PubMed:21070631
Annnotations
Inflammaging
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-125 | Sentence | denotes | The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. |
| T2 | 126-137 | Sentence | denotes | BACKGROUND: |
| T3 | 138-243 | Sentence | denotes | The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). |
| T4 | 244-327 | Sentence | denotes | Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. |
| T5 | 328-521 | Sentence | denotes | Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD. |
| T6 | 522-698 | Sentence | denotes | We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls. |
| T7 | 699-707 | Sentence | denotes | METHODS: |
| T8 | 708-804 | Sentence | denotes | We genotyped eight single nucleotide polymorphisms (SNPs) in the three genes, DBH, IL1A and IL6. |
| T9 | 805-927 | Sentence | denotes | We used logistic regression models and synergy factor analysis to examine potential interactions and associations with AD. |
| T10 | 928-936 | Sentence | denotes | RESULTS: |
| T11 | 937-1051 | Sentence | denotes | We found that the presence of the -1021T allele was associated with AD: odds ratio = 1.2 (95% confidence interval: |
| T12 | 1052-1073 | Sentence | denotes | 1.06-1.4, p = 0.005). |
| T13 | 1074-1171 | Sentence | denotes | This association was nearly restricted to men < 75 years old: odds ratio = 2.2 (1.4-3.3, 0.0004). |
| T14 | 1172-1319 | Sentence | denotes | We also found an interaction between the presence of DBH -1021T and the -889TT genotype (rs1800587) of IL1A: synergy factor = 1.9 (1.2-3.1, 0.005). |
| T15 | 1320-1391 | Sentence | denotes | All these results were consistent between North Europe and North Spain. |
| T16 | 1392-1404 | Sentence | denotes | CONCLUSIONS: |
| T17 | 1405-1540 | Sentence | denotes | Extensive, previous evidence (reviewed here) indicates an important role for noradrenaline in the control of inflammation in the brain. |
| T18 | 1541-1688 | Sentence | denotes | Thus, the -1021T allele with presumed low activity may be associated with misregulation of inflammation, which could contribute to the onset of AD. |
| T19 | 1689-1787 | Sentence | denotes | We suggest that such misregulation is the predominant mechanism of the association we report here. |
| T1 | 0-125 | Sentence | denotes | The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. |
| T2 | 126-137 | Sentence | denotes | BACKGROUND: |
| T3 | 138-243 | Sentence | denotes | The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). |
| T4 | 244-327 | Sentence | denotes | Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. |
| T5 | 328-521 | Sentence | denotes | Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD. |
| T6 | 522-698 | Sentence | denotes | We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls. |
| T7 | 699-707 | Sentence | denotes | METHODS: |
| T8 | 708-804 | Sentence | denotes | We genotyped eight single nucleotide polymorphisms (SNPs) in the three genes, DBH, IL1A and IL6. |
| T9 | 805-927 | Sentence | denotes | We used logistic regression models and synergy factor analysis to examine potential interactions and associations with AD. |
| T10 | 928-936 | Sentence | denotes | RESULTS: |
| T11 | 937-1051 | Sentence | denotes | We found that the presence of the -1021T allele was associated with AD: odds ratio = 1.2 (95% confidence interval: |
| T12 | 1052-1073 | Sentence | denotes | 1.06-1.4, p = 0.005). |
| T13 | 1074-1171 | Sentence | denotes | This association was nearly restricted to men < 75 years old: odds ratio = 2.2 (1.4-3.3, 0.0004). |
