PubMed:21067489
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-21 | Sentence | denotes | Diabetic retinopathy: |
| TextSentencer_T2 | 22-107 | Sentence | denotes | Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort. |
| TextSentencer_T3 | 108-116 | Sentence | denotes | PURPOSE: |
| TextSentencer_T4 | 117-695 | Sentence | denotes | We previously reported the association of the Z-2 allele of the promoter dinucleotide repeat in the Aldose reductase (ALR2) gene, the (CCTTT)₁₅ allele in the promoter of inductible nitric oxide synthase (iNOS) gene, and the (GT)₁₃ promoter polymorphism in the tumor necrosis factor β (TNFB) gene with an increased risk for diabetic retinopathy (DR), and the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene and the (GT)₉ allele of the TNFB gene with low-risk for DR in a hospital-based self-reported type 2 diabetes mellitus (T2DM) patients. |
| TextSentencer_T5 | 696-812 | Sentence | denotes | We have repeated the study in a population-based south Indian cohort to validate the same variations in these genes. |
| TextSentencer_T6 | 813-835 | Sentence | denotes | MATERIALS AND METHODS: |
| TextSentencer_T7 | 836-1132 | Sentence | denotes | Type 2 diabetic patients with and without retinopathy (DR+ and DR- respectively) were recruited. (CA)(n) repeat, Gly82Ser, (CCTTT)(n) repeat and (GT)(n) repeat in ALR2, RAGE, iNOS and TNFB genes respectively were genotyped and their frequencies were analyzed using the relevant statistical tests. |
| TextSentencer_T8 | 1133-1141 | Sentence | denotes | RESULTS: |
| TextSentencer_T9 | 1142-1244 | Sentence | denotes | Different allelic associations were observed in the present study as compared to our previous reports. |
| TextSentencer_T10 | 1245-1370 | Sentence | denotes | Z+2 allele of ALR2, 13-repeat genotype of iNOS, 15-repeat genotype of TNF-β, genes were associated with susceptibility to DR. |
| TextSentencer_T11 | 1371-1460 | Sentence | denotes | Gly82Ser polymorphisms of the RAGE gene were not associated with DR in the present study. |
| TextSentencer_T12 | 1461-1472 | Sentence | denotes | CONCLUSION: |
| TextSentencer_T13 | 1473-1719 | Sentence | denotes | The present data show a difference in the association of variations in ALR2, iNOS and TNFB genes with DR, when compared to our previous reports; this could be attributed to differences between the study populations of the past and present report. |
| T1 | 0-21 | Sentence | denotes | Diabetic retinopathy: |
| T2 | 22-107 | Sentence | denotes | Validation study of ALR2, RAGE, iNOS and TNFB gene variants in a south Indian cohort. |
| T3 | 108-116 | Sentence | denotes | PURPOSE: |
| T4 | 117-695 | Sentence | denotes | We previously reported the association of the Z-2 allele of the promoter dinucleotide repeat in the Aldose reductase (ALR2) gene, the (CCTTT)₁₅ allele in the promoter of inductible nitric oxide synthase (iNOS) gene, and the (GT)₁₃ promoter polymorphism in the tumor necrosis factor β (TNFB) gene with an increased risk for diabetic retinopathy (DR), and the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene and the (GT)₉ allele of the TNFB gene with low-risk for DR in a hospital-based self-reported type 2 diabetes mellitus (T2DM) patients. |
