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PubMed:21147760 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 195-206 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 337-343 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T3 497-503 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 195-206 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 337-343 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 497-503 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 195-206 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 337-343 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T3 497-503 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 176-181 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 835-840 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T3 1181-1186 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 337-343 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 497-503 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

DisGeNET

Id Subject Object Predicate Lexical cue
T0 106-113 gene:6480 denotes ST6GAL1
T1 135-160 disease:C2239176 denotes hepatocellular carcinomas
T2 118-125 gene:10402 denotes ST3GAL6
T3 135-160 disease:C2239176 denotes hepatocellular carcinomas
T4 606-613 gene:6480 denotes ST6GAL1
T5 716-719 disease:C2239176 denotes HCC
T6 606-613 gene:6480 denotes ST6GAL1
T7 690-714 disease:C2239176 denotes hepatocellular carcinoma
T8 639-658 gene:6487 denotes sialyltransferase 6
T9 690-714 disease:C2239176 denotes hepatocellular carcinoma
T10 660-667 gene:10402 denotes ST3GAL6
T11 690-714 disease:C2239176 denotes hepatocellular carcinoma
T12 660-667 gene:10402 denotes ST3GAL6
T13 716-719 disease:C2239176 denotes HCC
R1 T0 T1 associated_with ST6GAL1,hepatocellular carcinomas
R2 T2 T3 associated_with ST3GAL6,hepatocellular carcinomas
R3 T4 T5 associated_with ST6GAL1,HCC
R4 T6 T7 associated_with ST6GAL1,hepatocellular carcinoma
R5 T8 T9 associated_with sialyltransferase 6,hepatocellular carcinoma
R6 T10 T11 associated_with ST3GAL6,hepatocellular carcinoma
R7 T12 T13 associated_with ST3GAL6,HCC

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 690-714 HP_0001402 denotes hepatocellular carcinoma
T2 1071-1076 HP_0002664 denotes tumor
T3 1472-1480 HP_0002664 denotes tumorous
T4 1658-1667 HP_0002664 denotes cancerous
T5 1872-1877 HP_0002664 denotes tumor

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 36-47 FMAID:82816 denotes ganglioside
_T2 36-47 FMAID:196811 denotes ganglioside
_T3 176-181 FMAID:93672 denotes liver
_T4 176-181 FMAID:7197 denotes liver
_T5 182-189 FMAID:256050 denotes tissues
_T6 310-322 FMAID:196811 denotes gangliosides
_T7 310-322 FMAID:82816 denotes gangliosides
_T8 426-438 FMAID:82816 denotes gangliosides
_T9 426-438 FMAID:196811 denotes gangliosides
_T10 469-481 FMAID:82816 denotes gangliosides
_T11 469-481 FMAID:196811 denotes gangliosides
_T12 535-539 FMAID:198663 denotes gene
_T13 731-742 FMAID:82816 denotes Ganglioside
_T14 731-742 FMAID:196811 denotes Ganglioside
_T15 773-778 FMAID:165448 denotes lipid
_T16 773-778 FMAID:67264 denotes lipid
_T17 835-840 FMAID:7197 denotes liver
_T18 835-840 FMAID:93672 denotes liver
_T19 841-848 FMAID:256050 denotes tissues
_T20 1026-1038 FMAID:196811 denotes gangliosides
_T21 1026-1038 FMAID:82816 denotes gangliosides
_T22 1077-1084 FMAID:256050 denotes tissues
_T23 1181-1186 FMAID:93672 denotes liver
_T24 1181-1186 FMAID:7197 denotes liver
_T25 1187-1194 FMAID:256050 denotes tissues
_T26 1267-1278 FMAID:82816 denotes ganglioside
_T27 1267-1278 FMAID:196811 denotes ganglioside
_T28 1408-1419 FMAID:196811 denotes ganglioside
_T29 1408-1419 FMAID:82816 denotes ganglioside
_T30 1481-1488 FMAID:256050 denotes tissues
_T31 1562-1566 FMAID:198663 denotes gene
_T32 1694-1701 FMAID:256050 denotes tissues
_T33 1856-1868 FMAID:196811 denotes gangliosides
_T34 1856-1868 FMAID:82816 denotes gangliosides
_T35 1878-1885 FMAID:256050 denotes tissues
_T36 2069-2080 FMAID:82816 denotes ganglioside
_T37 2069-2080 FMAID:196811 denotes ganglioside
_T38 2145-2157 FMAID:196811 denotes gangliosides
_T39 2145-2157 FMAID:82816 denotes gangliosides