| T14 | 1172-1319 | Sentence | denotes | We also found an interaction between the presence of DBH -1021T and the -889TT genotype (rs1800587) of IL1A: synergy factor = 1.9 (1.2-3.1, 0.005). |
| T15 | 1320-1391 | Sentence | denotes | All these results were consistent between North Europe and North Spain. |
| T16 | 1392-1404 | Sentence | denotes | CONCLUSIONS: |
| T17 | 1405-1540 | Sentence | denotes | Extensive, previous evidence (reviewed here) indicates an important role for noradrenaline in the control of inflammation in the brain. |
| T18 | 1541-1688 | Sentence | denotes | Thus, the -1021T allele with presumed low activity may be associated with misregulation of inflammation, which could contribute to the onset of AD. |
| T19 | 1689-1787 | Sentence | denotes | We suggest that such misregulation is the predominant mechanism of the association we report here. |
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 8288 | 4-26 | GeneOrGeneProduct | denotes | dopamine β-hydroxylase | NCBIGene:1621 |
| 8289 | 27-35 | SequenceVariant | denotes | -1021C/T | DBSNP:rs1611115 |
| 8290 | 80-99 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | MESH:D000544 |
| 8291 | 218-237 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | MESH:D000544 |
| 8292 | 239-241 | DiseaseOrPhenotypicFeature | denotes | AD | MESH:D000544 |
| 8293 | 244-266 | GeneOrGeneProduct | denotes | Dopamine β-hydroxylase | NCBIGene:1621 |
| 8294 | 268-271 | GeneOrGeneProduct | denotes | DBH | NCBIGene:1621 |
| 8295 | 301-309 | ChemicalEntity | denotes | dopamine | MESH:D004298 |
| 8296 | 313-326 | ChemicalEntity | denotes | noradrenaline | MESH:D009638 |
| 8297 | 385-391 | SequenceVariant | denotes | -1021T | DBSNP:rs1611115 |
| 8298 | 400-409 | SequenceVariant | denotes | rs1611115 | DBSNP:rs1611115 |
| 8299 | 414-417 | GeneOrGeneProduct | denotes | DBH | NCBIGene:1621 |
| 8300 | 447-459 | DiseaseOrPhenotypicFeature | denotes | inflammatory | MESH:D007249 |
| 8301 | 476-480 | GeneOrGeneProduct | denotes | IL1A | NCBIGene:3552 |
| 8302 | 485-488 | GeneOrGeneProduct | denotes | IL6 | NCBIGene:3569 |
| 8303 | 518-520 | DiseaseOrPhenotypicFeature | denotes | AD | MESH:D000544 |
| 8304 | 566-568 | DiseaseOrPhenotypicFeature | denotes | AD | MESH:D000544 |
| 8305 | 576-579 | GeneOrGeneProduct | denotes | DBH | NCBIGene:1621 |
| 8306 | 580-586 | SequenceVariant | denotes | -1021T | DBSNP:rs1611115 |
| 8307 | 669-671 | DiseaseOrPhenotypicFeature | denotes | AD | MESH:D000544 |
| 8308 | 786-789 | GeneOrGeneProduct | denotes | DBH | NCBIGene:1621 |
| 8309 | 791-795 | GeneOrGeneProduct | denotes | IL1A | NCBIGene:3552 |
| 8310 | 800-803 | GeneOrGeneProduct | denotes | IL6 | NCBIGene:3569 |
| 8311 | 924-926 | DiseaseOrPhenotypicFeature | denotes | AD | MESH:D000544 |
| 8312 | 971-977 | SequenceVariant | denotes | -1021T | DBSNP:rs1611115 |
| 8313 | 1005-1007 | DiseaseOrPhenotypicFeature | denotes | AD | MESH:D000544 |
| 8314 | 1116-1119 | OrganismTaxon | denotes | men | NCBITaxon:9606 |
| 8315 | 1225-1228 | GeneOrGeneProduct | denotes | DBH | NCBIGene:1621 |
| 8316 | 1229-1235 | SequenceVariant | denotes | -1021T | DBSNP:rs1611115 |
| 8317 | 1244-1250 | SequenceVariant | denotes | -889TT | DBSNP:rs1800587 |
| 8318 | 1261-1270 | SequenceVariant | denotes | rs1800587 | DBSNP:rs1800587 |
| 8319 | 1275-1279 | GeneOrGeneProduct | denotes | IL1A | NCBIGene:3552 |
| 8320 | 1482-1495 | ChemicalEntity | denotes | noradrenaline | MESH:D009638 |
| 8321 | 1514-1526 | DiseaseOrPhenotypicFeature | denotes | inflammation | MESH:D007249 |
| 8322 | 1551-1557 | SequenceVariant | denotes | -1021T | DBSNP:rs1611115 |
| 8323 | 1632-1644 | DiseaseOrPhenotypicFeature | denotes | inflammation | MESH:D007249 |