| T5 | 696-812 | Sentence | denotes | We have repeated the study in a population-based south Indian cohort to validate the same variations in these genes. |
| T6 | 813-835 | Sentence | denotes | MATERIALS AND METHODS: |
| T7 | 836-1132 | Sentence | denotes | Type 2 diabetic patients with and without retinopathy (DR+ and DR- respectively) were recruited. (CA)(n) repeat, Gly82Ser, (CCTTT)(n) repeat and (GT)(n) repeat in ALR2, RAGE, iNOS and TNFB genes respectively were genotyped and their frequencies were analyzed using the relevant statistical tests. |
| T8 | 1133-1141 | Sentence | denotes | RESULTS: |
| T9 | 1142-1244 | Sentence | denotes | Different allelic associations were observed in the present study as compared to our previous reports. |
| T10 | 1245-1370 | Sentence | denotes | Z+2 allele of ALR2, 13-repeat genotype of iNOS, 15-repeat genotype of TNF-β, genes were associated with susceptibility to DR. |
| T11 | 1371-1460 | Sentence | denotes | Gly82Ser polymorphisms of the RAGE gene were not associated with DR in the present study. |
| T12 | 1461-1472 | Sentence | denotes | CONCLUSION: |
| T13 | 1473-1719 | Sentence | denotes | The present data show a difference in the association of variations in ALR2, iNOS and TNFB genes with DR, when compared to our previous reports; this could be attributed to differences between the study populations of the past and present report. |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 217-233 | gene:231 | denotes | Aldose reductase |
| T1 | 440-460 | disease:C0011884 | denotes | diabetic retinopathy |
| T2 | 217-233 | gene:231 | denotes | Aldose reductase |
| T3 | 617-619 | disease:C0011884 | denotes | DR |
| T4 | 217-233 | gene:231 | denotes | Aldose reductase |
| T5 | 654-678 | disease:C0011860 | denotes | type 2 diabetes mellitus |
| T6 | 235-239 | gene:231 | denotes | ALR2 |
| T7 | 440-460 | disease:C0011884 | denotes | diabetic retinopathy |
| T8 | 235-239 | gene:231 | denotes | ALR2 |
| T9 | 462-464 | disease:C0011884 | denotes | DR |
| T10 | 235-239 | gene:231 | denotes | ALR2 |
| T11 | 617-619 | disease:C0011884 | denotes | DR |
| T12 | 235-239 | gene:231 | denotes | ALR2 |
| T13 | 654-678 | disease:C0011860 | denotes | type 2 diabetes mellitus |
| T14 | 235-239 | gene:231 | denotes | ALR2 |
| T15 | 680-684 | disease:C0011860 | denotes | T2DM |
| T16 | 377-400 | gene:4049 | denotes | tumor necrosis factor β |
| T17 | 440-460 | disease:C0011884 | denotes | diabetic retinopathy |
| T18 | 377-400 | gene:4049 | denotes | tumor necrosis factor β |
| T19 | 462-464 | disease:C0011884 | denotes | DR |
| T20 | 377-400 | gene:4049 | denotes | tumor necrosis factor β |
| T21 | 617-619 | disease:C0011884 | denotes | DR |
| T22 | 377-400 | gene:4049 | denotes | tumor necrosis factor β |
| T23 | 654-678 | disease:C0011860 | denotes | type 2 diabetes mellitus |
| T24 | 377-400 | gene:4049 | denotes | tumor necrosis factor β |
| T25 | 680-684 | disease:C0011860 | denotes | T2DM |
| T26 | 402-406 | gene:4049 | denotes | TNFB |
| T27 | 440-460 | disease:C0011884 | denotes | diabetic retinopathy |
| T28 | 402-406 | gene:4049 | denotes | TNFB |
| T29 | 462-464 | disease:C0011884 | denotes | DR |
| T30 | 402-406 | gene:4049 | denotes | TNFB |
| T31 | 617-619 | disease:C0011884 | denotes | DR |
