> top > docs > PubMed:21190448 > annotations

PubMed:21190448 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-97 Sentence denotes Thyroid pathology in PTEN-hamartoma tumor syndrome: characteristic findings of a distinct entity.
TextSentencer_T2 98-109 Sentence denotes BACKGROUND:
TextSentencer_T3 110-304 Sentence denotes Phosphatase and tensin homolog deleted on chromosome ten (PTEN)-hamartoma tumor syndrome (PHTS) is a complex disorder caused by germline inactivating mutations of the PTEN tumor suppressor gene.
TextSentencer_T4 305-410 Sentence denotes PHTS includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), and Proteus-like syndromes.
TextSentencer_T5 411-520 Sentence denotes Affected individuals develop both benign and malignant tumors in a variety of tissues, including the thyroid.
TextSentencer_T6 521-748 Sentence denotes This study is to better characterize and describe the thyroid pathology within the different entities of this syndrome, and examine whether there is an association between specific thyroid findings and different PTEN mutations.
TextSentencer_T7 749-757 Sentence denotes METHODS:
TextSentencer_T8 758-874 Sentence denotes Twenty patients with known PTEN mutations, and/or clinical diagnosis of PHTS, and thyroid pathology were identified:
TextSentencer_T9 875-902 Sentence denotes 14 with CS and 6 with BRRS.
TextSentencer_T10 903-911 Sentence denotes RESULTS:
TextSentencer_T11 912-1173 Sentence denotes Thyroid pathology findings were as follows: multiple adenomatous nodules in a background of lymphocytic thyroiditis (LT) in 75%, papillary carcinoma in 60%, LT alone in 55%, follicular carcinoma in 45%, C-cell hyperplasia in 55%, and follicular adenomas in 25%.
TextSentencer_T12 1174-1286 Sentence denotes Within the papillary carcinoma group, there were 6 microcarcinomas, 5 follicular variants, and 1 classical type.
TextSentencer_T13 1287-1299 Sentence denotes CONCLUSIONS:
TextSentencer_T14 1300-1382 Sentence denotes There were no morphologic differences between the thyroid findings in CS and BRRS.
TextSentencer_T15 1383-1499 Sentence denotes Also, there was no correlation between specific PTEN germline mutations (exons 5, 6, and 8) and pathologic findings.
TextSentencer_T16 1500-1804 Sentence denotes Distinctive and characteristic findings in PHTS include multiple unique adenomatous nodules in a background of LT, and C-cell hyperplasia; it is vital that pathologists recognize the classical histologic features of this syndrome to alert clinicians to the possibility of this syndrome in their patients.
T1 0-97 Sentence denotes Thyroid pathology in PTEN-hamartoma tumor syndrome: characteristic findings of a distinct entity.
T2 98-109 Sentence denotes BACKGROUND:
T3 110-304 Sentence denotes Phosphatase and tensin homolog deleted on chromosome ten (PTEN)-hamartoma tumor syndrome (PHTS) is a complex disorder caused by germline inactivating mutations of the PTEN tumor suppressor gene.
T4 305-410 Sentence denotes PHTS includes Cowden syndrome (CS), Bannayan-Riley-Ruvalcaba syndrome (BRRS), and Proteus-like syndromes.
T5 411-520 Sentence denotes Affected individuals develop both benign and malignant tumors in a variety of tissues, including the thyroid.
T6 521-748 Sentence denotes This study is to better characterize and describe the thyroid pathology within the different entities of this syndrome, and examine whether there is an association between specific thyroid findings and different PTEN mutations.
T7 749-757 Sentence denotes METHODS:
T8 758-874 Sentence denotes Twenty patients with known PTEN mutations, and/or clinical diagnosis of PHTS, and thyroid pathology were identified:
T9 875-902 Sentence denotes 14 with CS and 6 with BRRS.
T10 903-911 Sentence denotes RESULTS:
T11 912-1173 Sentence denotes Thyroid pathology findings were as follows: multiple adenomatous nodules in a background of lymphocytic thyroiditis (LT) in 75%, papillary carcinoma in 60%, LT alone in 55%, follicular carcinoma in 45%, C-cell hyperplasia in 55%, and follicular adenomas in 25%.
T12 1174-1286 Sentence denotes Within the papillary carcinoma group, there were 6 microcarcinomas, 5 follicular variants, and 1 classical type.
T13 1287-1299 Sentence denotes CONCLUSIONS:
T14 1300-1382 Sentence denotes There were no morphologic differences between the thyroid findings in CS and BRRS.
T15 1383-1499 Sentence denotes Also, there was no correlation between specific PTEN germline mutations (exons 5, 6, and 8) and pathologic findings.
T16 1500-1804 Sentence denotes Distinctive and characteristic findings in PHTS include multiple unique adenomatous nodules in a background of LT, and C-cell hyperplasia; it is vital that pathologists recognize the classical histologic features of this syndrome to alert clinicians to the possibility of this syndrome in their patients.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 110-140 gene:5728 denotes Phosphatase and tensin homolog
T1 168-198 disease:C1959582 denotes PTEN)-hamartoma tumor syndrome
T2 110-140 gene:5728 denotes Phosphatase and tensin homolog
T3 200-204 disease:C1959582 denotes PHTS
R1 T0 T1 associated_with Phosphatase and tensin homolog,PTEN)-hamartoma tumor syndrome
R2 T2 T3 associated_with Phosphatase and tensin homolog,PHTS