| 8324 | 1685-1687 | DiseaseOrPhenotypicFeature | denotes | AD | MESH:D000544 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-125 | Sentence | denotes | The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. |
| T2 | 126-137 | Sentence | denotes | BACKGROUND: |
| T3 | 138-243 | Sentence | denotes | The loss of noradrenergic neurones of the locus coeruleus is a major feature of Alzheimer's disease (AD). |
| T4 | 244-327 | Sentence | denotes | Dopamine β-hydroxylase (DBH) catalyses the conversion of dopamine to noradrenaline. |
| T5 | 328-521 | Sentence | denotes | Interactions have been reported between the low-activity -1021T allele (rs1611115) of DBH and polymorphisms of the pro-inflammatory cytokine genes, IL1A and IL6, contributing to the risk of AD. |
| T6 | 522-698 | Sentence | denotes | We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls. |
| T7 | 699-707 | Sentence | denotes | METHODS: |
| T8 | 708-804 | Sentence | denotes | We genotyped eight single nucleotide polymorphisms (SNPs) in the three genes, DBH, IL1A and IL6. |
| T9 | 805-927 | Sentence | denotes | We used logistic regression models and synergy factor analysis to examine potential interactions and associations with AD. |
| T10 | 928-936 | Sentence | denotes | RESULTS: |
| T11 | 937-1051 | Sentence | denotes | We found that the presence of the -1021T allele was associated with AD: odds ratio = 1.2 (95% confidence interval: |
| T12 | 1052-1073 | Sentence | denotes | 1.06-1.4, p = 0.005). |
| T13 | 1074-1171 | Sentence | denotes | This association was nearly restricted to men < 75 years old: odds ratio = 2.2 (1.4-3.3, 0.0004). |
| T14 | 1172-1319 | Sentence | denotes | We also found an interaction between the presence of DBH -1021T and the -889TT genotype (rs1800587) of IL1A: synergy factor = 1.9 (1.2-3.1, 0.005). |
| T15 | 1320-1391 | Sentence | denotes | All these results were consistent between North Europe and North Spain. |
| T16 | 1392-1404 | Sentence | denotes | CONCLUSIONS: |
| T17 | 1405-1540 | Sentence | denotes | Extensive, previous evidence (reviewed here) indicates an important role for noradrenaline in the control of inflammation in the brain. |
| T18 | 1541-1688 | Sentence | denotes | Thus, the -1021T allele with presumed low activity may be associated with misregulation of inflammation, which could contribute to the onset of AD. |
| T19 | 1689-1787 | Sentence | denotes | We suggest that such misregulation is the predominant mechanism of the association we report here. |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 80-99 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | 0004975 |
| T2 | 164-172 | DiseaseOrPhenotypicFeature | denotes | neurones | 0004466 |
| T3 | 218-237 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | 0004975 |
LitCoin-SeqVar
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 28-33 | SequenceVariant | denotes | 1021C |
| T2 | 386-391 | SequenceVariant | denotes | 1021T |
| T3 | 400-409 | SequenceVariant | denotes | rs1611115 |
| T4 | 581-586 | SequenceVariant | denotes | 1021T |
| T5 | 972-977 | SequenceVariant | denotes | 1021T |
| T6 | 1230-1235 | SequenceVariant | denotes | 1021T |
| T7 | 1245-1250 | SequenceVariant | denotes | 889TT |
| T8 | 1261-1270 | SequenceVariant | denotes | rs1800587 |
| T9 | 1552-1557 | SequenceVariant | denotes | 1021T |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-26 | GeneOrGeneProduct | denotes | hydroxylase |
| T2 | 201-206 | GeneOrGeneProduct | denotes | major |
| T3 | 255-266 | GeneOrGeneProduct | denotes | hydroxylase |
| T4 | 376-384 | GeneOrGeneProduct | denotes | activity |