uniprot-human

Id Subject Object Predicate Lexical cue
T1 106-113 http://www.uniprot.org/uniprot/P15907 denotes ST6GAL1
T2 606-613 http://www.uniprot.org/uniprot/P15907 denotes ST6GAL1
T3 1636-1643 http://www.uniprot.org/uniprot/P15907 denotes ST6GAL1
T4 585-604 http://www.uniprot.org/uniprot/P15907 denotes sialyltransferase 1
T5 118-125 http://www.uniprot.org/uniprot/Q9Y274 denotes ST3GAL6
T6 660-667 http://www.uniprot.org/uniprot/Q9Y274 denotes ST3GAL6
T7 1722-1729 http://www.uniprot.org/uniprot/Q9Y274 denotes ST3GAL6
T8 1958-1965 http://www.uniprot.org/uniprot/Q9Y274 denotes ST3GAL6
T9 639-658 http://www.uniprot.org/uniprot/Q8IX54 denotes sialyltransferase 6

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 585-604 http://www.uniprot.org/uniprot/Q64685 denotes sialyltransferase 1
T2 639-658 http://www.uniprot.org/uniprot/P97325 denotes sialyltransferase 6
T3 1332-1333 http://www.uniprot.org/uniprot/P10637 denotes τ
T4 1443-1444 http://www.uniprot.org/uniprot/P10637 denotes τ
T5 1490-1491 http://www.uniprot.org/uniprot/P10637 denotes τ

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 26-29 http://purl.bioontology.org/ontology/NCBITAXON/238707 denotes iso
T2 150-160 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinomas
T3 182-189 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T4 451-458 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T5 459-462 http://purl.bioontology.org/ontology/NCBITAXON/238707 denotes iso
T6 705-714 http://purl.bioontology.org/ontology/NCBITAXON/166034 denotes carcinoma
T7 841-848 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T8 932-937 http://purl.bioontology.org/ontology/NCBITAXON/62990 denotes laser
T9 960-970 http://purl.bioontology.org/ontology/NCBITAXON/1271577 denotes orthogonal
T10 1016-1019 http://purl.bioontology.org/ontology/NCBITAXON/238707 denotes iso
T11 1077-1084 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T12 1187-1194 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T13 1257-1260 http://purl.bioontology.org/ontology/NCBITAXON/238707 denotes iso
T14 1398-1401 http://purl.bioontology.org/ontology/NCBITAXON/238707 denotes iso
T15 1481-1488 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T16 1658-1667 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancerous
T17 1694-1701 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T18 1846-1849 http://purl.bioontology.org/ontology/NCBITAXON/238707 denotes iso
T19 1878-1885 http://purl.bioontology.org/ontology/STY/T024 denotes tissues
T20 2135-2138 http://purl.bioontology.org/ontology/NCBITAXON/238707 denotes iso

GO-BP

Id Subject Object Predicate Lexical cue
T1 535-550 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T2 1562-1577 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T3 979-985 http://purl.obolibrary.org/obo/GO_0060361 denotes flight
T4 1916-1931 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional

GO-MF

Id Subject Object Predicate Lexical cue
T1 296-300 http://purl.obolibrary.org/obo/GO_0070026 denotes bind
T2 296-300 http://purl.obolibrary.org/obo/GO_0003680 denotes bind
T3 296-300 http://purl.obolibrary.org/obo/GO_0017091 denotes bind
T4 296-300 http://purl.obolibrary.org/obo/GO_0005488 denotes bind

UBERON-AE

Id Subject Object Predicate Lexical cue
T10 1878-1885 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T1 176-181 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T2 835-840 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T3 1181-1186 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T4 182-189 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T5 841-848 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T6 1077-1084 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T7 1187-1194 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T8 1481-1488 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T9 1694-1701 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

Allie

Id Subject Object Predicate Lexical cue
SS1_21147760_2_0 690-714 expanded denotes hepatocellular carcinoma
SS2_21147760_2_0 716-719 abbr denotes HCC
AE1_21147760_2_0 SS1_21147760_2_0 SS2_21147760_2_0 abbreviatedTo hepatocellular carcinoma,HCC

