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PubMed:21163864 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
8452 4-9 SequenceVariant denotes M235T DBSNP:rs699
8453 30-45 GeneOrGeneProduct denotes angiotensinogen NCBIGene:183
8454 67-75 OrganismTaxon denotes patients NCBITaxon:9606
8455 79-106 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy MESH:D002312
8456 122-149 DiseaseOrPhenotypicFeature denotes Hypertrophic cardiomyopathy MESH:D002312
8457 151-154 DiseaseOrPhenotypicFeature denotes HCM MESH:D002312
8458 206-221 DiseaseOrPhenotypicFeature denotes cardiac disease MESH:D006331
8459 327-332 SequenceVariant denotes T704C DBSNP:rs699
8460 363-378 GeneOrGeneProduct denotes angiotensinogen NCBIGene:183
8461 380-383 GeneOrGeneProduct denotes AGT NCBIGene:183
8462 395-398 DiseaseOrPhenotypicFeature denotes HCM MESH:D002312
8463 493-496 DiseaseOrPhenotypicFeature denotes HCM MESH:D002312
8464 501-537 DiseaseOrPhenotypicFeature denotes sporadic hypertrophic cardiomyopathy MESH:D002312
8465 539-543 DiseaseOrPhenotypicFeature denotes SHCM MESH:D002312
8466 552-588 DiseaseOrPhenotypicFeature denotes familial hypertrophic cardiomyopathy MESH:D024741
8467 590-594 DiseaseOrPhenotypicFeature denotes FHCM MESH:D024741
8468 597-605 OrganismTaxon denotes patients NCBITaxon:9606
8469 673-685 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
8470 690-718 DiseaseOrPhenotypicFeature denotes left ventricular hypertrophy MESH:D017379
8471 825-828 GeneOrGeneProduct denotes AGT NCBIGene:183
8472 862-911 SequenceVariant denotes methionine to threonine substitution at codon 235 DBSNP:rs699
8473 913-918 SequenceVariant denotes M235T DBSNP:rs699
8474 1054-1059 ChemicalEntity denotes SfaNI
8475 1202-1206 DiseaseOrPhenotypicFeature denotes SHCM MESH:D002312
8476 1207-1215 OrganismTaxon denotes patients NCBITaxon:9606
8477 1281-1285 DiseaseOrPhenotypicFeature denotes FHCM MESH:D024741
8478 1344-1347 GeneOrGeneProduct denotes AGT NCBIGene:183
8479 1386-1390 DiseaseOrPhenotypicFeature denotes SHCM MESH:D002312
8480 1516-1520 DiseaseOrPhenotypicFeature denotes FHCM MESH:D024741

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-107 Sentence denotes The M235T polymorphism of the angiotensinogen gene in South Indian patients of hypertrophic cardiomyopathy.
T2 108-121 Sentence denotes INTRODUCTION:
T3 122-253 Sentence denotes Hypertrophic cardiomyopathy (HCM) is a complex disorder and genetically transmitted cardiac disease with a diverse clinical course.
T4 254-448 Sentence denotes The objective of the present study was to examine the association of the T704C polymorphism of exon 2 of the angiotensinogen (AGT) gene with HCM in a South Indian population from Andhra Pradesh.
T5 449-470 Sentence denotes Subjects and methods.
T6 471-746 Sentence denotes One-hundred and fifty HCM (90 sporadic hypertrophic cardiomyopathy [SHCM] and 60 familial hypertrophic cardiomyopathy [FHCM]) patients and 165 age- and sex-matched normal healthy controls without known hypertension and left ventricular hypertrophy were included in the study.
T7 747-980 Sentence denotes DNA was isolated from peripheral leukocytes and the region of interest in the AGT gene bearing a missense mutation methionine to threonine substitution at codon 235 (M235T) of exon 2, was amplified by polymerase chain reaction (PCR).
T8 981-1060 Sentence denotes The PCR products were subjected to restriction digestion with the enzyme SfaNI.
T9 1061-1069 Sentence denotes RESULTS:
T10 1070-1229 Sentence denotes Significant differences were detected in genotypic distribution (p = 0.04) as well as the allelic frequency (p = 0.003) between the SHCM patients and controls.
T11 1230-1286 Sentence denotes The polymorphism did not show any association with FHCM.
T12 1287-1298 Sentence denotes CONCLUSION:
T13 1299-1440 Sentence denotes Our results suggest that the T allele of the AGT gene is significantly associated with SHCM in a South Indian population from Andhra Pradesh.
T14 1441-1521 Sentence denotes However, we did not find significant association of this polymorphism with FHCM.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 902-907 OrganismTaxon denotes codon NCBItxid:79338

