclear localization as revealed by elevated GPNMB mRNA and protein expression, and predominantly nuclear immunostaining of TFE3 in renal cancer cells, mouse embryo fibroblast cells, mouse kidneys and mouse and human renal tumors.
TextSentencer_T11 1509-1632 Sentence denotes Nuclear localization of TFE3 was associated with TFE3 post-translational modifications including decreased phosphorylation.
TextSentencer_T12 1633-1658 Sentence denotes CONCLUSIONS/SIGNIFICANCE:
TextSentencer_T13 1659-1792 Sentence denotes Increased TFE3 activity is a downstream event induced by FLCN inactivation and is likely to be important for renal tumor development.
TextSentencer_T14 1793-2013 Sentence denotes This study provides an important novel mechanism for induction of TFE3 activity in addition to TFE3 overexpression resulting from Xp11.2 translocations, suggesting that TFE3 may be more broadly involved in tumorigenesis.
T1 0-124 Sentence denotes Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization.
T2 125-136 Sentence denotes BACKGROUND:
T3 137-299 Sentence denotes Germline mutations in a tumor suppressor gene FLCN lead to development of fibrofolliculomas, lung cysts and renal cell carcinoma (RCC) in Birt-Hogg-Dubé syndrome.
T4 300-548 Sentence denotes TFE3 is a member of the MiTF/TFE transcription factor family and Xp11.2 translocations found in sporadic RCC involving TFE3 result in gene fusions and overexpression of chimeric fusion proteins that retain the C-terminal DNA binding domain of TFE3.
T5 549-710 Sentence denotes We found that GPNMB expression, which is regulated by MiTF, was greatly elevated in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
T6 711-866 Sentence denotes Since TFE3 is implicated in RCC, we hypothesized that elevated GPNMB expression was due to increased TFE3 activity resulting from the inactivation of FLCN.
T7 867-1019 Sentence denotes METHODOLOGY/PRINCIPAL FINDINGS: TFE3 knockdown reduced GPNMB expression in renal cancer cells harboring either TFE3 translocations or FLCN inactivation.
T8 1020-1106 Sentence denotes Moreover, FLCN knockdown induced GPNMB expression in FLCN-restored renal cancer cells.
T9 1107-1180 Sentence denotes Conversely, wildtype FLCN suppressed GPNMB expression in FLCN-null cells.
T10 1181-1508 Sentence denotes FLCN inactivation was correlated with increased TFE3 transcriptional activity accompanied by its nuclear localization as revealed by elevated GPNMB mRNA and protein expression, and predominantly nuclear immunostaining of TFE3 in renal cancer cells, mouse embryo fibroblast cells, mouse kidneys and mouse and human renal tumors.
T11 1509-1632 Sentence denotes Nuclear localization of TFE3 was associated with TFE3 post-translational modifications including decreased phosphorylation.
T12 1633-1658 Sentence denotes CONCLUSIONS/SIGNIFICANCE:
T13 1659-1792 Sentence denotes Increased TFE3 activity is a downstream event induced by FLCN inactivation and is likely to be important for renal tumor development.
T14 1793-2013 Sentence denotes This study provides an important novel mechanism for induction of TFE3 activity in addition to TFE3 overexpression resulting from Xp11.2 translocations, suggesting that TFE3 may be more broadly involved in tumorigenesis.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1669-1673 gene:7030 denotes TFE3
T1 1768-1779 disease:C0022665 denotes renal tumor
T2 1716-1720 gene:201163 denotes FLCN
T3 1768-1779 disease:C0022665 denotes renal tumor
T4 1859-1863 gene:7030 denotes TFE3
T5 1999-2012 disease:C0596263 denotes tumorigenesis
T6 1962-1966 gene:7030 denotes TFE3
T7 1999-2012 disease:C0596263 denotes tumorigenesis
R1 T0 T1 associated_with TFE3,renal tumor
R2 T2 T3 associated_with FLCN,renal tumor
R3 T4 T5 associated_with TFE3,tumorigenesis
R4 T6 T7 associated_with TFE3,tumorigenesis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 161-166 HP_0002664 denotes tumor
T2 211-228 HP_0030436 denotes fibrofolliculomas
T3 245-265 HP_0005584 denotes renal cell carcinoma
T4 633-645 HP_0009726 denotes renal cancer
T5 639-645 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_21209915_2_0 245-265 expanded denotes renal cell carcinoma
SS2_21209915_2_0 267-270 abbr denotes RCC
AE1_21209915_2_0 SS1_21209915_2_0 SS2_21209915_2_0 abbreviatedTo renal cell carcinoma,RCC

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21209915-1#46#50#gene201163 183-187 gene201163 denotes FLCN
21209915-1#74#91#diseaseC0346011 211-228 diseaseC0346011 denotes fibrofolliculomas
21209915-1#108#128#diseaseC0007134 245-265 diseaseC0007134 denotes renal cell carcinoma
21209915-1#130#133#diseaseC0007134 267-270 diseaseC0007134 denotes RCC
