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PubMed:21135538 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-76 Sentence denotes Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosis.
TextSentencer_T2 77-272 Sentence denotes Trisomy 21-linked Dyrk1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) overexpression is implicated in pathogenic mechanisms underlying mental retardation in Down syndrome (DS).
TextSentencer_T3 273-470 Sentence denotes It is known to phosphorylate multiple substrates including endocytic proteins in vitro, but the functional consequence of Dyrk1A-mediated phosphorylation on endocytosis has never been investigated.
TextSentencer_T4 471-661 Sentence denotes Here, we show that overexpression of Dyrk1A causes defects in clathrin-mediated endocytosis and specifically, in the recruitment of endocytic proteins to clathrin-coated pits in fibroblasts.
TextSentencer_T5 662-791 Sentence denotes Synaptic vesicle endocytosis also significantly slowed down as a result of Dyrk1A overexpression in cultured hippocampal neurons.
TextSentencer_T6 792-846 Sentence denotes These effects are dependent on Dyrk1A kinase activity.
TextSentencer_T7 847-1019 Sentence denotes The inhibitory effect of Dyrk1A on synaptic vesicle endocytosis was confirmed in neuronal cultures derived from transgenic mice overexpressing Dyrk1A at levels found in DS.
TextSentencer_T8 1020-1146 Sentence denotes Pharmacological blockade of Dyrk1A with epigallocatechin gallate rescued the endocytic phenotypes found in transgenic neurons.
TextSentencer_T9 1147-1377 Sentence denotes Together, our results suggest that aberrant Dyrk1A-mediated phosphorylation of the endocytic machinery perturbs synaptic vesicle endocytosis, which may contribute to synaptic dysfunctions and cognitive deficits associated with DS.
T1 0-76 Sentence denotes Overexpression of Dyrk1A causes the defects in synaptic vesicle endocytosis.
T2 77-272 Sentence denotes Trisomy 21-linked Dyrk1A (dual-specificity tyrosine phosphorylation-regulated kinase 1A) overexpression is implicated in pathogenic mechanisms underlying mental retardation in Down syndrome (DS).
T3 273-470 Sentence denotes It is known to phosphorylate multiple substrates including endocytic proteins in vitro, but the functional consequence of Dyrk1A-mediated phosphorylation on endocytosis has never been investigated.
T4 471-661 Sentence denotes Here, we show that overexpression of Dyrk1A causes defects in clathrin-mediated endocytosis and specifically, in the recruitment of endocytic proteins to clathrin-coated pits in fibroblasts.
T5 662-791 Sentence denotes Synaptic vesicle endocytosis also significantly slowed down as a result of Dyrk1A overexpression in cultured hippocampal neurons.
T6 792-846 Sentence denotes These effects are dependent on Dyrk1A kinase activity.
T7 847-1019 Sentence denotes The inhibitory effect of Dyrk1A on synaptic vesicle endocytosis was confirmed in neuronal cultures derived from transgenic mice overexpressing Dyrk1A at levels found in DS.
T8 1020-1146 Sentence denotes Pharmacological blockade of Dyrk1A with epigallocatechin gallate rescued the endocytic phenotypes found in transgenic neurons.
T9 1147-1377 Sentence denotes Together, our results suggest that aberrant Dyrk1A-mediated phosphorylation of the endocytic machinery perturbs synaptic vesicle endocytosis, which may contribute to synaptic dysfunctions and cognitive deficits associated with DS.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 103-164 gene:1859 denotes dual-specificity tyrosine phosphorylation-regulated kinase 1A
T1 77-87 disease:C0013080 denotes Trisomy 21
T2 103-164 gene:1859 denotes dual-specificity tyrosine phosphorylation-regulated kinase 1A
T3 253-266 disease:C0013080 denotes Down syndrome
T4 95-101 gene:1859 denotes Dyrk1A
T5 231-249 disease:C0025362 denotes mental retardation
T6 95-101 gene:1859 denotes Dyrk1A
T7 253-266 disease:C0013080 denotes Down syndrome
T8 103-164 gene:1859 denotes dual-specificity tyrosine phosphorylation-regulated kinase 1A
T9 231-249 disease:C0025362 denotes mental retardation
T10 103-164 gene:1859 denotes dual-specificity tyrosine phosphorylation-regulated kinase 1A
T11 268-270 disease:C0013080 denotes DS
T12 95-101 gene:1859 denotes Dyrk1A
T13 268-270 disease:C0013080 denotes DS
T14 872-878 gene:1859 denotes Dyrk1A
T15 1016-1018 disease:C0013080 denotes DS
T16 990-996 gene:1859 denotes Dyrk1A
T17 1016-1018 disease:C0013080 denotes DS
T18 1191-1197 gene:1859 denotes Dyrk1A
T19 1374-1376 disease:C0013080 denotes DS
T20 1191-1197 gene:1859 denotes Dyrk1A
T21 1339-1357 disease:C0679466 denotes cognitive deficits
R1 T0 T1 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,Trisomy 21
R2 T2 T3 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,Down syndrome
R3 T4 T5 associated_with Dyrk1A,mental retardation
R4 T6 T7 associated_with Dyrk1A,Down syndrome
R5 T8 T9 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,mental retardation
R6 T10 T11 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,DS
R7 T12 T13 associated_with Dyrk1A,DS
R8 T14 T15 associated_with Dyrk1A,DS
R9 T16 T17 associated_with Dyrk1A,DS
R10 T18 T19 associated_with Dyrk1A,DS
R11 T20 T21 associated_with Dyrk1A,cognitive deficits

