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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 15-26 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 672-683 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 814-825 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 961-972 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 1084-1096 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T6 1273-1285 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T7 1367-1379 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T8 1503-1515 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T9 1685-1696 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 15-26 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 672-683 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 814-825 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 961-972 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T5 1084-1096 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 1273-1285 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T7 1367-1379 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T8 1503-1515 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T9 1685-1696 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Involvement of sialic acid in the regulation of γ--aminobutyric acid uptake activity of γ-aminobutyric acid transporter 1.
TextSentencer_T2 123-254 Sentence denotes The γ-aminobutyric acid (GABA) transporters (GATs) have long been recognized for their key role in the uptake of neurotransmitters.
TextSentencer_T3 255-472 Sentence denotes The GAT1 belongs to the family of Na(+)- and Cl(-)-coupled transport proteins, which possess 12 putative transmembrane (TM) domains and three N-glycosylation sites on the extracellular loop between TM domains 3 and 4.
TextSentencer_T4 473-587 Sentence denotes Previously, we demonstrated that terminal trimming of N-glycans is important for the GABA uptake activity of GAT1.
TextSentencer_T5 588-770 Sentence denotes In this work, we examined the effect of deficiency, removal or oxidation of surface sialic acid residues on GABA uptake activity to investigate their role in the GABA uptake of GAT1.
TextSentencer_T6 771-1014 Sentence denotes We found that the reduced concentration of sialic acid on N-glycans was paralleled by a decreased GABA uptake activity of GAT1 in Chinese hamster ovary (CHO) Lec3 cells (mutant defective in sialic acid biosynthesis) in comparison to CHO cells.
TextSentencer_T7 1015-1196 Sentence denotes Likewise, either enzymatic removal or chemical oxidation of terminal sialic acids using sialidase or sodium periodate, respectively, resulted in a strong reduction in GAT1 activity.
TextSentencer_T8 1197-1322 Sentence denotes Kinetic analysis revealed that deficiency, removal or oxidation of terminal sialic acids did not affect the K(m) GABA values.
TextSentencer_T9 1323-1476 Sentence denotes However, deficiency and removal of terminal sialic acids of GAT1 reduced the V(max) GABA values with a reduced apparent affinity for extracellular Na(+).
TextSentencer_T10 1477-1620 Sentence denotes Oxidation of cell surface sialic acids also strongly reduced V(max) without affecting both affinities of GAT1 for GABA and Na(+), respectively.
TextSentencer_T11 1621-1785 Sentence denotes These results demonstrated for the first time that the terminal sialic acid of N-linked oligosaccharides of GAT1 plays a crucial role in the GABA transport process.
T1 0-122 Sentence denotes Involvement of sialic acid in the regulation of γ--aminobutyric acid uptake activity of γ-aminobutyric acid transporter 1.
T2 123-254 Sentence denotes The γ-aminobutyric acid (GABA) transporters (GATs) have long been recognized for their key role in the uptake of neurotransmitters.
T3 255-472 Sentence denotes The GAT1 belongs to the family of Na(+)- and Cl(-)-coupled transport proteins, which possess 12 putative transmembrane (TM) domains and three N-glycosylation sites on the extracellular loop between TM domains 3 and 4.
T4 473-587 Sentence denotes Previously, we demonstrated that terminal trimming of N-glycans is important for the GABA uptake activity of GAT1.
T5 588-770 Sentence denotes In this work, we examined the effect of deficiency, removal or oxidation of surface sialic acid residues on GABA uptake activity to investigate their role in the GABA uptake of GAT1.
T6 771-1014 Sentence denotes We found that the reduced concentration of sialic acid on N-glycans was paralleled by a decreased GABA uptake activity of GAT1 in Chinese hamster ovary (CHO) Lec3 cells (mutant defective in sialic acid biosynthesis) in comparison to CHO cells.