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 129-134 http://edamontology.org/topic_2815 denotes human
T2 328-336 http://edamontology.org/topic_0749 denotes terminal
T3 357-365 http://edamontology.org/topic_3168 denotes sequence
T4 357-365 http://edamontology.org/topic_0080 denotes sequence
T5 483-493 http://edamontology.org/topic_0749 denotes terminated
T6 517-525 http://edamontology.org/topic_0080 denotes sequence
T7 517-525 http://edamontology.org/topic_3168 denotes sequence
T8 535-550 http://edamontology.org/topic_0203 denotes gene expression
T9 773-778 http://edamontology.org/topic_0153 denotes lipid
T10 986-1003 http://edamontology.org/topic_0134 denotes mass spectrometry
T11 986-1003 http://edamontology.org/topic_3520 denotes mass spectrometry
T12 1196-1207 http://edamontology.org/topic_2269 denotes Statistical
T13 1536-1561 http://edamontology.org/topic_0195 denotes polymerase chain reaction
T14 1562-1577 http://edamontology.org/topic_0203 denotes gene expression
T15 1658-1667 http://edamontology.org/topic_2640 denotes cancerous
T16 1916-1931 http://edamontology.org/topic_3308 denotes transcriptional
T17 1916-1931 http://edamontology.org/topic_3512 denotes transcriptional
T18 1916-1931 http://edamontology.org/topic_0110 denotes transcriptional
T19 1916-1931 http://edamontology.org/topic_0203 denotes transcriptional
T20 2161-2168 http://edamontology.org/topic_0154 denotes targets

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 357-365 http://edamontology.org/data_2044 denotes sequence
T2 357-365 http://edamontology.org/operation_3218 denotes sequence
T3 517-525 http://edamontology.org/data_2044 denotes sequence
T4 517-525 http://edamontology.org/operation_3218 denotes sequence
T5 743-753 http://edamontology.org/data_0883 denotes structures
T6 743-769 http://edamontology.org/data_3035 denotes structures were identified
T7 759-769 http://edamontology.org/data_0842 denotes identified
T8 759-769 http://edamontology.org/data_2611 denotes identified
T9 791-798 http://edamontology.org/format_1990 denotes matched
T10 799-804 http://edamontology.org/format_1996 denotes pairs
T11 916-922 http://edamontology.org/data_2082 denotes matrix
T12 986-1003 http://edamontology.org/data_3147 denotes mass spectrometry
T13 986-1003 http://edamontology.org/data_2536 denotes mass spectrometry
T14 1196-1207 http://edamontology.org/operation_2238 denotes Statistical
T15 1196-1216 http://edamontology.org/operation_2238 denotes Statistical analysis
T16 1208-1216 http://edamontology.org/operation_2945 denotes analysis
T17 1228-1239 http://edamontology.org/operation_3465 denotes correlation
T18 1513-1525 http://edamontology.org/data_1426 denotes Quantitative
T19 1513-1525 http://edamontology.org/operation_3630 denotes Quantitative
T20 1562-1586 http://edamontology.org/operation_2495 denotes gene expression analysis
T21 1562-1586 http://edamontology.org/operation_0532 denotes gene expression analysis
T22 1562-1586 http://edamontology.org/operation_3232 denotes gene expression analysis
T23 1562-1586 http://edamontology.org/operation_2410 denotes gene expression analysis
T24 1562-1586 http://edamontology.org/operation_3463 denotes gene expression analysis
T25 1578-1586 http://edamontology.org/operation_2945 denotes analysis
T26 2094-2102 http://edamontology.org/operation_2428 denotes validate

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21147760-0#106#113#gene6480 106-113 gene6480 denotes ST6GAL1
21147760-0#118#125#gene10402 118-125 gene10402 denotes ST3GAL6
21147760-0#135#160#diseaseC2239176 135-160 diseaseC2239176 denotes hepatocellular carcinomas
21147760-2#272#291#gene6487 639-658 gene6487 denotes sialyltransferase 6
21147760-2#323#347#diseaseC2239176 690-714 diseaseC2239176 denotes hepatocellular carcinoma
106#113#gene6480135#160#diseaseC2239176 21147760-0#106#113#gene6480 21147760-0#135#160#diseaseC2239176 associated_with ST6GAL1,hepatocellular carcinomas
118#125#gene10402135#160#diseaseC2239176 21147760-0#118#125#gene10402 21147760-0#135#160#diseaseC2239176 associated_with ST3GAL6,hepatocellular carcinomas
272#291#gene6487323#347#diseaseC2239176 21147760-2#272#291#gene6487 21147760-2#323#347#diseaseC2239176 associated_with sialyltransferase 6,hepatocellular carcinoma

