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PubMed:2118525 JSONTXT

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GlyCosmos6-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 130-137 Body_part denotes element http://purl.obolibrary.org/obo/UBERON_0000062
T2 838-845 Body_part denotes element http://purl.obolibrary.org/obo/UBERON_0000062
T3 1163-1170 Body_part denotes simplex http://purl.obolibrary.org/obo/UBERON_0005350

sentences

Id Subject Object Predicate Lexical cue
T1 0-162 Sentence denotes A transcriptional enhancer essential for the expression of the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene.
T2 163-309 Sentence denotes We report the identification and characterization of the cis-acting elements responsible for the expression of the rat cholecystokinin (CCK) gene.
T3 310-481 Sentence denotes Deletion mutations were constructed by linking variable amounts of the 5'-flanking region of the CCK gene to the bacterial chloramphenicol acetyltransferase reporter gene.
T4 482-658 Sentence denotes The transcriptional activity of the CCK promoter deletion constructs was measured by monitoring chloramphenicol acetyltransferase enzyme activity after transient transfections.
T5 659-775 Sentence denotes It is shown that sequences within 102 base pairs of the cap site are required for the expression from this promoter.
T6 776-1017 Sentence denotes This region contains a sequence that is identical to the -296 element of the human c-fos gene and is homologous with the polyoma enhancer and the cAMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements described for several genes.
T7 1018-1253 Sentence denotes In addition, the -119 to -81 fragment of the CCK promoter contains a transcriptional enhancer that potentiates the transcription from the herpes simplex virus thymidine kinase promoter in a position- and orientation-independent manner.
T8 1254-1437 Sentence denotes DNase I protection and gel retardation experiments indicated the ability of several trans-acting factors found in nuclear extracts to bind specifically to regions of the CCK promoter.
T9 1438-1510 Sentence denotes In particular, two complexes formed adjacent to the CCK enhancer region.
T10 1511-1689 Sentence denotes One complex, CCK-1a, formed with sequences 5' to the enhancer whereas the other complex, CCK-1b, formed with the sequences identified by DNase I footprinting, 3' to the enhancer.
T11 1690-1849 Sentence denotes Oligonucleotide competition experiments indicated that these complexes are formed by the same transacting factor or factors with similar binding specificities.
T1 0-162 Sentence denotes A transcriptional enhancer essential for the expression of the rat cholecystokinin gene contains a sequence identical to the -296 element of the human c-fos gene.
T2 163-309 Sentence denotes We report the identification and characterization of the cis-acting elements responsible for the expression of the rat cholecystokinin (CCK) gene.
T3 310-481 Sentence denotes Deletion mutations were constructed by linking variable amounts of the 5'-flanking region of the CCK gene to the bacterial chloramphenicol acetyltransferase reporter gene.
T4 482-658 Sentence denotes The transcriptional activity of the CCK promoter deletion constructs was measured by monitoring chloramphenicol acetyltransferase enzyme activity after transient transfections.
T5 659-775 Sentence denotes It is shown that sequences within 102 base pairs of the cap site are required for the expression from this promoter.
T6 776-1017 Sentence denotes This region contains a sequence that is identical to the -296 element of the human c-fos gene and is homologous with the polyoma enhancer and the cAMP- and 12-O-tetradecanoylphorbol-13-acetate-responsive elements described for several genes.
T7 1018-1253 Sentence denotes In addition, the -119 to -81 fragment of the CCK promoter contains a transcriptional enhancer that potentiates the transcription from the herpes simplex virus thymidine kinase promoter in a position- and orientation-independent manner.
T8 1254-1437 Sentence denotes DNase I protection and gel retardation experiments indicated the ability of several trans-acting factors found in nuclear extracts to bind specifically to regions of the CCK promoter.
T9 1438-1510 Sentence denotes In particular, two complexes formed adjacent to the CCK enhancer region.
T10 1511-1689 Sentence denotes One complex, CCK-1a, formed with sequences 5' to the enhancer whereas the other complex, CCK-1b, formed with the sequences identified by DNase I footprinting, 3' to the enhancer.
T11 1690-1849 Sentence denotes Oligonucleotide competition experiments indicated that these complexes are formed by the same transacting factor or factors with similar binding specificities.

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1156-1170 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609

GlyCosmos6-CLO

Id Subject Object Predicate Lexical cue
T1 502-510 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T2 619-627 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T3 922-926 http://purl.obolibrary.org/obo/CLO_0053428 denotes cAMP

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 63-66 OrganismTaxon denotes rat NCBItxid:10114|NCBItxid:10116
T3 145-150 OrganismTaxon denotes human NCBItxid:9606
T4 278-281 OrganismTaxon denotes rat NCBItxid:10114|NCBItxid:10116
T6 853-858 OrganismTaxon denotes human NCBItxid:9606
T7 1163-1176 OrganismTaxon denotes simplex virus NCBItxid:10294

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
2118525-6#45#48#gene885 1063-1066 gene885 denotes CCK
2118525-6#138#152#diseaseC0019348 1156-1170 diseaseC0019348 denotes herpes simplex
45#48#gene885138#152#diseaseC0019348 2118525-6#45#48#gene885 2118525-6#138#152#diseaseC0019348 associated_with CCK,herpes simplex