T7 1015-1196 Sentence denotes Likewise, either enzymatic removal or chemical oxidation of terminal sialic acids using sialidase or sodium periodate, respectively, resulted in a strong reduction in GAT1 activity.
T8 1197-1322 Sentence denotes Kinetic analysis revealed that deficiency, removal or oxidation of terminal sialic acids did not affect the K(m) GABA values.
T9 1323-1476 Sentence denotes However, deficiency and removal of terminal sialic acids of GAT1 reduced the V(max) GABA values with a reduced apparent affinity for extracellular Na(+).
T10 1477-1620 Sentence denotes Oxidation of cell surface sialic acids also strongly reduced V(max) without affecting both affinities of GAT1 for GABA and Na(+), respectively.
T11 1621-1785 Sentence denotes These results demonstrated for the first time that the terminal sialic acid of N-linked oligosaccharides of GAT1 plays a crucial role in the GABA transport process.
T1 0-122 Sentence denotes Involvement of sialic acid in the regulation of γ--aminobutyric acid uptake activity of γ-aminobutyric acid transporter 1.
T2 123-254 Sentence denotes The γ-aminobutyric acid (GABA) transporters (GATs) have long been recognized for their key role in the uptake of neurotransmitters.
T3 255-472 Sentence denotes The GAT1 belongs to the family of Na(+)- and Cl(-)-coupled transport proteins, which possess 12 putative transmembrane (TM) domains and three N-glycosylation sites on the extracellular loop between TM domains 3 and 4.
T4 473-587 Sentence denotes Previously, we demonstrated that terminal trimming of N-glycans is important for the GABA uptake activity of GAT1.
T5 588-770 Sentence denotes In this work, we examined the effect of deficiency, removal or oxidation of surface sialic acid residues on GABA uptake activity to investigate their role in the GABA uptake of GAT1.
T6 771-1014 Sentence denotes We found that the reduced concentration of sialic acid on N-glycans was paralleled by a decreased GABA uptake activity of GAT1 in Chinese hamster ovary (CHO) Lec3 cells (mutant defective in sialic acid biosynthesis) in comparison to CHO cells.
T7 1015-1196 Sentence denotes Likewise, either enzymatic removal or chemical oxidation of terminal sialic acids using sialidase or sodium periodate, respectively, resulted in a strong reduction in GAT1 activity.
T8 1197-1322 Sentence denotes Kinetic analysis revealed that deficiency, removal or oxidation of terminal sialic acids did not affect the K(m) GABA values.
T9 1323-1476 Sentence denotes However, deficiency and removal of terminal sialic acids of GAT1 reduced the V(max) GABA values with a reduced apparent affinity for extracellular Na(+).
T10 1477-1620 Sentence denotes Oxidation of cell surface sialic acids also strongly reduced V(max) without affecting both affinities of GAT1 for GABA and Na(+), respectively.
T11 1621-1785 Sentence denotes These results demonstrated for the first time that the terminal sialic acid of N-linked oligosaccharides of GAT1 plays a crucial role in the GABA transport process.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 15-26 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 672-683 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 814-825 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 961-972 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 1084-1096 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T6 1273-1285 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T7 1367-1379 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T8 1503-1515 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T9 1685-1696 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 48-68 FMAID:199056 denotes γ--aminobutyric acid
_T2 48-68 FMAID:84786 denotes γ--aminobutyric acid
_T3 88-107 FMAID:199056 denotes γ-aminobutyric acid
_T4 88-107 FMAID:84786 denotes γ-aminobutyric acid
_T5 127-146 FMAID:84786 denotes γ-aminobutyric acid
_T6 127-146 FMAID:199056 denotes γ-aminobutyric acid
_T7 324-332 FMAID:165447 denotes proteins
_T8 324-332 FMAID:67257 denotes proteins
_T9 664-671 FMAID:50594 denotes surface
_T10 664-671 FMAID:146300 denotes surface
_T11 917-922 FMAID:93687 denotes ovary
_T12 917-922 FMAID:7209 denotes ovary
_T13 934-939 FMAID:68646 denotes cells
_T14 934-939 FMAID:169002 denotes cells
_T15 1008-1013 FMAID:68646 denotes cells
_T16 1008-1013 FMAID:169002 denotes cells
_T17 1490-1502 FMAID:200942 denotes cell surface
_T18 1490-1502 FMAID:212684 denotes cell surface
_T19 1495-1502 FMAID:146300 denotes surface
_T20 1495-1502 FMAID:50594 denotes surface
_T21 1709-1725 FMAID:82742 denotes oligosaccharides
_T22 1709-1725 FMAID:196731 denotes oligosaccharides