| T32 | 402-406 | gene:4049 | denotes | TNFB |
| T33 | 654-678 | disease:C0011860 | denotes | type 2 diabetes mellitus |
| T34 | 402-406 | gene:4049 | denotes | TNFB |
| T35 | 680-684 | disease:C0011860 | denotes | T2DM |
| T36 | 589-593 | gene:4049 | denotes | TNFB |
| T37 | 440-460 | disease:C0011884 | denotes | diabetic retinopathy |
| T38 | 589-593 | gene:4049 | denotes | TNFB |
| T39 | 462-464 | disease:C0011884 | denotes | DR |
| T40 | 589-593 | gene:4049 | denotes | TNFB |
| T41 | 617-619 | disease:C0011884 | denotes | DR |
| T42 | 589-593 | gene:4049 | denotes | TNFB |
| T43 | 654-678 | disease:C0011860 | denotes | type 2 diabetes mellitus |
| T44 | 589-593 | gene:4049 | denotes | TNFB |
| T45 | 680-684 | disease:C0011860 | denotes | T2DM |
| R1 | T0 | T1 | associated_with | Aldose reductase,diabetic retinopathy |
| R2 | T2 | T3 | associated_with | Aldose reductase,DR |
| R3 | T4 | T5 | associated_with | Aldose reductase,type 2 diabetes mellitus |
| R4 | T6 | T7 | associated_with | ALR2,diabetic retinopathy |
| R5 | T8 | T9 | associated_with | ALR2,DR |
| R6 | T10 | T11 | associated_with | ALR2,DR |
| R7 | T12 | T13 | associated_with | ALR2,type 2 diabetes mellitus |
| R8 | T14 | T15 | associated_with | ALR2,T2DM |
| R9 | T16 | T17 | associated_with | tumor necrosis factor β,diabetic retinopathy |
| R10 | T18 | T19 | associated_with | tumor necrosis factor β,DR |
| R11 | T20 | T21 | associated_with | tumor necrosis factor β,DR |
| R12 | T22 | T23 | associated_with | tumor necrosis factor β,type 2 diabetes mellitus |
| R13 | T24 | T25 | associated_with | tumor necrosis factor β,T2DM |
| R14 | T26 | T27 | associated_with | TNFB,diabetic retinopathy |
| R15 | T28 | T29 | associated_with | TNFB,DR |
| R16 | T30 | T31 | associated_with | TNFB,DR |
| R17 | T32 | T33 | associated_with | TNFB,type 2 diabetes mellitus |
| R18 | T34 | T35 | associated_with | TNFB,T2DM |
| R19 | T36 | T37 | associated_with | TNFB,diabetic retinopathy |
| R20 | T38 | T39 | associated_with | TNFB,DR |
| R21 | T40 | T41 | associated_with | TNFB,DR |
| R22 | T42 | T43 | associated_with | TNFB,type 2 diabetes mellitus |
| R23 | T44 | T45 | associated_with | TNFB,T2DM |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 377-382 | HP_0002664 | denotes | tumor |
| T2 | 449-460 | HP_0000488 | denotes | retinopathy |
| T3 | 661-678 | HP_0000819 | denotes | diabetes mellitus |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_21067489_2_0 | 287-319 | expanded | denotes | inductible nitric oxide synthase |
| SS2_21067489_2_0 | 321-325 | abbr | denotes | iNOS |
| SS1_21067489_2_1 | 327-340 | expanded | denotes | gene, and the |
| SS2_21067489_2_1 | 342-344 | abbr | denotes | GT |
| SS1_21067489_2_2 | 377-400 | expanded | denotes | tumor necrosis factor β |
| SS2_21067489_2_2 | 402-406 | abbr | denotes | TNFB |
| SS1_21067489_2_3 | 440-460 | expanded | denotes | diabetic retinopathy |
| SS2_21067489_2_3 | 462-464 | abbr | denotes | DR |
| SS1_21067489_2_4 | 504-548 | expanded | denotes | receptor for advanced glycation end products |
| SS2_21067489_2_4 | 550-554 | abbr | denotes | RAGE |
| SS1_21067489_2_5 | 556-568 | expanded | denotes | gene and the |
| SS2_21067489_2_5 | 570-572 | abbr | denotes | GT |
| SS1_21067489_2_6 | 654-678 | expanded | denotes | type 2 diabetes mellitus |