Allie

Id Subject Object Predicate Lexical cue
SS1_21135538_1_0 253-266 expanded denotes Down syndrome
SS2_21135538_1_0 268-270 abbr denotes DS
AE1_21135538_1_0 SS1_21135538_1_0 SS2_21135538_1_0 abbreviatedTo Down syndrome,DS

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 231-249 HP_0001249 denotes mental retardation
T2 1339-1357 HP_0100543 denotes cognitive deficits

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21135538-1#18#24#gene1859 95-101 gene1859 denotes Dyrk1A
21135538-1#26#87#gene1859 103-164 gene1859 denotes dual-specificity tyrosine phosphorylation-regulated kinase 1A
21135538-1#154#172#diseaseC0025362 231-249 diseaseC0025362 denotes mental retardation
21135538-1#154#172#diseaseC3714756 231-249 diseaseC3714756 denotes mental retardation
21135538-1#154#172#diseaseC0025362 231-249 diseaseC0025362 denotes mental retardation
21135538-1#154#172#diseaseC3714756 231-249 diseaseC3714756 denotes mental retardation
21135538-8#44#50#gene1859 1191-1197 gene1859 denotes Dyrk1A
21135538-8#227#229#diseaseC0013080 1374-1376 diseaseC0013080 denotes DS
18#24#gene1859154#172#diseaseC0025362 21135538-1#18#24#gene1859 21135538-1#154#172#diseaseC0025362 associated_with Dyrk1A,mental retardation
18#24#gene1859154#172#diseaseC3714756 21135538-1#18#24#gene1859 21135538-1#154#172#diseaseC3714756 associated_with Dyrk1A,mental retardation
18#24#gene1859154#172#diseaseC0025362 21135538-1#18#24#gene1859 21135538-1#154#172#diseaseC0025362 associated_with Dyrk1A,mental retardation
18#24#gene1859154#172#diseaseC3714756 21135538-1#18#24#gene1859 21135538-1#154#172#diseaseC3714756 associated_with Dyrk1A,mental retardation
26#87#gene1859154#172#diseaseC0025362 21135538-1#26#87#gene1859 21135538-1#154#172#diseaseC0025362 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,mental retardation
26#87#gene1859154#172#diseaseC3714756 21135538-1#26#87#gene1859 21135538-1#154#172#diseaseC3714756 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,mental retardation
26#87#gene1859154#172#diseaseC0025362 21135538-1#26#87#gene1859 21135538-1#154#172#diseaseC0025362 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,mental retardation
26#87#gene1859154#172#diseaseC3714756 21135538-1#26#87#gene1859 21135538-1#154#172#diseaseC3714756 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,mental retardation
44#50#gene1859227#229#diseaseC0013080 21135538-8#44#50#gene1859 21135538-8#227#229#diseaseC0013080 associated_with Dyrk1A,DS

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T779 95-101 gene:1859 denotes Dyrk1A
T780 231-249 disease:C0025362 denotes mental retardation
T781 103-164 gene:1859 denotes dual-specificity tyrosine phosphorylation-regulated kinase 1A
R1 T779 T780 associated_with Dyrk1A,mental retardation
R2 T779 T780 associated_with Dyrk1A,mental retardation
R3 T781 T780 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,mental retardation
R4 T781 T780 associated_with dual-specificity tyrosine phosphorylation-regulated kinase 1A,mental retardation

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 641-645 http://purl.obolibrary.org/obo/UBERON_0016566 denotes pits

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 783-790 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T2 928-936 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neuronal
PD-UBERON-AE-B_T3 1138-1145 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons
PD-UBERON-AE-B_T4 641-645 http://purl.obolibrary.org/obo/UBERON_0016566 denotes pits