> top > docs > PubMed:21183736 > annotations

PubMed:21183736 JSONTXT

Annnotations TAB JSON ListView MergeView

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations.
T2 133-143 Sentence denotes OBJECTIVE:
T3 144-352 Sentence denotes Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking.
T4 353-636 Sentence denotes The aim of this study was to evaluate the effect of iron on cytokine release in monocytes ex vivo and the correlation with vascular damage and to evaluate the relationship among serum levels of hepcidin, cytokines, and vascular damage in patients with metabolic syndrome alterations.
T5 637-657 Sentence denotes METHODS AND RESULTS:
T6 658-1116 Sentence denotes Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler.
T7 1117-1248 Sentence denotes In monocytes of healthy subjects (n=7), iron and hepcidin increased the mRNA levels and release of MCP-1, but not of interleukin-6.
T8 1249-1495 Sentence denotes In 130 patients with metabolic alterations, MCP-1 levels, as detected by ELISA, were correlated with hepcidin-25 measured by time-of-flight mass spectrometry (P=0.005) and were an independent predictor of the presence of carotid plaques (P=0.05).
T9 1496-1508 Sentence denotes CONCLUSIONS:
T10 1509-1639 Sentence denotes Hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in high-risk individuals with metabolic alterations.
T1 0-132 Sentence denotes Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations.
T2 133-143 Sentence denotes OBJECTIVE:
T3 144-352 Sentence denotes Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking.
T4 353-636 Sentence denotes The aim of this study was to evaluate the effect of iron on cytokine release in monocytes ex vivo and the correlation with vascular damage and to evaluate the relationship among serum levels of hepcidin, cytokines, and vascular damage in patients with metabolic syndrome alterations.
T5 637-657 Sentence denotes METHODS AND RESULTS:
T6 658-1116 Sentence denotes Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler.
T7 1117-1248 Sentence denotes In monocytes of healthy subjects (n=7), iron and hepcidin increased the mRNA levels and release of MCP-1, but not of interleukin-6.
T8 1249-1495 Sentence denotes In 130 patients with metabolic alterations, MCP-1 levels, as detected by ELISA, were correlated with hepcidin-25 measured by time-of-flight mass spectrometry (P=0.005) and were an independent predictor of the presence of carotid plaques (P=0.05).
T9 1496-1508 Sentence denotes CONCLUSIONS:
T10 1509-1639 Sentence denotes Hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in high-risk individuals with metabolic alterations.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 6-14 gene:57817 denotes hepcidin
T1 101-119 disease:C0524620 denotes metabolic syndrome
T2 50-55 gene:6347 denotes MCP-1
T3 101-119 disease:C0524620 denotes metabolic syndrome
R1 T0 T1 associated_with hepcidin,metabolic syndrome
R2 T2 T3 associated_with MCP-1,metabolic syndrome

Allie

Id Subject Object Predicate Lexical cue
SS1_21183736_5_0 739-771 expanded denotes monocyte chemoattractant protein
SS2_21183736_5_0 773-776 abbr denotes MCP
AE1_21183736_5_0 SS1_21183736_5_0 SS2_21183736_5_0 abbreviatedTo monocyte chemoattractant protein,MCP