| SS2_21067489_2_6 | 680-684 | abbr | denotes | T2DM |
| AE1_21067489_2_0 | SS1_21067489_2_0 | SS2_21067489_2_0 | abbreviatedTo | inductible nitric oxide synthase,iNOS |
| AE1_21067489_2_1 | SS1_21067489_2_1 | SS2_21067489_2_1 | abbreviatedTo | "gene, and the",GT |
| AE1_21067489_2_2 | SS1_21067489_2_2 | SS2_21067489_2_2 | abbreviatedTo | tumor necrosis factor β,TNFB |
| AE1_21067489_2_3 | SS1_21067489_2_3 | SS2_21067489_2_3 | abbreviatedTo | diabetic retinopathy,DR |
| AE1_21067489_2_4 | SS1_21067489_2_4 | SS2_21067489_2_4 | abbreviatedTo | receptor for advanced glycation end products,RAGE |
| AE1_21067489_2_5 | SS1_21067489_2_5 | SS2_21067489_2_5 | abbreviatedTo | gene and the,GT |
| AE1_21067489_2_6 | SS1_21067489_2_6 | SS2_21067489_2_6 | abbreviatedTo | type 2 diabetes mellitus,T2DM |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 21067489-1#433#437#gene177 | 550-554 | gene177 | denotes | RAGE |
| 21067489-1#204#208#gene4843 | 321-325 | gene4843 | denotes | iNOS |
| 21067489-1#387#431#gene177 | 504-548 | gene177 | denotes | receptor for advanced glycation end products |
| 21067489-1#537#561#diseaseC0011860 | 654-678 | diseaseC0011860 | denotes | type 2 diabetes mellitus |
| 21067489-1#563#567#diseaseC0011860 | 680-684 | diseaseC0011860 | denotes | T2DM |
| 21067489-1#537#561#diseaseC0011860 | 654-678 | diseaseC0011860 | denotes | type 2 diabetes mellitus |
| 21067489-1#563#567#diseaseC0011860 | 680-684 | diseaseC0011860 | denotes | T2DM |
| 21067489-1#537#561#diseaseC0011860 | 654-678 | diseaseC0011860 | denotes | type 2 diabetes mellitus |
| 21067489-1#563#567#diseaseC0011860 | 680-684 | diseaseC0011860 | denotes | T2DM |
| 21067489-6#14#18#gene231 | 1259-1263 | gene231 | denotes | ALR2 |
| 21067489-6#156#160#gene177 | 1401-1405 | gene177 | denotes | RAGE |
| 21067489-6#122#124#diseaseC0011884 | 1367-1369 | diseaseC0011884 | denotes | DR |
| 21067489-6#191#193#diseaseC0011884 | 1436-1438 | diseaseC0011884 | denotes | DR |
| 21067489-6#122#124#diseaseC0011884 | 1367-1369 | diseaseC0011884 | denotes | DR |
| 21067489-6#191#193#diseaseC0011884 | 1436-1438 | diseaseC0011884 | denotes | DR |
| 204#208#gene4843537#561#diseaseC0011860 | 21067489-1#204#208#gene4843 | 21067489-1#537#561#diseaseC0011860 | associated_with | iNOS,type 2 diabetes mellitus |
| 204#208#gene4843563#567#diseaseC0011860 | 21067489-1#204#208#gene4843 | 21067489-1#563#567#diseaseC0011860 | associated_with | iNOS,T2DM |
| 204#208#gene4843537#561#diseaseC0011860 | 21067489-1#204#208#gene4843 | 21067489-1#537#561#diseaseC0011860 | associated_with | iNOS,type 2 diabetes mellitus |
| 204#208#gene4843563#567#diseaseC0011860 | 21067489-1#204#208#gene4843 | 21067489-1#563#567#diseaseC0011860 | associated_with | iNOS,T2DM |
| 204#208#gene4843537#561#diseaseC0011860 | 21067489-1#204#208#gene4843 | 21067489-1#537#561#diseaseC0011860 | associated_with | iNOS,type 2 diabetes mellitus |
| 204#208#gene4843563#567#diseaseC0011860 | 21067489-1#204#208#gene4843 | 21067489-1#563#567#diseaseC0011860 | associated_with | iNOS,T2DM |
| 387#431#gene177537#561#diseaseC0011860 | 21067489-1#387#431#gene177 | 21067489-1#537#561#diseaseC0011860 | associated_with | receptor for advanced glycation end products,type 2 diabetes mellitus |
| 387#431#gene177563#567#diseaseC0011860 | 21067489-1#387#431#gene177 | 21067489-1#563#567#diseaseC0011860 | associated_with | receptor for advanced glycation end products,T2DM |
| 387#431#gene177537#561#diseaseC0011860 | 21067489-1#387#431#gene177 | 21067489-1#537#561#diseaseC0011860 | associated_with | receptor for advanced glycation end products,type 2 diabetes mellitus |
| 387#431#gene177563#567#diseaseC0011860 | 21067489-1#387#431#gene177 | 21067489-1#563#567#diseaseC0011860 | associated_with | receptor for advanced glycation end products,T2DM |
| 387#431#gene177537#561#diseaseC0011860 | 21067489-1#387#431#gene177 | 21067489-1#537#561#diseaseC0011860 | associated_with | receptor for advanced glycation end products,type 2 diabetes mellitus |
| 387#431#gene177563#567#diseaseC0011860 | 21067489-1#387#431#gene177 | 21067489-1#563#567#diseaseC0011860 | associated_with | receptor for advanced glycation end products,T2DM |
| 433#437#gene177537#561#diseaseC0011860 | 21067489-1#433#437#gene177 | 21067489-1#537#561#diseaseC0011860 | associated_with | RAGE,type 2 diabetes mellitus |
| 433#437#gene177563#567#diseaseC0011860 | 21067489-1#433#437#gene177 | 21067489-1#563#567#diseaseC0011860 | associated_with | RAGE,T2DM |
| 433#437#gene177537#561#diseaseC0011860 | 21067489-1#433#437#gene177 | 21067489-1#537#561#diseaseC0011860 | associated_with | RAGE,type 2 diabetes mellitus |
| 433#437#gene177563#567#diseaseC0011860 | 21067489-1#433#437#gene177 | 21067489-1#563#567#diseaseC0011860 | associated_with | RAGE,T2DM |
| 433#437#gene177537#561#diseaseC0011860 | 21067489-1#433#437#gene177 | 21067489-1#537#561#diseaseC0011860 | associated_with | RAGE,type 2 diabetes mellitus |
| 433#437#gene177563#567#diseaseC0011860 | 21067489-1#433#437#gene177 | 21067489-1#563#567#diseaseC0011860 | associated_with | RAGE,T2DM |
| 14#18#gene231122#124#diseaseC0011884 | 21067489-6#14#18#gene231 | 21067489-6#122#124#diseaseC0011884 | associated_with | ALR2,DR |
| 14#18#gene231191#193#diseaseC0011884 | 21067489-6#14#18#gene231 | 21067489-6#191#193#diseaseC0011884 | associated_with | ALR2,DR |
| 14#18#gene231122#124#diseaseC0011884 | 21067489-6#14#18#gene231 | 21067489-6#122#124#diseaseC0011884 | associated_with | ALR2,DR |
| 14#18#gene231191#193#diseaseC0011884 | 21067489-6#14#18#gene231 | 21067489-6#191#193#diseaseC0011884 | associated_with | ALR2,DR |
| 156#160#gene177122#124#diseaseC0011884 | 21067489-6#156#160#gene177 | 21067489-6#122#124#diseaseC0011884 | associated_with | RAGE,DR |
| 156#160#gene177191#193#diseaseC0011884 | 21067489-6#156#160#gene177 | 21067489-6#191#193#diseaseC0011884 | associated_with | RAGE,DR |
| 156#160#gene177122#124#diseaseC0011884 | 21067489-6#156#160#gene177 | 21067489-6#122#124#diseaseC0011884 | associated_with | RAGE,DR |
| 156#160#gene177191#193#diseaseC0011884 | 21067489-6#156#160#gene177 | 21067489-6#191#193#diseaseC0011884 | associated_with | RAGE,DR |
DisGeNet-2017-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T153 | 321-325 | gene:4843 | denotes | iNOS |
| T154 | 654-678 | disease:C0011860 | denotes | type 2 diabetes mellitus |
| T155 | 680-684 | disease:C0011860 | denotes | T2DM |
| R1 | T153 | T154 | associated_with | iNOS,type 2 diabetes mellitus |
| R2 | T153 | T155 | associated_with | iNOS,T2DM |