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 176-181 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 835-840 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T3 1181-1186 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-190 Sentence denotes Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
TextSentencer_T2 191-366 Sentence denotes The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence.
TextSentencer_T3 367-730 Sentence denotes We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4GlcNAc sequence) and the gene expression of associated β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) and β-galactoside α-2,3-sialyltransferase 6 (ST3GAL6), respectively, in 35 hepatocellular carcinoma (HCC) patients.
TextSentencer_T4 731-1004 Sentence denotes Ganglioside structures were identified in lipid extracts of matched pairs of malignant and nonmalignant liver tissues by thin-layer chromatography immunodetection coupled with infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry.
TextSentencer_T5 1005-1195 Sentence denotes CD75s- and iso-CD75s-gangliosides were found to be deregulated in tumor tissues and showed an elevated occurrence in 35 and 41% of HCCs, respectively, compared with nontumoral liver tissues.
TextSentencer_T6 1196-1512 Sentence denotes Statistical analysis revealed a correlation between enhanced iso-CD75s-ganglioside amount and a poor histopathological differentiation (τ = 0.317, P = 0.045) and a significant association of CD75s- and iso-CD75s-ganglioside levels in nontumorous (τ = 0.392, P = 0.003) and in tumorous tissues (τ = 0.650, P < 0.001).
TextSentencer_T7 1513-1702 Sentence denotes Quantitative real-time polymerase chain reaction gene expression analysis of sialyltransferases exhibited no difference in ST6GAL1 expression in cancerous and adjacent noncancerous tissues.
TextSentencer_T8 1703-1790 Sentence denotes Interestingly, the ST3GAL6 expression was significantly diminished in HCCs (P = 0.003).
TextSentencer_T9 1791-1980 Sentence denotes The results indicate that the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6, respectively.
TextSentencer_T10 1981-2198 Sentence denotes Thus, further experiments are required to explore the rationale behind the differential ganglioside level and to validate the applicability of CD75s- and iso-CD75s-gangliosides as targets for individual HCC therapies.
T1 0-190 Sentence denotes Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
T2 191-366 Sentence denotes The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence.
T3 367-730 Sentence denotes We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4GlcNAc sequence) and the gene expression of associated β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) and β-galactoside α-2,3-sialyltransferase 6 (ST3GAL6), respectively, in 35 hepatocellular carcinoma (HCC) patients.
T4 731-1004 Sentence denotes Ganglioside structures were identified in lipid extracts of matched pairs of malignant and nonmalignant liver tissues by thin-layer chromatography immunodetection coupled with infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry.
T5 1005-1195 Sentence denotes CD75s- and iso-CD75s-gangliosides were found to be deregulated in tumor tissues and showed an elevated occurrence in 35 and 41% of HCCs, respectively, compared with nontumoral liver tissues.
T6 1196-1512 Sentence denotes Statistical analysis revealed a correlation between enhanced iso-CD75s-ganglioside amount and a poor histopathological differentiation (τ = 0.317, P = 0.045) and a significant association of CD75s- and iso-CD75s-ganglioside levels in nontumorous (τ = 0.392, P = 0.003) and in tumorous tissues (τ = 0.650, P < 0.001).
T7 1513-1702 Sentence denotes Quantitative real-time polymerase chain reaction gene expression analysis of sialyltransferases exhibited no difference in ST6GAL1 expression in cancerous and adjacent noncancerous tissues.
T8 1703-1790 Sentence denotes Interestingly, the ST3GAL6 expression was significantly diminished in HCCs (P = 0.003).
T9 1791-1980 Sentence denotes The results indicate that the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6, respectively.
T10 1981-2198 Sentence denotes Thus, further experiments are required to explore the rationale behind the differential ganglioside level and to validate the applicability of CD75s- and iso-CD75s-gangliosides as targets for individual HCC therapies.
T1 0-190 Sentence denotes Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
T2 191-366 Sentence denotes The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence.
T3 367-730 Sentence denotes We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4GlcNAc sequence) and the gene expression of associated β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) and β-galactoside α-2,3-sialyltransferase 6 (ST3GAL6), respectively, in 35 hepatocellular carcinoma (HCC) patients.
T4 731-1004 Sentence denotes Ganglioside structures were identified in lipid extracts of matched pairs of malignant and nonmalignant liver tissues by thin-layer chromatography immunodetection coupled with infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry.
T5 1005-1195 Sentence denotes CD75s- and iso-CD75s-gangliosides were found to be deregulated in tumor tissues and showed an elevated occurrence in 35 and 41% of HCCs, respectively, compared with nontumoral liver tissues.
T6 1196-1512 Sentence denotes Statistical analysis revealed a correlation between enhanced iso-CD75s-ganglioside amount and a poor histopathological differentiation (τ = 0.317, P = 0.045) and a significant association of CD75s- and iso-CD75s-ganglioside levels in nontumorous (τ = 0.392, P = 0.003) and in tumorous tissues (τ = 0.650, P < 0.001).
T7 1513-1702 Sentence denotes Quantitative real-time polymerase chain reaction gene expression analysis of sialyltransferases exhibited no difference in ST6GAL1 expression in cancerous and adjacent noncancerous tissues.
T8 1703-1790 Sentence denotes Interestingly, the ST3GAL6 expression was significantly diminished in HCCs (P = 0.003).
T9 1791-1980 Sentence denotes The results indicate that the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6, respectively.
T10 1981-2198 Sentence denotes Thus, further experiments are required to explore the rationale behind the differential ganglioside level and to validate the applicability of CD75s- and iso-CD75s-gangliosides as targets for individual HCC therapies.

