PubMed:21124846 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PubMed/sourceid/21124846","sourcedb":"PubMed","sourceid":"21124846","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/21124846","text":"Functional identification of neuroprotective molecules.\nThe central nervous system has the capacity to activate profound neuroprotection following sub-lethal stress in a process termed preconditioning. To gain insight into this potent survival response we developed a functional cloning strategy that identified 31 putative neuroprotective genes of which 28 were confirmed to provide protection against oxygen-glucose deprivation (OGD) or excitotoxic exposure to N-methyl-D-aspartate (NMDA) in primary rat cortical neurons. These results reveal that the brain possesses a wide and diverse repertoire of neuroprotective genes. Further characterization of these and other protective signals could provide new treatment opportunities for neurological injury from ischemia or neurodegenerative disease.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_21124846_2_0","span":{"begin":403,"end":429},"obj":"expanded"},{"id":"SS2_21124846_2_0","span":{"begin":431,"end":434},"obj":"abbr"},{"id":"SS1_21124846_2_1","span":{"begin":463,"end":483},"obj":"expanded"},{"id":"SS2_21124846_2_1","span":{"begin":485,"end":489},"obj":"abbr"}],"relations":[{"id":"AE1_21124846_2_0","pred":"abbreviatedTo","subj":"SS1_21124846_2_0","obj":"SS2_21124846_2_0"},{"id":"AE1_21124846_2_1","pred":"abbreviatedTo","subj":"SS1_21124846_2_1","obj":"SS2_21124846_2_1"}],"attributes":[{"subj":"SS1_21124846_2_0","pred":"source","obj":"Allie"},{"subj":"SS2_21124846_2_0","pred":"source","obj":"Allie"},{"subj":"SS1_21124846_2_1","pred":"source","obj":"Allie"},{"subj":"SS2_21124846_2_1","pred":"source","obj":"Allie"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#ec93b1","default":true}]}]}}