| T5 | 443-446 | GeneOrGeneProduct | denotes | pro |
| T6 | 476-480 | GeneOrGeneProduct | denotes | IL1A |
| T7 | 485-488 | GeneOrGeneProduct | denotes | IL6 |
| T8 | 660-665 | GeneOrGeneProduct | denotes | cases |
| T9 | 699-706 | GeneOrGeneProduct | denotes | METHODS |
| T10 | 791-795 | GeneOrGeneProduct | denotes | IL1A |
| T11 | 800-803 | GeneOrGeneProduct | denotes | IL6 |
| T12 | 852-858 | GeneOrGeneProduct | denotes | factor |
| T13 | 1125-1130 | GeneOrGeneProduct | denotes | years |
| T14 | 1149-1152 | GeneOrGeneProduct | denotes | 2.2 |
| T15 | 1275-1279 | GeneOrGeneProduct | denotes | IL1A |
| T16 | 1289-1295 | GeneOrGeneProduct | denotes | factor |
| T17 | 1320-1323 | GeneOrGeneProduct | denotes | All |
| T18 | 1405-1414 | GeneOrGeneProduct | denotes | Extensive |
| T19 | 1534-1539 | GeneOrGeneProduct | denotes | brain |
| T20 | 1583-1591 | GeneOrGeneProduct | denotes | activity |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-26 | GeneOrGeneProduct | denotes | hydroxylase |
| T2 | 201-206 | GeneOrGeneProduct | denotes | major |
| T3 | 255-266 | GeneOrGeneProduct | denotes | hydroxylase |
| T4 | 476-480 | GeneOrGeneProduct | denotes | IL1A |
| T5 | 485-488 | GeneOrGeneProduct | denotes | IL6 |
| T6 | 791-795 | GeneOrGeneProduct | denotes | IL1A |
| T7 | 800-803 | GeneOrGeneProduct | denotes | IL6 |
| T8 | 852-858 | GeneOrGeneProduct | denotes | factor |
| T9 | 1275-1279 | GeneOrGeneProduct | denotes | IL1A |
| T10 | 1289-1295 | GeneOrGeneProduct | denotes | factor |
| T11 | 1534-1539 | GeneOrGeneProduct | denotes | brain |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T1 | 80-99 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 |
| T2 | 218-237 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 |
| T3 | 239-241 | DiseaseOrPhenotypicFeature | denotes | AD | D000544 |
| T4 | 447-459 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
| T5 | 518-520 | DiseaseOrPhenotypicFeature | denotes | AD | D000544 |
| T6 | 566-568 | DiseaseOrPhenotypicFeature | denotes | AD | D000544 |
| T7 | 669-671 | DiseaseOrPhenotypicFeature | denotes | AD | D000544 |
| T8 | 924-926 | DiseaseOrPhenotypicFeature | denotes | AD | D000544 |
| T9 | 1005-1007 | DiseaseOrPhenotypicFeature | denotes | AD | D000544 |
| T10 | 1514-1526 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T11 | 1632-1644 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T12 | 1685-1687 | DiseaseOrPhenotypicFeature | denotes | AD | D000544 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 15-26 | GeneOrGeneProduct | denotes | hydroxylase |
| T2 | 255-266 | GeneOrGeneProduct | denotes | hydroxylase |
| T3 | 476-480 | GeneOrGeneProduct | denotes | IL1A |
| T4 | 485-488 | GeneOrGeneProduct | denotes | IL6 |
| T5 | 791-795 | GeneOrGeneProduct | denotes | IL1A |
| T6 | 800-803 | GeneOrGeneProduct | denotes | IL6 |
| T7 | 1275-1279 | GeneOrGeneProduct | denotes | IL1A |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 80-99 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | 0004975 |
| T2 | 218-237 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | 0004975 |
| T3 | 239-241 | DiseaseOrPhenotypicFeature | denotes | AD | 0011913|0007088|0004975 |
| T6 | 518-520 | DiseaseOrPhenotypicFeature | denotes | AD | 0011913|0007088|0004975 |
| T9 | 566-568 | DiseaseOrPhenotypicFeature | denotes | AD | 0011913|0007088|0004975 |
| T12 | 669-671 | DiseaseOrPhenotypicFeature | denotes | AD | 0011913|0007088|0004975 |
| T15 | 924-926 | DiseaseOrPhenotypicFeature | denotes | AD | 0011913|0007088|0004975 |
| T18 | 1005-1007 | DiseaseOrPhenotypicFeature | denotes | AD | 0011913|0007088|0004975 |