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 176-181 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T2 835-840 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 1181-1186 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 182-189 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T5 841-848 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T6 1077-1084 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T7 1187-1194 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T8 1481-1488 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T9 1694-1701 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T10 1878-1885 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 337-343 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 497-503 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 135-160 Disease denotes hepatocellular carcinomas http://purl.obolibrary.org/obo/MONDO_0007256
T2 690-714 Disease denotes hepatocellular carcinoma http://purl.obolibrary.org/obo/MONDO_0007256
T3 716-719 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256
T4 1071-1076 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 1872-1877 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 2184-2187 Disease denotes HCC http://purl.obolibrary.org/obo/MONDO_0007256

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 176-181 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 835-840 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 1181-1186 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 135-160 Phenotype denotes hepatocellular carcinomas HP:0001402
T2 690-714 Phenotype denotes hepatocellular carcinoma HP:0001402
T3 716-719 Phenotype denotes HCC HP:0001402
T4 1071-1076 Phenotype denotes tumor HP:0002664
T5 1872-1877 Phenotype denotes tumor HP:0002664
T6 2184-2187 Phenotype denotes HCC HP:0001402

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 135-160 Phenotype denotes hepatocellular carcinomas HP:0001402
T2 690-714 Phenotype denotes hepatocellular carcinoma HP:0001402
T3 716-719 Phenotype denotes HCC HP:0001402
T4 1071-1076 Phenotype denotes tumor HP:0002664
T5 1872-1877 Phenotype denotes tumor HP:0002664
T6 2184-2187 Phenotype denotes HCC HP:0001402

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 176-181 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 835-840 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T3 1181-1186 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 135-160 Disease denotes hepatocellular carcinomas MONDO:0007256
T2 690-714 Disease denotes hepatocellular carcinoma MONDO:0007256
T3 716-719 Disease denotes HCC MONDO:0007256
T4 1071-1076 Disease denotes tumor MONDO:0005070
T5 1872-1877 Disease denotes tumor MONDO:0005070
T6 2184-2187 Disease denotes HCC MONDO:0007256

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 129-134 Organism denotes human 9606
T2 721-729 Organism denotes patients 9606