21209915-1#138#161#diseaseC0346010 275-298 diseaseC0346010 denotes Birt-Hogg-Dubé syndrome
21209915-10#10#14#gene7030 1669-1673 gene7030 denotes TFE3
21209915-10#57#61#gene201163 1716-1720 gene201163 denotes FLCN
21209915-10#109#120#diseaseC0022665 1768-1779 diseaseC0022665 denotes renal tumor
21209915-11#66#70#gene7030 1859-1863 gene7030 denotes TFE3
21209915-11#169#173#gene7030 1962-1966 gene7030 denotes TFE3
21209915-11#206#219#diseaseC0596263 1999-2012 diseaseC0596263 denotes tumorigenesis
21209915-4#6#10#gene7030 717-721 gene7030 denotes TFE3
21209915-4#28#31#diseaseC0007134 739-742 diseaseC0007134 denotes RCC
21209915-6#33#38#gene10457 1053-1058 gene10457 denotes GPNMB
21209915-6#67#79#diseaseC0740457 1087-1099 diseaseC0740457 denotes renal cancer
21209915-6#67#79#diseaseC1378703 1087-1099 diseaseC1378703 denotes renal cancer
21209915-8#0#4#gene201163 1181-1185 gene201163 denotes FLCN
21209915-8#221#225#gene7030 1402-1406 gene7030 denotes TFE3
21209915-8#229#241#diseaseC0740457 1410-1422 diseaseC0740457 denotes renal cancer
21209915-8#229#241#diseaseC1378703 1410-1422 diseaseC1378703 denotes renal cancer
21209915-8#229#241#diseaseC0740457 1410-1422 diseaseC0740457 denotes renal cancer
21209915-8#229#241#diseaseC1378703 1410-1422 diseaseC1378703 denotes renal cancer
46#50#gene20116374#91#diseaseC0346011 21209915-1#46#50#gene201163 21209915-1#74#91#diseaseC0346011 associated_with FLCN,fibrofolliculomas
46#50#gene201163108#128#diseaseC0007134 21209915-1#46#50#gene201163 21209915-1#108#128#diseaseC0007134 associated_with FLCN,renal cell carcinoma
46#50#gene201163130#133#diseaseC0007134 21209915-1#46#50#gene201163 21209915-1#130#133#diseaseC0007134 associated_with FLCN,RCC
46#50#gene201163138#161#diseaseC0346010 21209915-1#46#50#gene201163 21209915-1#138#161#diseaseC0346010 associated_with FLCN,Birt-Hogg-Dubé syndrome
10#14#gene7030109#120#diseaseC0022665 21209915-10#10#14#gene7030 21209915-10#109#120#diseaseC0022665 associated_with TFE3,renal tumor
57#61#gene201163109#120#diseaseC0022665 21209915-10#57#61#gene201163 21209915-10#109#120#diseaseC0022665 associated_with FLCN,renal tumor
66#70#gene7030206#219#diseaseC0596263 21209915-11#66#70#gene7030 21209915-11#206#219#diseaseC0596263 associated_with TFE3,tumorigenesis
169#173#gene7030206#219#diseaseC0596263 21209915-11#169#173#gene7030 21209915-11#206#219#diseaseC0596263 associated_with TFE3,tumorigenesis
6#10#gene703028#31#diseaseC0007134 21209915-4#6#10#gene7030 21209915-4#28#31#diseaseC0007134 associated_with TFE3,RCC
33#38#gene1045767#79#diseaseC0740457 21209915-6#33#38#gene10457 21209915-6#67#79#diseaseC0740457 associated_with GPNMB,renal cancer
33#38#gene1045767#79#diseaseC1378703 21209915-6#33#38#gene10457 21209915-6#67#79#diseaseC1378703 associated_with GPNMB,renal cancer
0#4#gene201163229#241#diseaseC0740457 21209915-8#0#4#gene201163 21209915-8#229#241#diseaseC0740457 associated_with FLCN,renal cancer
0#4#gene201163229#241#diseaseC1378703 21209915-8#0#4#gene201163 21209915-8#229#241#diseaseC1378703 associated_with FLCN,renal cancer
0#4#gene201163229#241#diseaseC0740457 21209915-8#0#4#gene201163 21209915-8#229#241#diseaseC0740457 associated_with FLCN,renal cancer
0#4#gene201163229#241#diseaseC1378703 21209915-8#0#4#gene201163 21209915-8#229#241#diseaseC1378703 associated_with FLCN,renal cancer
221#225#gene7030229#241#diseaseC0740457 21209915-8#221#225#gene7030 21209915-8#229#241#diseaseC0740457 associated_with TFE3,renal cancer
221#225#gene7030229#241#diseaseC1378703 21209915-8#221#225#gene7030 21209915-8#229#241#diseaseC1378703 associated_with TFE3,renal cancer
221#225#gene7030229#241#diseaseC0740457 21209915-8#221#225#gene7030 21209915-8#229#241#diseaseC0740457 associated_with TFE3,renal cancer
221#225#gene7030229#241#diseaseC1378703 21209915-8#221#225#gene7030 21209915-8#229#241#diseaseC1378703 associated_with TFE3,renal cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1348 1181-1185 gene:201163 denotes FLCN
T1349 1410-1422 disease:C0740457 denotes renal cancer
T1350 1402-1406 gene:7030 denotes TFE3
R1 T1348 T1349 associated_with FLCN,renal cancer
R2 T1348 T1349 associated_with FLCN,renal cancer
R3 T1350 T1349 associated_with TFE3,renal cancer
R4 T1350 T1349 associated_with TFE3,renal cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 230-234 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 1436-1442 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryo
PD-UBERON-AE-B_T3 1467-1474 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 230-234 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T2 1467-1474 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
PD-UBERON-AE-B_T3 1436-1442 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryo