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PubMed:2111447 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 24-58 DNA denotes lymphoid-specific enhancer element
T2 80-111 DNA denotes immunoglobulin heavy-chain gene
T3 145-162 DNA denotes enhancer elements
T4 199-230 DNA denotes octamer (OCTA)-nucleotide motif
T5 285-322 DNA denotes immunoglobulin heavy-chain (IgH) gene
T6 372-384 DNA denotes binding site
T7 391-449 protein denotes putative additional lymphoid-specific transcription factor
T8 462-471 protein denotes NF-microB
T9 480-499 DNA denotes murine IgH enhancer
T10 525-547 DNA denotes NF-microB-binding site
T11 577-589 DNA denotes IgH enhancer
T12 674-686 DNA denotes IgH enhancer
T13 703-717 cell_type denotes B-cell lineage
T14 729-746 cell_type denotes nonlymphoid cells
T15 832-841 DNA denotes OCTA site
T16 879-885 DNA denotes microB
T17 890-900 DNA denotes OCTA sites
T18 938-952 cell_type denotes lymphoid cells
T19 994-1000 DNA denotes microB
T20 1004-1011 DNA denotes E3 site
T21 1017-1038 DNA denotes 70-base-pair fragment
T22 1046-1058 DNA denotes IgH enhancer
T23 1127-1141 cell_type denotes lymphoid cells
T24 1186-1198 DNA denotes microB motif
T25 1310-1335 protein denotes lymphoid-specific protein
T26 1349-1365 DNA denotes microB DNA motif
T27 1396-1410 DNA denotes microB element
T28 1529-1545 DNA denotes enhancer element

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-123 Sentence denotes Involvement of a second lymphoid-specific enhancer element in the regulation of immunoglobulin heavy-chain gene expression.
S2 124-500 Sentence denotes To determine whether enhancer elements in addition to the highly conserved octamer (OCTA)-nucleotide motif are important for lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene, we have investigated the effect of mutating the binding site for a putative additional lymphoid-specific transcription factor, designated NF-microB, in the murine IgH enhancer.
S3 501-747 Sentence denotes We demonstrate that the NF-microB-binding site plays a critical role in the IgH enhancer, because mutation of the microB DNA motif decreased transcriptional activity of the IgH enhancer in cells of the B-cell lineage but not in nonlymphoid cells.
S4 748-842 Sentence denotes This effect was comparable to or even stronger than the effect of a mutation in the OCTA site.
S5 843-953 Sentence denotes Moreover, combined mutation of both microB and OCTA sites further reduced enhancer activity in lymphoid cells.
S6 954-1153 Sentence denotes Interestingly, alteration of either the microB or E3 site in a 70-base-pair fragment of the IgH enhancer that lacks the binding site for OCTA abolished enhancer activity in lymphoid cells completely.
S7 1154-1233 Sentence denotes Nevertheless, a multimer of the microB motif alone showed no enhancer activity.
S8 1234-1366 Sentence denotes DNase footprinting analysis corroborated the functional data showing that a lymphoid-specific protein binds to the microB DNA motif.
