PubMed:21099103 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/21099103","sourcedb":"PubMed","sourceid":"21099103","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/21099103","text":"The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer?\nThe retinoblastoma tumor suppressor gene (RB1; encoding RB) is often cited as a gatekeeper, whose inactivation - direct or indirect - is a rate-limiting step for tumor initiation. However, in this issue of the JCI, Sharma et al. show that RB1 loss is a late event in human prostate cancer that is coincident with the emergence of castrate-resistant metastatic disease. This role for RB1 was linked to both E2F transcription factor 1-driven upregulation of the androgen receptor (AR) and increased recruitment of the AR to target gene promoters. This unexpected function for RB1 in late-stage cancer calls upon us to reassess the significance of RB1 inactivation in other cancers in terms of its timing, function in disease etiology, and relevance for cancer therapy.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_21099103_3_0","span":{"begin":542,"end":559},"obj":"expanded"},{"id":"SS2_21099103_3_0","span":{"begin":561,"end":563},"obj":"abbr"}],"relations":[{"id":"AE1_21099103_3_0","pred":"abbreviatedTo","subj":"SS1_21099103_3_0","obj":"SS2_21099103_3_0"}],"attributes":[{"subj":"SS1_21099103_3_0","pred":"source","obj":"Allie"},{"subj":"SS2_21099103_3_0","pred":"source","obj":"Allie"}]},{"project":"CoMAGC","denotations":[{"id":"T1","span":{"begin":321,"end":324},"obj":"Gene"},{"id":"E2","span":{"begin":325,"end":329},"obj":"Negative_regulation"},{"id":"T2","span":{"begin":355,"end":370},"obj":"prostate cancer"}],"relations":[{"id":"R1","pred":"themeOf","subj":"T1","obj":"E2"},{"id":"R3","pred":"CGE-decreased","subj":"T1","obj":"T2"},{"id":"R4","pred":"CCS-normalTOcancer","subj":"T1","obj":"T2"},{"id":"R5","pred":"PT-observation","subj":"T1","obj":"T2"},{"id":"R3","pred":"IGE-unidentifiable","subj":"T1","obj":"T2"}],"attributes":[{"subj":"T1","pred":"source","obj":"CoMAGC"},{"subj":"E2","pred":"source","obj":"CoMAGC"},{"subj":"T2","pred":"source","obj":"CoMAGC"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":86,"end":100},"obj":"HP_0009919"},{"id":"T2","span":{"begin":101,"end":106},"obj":"HP_0002664"},{"id":"T3","span":{"begin":244,"end":249},"obj":"HP_0002664"},{"id":"T4","span":{"begin":355,"end":370},"obj":"HP_0012125"},{"id":"T5","span":{"begin":364,"end":370},"obj":"HP_0002664"},{"id":"T6","span":{"begin":674,"end":680},"obj":"HP_0002664"},{"id":"T7","span":{"begin":753,"end":760},"obj":"HP_0002664"},{"id":"T8","span":{"begin":833,"end":839},"obj":"HP_0002664"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"},{"subj":"T6","pred":"source","obj":"PubmedHPO"},{"subj":"T7","pred":"source","obj":"PubmedHPO"},{"subj":"T8","pred":"source","obj":"PubmedHPO"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#eca793","default":true},{"id":"CoMAGC","color":"#9399ec"},{"id":"PubmedHPO","color":"#b3ec93"}]}]}}