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 79-106 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy 0005045
T2 92-106 DiseaseOrPhenotypicFeature denotes cardiomyopathy 0004994
T3 122-149 DiseaseOrPhenotypicFeature denotes Hypertrophic cardiomyopathy 0005045
T4 135-149 DiseaseOrPhenotypicFeature denotes cardiomyopathy 0004994
T5 510-537 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy 0005045
T6 523-537 DiseaseOrPhenotypicFeature denotes cardiomyopathy 0004994
T7 552-588 DiseaseOrPhenotypicFeature denotes familial hypertrophic cardiomyopathy 0024573
T8 561-588 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy 0005045
T9 574-588 DiseaseOrPhenotypicFeature denotes cardiomyopathy 0004994

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 4-9 SequenceVariant denotes M235T
T2 327-332 SequenceVariant denotes T704C
T3 913-918 SequenceVariant denotes M235T

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 30-45 GeneOrGeneProduct denotes angiotensinogen
T2 363-378 GeneOrGeneProduct denotes angiotensinogen
T3 380-383 GeneOrGeneProduct denotes AGT
T4 399-403 GeneOrGeneProduct denotes in a
T5 462-469 GeneOrGeneProduct denotes methods
T6 673-685 GeneOrGeneProduct denotes hypertension
T7 825-828 GeneOrGeneProduct denotes AGT
T8 844-852 GeneOrGeneProduct denotes missense
T9 853-861 GeneOrGeneProduct denotes mutation
T10 928-934 GeneOrGeneProduct denotes 2, was
T11 948-958 GeneOrGeneProduct denotes polymerase
T12 959-964 GeneOrGeneProduct denotes chain
T13 989-997 GeneOrGeneProduct denotes products
T14 1047-1053 GeneOrGeneProduct denotes enzyme
T15 1168-1177 GeneOrGeneProduct denotes frequency
T16 1344-1347 GeneOrGeneProduct denotes AGT
T17 1391-1395 GeneOrGeneProduct denotes in a
T18 1461-1465 GeneOrGeneProduct denotes find

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 30-45 GeneOrGeneProduct denotes angiotensinogen
T2 363-378 GeneOrGeneProduct denotes angiotensinogen
T3 380-383 GeneOrGeneProduct denotes AGT
T4 673-685 GeneOrGeneProduct denotes hypertension
T5 825-828 GeneOrGeneProduct denotes AGT
T6 948-958 GeneOrGeneProduct denotes polymerase
T7 959-964 GeneOrGeneProduct denotes chain
T8 1047-1053 GeneOrGeneProduct denotes enzyme
T9 1168-1177 GeneOrGeneProduct denotes frequency
T10 1344-1347 GeneOrGeneProduct denotes AGT

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 79-106 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T2 122-149 DiseaseOrPhenotypicFeature denotes Hypertrophic cardiomyopathy D002312
T3 151-154 DiseaseOrPhenotypicFeature denotes HCM D002312
T4 206-221 DiseaseOrPhenotypicFeature denotes cardiac disease D006331
T5 395-398 DiseaseOrPhenotypicFeature denotes HCM D002312
T6 493-496 DiseaseOrPhenotypicFeature denotes HCM D002312
T7 510-537 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T8 552-588 DiseaseOrPhenotypicFeature denotes familial hypertrophic cardiomyopathy D024741
T9 673-685 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 690-718 DiseaseOrPhenotypicFeature denotes left ventricular hypertrophy D017379

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 30-45 GeneOrGeneProduct denotes angiotensinogen
T2 363-378 GeneOrGeneProduct denotes angiotensinogen
T3 380-383 GeneOrGeneProduct denotes AGT
T4 825-828 GeneOrGeneProduct denotes AGT
T5 1344-1347 GeneOrGeneProduct denotes AGT

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 79-106 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy 0005045
T2 122-149 DiseaseOrPhenotypicFeature denotes Hypertrophic cardiomyopathy 0005045
T3 151-154 DiseaseOrPhenotypicFeature denotes HCM 0005045
T4 206-221 DiseaseOrPhenotypicFeature denotes cardiac disease 0005267
T5 395-398 DiseaseOrPhenotypicFeature denotes HCM 0005045
T6 493-496 DiseaseOrPhenotypicFeature denotes HCM 0005045
T7 510-537 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy 0005045
T8 552-588 DiseaseOrPhenotypicFeature denotes familial hypertrophic cardiomyopathy 0024573
T9 673-685 DiseaseOrPhenotypicFeature denotes hypertension 0005044