| T21 | 1116-1119 | DiseaseOrPhenotypicFeature | denotes | men | 0017169 |
| T22 | 1685-1687 | DiseaseOrPhenotypicFeature | denotes | AD | 0011913|0007088|0004975 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 80-99 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 |
| T2 | 218-237 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 |
| T3 | 239-241 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T5 | 447-459 | DiseaseOrPhenotypicFeature | denotes | inflammatory | DISEASE |
| T6 | 518-520 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T8 | 566-568 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T10 | 669-671 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T12 | 924-926 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T14 | 1005-1007 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T16 | 1514-1539 | DiseaseOrPhenotypicFeature | denotes | inflammation in the brain | D004660 |
| T17 | 1632-1644 | DiseaseOrPhenotypicFeature | denotes | inflammation | DISEASE|D007249 |
| T19 | 1685-1687 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T1 | 80-99 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 |
| T2 | 218-237 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 |
| T3 | 239-241 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T5 | 443-459 | DiseaseOrPhenotypicFeature | denotes | pro-inflammatory | DISEASE |
| T6 | 518-520 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T8 | 566-568 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T10 | 669-671 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T12 | 924-926 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T14 | 1005-1007 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
| T16 | 1514-1526 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T17 | 1632-1644 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 |
| T18 | 1685-1687 | DiseaseOrPhenotypicFeature | denotes | AD | DISEASE|D000544 |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T1 | 4-12 | ChemicalEntity | denotes | dopamine | D004298|http://purl.obolibrary.org/obo/CHEBI_59905|http://purl.obolibrary.org/obo/CHEBI_18243 |
| T4 | 15-26 | ChemicalEntity | denotes | hydroxylase | D006899 |
| T5 | 244-252 | ChemicalEntity | denotes | Dopamine | http://purl.obolibrary.org/obo/CHEBI_18243 |
| T6 | 255-266 | ChemicalEntity | denotes | hydroxylase | D006899 |
| T7 | 301-309 | ChemicalEntity | denotes | dopamine | D004298|http://purl.obolibrary.org/obo/CHEBI_59905|http://purl.obolibrary.org/obo/CHEBI_18243 |
| T10 | 313-326 | ChemicalEntity | denotes | noradrenaline | D009638|http://purl.obolibrary.org/obo/CHEBI_33569|http://purl.obolibrary.org/obo/CHEBI_166902 |
| T13 | 1482-1495 | ChemicalEntity | denotes | noradrenaline | D009638|http://purl.obolibrary.org/obo/CHEBI_33569|http://purl.obolibrary.org/obo/CHEBI_166902 |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1116-1119 | OrganismTaxon | denotes | men |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T13 | 1482-1495 | ChemicalEntity | denotes | noradrenaline | http://purl.obolibrary.org/obo/CHEBI_166902|http://purl.obolibrary.org/obo/CHEBI_33569|D009638 | |
| T10 | 313-326 | ChemicalEntity | denotes | noradrenaline | http://purl.obolibrary.org/obo/CHEBI_166902|http://purl.obolibrary.org/obo/CHEBI_33569|D009638 | |
| T7 | 301-309 | ChemicalEntity | denotes | dopamine | http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905|D004298 | |
| T6 | 255-266 | ChemicalEntity | denotes | hydroxylase | D006899 | |
| T5 | 244-252 | ChemicalEntity | denotes | Dopamine | http://purl.obolibrary.org/obo/CHEBI_18243 | |
| T4 | 15-26 | ChemicalEntity | denotes | hydroxylase | D006899 | |
| T1 | 4-12 | ChemicalEntity | denotes | dopamine | http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905|D004298 | |
| T22877 | 1275-1279 | GeneOrGeneProduct | denotes | IL1A | ||
| T27127 | 800-803 | GeneOrGeneProduct | denotes | IL6 | ||
| T34025 | 791-795 | GeneOrGeneProduct | denotes | IL1A | ||
| T77247 | 485-488 | GeneOrGeneProduct | denotes | IL6 | ||
| T3 | 476-480 | GeneOrGeneProduct | denotes | IL1A | ||
| T2 | 255-266 | GeneOrGeneProduct | denotes | hydroxylase | ||
| T21395 | 15-26 | GeneOrGeneProduct | denotes | hydroxylase | ||
| T18 | 1685-1687 | DiseaseOrPhenotypicFeature | denotes | AD | D000544|DISEASE | |
| T17 | 1632-1644 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 | |
| T16 | 1514-1526 | DiseaseOrPhenotypicFeature | denotes | inflammation | D007249 | |
| T14 | 1005-1007 | DiseaseOrPhenotypicFeature | denotes | AD | D000544|DISEASE | |
| T12 | 924-926 | DiseaseOrPhenotypicFeature | denotes | AD | D000544|DISEASE | |
| T60878 | 669-671 | DiseaseOrPhenotypicFeature | denotes | AD | D000544|DISEASE | |
| T8 | 566-568 | DiseaseOrPhenotypicFeature | denotes | AD | D000544|DISEASE | |
| T54682 | 518-520 | DiseaseOrPhenotypicFeature | denotes | AD | D000544|DISEASE | |
| T72437 | 443-459 | DiseaseOrPhenotypicFeature | denotes | pro-inflammatory | DISEASE | |
| T97616 | 239-241 | DiseaseOrPhenotypicFeature | denotes | AD | D000544|DISEASE | |
| T77620 | 218-237 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 | |
| T11413 | 80-99 | DiseaseOrPhenotypicFeature | denotes | Alzheimer's disease | D000544 | |
| T37082 | 1116-1119 | OrganismTaxon | denotes | men | ||
| T9 | 1552-1557 | SequenceVariant | denotes | 1021T | ||
| T66338 | 1261-1270 | SequenceVariant | denotes | rs1800587 | ||
| T90062 | 1245-1250 | SequenceVariant | denotes | 889TT | ||
| T87524 | 1230-1235 | SequenceVariant | denotes | 1021T | ||
| T57872 | 972-977 | SequenceVariant | denotes | 1021T | ||
| T7004 | 581-586 | SequenceVariant | denotes | 1021T | ||
| T39658 | 400-409 | SequenceVariant | denotes | rs1611115 | ||
| T11035 | 386-391 | SequenceVariant | denotes | 1021T | ||
| T74969 | 28-33 | SequenceVariant | denotes | 1021C |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 218-237 | HP_0002511 | denotes | Alzheimer's disease |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_21070631_2_0 | 218-237 | expanded | denotes | Alzheimer's disease |
| SS2_21070631_2_0 | 239-241 | abbr | denotes | AD |
| SS1_21070631_3_0 | 244-266 | expanded | denotes | Dopamine β-hydroxylase |
| SS2_21070631_3_0 | 268-271 | abbr | denotes | DBH |
| SS1_21070631_7_0 | 727-758 | expanded | denotes | single nucleotide polymorphisms |
| SS2_21070631_7_0 | 760-764 | abbr | denotes | SNPs |
| AE1_21070631_2_0 | SS1_21070631_2_0 | SS2_21070631_2_0 | abbreviatedTo | Alzheimer's disease,AD |
| AE1_21070631_3_0 | SS1_21070631_3_0 | SS2_21070631_3_0 | abbreviatedTo | Dopamine β-hydroxylase,DBH |
| AE1_21070631_7_0 | SS1_21070631_7_0 | SS2_21070631_7_0 | abbreviatedTo | single nucleotide polymorphisms,SNPs |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 21070631-3#157#160#gene3569 | 485-488 | gene3569 | denotes | IL6 |
| 21070631-3#190#192#diseaseC0002395 | 518-520 | diseaseC0002395 | denotes | AD |
| 157#160#gene3569190#192#diseaseC0002395 | 21070631-3#157#160#gene3569 | 21070631-3#190#192#diseaseC0002395 | associated_with | IL6,AD |
tmVarCorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 27-35 | DNAMutation:c|SUB|C|-1021|T | denotes | -1021C/T |
| T2 | 400-409 | SNP:rs1611115 | denotes | rs1611115 |
| T3 | 1261-1270 | SNP:rs1800587 | denotes | rs1800587 |