uniprot-human

Id Subject Object Predicate Lexical cue
T1 259-263 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T2 582-586 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T3 765-769 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T4 893-897 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T5 1182-1186 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T6 1383-1387 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T7 1582-1586 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T8 1729-1733 http://www.uniprot.org/uniprot/P30531 denotes GAT1
T9 375-377 http://www.uniprot.org/uniprot/P07204 denotes TM
T10 453-455 http://www.uniprot.org/uniprot/P07204 denotes TM
T11 375-377 http://www.uniprot.org/uniprot/Q14264 denotes TM
T12 453-455 http://www.uniprot.org/uniprot/Q14264 denotes TM
T13 375-377 http://www.uniprot.org/uniprot/P60507 denotes TM
T14 453-455 http://www.uniprot.org/uniprot/P60507 denotes TM
T15 375-377 http://www.uniprot.org/uniprot/P60608 denotes TM
T16 453-455 http://www.uniprot.org/uniprot/P60608 denotes TM
T17 375-377 http://www.uniprot.org/uniprot/P60508 denotes TM
T18 453-455 http://www.uniprot.org/uniprot/P60508 denotes TM
T19 375-377 http://www.uniprot.org/uniprot/Q902F9 denotes TM
T20 453-455 http://www.uniprot.org/uniprot/Q902F9 denotes TM
T21 375-377 http://www.uniprot.org/uniprot/Q9NX77 denotes TM
T22 453-455 http://www.uniprot.org/uniprot/Q9NX77 denotes TM
T23 375-377 http://www.uniprot.org/uniprot/O42043 denotes TM
T24 453-455 http://www.uniprot.org/uniprot/O42043 denotes TM
T25 375-377 http://www.uniprot.org/uniprot/O71037 denotes TM
T26 453-455 http://www.uniprot.org/uniprot/O71037 denotes TM
T27 375-377 http://www.uniprot.org/uniprot/P61565 denotes TM
T28 453-455 http://www.uniprot.org/uniprot/P61565 denotes TM
T29 375-377 http://www.uniprot.org/uniprot/P61566 denotes TM
T30 453-455 http://www.uniprot.org/uniprot/P61566 denotes TM
T31 375-377 http://www.uniprot.org/uniprot/P61570 denotes TM
T32 453-455 http://www.uniprot.org/uniprot/P61570 denotes TM
T33 375-377 http://www.uniprot.org/uniprot/Q69384 denotes TM
T34 453-455 http://www.uniprot.org/uniprot/Q69384 denotes TM
T35 375-377 http://www.uniprot.org/uniprot/P61567 denotes TM
T36 453-455 http://www.uniprot.org/uniprot/P61567 denotes TM
T37 375-377 http://www.uniprot.org/uniprot/Q902F8 denotes TM
T38 453-455 http://www.uniprot.org/uniprot/Q902F8 denotes TM
T39 375-377 http://www.uniprot.org/uniprot/Q9UKH3 denotes TM
T40 453-455 http://www.uniprot.org/uniprot/Q9UKH3 denotes TM
T41 375-377 http://www.uniprot.org/uniprot/P60509 denotes TM
T42 453-455 http://www.uniprot.org/uniprot/P60509 denotes TM
T43 375-377 http://www.uniprot.org/uniprot/P61550 denotes TM
T44 453-455 http://www.uniprot.org/uniprot/P61550 denotes TM
T45 375-377 http://www.uniprot.org/uniprot/Q9UQF0 denotes TM
T46 453-455 http://www.uniprot.org/uniprot/Q9UQF0 denotes TM
T47 375-377 http://www.uniprot.org/uniprot/Q9N2J8 denotes TM
T48 453-455 http://www.uniprot.org/uniprot/Q9N2J8 denotes TM
T49 375-377 http://www.uniprot.org/uniprot/Q9N2K0 denotes TM
T50 453-455 http://www.uniprot.org/uniprot/Q9N2K0 denotes TM
T51 1402-1405 http://www.uniprot.org/uniprot/Q96CY8 denotes max
T52 1540-1543 http://www.uniprot.org/uniprot/Q96CY8 denotes max