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 79-106 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T2 122-149 DiseaseOrPhenotypicFeature denotes Hypertrophic cardiomyopathy D002312
T3 151-154 DiseaseOrPhenotypicFeature denotes HCM D002312
T4 206-221 DiseaseOrPhenotypicFeature denotes cardiac disease D006331
T5 395-398 DiseaseOrPhenotypicFeature denotes HCM D002312
T6 493-496 DiseaseOrPhenotypicFeature denotes HCM D002312
T7 510-537 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T8 539-543 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T9 552-588 DiseaseOrPhenotypicFeature denotes familial hypertrophic cardiomyopathy D024741
T10 590-594 DiseaseOrPhenotypicFeature denotes FHCM DISEASE
T11 673-685 DiseaseOrPhenotypicFeature denotes hypertension D006973
T12 690-718 DiseaseOrPhenotypicFeature denotes left ventricular hypertrophy D017379
T13 1202-1206 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T14 1281-1285 DiseaseOrPhenotypicFeature denotes FHCM DISEASE
T15 1386-1390 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T16 1516-1520 DiseaseOrPhenotypicFeature denotes FHCM DISEASE

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 79-106 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T2 122-149 DiseaseOrPhenotypicFeature denotes Hypertrophic cardiomyopathy D002312
T3 151-154 DiseaseOrPhenotypicFeature denotes HCM D002312
T4 206-221 DiseaseOrPhenotypicFeature denotes cardiac disease D006331
T5 395-398 DiseaseOrPhenotypicFeature denotes HCM D002312
T6 493-496 DiseaseOrPhenotypicFeature denotes HCM D002312
T7 510-537 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T8 539-543 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T9 552-588 DiseaseOrPhenotypicFeature denotes familial hypertrophic cardiomyopathy D024741
T10 590-594 DiseaseOrPhenotypicFeature denotes FHCM DISEASE
T11 673-685 DiseaseOrPhenotypicFeature denotes hypertension D006973
T12 690-718 DiseaseOrPhenotypicFeature denotes left ventricular hypertrophy D017379
T13 1202-1206 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T14 1281-1285 DiseaseOrPhenotypicFeature denotes FHCM DISEASE
T15 1386-1390 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T16 1516-1520 DiseaseOrPhenotypicFeature denotes FHCM DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 30-45 ChemicalEntity denotes angiotensinogen http://purl.obolibrary.org/obo/CHEBI_2720
T2 363-378 ChemicalEntity denotes angiotensinogen http://purl.obolibrary.org/obo/CHEBI_2720
T3 380-383 ChemicalEntity denotes AGT http://purl.obolibrary.org/obo/CHEBI_2720
T4 825-828 ChemicalEntity denotes AGT http://purl.obolibrary.org/obo/CHEBI_2720
T5 862-872 ChemicalEntity denotes methionine http://purl.obolibrary.org/obo/CHEBI_64558|http://purl.obolibrary.org/obo/CHEBI_16811
T7 876-885 ChemicalEntity denotes threonine http://purl.obolibrary.org/obo/CHEBI_26986
T8 1054-1059 ChemicalEntity denotes SfaNI ChemicalEntity
T9 1344-1347 ChemicalEntity denotes AGT http://purl.obolibrary.org/obo/CHEBI_2720