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 218-233 HP_0002621 denotes atherosclerosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21183736-0#6#14#gene57817 6-14 gene57817 denotes hepcidin
21183736-0#50#55#gene6347 50-55 gene6347 denotes MCP-1
21183736-0#101#119#diseaseC0524620 101-119 diseaseC0524620 denotes metabolic syndrome
21183736-1#31#39#gene57817 175-183 gene57817 denotes hepcidin
21183736-1#74#89#diseaseC0003850 218-233 diseaseC0003850 denotes atherosclerosis
21183736-1#74#89#diseaseC0004153 218-233 diseaseC0004153 denotes atherosclerosis
21183736-3#61#69#gene57817 719-727 gene57817 denotes hepcidin
21183736-3#126#139#gene3569 784-797 gene3569 denotes interleukin-6
21183736-3#301#304#gene3077 959-962 gene3077 denotes HFE
21183736-3#126#139#gene3569 784-797 gene3569 denotes interleukin-6
21183736-3#301#304#gene3077 959-962 gene3077 denotes HFE
21183736-3#282#297#diseaseC0018995 940-955 diseaseC0018995 denotes hemochromatosis
21183736-3#282#297#diseaseC3469186 940-955 diseaseC3469186 denotes hemochromatosis
21183736-3#282#297#diseaseC0018995 940-955 diseaseC0018995 denotes hemochromatosis
21183736-3#282#297#diseaseC3469186 940-955 diseaseC3469186 denotes hemochromatosis
21183736-3#282#297#diseaseC0018995 940-955 diseaseC0018995 denotes hemochromatosis
21183736-3#282#297#diseaseC3469186 940-955 diseaseC3469186 denotes hemochromatosis
21183736-3#230#248#diseaseC0524620 888-906 diseaseC0524620 denotes metabolic syndrome
6#14#gene57817101#119#diseaseC0524620 21183736-0#6#14#gene57817 21183736-0#101#119#diseaseC0524620 associated_with hepcidin,metabolic syndrome
50#55#gene6347101#119#diseaseC0524620 21183736-0#50#55#gene6347 21183736-0#101#119#diseaseC0524620 associated_with MCP-1,metabolic syndrome
31#39#gene5781774#89#diseaseC0003850 21183736-1#31#39#gene57817 21183736-1#74#89#diseaseC0003850 associated_with hepcidin,atherosclerosis
31#39#gene5781774#89#diseaseC0004153 21183736-1#31#39#gene57817 21183736-1#74#89#diseaseC0004153 associated_with hepcidin,atherosclerosis
61#69#gene57817282#297#diseaseC0018995 21183736-3#61#69#gene57817 21183736-3#282#297#diseaseC0018995 associated_with hepcidin,hemochromatosis
61#69#gene57817282#297#diseaseC3469186 21183736-3#61#69#gene57817 21183736-3#282#297#diseaseC3469186 associated_with hepcidin,hemochromatosis
61#69#gene57817282#297#diseaseC0018995 21183736-3#61#69#gene57817 21183736-3#282#297#diseaseC0018995 associated_with hepcidin,hemochromatosis
61#69#gene57817282#297#diseaseC3469186 21183736-3#61#69#gene57817 21183736-3#282#297#diseaseC3469186 associated_with hepcidin,hemochromatosis
61#69#gene57817282#297#diseaseC0018995 21183736-3#61#69#gene57817 21183736-3#282#297#diseaseC0018995 associated_with hepcidin,hemochromatosis
61#69#gene57817282#297#diseaseC3469186 21183736-3#61#69#gene57817 21183736-3#282#297#diseaseC3469186 associated_with hepcidin,hemochromatosis
61#69#gene57817230#248#diseaseC0524620 21183736-3#61#69#gene57817 21183736-3#230#248#diseaseC0524620 associated_with hepcidin,metabolic syndrome
126#139#gene3569282#297#diseaseC0018995 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC0018995 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC3469186 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC3469186 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC0018995 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC0018995 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC3469186 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC3469186 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC0018995 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC0018995 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC3469186 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC3469186 associated_with interleukin-6,hemochromatosis
126#139#gene3569230#248#diseaseC0524620 21183736-3#126#139#gene3569 21183736-3#230#248#diseaseC0524620 associated_with interleukin-6,metabolic syndrome
301#304#gene3077282#297#diseaseC0018995 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC0018995 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC3469186 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC3469186 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC0018995 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC0018995 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC3469186 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC3469186 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC0018995 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC0018995 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC3469186 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC3469186 associated_with HFE,hemochromatosis
301#304#gene3077230#248#diseaseC0524620 21183736-3#301#304#gene3077 21183736-3#230#248#diseaseC0524620 associated_with HFE,metabolic syndrome
126#139#gene3569282#297#diseaseC0018995 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC0018995 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC3469186 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC3469186 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC0018995 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC0018995 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC3469186 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC3469186 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC0018995 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC0018995 associated_with interleukin-6,hemochromatosis
126#139#gene3569282#297#diseaseC3469186 21183736-3#126#139#gene3569 21183736-3#282#297#diseaseC3469186 associated_with interleukin-6,hemochromatosis
126#139#gene3569230#248#diseaseC0524620 21183736-3#126#139#gene3569 21183736-3#230#248#diseaseC0524620 associated_with interleukin-6,metabolic syndrome
301#304#gene3077282#297#diseaseC0018995 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC0018995 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC3469186 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC3469186 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC0018995 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC0018995 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC3469186 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC3469186 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC0018995 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC0018995 associated_with HFE,hemochromatosis
301#304#gene3077282#297#diseaseC3469186 21183736-3#301#304#gene3077 21183736-3#282#297#diseaseC3469186 associated_with HFE,hemochromatosis
301#304#gene3077230#248#diseaseC0524620 21183736-3#301#304#gene3077 21183736-3#230#248#diseaseC0524620 associated_with HFE,metabolic syndrome