S9 1367-1576 Sentence denotes Our results suggest that the microB element is a new crucial element important for lymphoid-specific expression of the IgH gene but that interaction with another enhancer element is essential for its activity.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 80-122 NP denotes immunoglobulin heavy-chain gene expression
C2 249-322 NP denotes lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene
C4 389-449 NP denotes a putative additional lymphoid-specific transcription factor
C5 462-471 NP denotes NF-microB
C3 368-471 NP denotes the binding site for a putative additional lymphoid-specific transcription factor, designated NF-microB
C6 476-499 NP denotes the murine IgH enhancer
C7 521-547 NP denotes the NF-microB-binding site
C8 573-589 NP denotes the IgH enhancer
C9 611-631 NP denotes the microB DNA motif
C10 670-686 NP denotes the IgH enhancer
C11 828-841 NP denotes the OCTA site
C13 1042-1058 NP denotes the IgH enhancer
C12 1015-1058 NP denotes a 70-base-pair fragment of the IgH enhancer
C14 1059-1063 NP denotes that
C15 1070-1095 NP denotes the binding site for OCTA
C16 1182-1198 NP denotes the microB motif
C17 1345-1365 NP denotes the microB DNA motif
C18 1450-1494 NP denotes lymphoid-specific expression of the IgH gene
C19 1563-1566 NP denotes its
R1 C2 C1 coref-ident lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene,immunoglobulin heavy-chain gene expression
R2 C5 C4 coref-ident NF-microB,a putative additional lymphoid-specific transcription factor
R3 C7 C3 coref-ident the NF-microB-binding site,"the binding site for a putative additional lymphoid-specific transcription factor, designated NF-microB"
R4 C8 C6 coref-ident the IgH enhancer,the murine IgH enhancer
R5 C10 C8 coref-ident the IgH enhancer,the IgH enhancer
R6 C13 C10 coref-ident the IgH enhancer,the IgH enhancer
R7 C14 C12 coref-relat that,a 70-base-pair fragment of the IgH enhancer
R8 C15 C11 coref-ident the binding site for OCTA,the OCTA site
R9 C16 C9 coref-ident the microB motif,the microB DNA motif
R10 C17 C16 coref-ident the microB DNA motif,the microB motif
R11 C18 C2 coref-ident lymphoid-specific expression of the IgH gene,lymphoid-specific expression of the immunoglobulin heavy-chain (IgH) gene
R12 C19 C18 coref-pron its,lymphoid-specific expression of the IgH gene

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 24-58 DNA_domain_or_region denotes lymphoid-specific enhancer element
T2 80-111 DNA_domain_or_region denotes immunoglobulin heavy-chain gene
T3 145-162 DNA_family_or_group denotes enhancer elements
T4 199-230 DNA_family_or_group denotes octamer (OCTA)-nucleotide motif
T5 249-277 other_name denotes lymphoid-specific expression
T6 285-322 DNA_domain_or_region denotes immunoglobulin heavy-chain (IgH) gene
T7 372-384 DNA_domain_or_region denotes binding site
T8 391-449 protein_family_or_group denotes putative additional lymphoid-specific transcription factor
T9 462-471 protein_molecule denotes NF-microB
T10 480-499 DNA_domain_or_region denotes murine IgH enhancer
T11 525-547 DNA_domain_or_region denotes NF-microB-binding site
T12 577-589 DNA_domain_or_region denotes IgH enhancer
T13 642-666 other_name denotes transcriptional activity
T14 674-686 DNA_domain_or_region denotes IgH enhancer
T15 703-717 cell_type denotes B-cell lineage
T16 729-746 cell_type denotes nonlymphoid cells
T17 832-841 DNA_domain_or_region denotes OCTA site
T18 879-885 DNA_domain_or_region denotes microB
T19 890-900 DNA_domain_or_region denotes OCTA sites
T20 917-934 other_name denotes enhancer activity
T21 938-952 cell_type denotes lymphoid cells
T22 994-1000 DNA_domain_or_region denotes microB
T23 1004-1011 DNA_domain_or_region denotes E3 site
T24 1017-1038 DNA_domain_or_region denotes 70-base-pair fragment
T25 1046-1058 DNA_domain_or_region denotes IgH enhancer
T26 1091-1123 other_name denotes OCTA abolished enhancer activity
T27 1127-1141 cell_type denotes lymphoid cells
T28 1186-1192 DNA_domain_or_region denotes microB
T29 1215-1232 other_name denotes enhancer activity
T30 1310-1335 protein_family_or_group denotes lymphoid-specific protein
T31 1349-1355 DNA_domain_or_region denotes microB
T32 1396-1402 DNA_domain_or_region denotes microB
T33 1450-1478 other_name denotes lymphoid-specific expression
T34 1529-1545 DNA_domain_or_region denotes enhancer element