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 67-75 OrganismTaxon denotes patients
T2 597-605 OrganismTaxon denotes patients
T3 1207-1215 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T9 1344-1347 ChemicalEntity denotes AGT http://purl.obolibrary.org/obo/CHEBI_2720
T8 1054-1059 ChemicalEntity denotes SfaNI ChemicalEntity
T7 876-885 ChemicalEntity denotes threonine http://purl.obolibrary.org/obo/CHEBI_26986
T5 862-872 ChemicalEntity denotes methionine http://purl.obolibrary.org/obo/CHEBI_16811|http://purl.obolibrary.org/obo/CHEBI_64558
T4 825-828 ChemicalEntity denotes AGT http://purl.obolibrary.org/obo/CHEBI_2720
T3 380-383 ChemicalEntity denotes AGT http://purl.obolibrary.org/obo/CHEBI_2720
T2 363-378 ChemicalEntity denotes angiotensinogen http://purl.obolibrary.org/obo/CHEBI_2720
T1 30-45 ChemicalEntity denotes angiotensinogen http://purl.obolibrary.org/obo/CHEBI_2720
T3742 1344-1347 GeneOrGeneProduct denotes AGT
T80293 825-828 GeneOrGeneProduct denotes AGT
T11450 380-383 GeneOrGeneProduct denotes AGT
T32452 363-378 GeneOrGeneProduct denotes angiotensinogen
T17276 30-45 GeneOrGeneProduct denotes angiotensinogen
T16 1516-1520 DiseaseOrPhenotypicFeature denotes FHCM DISEASE
T15 1386-1390 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T14 1281-1285 DiseaseOrPhenotypicFeature denotes FHCM DISEASE
T13 1202-1206 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T12 690-718 DiseaseOrPhenotypicFeature denotes left ventricular hypertrophy D017379
T11 673-685 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 590-594 DiseaseOrPhenotypicFeature denotes FHCM DISEASE
T74733 552-588 DiseaseOrPhenotypicFeature denotes familial hypertrophic cardiomyopathy D024741
T92499 539-543 DiseaseOrPhenotypicFeature denotes SHCM DISEASE
T48987 510-537 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T6 493-496 DiseaseOrPhenotypicFeature denotes HCM D002312
T56346 395-398 DiseaseOrPhenotypicFeature denotes HCM D002312
T95815 206-221 DiseaseOrPhenotypicFeature denotes cardiac disease D006331
T29946 151-154 DiseaseOrPhenotypicFeature denotes HCM D002312
T22764 122-149 DiseaseOrPhenotypicFeature denotes Hypertrophic cardiomyopathy D002312
T82531 79-106 DiseaseOrPhenotypicFeature denotes hypertrophic cardiomyopathy D002312
T74231 1207-1215 OrganismTaxon denotes patients
T51459 597-605 OrganismTaxon denotes patients
T20650 67-75 OrganismTaxon denotes patients
T66735 913-918 SequenceVariant denotes M235T
T80 327-332 SequenceVariant denotes T704C
T51700 4-9 SequenceVariant denotes M235T

DisGeNET

Id Subject Object Predicate Lexical cue
T0 30-45 gene:183 denotes angiotensinogen
T1 79-106 disease:C0007194 denotes hypertrophic cardiomyopathy
R1 T0 T1 associated_with angiotensinogen,hypertrophic cardiomyopathy

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 122-149 HP_0001639 denotes Hypertrophic cardiomyopathy
T2 135-149 HP_0001638 denotes cardiomyopathy
T3 510-537 HP_0001639 denotes hypertrophic cardiomyopathy
T4 523-537 HP_0001638 denotes cardiomyopathy
T5 561-588 HP_0001639 denotes hypertrophic cardiomyopathy
T6 574-588 HP_0001638 denotes cardiomyopathy
T7 673-685 HP_0000822 denotes hypertension
T8 695-718 HP_0001714 denotes ventricular hypertrophy

Allie

Id Subject Object Predicate Lexical cue
SS1_21163864_2_0 122-149 expanded denotes Hypertrophic cardiomyopathy
SS2_21163864_2_0 151-154 abbr denotes HCM
SS1_21163864_3_0 363-378 expanded denotes angiotensinogen
SS2_21163864_3_0 380-383 abbr denotes AGT
SS1_21163864_5_0 501-537 expanded denotes sporadic hypertrophic cardiomyopathy
SS2_21163864_5_0 539-543 abbr denotes SHCM
SS1_21163864_5_1 552-588 expanded denotes familial hypertrophic cardiomyopathy
SS2_21163864_5_1 590-594 abbr denotes FHCM
SS1_21163864_6_0 862-911 expanded denotes methionine to threonine substitution at codon 235
SS2_21163864_6_0 913-918 abbr denotes M235T
SS1_21163864_6_1 948-973 expanded denotes polymerase chain reaction
SS2_21163864_6_1 975-978 abbr denotes PCR
AE1_21163864_2_0 SS1_21163864_2_0 SS2_21163864_2_0 abbreviatedTo Hypertrophic cardiomyopathy,HCM
AE1_21163864_3_0 SS1_21163864_3_0 SS2_21163864_3_0 abbreviatedTo angiotensinogen,AGT
AE1_21163864_5_0 SS1_21163864_5_0 SS2_21163864_5_0 abbreviatedTo sporadic hypertrophic cardiomyopathy,SHCM
AE1_21163864_5_1 SS1_21163864_5_1 SS2_21163864_5_1 abbreviatedTo familial hypertrophic cardiomyopathy,FHCM
AE1_21163864_6_0 SS1_21163864_6_0 SS2_21163864_6_0 abbreviatedTo methionine to threonine substitution at codon 235,M235T
AE1_21163864_6_1 SS1_21163864_6_1 SS2_21163864_6_1 abbreviatedTo polymerase chain reaction,PCR

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 4-9 ProteinMutation:p|SUB|M|235|T denotes M235T
T2 327-332 DNAMutation:c|SUB|T|704|C denotes T704C
T3 913-918 ProteinMutation:p|SUB|M|235|T denotes M235T