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PubMed:21047796 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 77-97 Cell denotes effector CD4 T cells http://purl.obolibrary.org/obo/CL:0001044
T2 316-319 Cell denotes Th9 http://purl.obolibrary.org/obo/CL:0002061
T3 454-457 Cell denotes Th9 http://purl.obolibrary.org/obo/CL:0002061
T4 591-594 Cell denotes Th9 http://purl.obolibrary.org/obo/CL:0002061
T5 630-639 Cell denotes Th1 cells http://purl.obolibrary.org/obo/CL:0000545
T6 869-872 Cell denotes Th9 http://purl.obolibrary.org/obo/CL:0002061
T7 914-923 Cell denotes Th17 cell http://purl.obolibrary.org/obo/CL:0000899
T8 981-984 Cell denotes Th9 http://purl.obolibrary.org/obo/CL:0002061
T9 1048-1051 Cell denotes Th9 http://purl.obolibrary.org/obo/CL:0002061
T10 1099-1109 Cell denotes Th17 cells http://purl.obolibrary.org/obo/CL:0000899
T11 1475-1478 Cell denotes Th9 http://purl.obolibrary.org/obo/CL:0002061
T12 1530-1537 Cell denotes T cells http://purl.obolibrary.org/obo/CL:0000084

sentences

Id Subject Object Predicate Lexical cue
T1 0-98 Sentence denotes Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells.
T2 99-156 Sentence denotes Vitamin D deficiency is implicated in autoimmune disease.
T3 157-403 Sentence denotes We therefore evaluated the effects of 1α,25-dihydroxyvitamin D(3) (1,25-D(3)), the active form of vitamin D, on the development of T helper 1 (Th1), Th17, and Th9 cells, which are implicated in the pathogenesis of different types of autoimmunity.
T4 404-569 Sentence denotes 1,25-D(3) compromised the development of Th17 and Th9 cells, including IL-22-expressing cells while simultaneously increasing the frequency of IL-10-competent cells.
T5 570-743 Sentence denotes Relative to Th17 and Th9 cells, the effects of 1,25-D(3) on Th1 cells were modest, reflecting the significantly reduced levels of the receptor for vitamin D in this lineage.
T6 744-936 Sentence denotes The use of cells deficient in IL-10 or antibodies that block IL-10 signaling abolished the inhibitory effect of 1,25-D(3) on Th9 cells but had no effect on inhibition of Th17 cell frequencies.
T7 937-1110 Sentence denotes Thus, the induction of IL-10 in cultures of Th9 cells is an important mechanism by which 1,25-D(3) compromises Th9 development but does not explain inhibition of Th17 cells.
T8 1111-1354 Sentence denotes A survey of select representatives of the Th17 transcriptome revealed that the levels of mRNA that encode RORγt, IL-17A, IL-17F, IL-23R, and IL-22, were reduced by 1,25-D(3), whereas IL-21 and aryl hydrocarbon receptor mRNA remained unchanged.
T9 1355-1538 Sentence denotes These data suggest that vitamin D deficiency may promote autoimmunity by favoring the inordinate production of Th17 and Th9 cells at the expense of regulatory IL-10-producing T cells.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 99-119 HP_0100512 denotes Vitamin D deficiency
T2 99-119 HP_0004905 denotes Vitamin D deficiency
T3 137-155 HP_0002960 denotes autoimmune disease
T4 137-147 HP_0002960 denotes autoimmune
T5 390-402 HP_0002960 denotes autoimmunity
T6 1379-1399 HP_0100512 denotes vitamin D deficiency
T7 1412-1424 HP_0002960 denotes autoimmunity

Allie

Id Subject Object Predicate Lexical cue
SS1_21047796_2_0 288-298 expanded denotes T helper 1
SS2_21047796_2_0 300-303 abbr denotes Th1
AE1_21047796_2_0 SS1_21047796_2_0 SS2_21047796_2_0 abbreviatedTo T helper 1,Th1

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 137-155 Disease denotes autoimmune disease http://purl.obolibrary.org/obo/MONDO_0007179

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 99-119 Phenotype denotes Vitamin D deficiency HP:0100512
T2 137-155 Phenotype denotes autoimmune disease HP:0002960
T3 390-402 Phenotype denotes autoimmunity HP:0002960
T4 1379-1399 Phenotype denotes vitamin D deficiency HP:0100512
T5 1412-1424 Phenotype denotes autoimmunity HP:0002960