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 375-377 http://www.uniprot.org/uniprot/P15306 denotes TM
T2 453-455 http://www.uniprot.org/uniprot/P15306 denotes TM
T3 375-377 http://www.uniprot.org/uniprot/Q811M9 denotes TM
T4 453-455 http://www.uniprot.org/uniprot/Q811M9 denotes TM
T5 929-933 http://www.uniprot.org/uniprot/Q80TS3 denotes Lec3
T6 1402-1405 http://www.uniprot.org/uniprot/P28574 denotes max
T7 1540-1543 http://www.uniprot.org/uniprot/P28574 denotes max

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 843-853 http://purl.bioontology.org/ontology/NCBITAXON/871272 denotes paralleled
T2 934-939 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 1008-1013 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T4 1402-1405 http://purl.bioontology.org/ontology/NCBITAXON/1106673 denotes max
T5 1540-1543 http://purl.bioontology.org/ontology/NCBITAXON/1106673 denotes max

GO-BP

Id Subject Object Predicate Lexical cue
T1 34-44 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T2 69-75 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T3 226-232 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T4 563-569 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T5 701-707 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T6 755-761 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T7 874-880 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake
T8 90-119 http://purl.obolibrary.org/obo/GO_0015812 denotes aminobutyric acid transporter
T9 108-119 http://purl.obolibrary.org/obo/GO_0006810 denotes transporter
T10 154-166 http://purl.obolibrary.org/obo/GO_0006810 denotes transporters
T11 314-323 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T12 1767-1776 http://purl.obolibrary.org/obo/GO_0006810 denotes transport
T13 148-166 http://purl.obolibrary.org/obo/GO_0015812 denotes GABA) transporters
T14 1762-1776 http://purl.obolibrary.org/obo/GO_0015812 denotes GABA transport
T15 226-253 http://purl.obolibrary.org/obo/GO_0001504 denotes uptake of neurotransmitters
T16 300-302 http://purl.obolibrary.org/obo/GO_0008813 denotes Cl
T17 314-332 http://purl.obolibrary.org/obo/GO_0015031 denotes transport proteins
T18 399-412 http://purl.obolibrary.org/obo/GO_0070085 denotes glycosylation
T19 540-562 http://purl.obolibrary.org/obo/GO_0051939 denotes important for the GABA
T20 924-927 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO
T21 1004-1007 http://purl.obolibrary.org/obo/GO_0043848 denotes CHO
T22 973-985 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis

GO-CC

Id Subject Object Predicate Lexical cue
T1 360-373 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T2 360-373 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane
T3 426-439 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T4 1456-1469 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T5 934-939 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6 1008-1013 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7 1490-1494 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T8 1490-1502 http://purl.obolibrary.org/obo/GO_0009986 denotes cell surface

Allie

Id Subject Object Predicate Lexical cue
SS1_21045010_1_0 127-146 expanded denotes γ-aminobutyric acid
SS2_21045010_1_0 148-152 abbr denotes GABA
SS1_21045010_2_0 360-373 expanded denotes transmembrane
SS2_21045010_2_0 375-377 abbr denotes TM
SS1_21045010_5_0 901-922 expanded denotes Chinese hamster ovary
SS2_21045010_5_0 924-927 abbr denotes CHO
AE1_21045010_1_0 SS1_21045010_1_0 SS2_21045010_1_0 abbreviatedTo γ-aminobutyric acid,GABA
AE1_21045010_2_0 SS1_21045010_2_0 SS2_21045010_2_0 abbreviatedTo transmembrane,TM
AE1_21045010_5_0 SS1_21045010_5_0 SS2_21045010_5_0 abbreviatedTo Chinese hamster ovary,CHO

GlycoBiology-Motifs

Id Subject Object Predicate Lexical cue
T1 527-536 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans
T2 829-838 http://rdf.glycoinfo.org/glycan/G00027MO denotes N-glycans

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 901-916 OrganismTaxon denotes Chinese hamster 10029

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 360-373 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T2 375-377 Body_part denotes TM http://purl.obolibrary.org/obo/GO_0016020
T3 426-439 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T4 453-455 Body_part denotes TM http://purl.obolibrary.org/obo/GO_0016020
T5 917-922 Body_part denotes ovary http://purl.obolibrary.org/obo/UBERON_0000992
T6 1456-1469 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576