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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 118-310 DRI_Approach denotes The transmembrane protein Niemann-Pick C1 Like 1 (NPC1L1) belongs to the Niemann-Pick C1 (NPC1) family of cholesterol transporters and is mainly expressed in the liver and the small intestine.
T2 311-411 DRI_Background denotes NPC1L1 is believed to be the main transporter responsible for the absorption of dietary cholesterol.
T3 412-525 DRI_Background denotes Like NPC1, NPC1L1 contains a sterol sensing domain, suggesting that it might be sensitive to dietary cholesterol.
T4 526-624 DRI_Background denotes To test this hypothesis, mucosal explants were cultured in the presence or absence of cholesterol.
T5 625-852 DRI_Background denotes In the absence of cholesterol NPC1L1 was localized mainly in the brush border of the enterocyte, colocalizing with the brush border enzyme aminopeptidase N (APN), and only a minor part was present in intracellular compartments.
T6 853-1103 DRI_Background denotes In contrast, following culture in the presence of cholesterol a major part of NPC1L1 was found in intracellular compartments positive for the early endosomal marker early endosome antigen 1, whereas only a minor fraction was left in the brush border.
T7 1104-1259 DRI_Outcome denotes Neither APN, lactase, nor sucrase-isomaltase was endocytosed in parallel, demonstrating that this is a selective cholesterol-induced endocytosis of NPC1L1.
T8 1260-1434 DRI_Challenge denotes Conceivably either the induced internalization could be due to NPC1L1 acting as an endocytic cholesterol receptor or it could be a mechanism to reduce the cholesterol uptake.
T9 1435-1613 DRI_Background denotes The fluorescent cholesterol analog NBD-cholesterol readily labeled the cytoplasm also under conditions nonpermissible for endocytosis, arguing against a receptor-mediated uptake.
T10 1614-1807 DRI_Challenge denotes We therefore propose that cholesterol is absorbed by NPC1L1 acting as a membrane transporter and that NPC1L1 is internalized to an endosomal compartment to reduce the absorption of cholesterol.

Goldhamster2_Cellosaurus

Id Subject Object Predicate Lexical cue
T1 72-74 CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes denotes C1
T2 72-74 CVCL_L326|Cancer_cell_line|Canis lupus familiaris denotes C1
T3 72-74 CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens denotes C1
T4 72-74 CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens denotes C1
T5 157-159 CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes denotes C1
T6 157-159 CVCL_L326|Cancer_cell_line|Canis lupus familiaris denotes C1
T7 157-159 CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens denotes C1
T8 157-159 CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens denotes C1
T9 204-206 CVCL_1G30|Induced_pluripotent_stem_cell|Pan troglodytes denotes C1
T10 204-206 CVCL_L326|Cancer_cell_line|Canis lupus familiaris denotes C1