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-190 Sentence denotes Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
T2 191-366 Sentence denotes The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence.
T3 367-730 Sentence denotes We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4GlcNAc sequence) and the gene expression of associated β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) and β-galactoside α-2,3-sialyltransferase 6 (ST3GAL6), respectively, in 35 hepatocellular carcinoma (HCC) patients.
T4 731-1004 Sentence denotes Ganglioside structures were identified in lipid extracts of matched pairs of malignant and nonmalignant liver tissues by thin-layer chromatography immunodetection coupled with infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry.
T5 1005-1195 Sentence denotes CD75s- and iso-CD75s-gangliosides were found to be deregulated in tumor tissues and showed an elevated occurrence in 35 and 41% of HCCs, respectively, compared with nontumoral liver tissues.
T6 1196-1512 Sentence denotes Statistical analysis revealed a correlation between enhanced iso-CD75s-ganglioside amount and a poor histopathological differentiation (τ = 0.317, P = 0.045) and a significant association of CD75s- and iso-CD75s-ganglioside levels in nontumorous (τ = 0.392, P = 0.003) and in tumorous tissues (τ = 0.650, P < 0.001).
T7 1513-1702 Sentence denotes Quantitative real-time polymerase chain reaction gene expression analysis of sialyltransferases exhibited no difference in ST6GAL1 expression in cancerous and adjacent noncancerous tissues.
T8 1703-1790 Sentence denotes Interestingly, the ST3GAL6 expression was significantly diminished in HCCs (P = 0.003).
T9 1791-1980 Sentence denotes The results indicate that the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6, respectively.
T10 1981-2198 Sentence denotes Thus, further experiments are required to explore the rationale behind the differential ganglioside level and to validate the applicability of CD75s- and iso-CD75s-gangliosides as targets for individual HCC therapies.

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-190 Sentence denotes Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
T2 191-366 Sentence denotes The sialic acid-specific cytotoxic lectin viscumin and its recombinant equivalent rViscumin specifically bind to CD75s-gangliosides with terminal Neu5Acα6Galβ4GlcNAc sequence.
T3 367-730 Sentence denotes We, therefore, comparatively analyzed the content of CD75s-gangliosides and closely related iso-CD75s-gangliosides (terminated by Neu5Acα3Galβ4GlcNAc sequence) and the gene expression of associated β-galactoside α-2,6-sialyltransferase 1 (ST6GAL1) and β-galactoside α-2,3-sialyltransferase 6 (ST3GAL6), respectively, in 35 hepatocellular carcinoma (HCC) patients.
T4 731-1004 Sentence denotes Ganglioside structures were identified in lipid extracts of matched pairs of malignant and nonmalignant liver tissues by thin-layer chromatography immunodetection coupled with infrared matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry.
T5 1005-1195 Sentence denotes CD75s- and iso-CD75s-gangliosides were found to be deregulated in tumor tissues and showed an elevated occurrence in 35 and 41% of HCCs, respectively, compared with nontumoral liver tissues.
T6 1196-1512 Sentence denotes Statistical analysis revealed a correlation between enhanced iso-CD75s-ganglioside amount and a poor histopathological differentiation (τ = 0.317, P = 0.045) and a significant association of CD75s- and iso-CD75s-ganglioside levels in nontumorous (τ = 0.392, P = 0.003) and in tumorous tissues (τ = 0.650, P < 0.001).
T7 1513-1702 Sentence denotes Quantitative real-time polymerase chain reaction gene expression analysis of sialyltransferases exhibited no difference in ST6GAL1 expression in cancerous and adjacent noncancerous tissues.
T8 1703-1790 Sentence denotes Interestingly, the ST3GAL6 expression was significantly diminished in HCCs (P = 0.003).
T9 1791-1980 Sentence denotes The results indicate that the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6, respectively.
T10 1981-2198 Sentence denotes Thus, further experiments are required to explore the rationale behind the differential ganglioside level and to validate the applicability of CD75s- and iso-CD75s-gangliosides as targets for individual HCC therapies.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 176-181 Body_part denotes liver FMA:7197
T2 182-189 Body_part denotes tissues FMA:9637
T3 835-840 Body_part denotes liver FMA:7197
T4 841-848 Body_part denotes tissues FMA:9637
T5 1077-1084 Body_part denotes tissues FMA:9637
T6 1181-1186 Body_part denotes liver FMA:7197
T7 1187-1194 Body_part denotes tissues FMA:9637
T8 1481-1488 Body_part denotes tissues FMA:9637
T9 1694-1701 Body_part denotes tissues FMA:9637
T10 1878-1885 Body_part denotes tissues FMA:9637

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 176-181 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 835-840 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T3 1181-1186 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 129-134 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 176-181 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 835-840 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T3 857-862 Body_part denotes layer http://purl.obolibrary.org/obo/UBERON_0000119|http://purl.obolibrary.org/obo/UBERON_0022303
T5 1181-1186 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107