PubMed:2105946
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 79-88 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T3 | 466-475 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T5 | 756-765 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T7 | 893-902 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T9 | 1027-1036 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
| T11 | 1785-1794 | Cell | denotes | monocytic | http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-137 | Sentence | denotes | Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells. |
| T2 | 138-370 | Sentence | denotes | AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA). |
| T3 | 371-492 | Sentence | denotes | We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation. |
| T4 | 493-673 | Sentence | denotes | Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA. |
| T5 | 674-781 | Sentence | denotes | Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells. |
| T6 | 782-919 | Sentence | denotes | Similar findings were obtained with bryostatin 1 (10 nM), another activator of protein kinase C and inducer of monocytic differentiation. |
| T7 | 920-1081 | Sentence | denotes | Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation, increased c-jun expression. |
| T8 | 1082-1200 | Sentence | denotes | TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts. |
| T9 | 1201-1356 | Sentence | denotes | Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold. |
| T10 | 1357-1464 | Sentence | denotes | Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription. |
| T11 | 1465-1568 | Sentence | denotes | The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min. |
| T12 | 1569-1700 | Sentence | denotes | In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. |
| T13 | 1701-1883 | Sentence | denotes | These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms. |
| T1 | 0-137 | Sentence | denotes | Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells. |
| T2 | 138-370 | Sentence | denotes | AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA). |
| T3 | 371-492 | Sentence | denotes | We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation. |
| T4 | 493-673 | Sentence | denotes | Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA. |
| T5 | 674-781 | Sentence | denotes | Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells. |
| T6 | 782-919 | Sentence | denotes | Similar findings were obtained with bryostatin 1 (10 nM), another activator of protein kinase C and inducer of monocytic differentiation. |
| T7 | 920-1081 | Sentence | denotes | Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation, increased c-jun expression. |
| T8 | 1082-1200 | Sentence | denotes | TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts. |
| T9 | 1201-1356 | Sentence | denotes | Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold. |
| T10 | 1357-1464 | Sentence | denotes | Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription. |
| T11 | 1465-1568 | Sentence | denotes | The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min. |
| T12 | 1569-1700 | Sentence | denotes | In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. |
| T13 | 1701-1883 | Sentence | denotes | These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms. |
jnlpba-st-training
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 55-60 | DNA | denotes | c-jun |
| T2 | 108-136 | cell_line | denotes | human myeloid leukemic cells |
| T3 | 138-142 | protein | denotes | AP-1 |
| T4 | 171-176 | DNA | denotes | c-jun |
| T5 | 257-262 | DNA | denotes | genes |
| T6 | 422-427 | DNA | denotes | c-jun |
| T7 | 447-458 | cell_line | denotes | HL-60 cells |
| T8 | 507-524 | RNA | denotes | c-jun transcripts |
| T9 | 544-574 | cell_line | denotes | untreated HL-60 leukemic cells |
| T10 | 694-699 | DNA | denotes | c-jun |
| T11 | 734-745 | cell_line | denotes | human U-937 |
| T12 | 750-780 | cell_line | denotes | THP-1 monocytic leukemia cells |
| T13 | 861-877 | protein | denotes | protein kinase C |
| T14 | 1064-1069 | DNA | denotes | c-jun |
| T15 | 1099-1110 | cell_line | denotes | HL-60 cells |
| T16 | 1182-1187 | DNA | denotes | c-jun |
| T17 | 1251-1256 | DNA | denotes | c-jun |
| T18 | 1279-1300 | cell_line | denotes | untreated HL-60 cells |
| T19 | 1370-1381 | cell_line | denotes | HL-60 cells |
| T20 | 1444-1449 | DNA | denotes | c-jun |
| T21 | 1482-1491 | RNA | denotes | c-jun RNA |
| T22 | 1518-1529 | cell_line | denotes | HL-60 cells |
| T23 | 1599-1608 | RNA | denotes | c-jun RNA |
| T24 | 1612-1635 | cell_line | denotes | TPA-treated HL-60 cells |
| T25 | 1747-1756 | RNA | denotes | c-jun RNA |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 766-774 | HP_0001909 | denotes | leukemia |
semrep-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| E1-ti-1 | 0-15 | cui:C0040649 | denotes | Transcriptional |
| E2-ti-1 | 20-51 | cui:C1514248 | denotes | post-transcriptional regulation |
| E3-ti-1 | 55-60 | cui:C0085942 | denotes | c-jun |
| E4-ti-1 | 61-71 | cui:C0185117 | denotes | expression |
| E5-ti-1 | 79-88 | cui:C0026473 | denotes | monocytic |
| E6-ti-1 | 108-113 | cui:C0020114 | denotes | human |
| E7-ti-1 | 114-121 | cui:C0439677 | denotes | myeloid |
| E8-ti-1 | 122-136 | cui:C1517806 | denotes | leukemic cells |
| E1-ab-1 | 138-142 | cui:C0002059 | denotes | AP-1 |
| E2-ab-1 | 148-159 | cui:C1305923 | denotes | polypeptide |
| E3-ab-1 | 160-167 | cui:C1514468 | denotes | product |
| E4-ab-1 | 171-176 | cui:C0085942 | denotes | c-jun |
| E5-ab-1 | 211-224 | cui:C0162326 | denotes | DNA sequences |
| E6-ab-1 | 240-253 | cui:C0040649 | denotes | transcription |
| E7-ab-1 | 257-262 | cui:C0017337 | denotes | genes |
| E8-ab-1 | 263-273 | cui:C0205342 | denotes | responsive |
| E9-ab-1 | 277-284 | cui:C0205423 | denotes | certain |
| E10-ab-1 | 285-299 | cui:C0018284 | denotes | growth factors |
| E11-ab-1 | 304-318 | cui:C0031586 | denotes | phorbol esters |
| E12-ab-1 | 327-363 | cui:C0039654 | denotes | 12-O-tetradecanoylphorbol-13-acetate |
| T1 | 304-363 | ISA | denotes | phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate |
| T2 | 160-167 | PRODUCES | denotes | product |
| T3 | 193-198 | INTERACTS_WITH | denotes | binds |
| T4 | 229-239 | STIMULATES | denotes | stimulates |
| E1-ab-2 | 386-393 | cui:C1280500 | denotes | effects |
| E2-ab-2 | 397-400 | cui:C0039654 | denotes | TPA |
| E3-ab-2 | 408-418 | cui:C0851285 | denotes | regulation |
| E4-ab-2 | 422-432 | cui:C0085299 | denotes | c-jun gene |
| E5-ab-2 | 433-443 | cui:C0185117 | denotes | expression |
| E6-ab-2 | 447-458 | cui:C0282549 | denotes | HL-60 cells |
| E7-ab-2 | 466-475 | cui:C0026473 | denotes | monocytic |
| T5 | 386-393 | INTERACTS_WITH | denotes | effects |
| T6 | 444-446 | LOCATION_OF | denotes | in |
| E1-ab-3 | 493-496 | cui:C0205251 | denotes | Low |
| E2-ab-3 | 497-503 | cui:C0441889 | denotes | levels |
| E3-ab-3 | 507-512 | cui:C0085942 | denotes | c-jun |
| E4-ab-3 | 513-524 | cui:C1519595 | denotes | transcripts |
| E5-ab-3 | 554-574 | cui:C0282549 | denotes | HL-60 leukemic cells |
| E6-ab-3 | 625-632 | cui:C0205289 | denotes | maximal |
| E7-ab-3 | 633-639 | cui:C0441889 | denotes | levels |
| E8-ab-3 | 643-647 | cui:C0456696 | denotes | 24 h |
| E9-ab-3 | 669-672 | cui:C0039654 | denotes | TPA |
| E1-ab-4 | 674-681 | cui:C0871364 | denotes | Similar |
| E2-ab-4 | 682-690 | cui:C0220865 | denotes | kinetics |
| E3-ab-4 | 694-699 | cui:C0085942 | denotes | c-jun |
| E4-ab-4 | 700-709 | cui:C0857127 | denotes | induction |
| E5-ab-4 | 713-716 | cui:C0039654 | denotes | TPA |
| E6-ab-4 | 734-739 | cui:C0020114 | denotes | human |
| E7-ab-4 | 750-755 | entrez:2736 | denotes | THP-1 |
| E8-ab-4 | 756-774 | cui:C0598894 | denotes | monocytic leukemia |
| E9-ab-4 | 775-780 | cui:C0007634 | denotes | cells |
| T7 | 700-709 | STIMULATES | denotes | induction |
| E1-ab-5 | 782-789 | cui:C0871364 | denotes | Similar |
| E2-ab-5 | 790-798 | cui:C0243095 | denotes | findings |
| E3-ab-5 | 818-830 | cui:C0054173 | denotes | bryostatin 1 |
| E4-ab-5 | 861-877 | cui:C0033634 | denotes | protein kinase C |
| E5-ab-5 | 893-902 | cui:C0026473 | denotes | monocytic |
| T8 | 848-857 | STIMULATES | denotes | activator |
| E1-ab-6 | 938-957 | cui:C0766510 | denotes | dihydroxyvitamin D3 |
| E2-ab-6 | 959-962 | cui:C0444499 | denotes | 0.5 |
| E3-ab-6 | 963-969 | cui:C0439201 | denotes | microM |
| E4-ab-6 | 996-1001 | cui:C0450442 | denotes | agent |
| E5-ab-6 | 1021-1026 | cui:C1512310 | denotes | HL-60 |
| E6-ab-6 | 1027-1036 | cui:C0026473 | denotes | monocytic |
| E7-ab-6 | 1054-1063 | cui:C0205217 | denotes | increased |
| E8-ab-6 | 1066-1069 | cui:C0085296 | denotes | jun |
| E9-ab-6 | 1070-1080 | cui:C0185117 | denotes | expression |
| E1-ab-7 | 1082-1085 | cui:C0039654 | denotes | TPA |
| E2-ab-7 | 1099-1110 | cui:C0282549 | denotes | HL-60 cells |
| E3-ab-7 | 1130-1143 | cui:C0010572 | denotes | cycloheximide |
| E4-ab-7 | 1182-1187 | cui:C0085942 | denotes | c-jun |
| E5-ab-7 | 1188-1199 | cui:C1519595 | denotes | transcripts |
| E1-ab-8 | 1201-1205 | cui:C0600140 | denotes | Run- |
| E2-ab-8 | 1208-1216 | cui:C0936012 | denotes | analysis |
| E3-ab-8 | 1241-1247 | cui:C0441889 | denotes | levels |
| E4-ab-8 | 1251-1261 | cui:C0085299 | denotes | c-jun gene |
| E5-ab-8 | 1262-1275 | cui:C0040649 | denotes | transcription |
| E6-ab-8 | 1289-1300 | cui:C0282549 | denotes | HL-60 cells |
| E7-ab-8 | 1323-1326 | cui:C0039654 | denotes | TPA |
| E8-ab-8 | 1342-1346 | cui:C1521828 | denotes | rate |
| E9-ab-8 | 1351-1355 | cui:C0332462 | denotes | fold |
| T9 | 1276-1278 | LOCATION_OF | denotes | in |
| E1-ab-9 | 1357-1366 | cui:C0087111 | denotes | Treatment |
| E2-ab-9 | 1370-1381 | cui:C0282549 | denotes | HL-60 cells |
| E3-ab-9 | 1392-1395 | cui:C0039654 | denotes | TPA |
| E4-ab-9 | 1400-1413 | cui:C0010572 | denotes | cycloheximide |
| E5-ab-9 | 1421-1427 | cui:C1280500 | denotes | effect |
| E6-ab-9 | 1435-1440 | cui:C1521828 | denotes | rates |
| E7-ab-9 | 1444-1449 | cui:C0085942 | denotes | c-jun |
| E8-ab-9 | 1450-1463 | cui:C0040649 | denotes | transcription |
| T10 | 1382-1386 | USES | denotes | with |
| T11 | 1382-1386 | USES | denotes | with |
| E1-ab-10 | 1469-1478 | cui:C0018517 | denotes | half-life |
| E2-ab-10 | 1482-1487 | cui:C0085942 | denotes | c-jun |
| E3-ab-10 | 1488-1491 | cui:C0035668 | denotes | RNA |
| E4-ab-10 | 1509-1517 | cui:C1522326 | denotes | treating |
| E5-ab-10 | 1518-1529 | cui:C0282549 | denotes | HL-60 cells |
| E6-ab-10 | 1535-1538 | cui:C0039654 | denotes | TPA |
| E7-ab-10 | 1543-1556 | cui:C0010934 | denotes | actinomycin D |
| E8-ab-10 | 1561-1567 | cui:C0456693 | denotes | 30 min |
| E1-ab-11 | 1586-1595 | cui:C0018517 | denotes | half-life |
| E2-ab-11 | 1599-1604 | cui:C0085942 | denotes | c-jun |
| E3-ab-11 | 1605-1608 | cui:C0035668 | denotes | RNA |
| E4-ab-11 | 1612-1615 | cui:C0039654 | denotes | TPA |
| E5-ab-11 | 1616-1623 | cui:C1522326 | denotes | treated |
| E6-ab-11 | 1624-1635 | cui:C0282549 | denotes | HL-60 cells |
| E7-ab-11 | 1647-1660 | cui:C0010572 | denotes | cycloheximide |
| E8-ab-11 | 1665-1678 | cui:C0010934 | denotes | actinomycin D |
| E9-ab-11 | 1683-1690 | cui:C0443228 | denotes | greater |
| E1-ab-12 | 1707-1715 | cui:C0243095 | denotes | findings |
| E2-ab-12 | 1735-1743 | cui:C0442805 | denotes | increase |
| E3-ab-12 | 1747-1752 | cui:C0085942 | denotes | c-jun |
| E4-ab-12 | 1753-1756 | cui:C0035668 | denotes | RNA |
| E5-ab-12 | 1773-1776 | cui:C0039654 | denotes | TPA |
| E6-ab-12 | 1777-1784 | cui:C0205263 | denotes | induced |
| E7-ab-12 | 1785-1794 | cui:C0026473 | denotes | monocytic |
| E8-ab-12 | 1831-1846 | cui:C0040649 | denotes | transcriptional |
| E9-ab-12 | 1851-1856 | cui:C0687676 | denotes | post- |
| E10-ab-12 | 1856-1871 | cui:C0040649 | denotes | transcriptional |
| E11-ab-12 | 1872-1882 | cui:C0441712 | denotes | mechanisms |
| R1 | E12-ab-1 | T1 | subjectOf | 12-O-tetradecanoylphorbol-13-acetate,phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate |
| R2 | E11-ab-1 | T1 | objectOf | phorbol esters,phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate |
| R3 | E4-ab-1 | T2 | subjectOf | c-jun,product |
| R4 | E2-ab-1 | T2 | objectOf | polypeptide,product |
| R5 | E2-ab-1 | T3 | subjectOf | polypeptide,binds |
| R6 | E5-ab-1 | T3 | objectOf | DNA sequences,binds |
| R7 | E2-ab-1 | T4 | subjectOf | polypeptide,stimulates |
| R8 | E7-ab-1 | T4 | objectOf | genes,stimulates |
| R9 | E4-ab-2 | T5 | subjectOf | c-jun gene,effects |
| R10 | E2-ab-2 | T5 | objectOf | TPA,effects |
| R11 | E6-ab-2 | T6 | subjectOf | HL-60 cells,in |
| R12 | E4-ab-2 | T6 | objectOf | c-jun gene,in |
| R13 | E5-ab-4 | T7 | subjectOf | TPA,induction |
| R14 | E3-ab-4 | T7 | objectOf | c-jun,induction |
| R15 | E3-ab-5 | T8 | subjectOf | bryostatin 1,activator |
| R16 | E4-ab-5 | T8 | objectOf | protein kinase C,activator |
| R17 | E6-ab-8 | T9 | subjectOf | HL-60 cells,in |
| R18 | E4-ab-8 | T9 | objectOf | c-jun gene,in |
| R19 | E1-ab-9 | T10 | subjectOf | Treatment,with |
| R20 | E3-ab-9 | T10 | objectOf | TPA,with |
| R21 | E1-ab-9 | T11 | subjectOf | Treatment,with |
| R22 | E4-ab-9 | T11 | objectOf | cycloheximide,with |
pubmed-sentences-benchmark
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| S1 | 0-137 | Sentence | denotes | Transcriptional and post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells. |
| S2 | 138-370 | Sentence | denotes | AP-1, the polypeptide product of c-jun, recognizes and binds to specific DNA sequences and stimulates transcription of genes responsive to certain growth factors and phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA). |
| S3 | 371-492 | Sentence | denotes | We studied the effects of TPA on the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation. |
| S4 | 493-673 | Sentence | denotes | Low levels of c-jun transcripts were detectable in untreated HL-60 leukemic cells, increased significantly by 6 h, and reached near maximal levels by 24 h of exposure to 32 nM TPA. |
| S5 | 674-781 | Sentence | denotes | Similar kinetics of c-jun induction by TPA were observed in human U-937 and THP-1 monocytic leukemia cells. |
| S6 | 782-919 | Sentence | denotes | Similar findings were obtained with bryostatin 1 (10 nM), another activator of protein kinase C and inducer of monocytic differentiation. |
| S7 | 920-1081 | Sentence | denotes | Furthermore, 1,25-dihydroxyvitamin D3 (0.5 microM), a structurally distinct agent which also induces HL-60 monocytic differentiation, increased c-jun expression. |
| S8 | 1082-1200 | Sentence | denotes | TPA treatment of HL-60 cells in the presence of cycloheximide was associated with superinduction of c-jun transcripts. |
| S9 | 1201-1356 | Sentence | denotes | Run-on analysis demonstrated detectable levels of c-jun gene transcription in untreated HL-60 cells, and that exposure to TPA increases this rate 3.3-fold. |
| S10 | 1357-1464 | Sentence | denotes | Treatment of HL-60 cells with both TPA and cycloheximide had no effect on the rates of c-jun transcription. |
| S11 | 1465-1568 | Sentence | denotes | The half-life of c-jun RNA as determined by treating HL-60 cells with TPA and actinomycin D was 30 min. |
| S12 | 1569-1700 | Sentence | denotes | In contrast, the half-life of c-jun RNA in TPA-treated HL-60 cells exposed to cycloheximide and actinomycin D was greater than 2 h. |
| S13 | 1701-1883 | Sentence | denotes | These findings suggested that the increase in c-jun RNA observed during TPA-induced monocytic differentiation is mediated by both transcriptional and post-transcriptional mechanisms. |
genia-medco-coref
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| C2 | 55-71 | NP | denotes | c-jun expression |
| C3 | 79-104 | NP | denotes | monocytic differentiation |
| C1 | 20-136 | NP | denotes | post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells |
| C4 | 327-369 | NP | denotes | 12-O-tetradecanoylphorbol-13-acetate (TPA) |
| C5 | 397-400 | NP | denotes | TPA |
| C7 | 447-458 | NP | denotes | HL-60 cells |
| C8 | 466-491 | NP | denotes | monocytic differentiation |
| C6 | 404-491 | NP | denotes | the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation |
| C9 | 507-524 | NP | denotes | c-jun transcripts |
| C10 | 544-574 | NP | denotes | untreated HL-60 leukemic cells |
| C11 | 663-672 | NP | denotes | 32 nM TPA |
| C12 | 713-716 | NP | denotes | TPA |
| C13 | 893-918 | NP | denotes | monocytic differentiation |
| C15 | 1021-1026 | NP | denotes | HL-60 |
| C14 | 1021-1052 | NP | denotes | HL-60 monocytic differentiation |
| C16 | 1064-1080 | NP | denotes | c-jun expression |
| C18 | 1099-1110 | NP | denotes | HL-60 cells |
| C17 | 1082-1110 | NP | denotes | TPA treatment of HL-60 cells |
| C19 | 1182-1199 | NP | denotes | c-jun transcripts |
| C20 | 1251-1275 | NP | denotes | c-jun gene transcription |
| C21 | 1279-1300 | NP | denotes | untreated HL-60 cells |
| C22 | 1323-1326 | NP | denotes | TPA |
| C23 | 1337-1346 | NP | denotes | this rate |
| C25 | 1370-1381 | NP | denotes | HL-60 cells |
| C24 | 1357-1381 | NP | denotes | Treatment of HL-60 cells |
| C26 | 1392-1395 | NP | denotes | TPA |
| C28 | 1444-1463 | NP | denotes | c-jun transcription |
| C27 | 1435-1463 | NP | denotes | rates of c-jun transcription |
| C29 | 1518-1529 | NP | denotes | HL-60 cells |
| C30 | 1535-1538 | NP | denotes | TPA |
| C31 | 1543-1556 | NP | denotes | actinomycin D |
| C32 | 1665-1678 | NP | denotes | actinomycin D |
| C33 | 1773-1810 | NP | denotes | TPA-induced monocytic differentiation |
| R1 | C5 | C4 | coref-ident | TPA,12-O-tetradecanoylphorbol-13-acetate (TPA) |
| R2 | C8 | C3 | coref-ident | monocytic differentiation,monocytic differentiation |
| R3 | C6 | C1 | coref-ident | the regulation of c-jun gene expression in HL-60 cells during monocytic differentiation,post-transcriptional regulation of c-jun expression during monocytic differentiation of human myeloid leukemic cells |
| R4 | C10 | C7 | coref-ident | untreated HL-60 leukemic cells,HL-60 cells |
| R5 | C11 | C5 | coref-ident | 32 nM TPA,TPA |
| R6 | C12 | C11 | coref-ident | TPA,32 nM TPA |
| R7 | C13 | C8 | coref-ident | monocytic differentiation,monocytic differentiation |
| R8 | C15 | C10 | coref-ident | HL-60,untreated HL-60 leukemic cells |
| R9 | C14 | C13 | coref-ident | HL-60 monocytic differentiation,monocytic differentiation |
| R10 | C16 | C2 | coref-ident | c-jun expression,c-jun expression |
| R11 | C18 | C21 | coref-ident | HL-60 cells,untreated HL-60 cells |
| R12 | C19 | C9 | coref-ident | c-jun transcripts,c-jun transcripts |
| R13 | C21 | C15 | coref-ident | untreated HL-60 cells,HL-60 |
| R14 | C22 | C12 | coref-ident | TPA,TPA |
| R15 | C25 | C21 | coref-ident | HL-60 cells,untreated HL-60 cells |
| R16 | C24 | C17 | coref-ident | Treatment of HL-60 cells,TPA treatment of HL-60 cells |
| R17 | C26 | C22 | coref-ident | TPA,TPA |
| R18 | C28 | C20 | coref-ident | c-jun transcription,c-jun gene transcription |
| R19 | C27 | C23 | coref-ident | rates of c-jun transcription,this rate |
| R20 | C29 | C25 | coref-ident | HL-60 cells,HL-60 cells |
| R21 | C30 | C26 | coref-ident | TPA,TPA |
| R22 | C32 | C31 | coref-ident | actinomycin D,actinomycin D |
| R23 | C33 | C14 | coref-ident | TPA-induced monocytic differentiation,HL-60 monocytic differentiation |
GENIAcorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 55-60 | DNA_domain_or_region | denotes | c-jun |
| T2 | 79-88 | other_name | denotes | monocytic |
| T3 | 89-104 | other_name | denotes | differentiation |
| T4 | 108-136 | cell_line | denotes | human myeloid leukemic cells |
| T5 | 138-142 | protein_molecule | denotes | AP-1 |
| T6 | 171-176 | DNA_domain_or_region | denotes | c-jun |
| T7 | 257-262 | DNA_domain_or_region | denotes | genes |
| T8 | 285-299 | other_name | denotes | growth factors |
| T9 | 304-318 | other_organic_compound | denotes | phorbol esters |
| T10 | 327-363 | other_organic_compound | denotes | 12-O-tetradecanoylphorbol-13-acetate |
| T11 | 365-368 | other_organic_compound | denotes | TPA |
| T12 | 397-400 | other_organic_compound | denotes | TPA |
| T13 | 422-427 | DNA_domain_or_region | denotes | c-jun |
| T14 | 447-458 | cell_line | denotes | HL-60 cells |
| T15 | 466-475 | other_name | denotes | monocytic |
| T16 | 476-491 | other_name | denotes | differentiation |
| T17 | 507-512 | DNA_domain_or_region | denotes | c-jun |
| T18 | 544-574 | cell_line | denotes | untreated HL-60 leukemic cells |
| T19 | 625-639 | other_name | denotes | maximal levels |
| T20 | 663-668 | other_organic_compound | denotes | 32 nM |
| T21 | 669-672 | other_organic_compound | denotes | TPA |
| T22 | 694-699 | DNA_domain_or_region | denotes | c-jun |
| T23 | 713-716 | other_organic_compound | denotes | TPA |
| T24 | 734-745 | cell_line | denotes | human U-937 |
| T25 | 750-780 | cell_line | denotes | THP-1 monocytic leukemia cells |
| T26 | 818-830 | other_organic_compound | denotes | bryostatin 1 |
| T27 | 848-860 | other_name | denotes | activator of |
| T28 | 861-877 | protein_molecule | denotes | protein kinase C |
| T29 | 893-902 | other_name | denotes | monocytic |
| T30 | 903-918 | other_name | denotes | differentiation |
| T31 | 933-957 | lipid | denotes | 1,25-dihydroxyvitamin D3 |
| T32 | 1021-1036 | other_name | denotes | HL-60 monocytic |
| T33 | 1037-1052 | other_name | denotes | differentiation |
| T34 | 1064-1069 | DNA_domain_or_region | denotes | c-jun |
| T35 | 1082-1085 | other_organic_compound | denotes | TPA |
| T36 | 1099-1110 | cell_line | denotes | HL-60 cells |
| T37 | 1130-1143 | other_organic_compound | denotes | cycloheximide |
| T38 | 1182-1187 | DNA_domain_or_region | denotes | c-jun |
| T39 | 1201-1216 | other_name | denotes | Run-on analysis |
| T40 | 1230-1247 | other_name | denotes | detectable levels |
| T41 | 1251-1256 | DNA_domain_or_region | denotes | c-jun |
| T42 | 1279-1288 | cell_line | denotes | untreated |
| T43 | 1289-1300 | cell_line | denotes | HL-60 cells |
| T44 | 1323-1326 | other_organic_compound | denotes | TPA |
| T45 | 1370-1381 | cell_line | denotes | HL-60 cells |
| T46 | 1392-1395 | other_organic_compound | denotes | TPA |
| T47 | 1400-1413 | other_organic_compound | denotes | cycloheximide |
| T48 | 1444-1449 | DNA_domain_or_region | denotes | c-jun |
| T49 | 1482-1487 | DNA_domain_or_region | denotes | c-jun |
| T50 | 1518-1529 | cell_line | denotes | HL-60 cells |
| T51 | 1535-1538 | other_organic_compound | denotes | TPA |
| T52 | 1543-1556 | other_organic_compound | denotes | actinomycin D |
| T53 | 1599-1604 | DNA_domain_or_region | denotes | c-jun |
| T54 | 1612-1615 | other_organic_compound | denotes | TPA |
| T55 | 1624-1635 | cell_line | denotes | HL-60 cells |
| T56 | 1647-1660 | other_organic_compound | denotes | cycloheximide |
| T57 | 1665-1678 | other_organic_compound | denotes | actinomycin D |
| T58 | 1747-1752 | DNA_domain_or_region | denotes | c-jun |
| T59 | 1773-1776 | other_organic_compound | denotes | TPA |
| T60 | 1795-1810 | other_name | denotes | differentiation |
metamap-sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 735-740 | C0086418 | denotes | uman |
| T2 | 109-114 | C0086418 | denotes | uman |
| T3 | 1786-1794 | C0026473 | denotes | onocytic |
| T4 | 1028-1037 | C0026473 | denotes | onocytic |
| T5 | 894-903 | C0026473 | denotes | onocytic |
| T6 | 467-476 | C0026473 | denotes | onocytic |
| T7 | 80-89 | C0026473 | denotes | onocytic |
| T8 | 1451-1464 | C0040649 | denotes | ranscription. |
| T9 | 1258-1276 | C0040649 | denotes | ene transcription |
| T10 | 1263-1276 | C0040649 | denotes | ranscription |
| T11 | 1-16 | C0040649 | denotes | ranscriptional |
| T12 | 1796-1811 | C0007589 | denotes | ifferentiation |
| T13 | 1038-1053 | C0007589 | denotes | ifferentiation, |
| T14 | 477-492 | C0007589 | denotes | ifferentiation. |
| T15 | 90-105 | C0007589 | denotes | ifferentiation |
| T16 | 1774-1777 | C0039654 | denotes | PA- |
| T17 | 1613-1616 | C0039654 | denotes | PA- |
| T18 | 1536-1539 | C0039654 | denotes | PA |
| T19 | 1393-1396 | C0039654 | denotes | PA |
| T20 | 1324-1327 | C0039654 | denotes | PA |
| T21 | 1083-1086 | C0039654 | denotes | PA |
| T22 | 714-717 | C0039654 | denotes | PA |
| T23 | 670-673 | C0039654 | denotes | PA. |
| T24 | 398-401 | C0039654 | denotes | PA |
| T25 | 328-364 | C0039654 | denotes | 2-O-tetradecanoylphorbol-13-acetate |
| T26 | 1625-1636 | C0282549 | denotes | L-60 cells |
| T27 | 1519-1530 | C0282549 | denotes | L-60 cells |
| T28 | 1371-1382 | C0282549 | denotes | L-60 cells |
| T29 | 1290-1301 | C0282549 | denotes | L-60 cells, |
| T30 | 1100-1111 | C0282549 | denotes | L-60 cells |
| T31 | 123-137 | C1517806 | denotes | eukemic cells. |
| T32 | 21-52 | C1514248 | denotes | ost-transcriptional regulation |
| T33 | 1071-1081 | C0185117 | denotes | xpression. |
| T34 | 62-72 | C0185117 | denotes | xpression |
| T35 | 115-122 | C0439677 | denotes | yeloid |
| T36 | 1750-1753 | C3536909 | denotes | un |
| T37 | 1602-1605 | C3536909 | denotes | un |
| T38 | 1485-1488 | C3536909 | denotes | un |
| T39 | 1447-1450 | C3536909 | denotes | un |
| T40 | 1254-1257 | C3536909 | denotes | un |
| T41 | 1185-1188 | C3536909 | denotes | un |
| T42 | 1067-1070 | C3536909 | denotes | un |
| T43 | 697-700 | C3536909 | denotes | un |
| T44 | 510-513 | C3536909 | denotes | un |
| T45 | 174-177 | C3536909 | denotes | un, |
| T46 | 58-61 | C3536909 | denotes | un |
| T47 | 1648-1661 | C0010572 | denotes | ycloheximide |
| T48 | 1401-1414 | C0010572 | denotes | ycloheximide |
| T49 | 1131-1144 | C0010572 | denotes | ycloheximide |
| T50 | 1754-1757 | C0035668 | denotes | NA |
| T51 | 1606-1609 | C0035668 | denotes | NA |
| T52 | 1489-1492 | C0035668 | denotes | NA |
| T53 | 1666-1679 | C0010934 | denotes | ctinomycin D |
| T54 | 1544-1557 | C0010934 | denotes | ctinomycin D |
| T55 | 1254-1262 | C0085299 | denotes | un gene |
| T56 | 836-838 | C0312860 | denotes | M) |
| T57 | 667-669 | C0312860 | denotes | M |
| T58 | 1202-1205 | C0035953 | denotes | un- |
| T59 | 1587-1596 | C0018517 | denotes | alf-life |
| T60 | 1470-1479 | C0018517 | denotes | alf-life |
| T61 | 647-648 | C0033727 | denotes | |
| T62 | 305-319 | C0031586 | denotes | horbol esters |
| T63 | 139-143 | C0085828 | denotes | P-1, |
| T64 | 939-958 | C0766510 | denotes | ihydroxyvitamin D3 |
| T65 | 819-831 | C0054173 | denotes | ryostatin 1 |
| T66 | 1209-1217 | C1524024 | denotes | nalysis |
| T67 | 1697-1700 | C0011744 | denotes | h. |
| T68 | 1312-1322 | C0332157 | denotes | xposure to |
| T69 | 652-660 | C0332157 | denotes | xposure |
| T70 | 1778-1785 | C0205263 | denotes | nduced |
| T71 | 1014-1021 | C0205263 | denotes | nduces |
| T72 | 701-710 | C0205263 | denotes | nduction |
| T73 | 1242-1248 | C0441889 | denotes | evels |
| T74 | 429-444 | C0017262 | denotes | ene expression |
| T75 | 1708-1716 | C2926606 | denotes | indings |
| T76 | 791-799 | C2926606 | denotes | indings |
| T77 | 1736-1744 | C0442805 | denotes | ncrease |
| T78 | 1328-1337 | C0442805 | denotes | ncreases |
| T79 | 1055-1064 | C0205217 | denotes | ncreased |
| T80 | 577-586 | C0205217 | denotes | ncreased |
| T81 | 1758-1766 | C1441672 | denotes | bserved |
| T82 | 723-731 | C1441672 | denotes | bserved |
| T83 | 1358-1367 | C0087111 | denotes | reatment |
| T84 | 1087-1096 | C0087111 | denotes | reatment |
| T85 | 1617-1624 | C0332293 | denotes | reated |
| T86 | 1510-1518 | C0332293 | denotes | reating |
| T87 | 1189-1200 | C1519595 | denotes | ranscripts. |
| T88 | 514-525 | C1519595 | denotes | ranscripts |
| T89 | 783-790 | C2348205 | denotes | imilar |
| T90 | 675-682 | C2348205 | denotes | imilar |
| T91 | 1280-1289 | C0332155 | denotes | ntreated |
| T92 | 545-554 | C0332155 | denotes | ntreated |
| T93 | 1436-1441 | C0871208 | denotes | ates |
| T94 | 1343-1347 | C0871208 | denotes | ate |
| T95 | 862-869 | C0033684 | denotes | rotein |
| T96 | 934-935 | C2827734 | denotes | , |
| T97 | 1573-1581 | C1979874 | denotes | ontrast, |
| T98 | 1119-1127 | C0392148 | denotes | resence |
| T99 | 409-419 | C1327622 | denotes | egulation |
| T100 | 375-382 | C2603343 | denotes | tudied |
| T101 | 1717-1725 | C1705535 | denotes | uggested |
| T102 | 1684-1696 | C0439093 | denotes | reater than |
| T103 | 1873-1883 | C0441712 | denotes | echanisms. |
| T104 | 997-1001 | C1254351 | denotes | gent |
| T105 | 604-607 | C0444953 | denotes | h, |
| T106 | 1352-1356 | C0332462 | denotes | old. |
| T107 | 776-781 | C0007634 | denotes | ells. |
| T108 | 1149-1163 | C0332281 | denotes | ssociated with |
| T109 | 626-633 | C0806909 | denotes | aximal |
| T110 | 1815-1823 | C0127400 | denotes | ediated |
| T111 | 805-813 | C1301820 | denotes | btained |
| T112 | 1419-1428 | C1301751 | denotes | o effect |
| T113 | 194-199 | C1145667 | denotes | inds |
| T114 | 203-211 | C1552740 | denotes | pecific |
| T115 | 264-274 | C0205342 | denotes | esponsive |
| T116 | 387-394 | C1280500 | denotes | ffects |
| T117 | 683-691 | C0220865 | denotes | inetics |
| T118 | 161-168 | C1514468 | denotes | roduct |
| T119 | 613-620 | C2584321 | denotes | eached |
| T120 | 960-963 | C0444499 | denotes | .5 |
| T121 | 1022-1027 | C1512310 | denotes | L-60 |
| T122 | 423-428 | C0162508 | denotes | -jun |
| T123 | 757-775 | C1318544 | denotes | onocytic leukemia |
| T124 | 1852-1856 | C0687676 | denotes | ost- |
| T125 | 751-754 | C1705396 | denotes | HP- |
| T126 | 494-497 | C0205251 | denotes | ow |
| T127 | 278-285 | C0205423 | denotes | ertain |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 756-774 | Disease | denotes | monocytic leukemia | http://purl.obolibrary.org/obo/MONDO_0004600|http://purl.obolibrary.org/obo/MONDO_0007896 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 108-113 | OrganismTaxon | denotes | human | 9606 |
| T2 | 734-739 | OrganismTaxon | denotes | human | 9606 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 766-774 | Phenotype | denotes | leukemia | HP:0001909 |