T11 204-206 CVCL_RG57|Induced_pluripotent_stem_cell|Homo sapiens denotes C1
T12 204-206 CVCL_WT75|Induced_pluripotent_stem_cell|Homo sapiens denotes C1
T13 439-440 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T14 722-734 CVCL_U289|Cancer_cell_line|Homo sapiens denotes colocalizing
T15 797-798 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T16 915-916 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T17 1057-1058 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T18 1205-1206 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T19 1340-1342 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T20 1340-1342 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an
T21 1389-1390 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T22 1494-1501 CVCL_3734|Finite_cell_line|Homo sapiens denotes labeled
T23 1586-1587 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T24 1614-1616 CVCL_5M23|Cancer_cell_line|Mesocricetus auratus denotes We
T25 1684-1685 CVCL_6479|Finite_cell_line|Mus musculus denotes a
T26 1742-1744 CVCL_8754|Cancer_cell_line|Homo sapiens denotes an
T27 1742-1744 CVCL_H241|Cancer_cell_line|Homo sapiens denotes an

GoldHamster

Id Subject Object Predicate Lexical cue
T1 0-19 D002791 denotes Dietary cholesterol
T2 0-19 D002791 denotes Dietary cholesterol
T5 8-19 2438 denotes cholesterol
T7 54-66 D009542 denotes Niemann-Pick
T8 54-66 D009542 denotes Niemann-Pick
T9 91-103 UBERON:0012424 denotes brush border
T10 91-103 GO:0005903 denotes brush border
T11 122-135 SO:0001077 denotes transmembrane
T12 122-135 GO:0044214 denotes transmembrane
T13 122-135 GO:0016021 denotes transmembrane
T14 122-143 PR:000003230 denotes transmembrane protein
T19 136-143 SO:0000104 denotes protein
T16 136-143 CHEBI:36080 denotes protein
T17 136-143 CHEBI:11122 denotes protein
T15 136-143 GO:0003675 denotes protein
T20 144-156 D009542 denotes Niemann-Pick
T21 144-156 D009542 denotes Niemann-Pick
T23 168-171 CHEBI:80552 denotes NPC
T22 168-171 GO:0005643 denotes NPC
T29 168-172 D052556 denotes NPC1
T33 168-174 PR:000011356 denotes NPC1L1
T34 168-174 PR:Q9UHC9 denotes NPC1L1
T35 168-174 PR:Q6T3U4 denotes NPC1L1
T36 168-174 PR:Q6T3U3 denotes NPC1L1
T37 191-203 D009542 denotes Niemann-Pick
T38 191-203 D009542 denotes Niemann-Pick
T40 208-211 CHEBI:80552 denotes NPC
T39 208-211 GO:0005643 denotes NPC
T44 208-212 PR:000011355 denotes NPC1
T45 208-212 PR:O35604 denotes NPC1
T47 208-212 PR:Q8L7Y9 denotes NPC1
T48 208-212 PR:O15118 denotes NPC1
T49 208-212 PR:Q19127 denotes NPC1
T46 208-212 D052556 denotes NPC1
T52 224-235 2438 denotes cholesterol
T50 224-235 D002784 denotes cholesterol
T51 224-235 CHEBI:16113 denotes cholesterol
T53 224-235 D002784 denotes cholesterol
T54 280-285 UBERON:0002107 denotes liver
T55 294-309 UBERON:0002108 denotes small intestine
T58 311-314 CHEBI:80552 denotes NPC
T57 311-314 GO:0005643 denotes NPC
T64 311-315 D052556 denotes NPC1
T68 311-317 PR:000011356 denotes NPC1L1
T69 311-317 PR:Q9UHC9 denotes NPC1L1
T70 311-317 PR:Q6T3U4 denotes NPC1L1
T71 311-317 PR:Q6T3U3 denotes NPC1L1
T72 391-410 D002791 denotes dietary cholesterol
T73 391-410 D002791 denotes dietary cholesterol
T76 399-410 2438 denotes cholesterol
T78 417-420 GO:0005643 denotes NPC
T79 417-420 CHEBI:80552 denotes NPC
T83 417-421 PR:000011355 denotes NPC1
T84 417-421 PR:O35604 denotes NPC1
T86 417-421 PR:Q8L7Y9 denotes NPC1
T87 417-421 PR:O15118 denotes NPC1
T88 417-421 PR:Q19127 denotes NPC1
T85 417-421 D052556 denotes NPC1
T89 423-426 GO:0005643 denotes NPC
T90 423-426 CHEBI:80552 denotes NPC
T96 423-427 D052556 denotes NPC1
T100 423-429 PR:000011356 denotes NPC1L1
T101 423-429 PR:Q9UHC9 denotes NPC1L1
T102 423-429 PR:Q6T3U4 denotes NPC1L1
T103 423-429 PR:Q6T3U3 denotes NPC1L1
T104 439-447 CHEBI:15889 denotes a sterol
T106 441-462 GO:0032935 denotes sterol sensing domain
T107 456-462 SO:0000417 denotes domain
T108 505-524 D002791 denotes dietary cholesterol
T109 505-524 D002791 denotes dietary cholesterol
T112 513-524 2438 denotes cholesterol
T116 612-623 2438 denotes cholesterol
T114 612-623 D002784 denotes cholesterol
T115 612-623 CHEBI:16113 denotes cholesterol
T117 612-623 D002784 denotes cholesterol
T120 643-654 2438 denotes cholesterol
T118 643-654 D002784 denotes cholesterol
T119 643-654 CHEBI:16113 denotes cholesterol
T121 643-654 D002784 denotes cholesterol
T123 655-658 CHEBI:80552 denotes NPC
T122 655-658 GO:0005643 denotes NPC
T129 655-659 D052556 denotes NPC1
T133 655-661 PR:000011356 denotes NPC1L1
T134 655-661 PR:Q9UHC9 denotes NPC1L1
T135 655-661 PR:Q6T3U4 denotes NPC1L1
T136 655-661 PR:Q6T3U3 denotes NPC1L1
T137 690-702 UBERON:0012424 denotes brush border
T138 690-702 GO:0005903 denotes brush border
T139 710-720 CL:0000584 denotes enterocyte
T140 744-756 UBERON:0012424 denotes brush border
T141 744-756 GO:0005903 denotes brush border
T145 764-780 P37896 denotes aminopeptidase N
T146 764-780 P37893 denotes aminopeptidase N
T148 764-780 Q10736 denotes aminopeptidase N
T149 764-780 Q10737 denotes aminopeptidase N
T150 764-780 P79143 denotes aminopeptidase N
T151 764-780 Q48656 denotes aminopeptidase N
T152 764-780 P15684 denotes aminopeptidase N
T153 764-780 P79171 denotes aminopeptidase N
T154 764-780 P79098 denotes aminopeptidase N
T155 764-780 P04825 denotes aminopeptidase N
T157 764-780 Q10730 denotes aminopeptidase N
T158 764-780 P91885 denotes aminopeptidase N
T159 764-780 P15541 denotes aminopeptidase N
T160 764-780 P45274 denotes aminopeptidase N
T161 764-780 O57579 denotes aminopeptidase N
T162 764-780 Q11010 denotes aminopeptidase N
T163 764-780 P91887 denotes aminopeptidase N
T164 764-780 A2RI32 denotes aminopeptidase N
T165 764-780 P81731 denotes aminopeptidase N
T166 764-780 PR:000002031 denotes aminopeptidase N
T167 764-780 P97449 denotes aminopeptidase N
T168 764-780 P0C2T8 denotes aminopeptidase N
T169 764-780 P15145 denotes aminopeptidase N
T170 764-780 P15144 denotes aminopeptidase N
T171 764-780 Q9CIQ1 denotes aminopeptidase N
T147 764-780 D018826 denotes aminopeptidase N
T156 764-780 D018826 denotes aminopeptidase N
T172 782-785 PR:Q9VFX3 denotes APN
T174 782-785 PR:P79098 denotes APN
T175 782-785 PR:000002031 denotes APN
T176 782-785 PR:P15144 denotes APN
T173 782-785 UBERON:0035567 denotes APN
T177 825-838 GO:0005622 denotes intracellular
T180 903-914 2438 denotes cholesterol
T178 903-914 D002784 denotes cholesterol
T179 903-914 CHEBI:16113 denotes cholesterol
T181 903-914 D002784 denotes cholesterol
T183 931-934 CHEBI:80552 denotes NPC
T182 931-934 GO:0005643 denotes NPC
T189 931-935 D052556 denotes NPC1
T193 931-937 PR:000011356 denotes NPC1L1
T194 931-937 PR:Q9UHC9 denotes NPC1L1
T195 931-937 PR:Q6T3U4 denotes NPC1L1
T196 931-937 PR:Q6T3U3 denotes NPC1L1
T197 951-964 GO:0005622 denotes intracellular
T198 1018-1032 GO:0005769 denotes early endosome
T199 1018-1042 PR:000006901 denotes early endosome antigen 1
T201 1018-1042 Q8BL66 denotes early endosome antigen 1
T202 1018-1042 Q15075 denotes early endosome antigen 1
T200 1018-1042 C093846 denotes early endosome antigen 1
T209 1090-1102 UBERON:0012424 denotes brush border
T210 1090-1102 GO:0005903 denotes brush border
T211 1112-1115 PR:Q9VFX3 denotes APN
T213 1112-1115 PR:P79098 denotes APN
T214 1112-1115 PR:000002031 denotes APN
T215 1112-1115 PR:P15144 denotes APN
T212 1112-1115 UBERON:0035567 denotes APN
T224 1117-1124 41397 denotes lactase
T216 1117-1124 Q5R7P4 denotes lactase
T217 1117-1124 Q669R9 denotes lactase
T218 1117-1124 B2VHN8 denotes lactase
T219 1117-1124 P00723 denotes lactase
T220 1117-1124 O52847 denotes lactase
T221 1117-1124 Q1CI76 denotes lactase
T222 1117-1124 P45582 denotes lactase
T223 1117-1124 Q9TRY9 denotes lactase
T225 1117-1124 Q48727 denotes lactase
T226 1117-1124 P23989 denotes lactase
T227 1117-1124 Q56307 denotes lactase
T228 1117-1124 P49676 denotes lactase
T229 1117-1124 A1SWB8 denotes lactase
T230 1117-1124 B1JI86 denotes lactase
T231 1117-1124 A4TLL5 denotes lactase
T232 1117-1124 A3FEW8 denotes lactase
T233 1117-1124 Q7CIZ3 denotes lactase
T234 1117-1124 Q3Z583 denotes lactase
T235 1117-1124 O52629 denotes lactase
T236 1117-1124 Q0TKT1 denotes lactase
T237 1117-1124 Q2XQU3 denotes lactase
T238 1117-1124 Q8FKG6 denotes lactase
T239 1117-1124 A7ZI91 denotes lactase
T240 1117-1124 A5F5U6 denotes lactase
T241 1117-1124 PR:000008016 denotes lactase
T242 1117-1124 P23780 denotes lactase
T243 1117-1124 A1JTC4 denotes lactase
T244 1117-1124 A7MN76 denotes lactase
T245 1117-1124 P16278 denotes lactase
T246 1117-1124 P24131 denotes lactase
T247 1117-1124 P0C1Y0 denotes lactase
T248 1117-1124 O19015 denotes lactase
T249 1117-1124 Q04F24 denotes lactase
T250 1117-1124 P77989 denotes lactase
T251 1117-1124 Q1G9Z4 denotes lactase
T252 1117-1124 B1J0T5 denotes lactase
T253 1117-1124 A9R0J8 denotes lactase
T254 1117-1124 P81650 denotes lactase
T255 1117-1124 P48981 denotes lactase
T256 1117-1124 P50388 denotes lactase
T257 1117-1124 A7KGA5 denotes lactase
T258 1117-1124 P83252 denotes lactase
T259 1117-1124 C9S0R2 denotes lactase
T260 1117-1124 A8GGN3 denotes lactase
T261 1117-1124 A0KQH4 denotes lactase
T262 1117-1124 Q8D4H3 denotes lactase
T263 1117-1124 P06864 denotes lactase
T264 1117-1124 P22498 denotes lactase
T265 1117-1124 A9MQ82 denotes lactase
T266 1117-1124 P06219 denotes lactase
T267 1117-1124 P30812 denotes lactase
T268 1117-1124 Q59750 denotes lactase
T269 1117-1124 Q1C6T8 denotes lactase
T270 1117-1124 B2K6E6 denotes lactase
T271 1117-1124 B5XQY2 denotes lactase
T272 1117-1124 P48980 denotes lactase
T273 1117-1124 P85412 denotes lactase
T274 1117-1124 O69315 denotes lactase
T275 1117-1124 A4W7D2 denotes lactase
T276 1117-1124 Q58D55 denotes lactase
T277 1117-1124 P00722 denotes lactase
T278 1117-1124 Q32JB6 denotes lactase
T279 1117-1124 P81669 denotes lactase
T280 1117-1124 P48982 denotes lactase
T281 1117-1124 Q6D736 denotes lactase
T282 1117-1124 B7N8Q1 denotes lactase
T283 1117-1124 A1A831 denotes lactase
T285 1117-1124 O33815 denotes lactase
T286 1117-1124 B7UJI9 denotes lactase
T287 1117-1124 Q00662 denotes lactase
T288 1117-1124 Q59140 denotes lactase
T289 1117-1124 P26257 denotes lactase
T290 1117-1124 Q60HF6 denotes lactase
T291 1117-1124 Q9K9C6 denotes lactase
T292 1117-1124 PR:000022498 denotes lactase
T293 1117-1124 Q6LL68 denotes lactase
T294 1117-1124 Q47077 denotes lactase
T295 1117-1124 Q1RFJ2 denotes lactase
T296 1117-1124 A8AKB8 denotes lactase
T297 1117-1124 Q03WL0 denotes lactase
T298 1117-1124 P29853 denotes lactase
T299 1117-1124 PR:000033987 denotes lactase
T300 1117-1124 Q8X685 denotes lactase
T301 1117-1124 B1LIM9 denotes lactase
T302 1117-1124 P19668 denotes lactase
T303 1117-1124 B5Z2P7 denotes lactase
T304 1117-1124 B4S2K9 denotes lactase
T305 1117-1124 A7ZWZ1 denotes lactase
T306 1117-1124 P70753 denotes lactase
T307 1117-1124 A7FH78 denotes lactase
T308 1117-1124 PR:000022497 denotes lactase
T309 1117-1124 P14288 denotes lactase
T310 1117-1124 Q8VNN2 denotes lactase
T311 1117-1124 Q7MG04 denotes lactase
T284 1117-1124 D043322 denotes lactase
T322 1130-1137 D013393 denotes sucrase
T330 1130-1148 P29093 denotes sucrase-isomaltase
T331 1130-1148 P29094 denotes sucrase-isomaltase
T332 1130-1148 P21332 denotes sucrase-isomaltase
T333 1130-1148 Q45101 denotes sucrase-isomaltase
T334 1130-1148 Q9K8U9 denotes sucrase-isomaltase
T337 1138-1148 D009834 denotes isomaltase
T343 1217-1228 2438 denotes cholesterol
T341 1217-1228 D002784 denotes cholesterol
T342 1217-1228 CHEBI:16113 denotes cholesterol
T344 1217-1228 D002784 denotes cholesterol
T345 1237-1248 GO:0006897 denotes endocytosis
T346 1252-1255 GO:0005643 denotes NPC
T347 1252-1255 CHEBI:80552 denotes NPC
T353 1252-1256 D052556 denotes NPC1
T357 1252-1258 PR:000011356 denotes NPC1L1
T358 1252-1258 PR:Q9UHC9 denotes NPC1L1
T359 1252-1258 PR:Q6T3U4 denotes NPC1L1
T360 1252-1258 PR:Q6T3U3 denotes NPC1L1
T361 1323-1326 GO:0005643 denotes NPC
T362 1323-1326 CHEBI:80552 denotes NPC
T368 1323-1327 D052556 denotes NPC1
T372 1323-1329 PR:000011356 denotes NPC1L1
T373 1323-1329 PR:Q9UHC9 denotes NPC1L1
T374 1323-1329 PR:Q6T3U4 denotes NPC1L1
T375 1323-1329 PR:Q6T3U3 denotes NPC1L1
T378 1353-1364 2438 denotes cholesterol
T376 1353-1364 D002784 denotes cholesterol
T377 1353-1364 CHEBI:16113 denotes cholesterol
T379 1353-1364 D002784 denotes cholesterol
T382 1415-1426 2438 denotes cholesterol
T380 1415-1426 D002784 denotes cholesterol
T381 1415-1426 CHEBI:16113 denotes cholesterol
T383 1415-1426 D002784 denotes cholesterol
T384 1415-1433 GO:0070508 denotes cholesterol uptake
T389 1451-1462 2438 denotes cholesterol
T387 1451-1462 D002784 denotes cholesterol
T388 1451-1462 CHEBI:16113 denotes cholesterol
T390 1451-1462 D002784 denotes cholesterol
T391 1470-1485 C077527 denotes NBD-cholesterol
T392 1470-1485 C077527 denotes NBD-cholesterol
T395 1474-1485 2438 denotes cholesterol
T397 1506-1515 GO:0005737 denotes cytoplasm
T398 1557-1568 GO:0006897 denotes endocytosis
T399 1606-1612 GO:0098657 denotes uptake
T400 1606-1612 GO:0098739 denotes uptake
T403 1640-1651 2438 denotes cholesterol
T401 1640-1651 D002784 denotes cholesterol
T402 1640-1651 CHEBI:16113 denotes cholesterol
T404 1640-1651 D002784 denotes cholesterol
T406 1667-1670 CHEBI:80552 denotes NPC
T405 1667-1670 GO:0005643 denotes NPC
T412 1667-1671 D052556 denotes NPC1
T416 1667-1673 PR:000011356 denotes NPC1L1
T417 1667-1673 PR:Q9UHC9 denotes NPC1L1
T418 1667-1673 PR:Q6T3U4 denotes NPC1L1
T419 1667-1673 PR:Q6T3U3 denotes NPC1L1
T420 1686-1694 UBERON:0000094 denotes membrane
T422 1686-1694 UBERON:0000158 denotes membrane
T421 1686-1694 GO:0016020 denotes membrane
T424 1716-1719 CHEBI:80552 denotes NPC
T423 1716-1719 GO:0005643 denotes NPC
T430 1716-1720 D052556 denotes NPC1
T434 1716-1722 PR:000011356 denotes NPC1L1
T435 1716-1722 PR:Q9UHC9 denotes NPC1L1
T436 1716-1722 PR:Q6T3U4 denotes NPC1L1
T437 1716-1722 PR:Q6T3U3 denotes NPC1L1
T440 1795-1806 2438 denotes cholesterol
T438 1795-1806 D002784 denotes cholesterol
T439 1795-1806 CHEBI:16113 denotes cholesterol
T441 1795-1806 D002784 denotes cholesterol

Allie

Id Subject Object Predicate Lexical cue
SS1_21051527_1_0 144-166 expanded denotes Niemann-Pick C1 Like 1
SS2_21051527_1_0 168-174 abbr denotes NPC1L1
SS1_21051527_1_1 144-159 expanded denotes Niemann-Pick C1
SS2_21051527_1_1 168-172 abbr denotes NPC1
SS1_21051527_5_0 764-780 expanded denotes aminopeptidase N
SS2_21051527_5_0 782-785 abbr denotes APN
AE1_21051527_1_0 SS1_21051527_1_0 SS2_21051527_1_0 abbreviatedTo Niemann-Pick C1 Like 1,NPC1L1
AE1_21051527_1_1 SS1_21051527_1_1 SS2_21051527_1_1 abbreviatedTo Niemann-Pick C1,NPC1
AE1_21051527_5_0 SS1_21051527_5_0 SS2_21051527_5_0 abbreviatedTo aminopeptidase N,APN