Allie

Id Subject Object Predicate Lexical cue
SS1_21190448_2_0 110-166 expanded denotes Phosphatase and tensin homolog deleted on chromosome ten
SS2_21190448_2_0 168-172 abbr denotes PTEN
SS1_21190448_3_0 319-334 expanded denotes Cowden syndrome
SS2_21190448_3_0 336-338 abbr denotes CS
SS1_21190448_3_1 341-374 expanded denotes Bannayan-Riley-Ruvalcaba syndrome
SS2_21190448_3_1 376-380 abbr denotes BRRS
SS1_21190448_9_0 1004-1027 expanded denotes lymphocytic thyroiditis
SS2_21190448_9_0 1029-1031 abbr denotes LT
AE1_21190448_2_0 SS1_21190448_2_0 SS2_21190448_2_0 abbreviatedTo Phosphatase and tensin homolog deleted on chromosome ten,PTEN
AE1_21190448_3_0 SS1_21190448_3_0 SS2_21190448_3_0 abbreviatedTo Cowden syndrome,CS
AE1_21190448_3_1 SS1_21190448_3_1 SS2_21190448_3_1 abbreviatedTo Bannayan-Riley-Ruvalcaba syndrome,BRRS
AE1_21190448_9_0 SS1_21190448_9_0 SS2_21190448_9_0 abbreviatedTo lymphocytic thyroiditis,LT

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 174-183 HP_0010566 denotes hamartoma
T2 184-189 HP_0002664 denotes tumor
T3 282-287 HP_0002664 denotes tumor
T4 466-472 HP_0002664 denotes tumors
T5 702-718 HP_0000820 denotes thyroid findings

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21190448-1#0#30#gene5728 110-140 gene5728 denotes Phosphatase and tensin homolog
21190448-1#58#88#diseaseC1959582 168-198 diseaseC1959582 denotes PTEN)-hamartoma tumor syndrome
21190448-1#90#94#diseaseC1959582 200-204 diseaseC1959582 denotes PHTS
0#30#gene572858#88#diseaseC1959582 21190448-1#0#30#gene5728 21190448-1#58#88#diseaseC1959582 associated_with Phosphatase and tensin homolog,PTEN)-hamartoma tumor syndrome
0#30#gene572890#94#diseaseC1959582 21190448-1#0#30#gene5728 21190448-1#90#94#diseaseC1959582 associated_with Phosphatase and tensin homolog,PHTS

PubCasesHPO

Id Subject Object Predicate Lexical cue
TI1 26-35 HP:0010566 denotes hamartoma
AB1 174-183 HP:0010566 denotes hamartoma
AB2 1016-1027 HP:0100646 denotes thyroiditis
AB3 1051-1060 HP:0030731 denotes carcinoma
AB4 1097-1106 HP:0030731 denotes carcinoma
AB5 1195-1204 HP:0030731 denotes carcinoma

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 489-496 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 319-334 ORDO:201 denotes Cowden syndrome
AB2 341-374 ORDO:109 denotes Bannayan-Riley-Ruvalcaba syndrome
AB3 376-380 ORDO:109 denotes BRRS
AB4 387-409 ORDO:2969 denotes Proteus-like syndromes
AB5 897-901 ORDO:109 denotes BRRS
AB6 1377-1381 ORDO:109 denotes BRRS

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 489-496 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues