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PubMed:21045008 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 10-17 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 109-116 https://glytoucan.org/Structures/Glycans/G70323CJ denotes Mannose
T3 229-236 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 238-244 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T5 248-267 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-80 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis:
T2 81-108 Sentence denotes A review and meta-analysis.
T3 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
T4 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
T5 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
T6 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
T7 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
T8 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
T9 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
T10 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
T11 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
T12 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
T13 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.
T1 0-80 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis:
T2 81-108 Sentence denotes A review and meta-analysis.
T3 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
T4 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
T5 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
T6 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
T7 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
T8 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
T9 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
T10 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
T11 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
T12 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
T13 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 10-17 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T2 109-116 Glycan_Motif denotes Mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T3 229-236 Glycan_Motif denotes mannose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G70323CJ
T4 238-244 Glycan_Motif denotes fucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO
T5 248-267 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 10-17 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T2 109-116 https://glytoucan.org/Structures/Glycans/G70323CJ denotes Mannose
T3 229-236 https://glytoucan.org/Structures/Glycans/G70323CJ denotes mannose
T4 238-244 https://glytoucan.org/Structures/Glycans/G82576YO denotes fucose
T5 248-267 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-80 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis:
TextSentencer_T2 81-108 Sentence denotes A review and meta-analysis.
TextSentencer_T3 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
TextSentencer_T4 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
TextSentencer_T5 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
TextSentencer_T6 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
TextSentencer_T7 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
TextSentencer_T8 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
TextSentencer_T9 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
TextSentencer_T10 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
TextSentencer_T11 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
TextSentencer_T12 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
TextSentencer_T13 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.
T1 0-108 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: A review and meta-analysis.
T2 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
T3 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
T4 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
T5 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
T6 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
T7 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
T8 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
T9 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
T10 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
T11 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
T12 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.
T1 0-80 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis:
T2 81-108 Sentence denotes A review and meta-analysis.
T3 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
T4 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
T5 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
T6 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
T7 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
T8 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
T9 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
T10 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
T11 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
T12 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
T13 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 182-187 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 509-513 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T3 773-777 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T4 1311-1315 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T5 1464-1468 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

DisGeNET

Id Subject Object Predicate Lexical cue
T0 10-32 gene:4153 denotes mannose-binding lectin
T1 64-79 disease:C0010674 denotes cystic fibrosis
R1 T0 T1 associated_with mannose-binding lectin,cystic fibrosis

GlycoBiology-PACDB

Id Subject Object Predicate Lexical cue
_T1 1133-1155 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC001,LEC005,LEC007,LEC029,LEC030,LEC032,LEC135,LEC191,LEC229,LEC231,LEC368,LEC447,LEC617,LEC676,PGG008 denotes Pseudomonas aeruginosa
_T2 1133-1155 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC584 denotes Pseudomonas aeruginosa
_T3 1133-1155 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC709 denotes Pseudomonas aeruginosa
_T4 1133-1155 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC325 denotes Pseudomonas aeruginosa
_T5 1133-1155 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC466 denotes Pseudomonas aeruginosa
_T6 1133-1155 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC703 denotes Pseudomonas aeruginosa
_T7 1133-1155 http://acgg.asia/db/diseases/pacdb/lec?ids=LEC721 denotes Pseudomonas aeruginosa

ICD10

Id Subject Object Predicate Lexical cue
T1 64-79 http://purl.bioontology.org/ontology/ICD10/E84 denotes cystic fibrosis
T2 630-645 http://purl.bioontology.org/ontology/ICD10/E84 denotes Cystic fibrosis
T3 64-79 http://purl.bioontology.org/ontology/ICD10/E84.9 denotes cystic fibrosis
T4 630-645 http://purl.bioontology.org/ontology/ICD10/E84.9 denotes Cystic fibrosis

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 10-17 FMAID:82801 denotes mannose
_T2 10-17 FMAID:196796 denotes mannose
_T3 109-116 FMAID:196796 denotes Mannose
_T4 109-116 FMAID:82801 denotes Mannose
_T5 158-165 FMAID:67257 denotes protein
_T6 158-165 FMAID:165447 denotes protein
_T7 182-187 FMAID:7197 denotes liver
_T8 182-187 FMAID:93672 denotes liver
_T9 202-217 FMAID:82782 denotes glycoconjugates
_T10 202-217 FMAID:196776 denotes glycoconjugates
_T11 229-236 FMAID:82801 denotes mannose
_T12 229-236 FMAID:196796 denotes mannose
_T13 238-244 FMAID:196784 denotes fucose
_T14 238-244 FMAID:82790 denotes fucose
_T15 248-267 FMAID:82787 denotes N-acetylglucosamine
_T16 248-267 FMAID:196781 denotes N-acetylglucosamine
_T17 418-427 FMAID:166081 denotes organisms
_T18 418-427 FMAID:67498 denotes organisms
_T19 472-477 FMAID:167330 denotes serum
_T20 478-485 FMAID:67257 denotes protein
_T21 478-485 FMAID:165447 denotes protein
_T22 509-513 FMAID:169341 denotes lung
_T23 509-513 FMAID:7195 denotes lung
_T24 509-513 FMAID:93670 denotes lung
_T25 703-707 FMAID:198663 denotes gene
_T26 773-777 FMAID:93670 denotes lung
_T27 773-777 FMAID:169341 denotes lung
_T28 773-777 FMAID:7195 denotes lung
_T29 883-888 FMAID:198663 denotes genes
_T30 1178-1187 FMAID:66326 denotes pulmonary
_T31 1178-1187 FMAID:171535 denotes pulmonary
_T32 1252-1258 FMAID:50593 denotes volume
_T33 1252-1258 FMAID:146298 denotes volume
_T34 1278-1282 FMAID:217859 denotes rate
_T35 1311-1315 FMAID:93670 denotes lung
_T36 1311-1315 FMAID:7195 denotes lung
_T37 1311-1315 FMAID:169341 denotes lung
_T38 1464-1468 FMAID:169341 denotes lung
_T39 1464-1468 FMAID:7195 denotes lung
_T40 1464-1468 FMAID:93670 denotes lung

uniprot-human

Id Subject Object Predicate Lexical cue
T1 10-32 http://www.uniprot.org/uniprot/Q9UQG6 denotes mannose-binding lectin
T2 109-131 http://www.uniprot.org/uniprot/Q9UQG6 denotes Mannose-binding lectin
T3 10-32 http://www.uniprot.org/uniprot/Q12907 denotes mannose-binding lectin
T4 109-131 http://www.uniprot.org/uniprot/Q12907 denotes Mannose-binding lectin
T5 10-32 http://www.uniprot.org/uniprot/Q96TF8 denotes mannose-binding lectin
T6 109-131 http://www.uniprot.org/uniprot/Q96TF8 denotes Mannose-binding lectin
T7 133-136 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T8 189-192 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T9 349-352 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T10 453-456 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T11 588-591 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T12 918-921 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T13 1071-1074 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T14 1408-1411 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL
T15 1040-1044 http://www.uniprot.org/uniprot/Q96TF8 denotes MBL2
T16 749-753 http://www.uniprot.org/uniprot/P13569 denotes CFTR
T17 836-840 http://www.uniprot.org/uniprot/P13569 denotes CFTR

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 749-753 http://www.uniprot.org/uniprot/P26361 denotes CFTR
T2 836-840 http://www.uniprot.org/uniprot/P26361 denotes CFTR

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 306-314 http://purl.bioontology.org/ontology/NCBITAXON/2 denotes bacteria
T2 306-314 http://purl.bioontology.org/ontology/NCBITAXON/629395 denotes bacteria
T3 1133-1144 http://purl.bioontology.org/ontology/NCBITAXON/135621 denotes Pseudomonas
T4 1133-1144 http://purl.bioontology.org/ontology/NCBITAXON/651740 denotes Pseudomonas
T5 1133-1155 http://purl.bioontology.org/ontology/NCBITAXON/287 denotes Pseudomonas aeruginosa
T6 1178-1187 http://purl.bioontology.org/ontology/NCBITAXON/136615 denotes pulmonary

GO-BP

Id Subject Object Predicate Lexical cue
T1 144-157 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune
T2 409-417 http://purl.obolibrary.org/obo/GO_0008228 denotes opsonize
T3 439-451 http://purl.obolibrary.org/obo/GO_0006909 denotes phagocytosis
T4 527-539 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T5 738-747 http://purl.obolibrary.org/obo/GO_0065007 denotes regulator
T6 1286-1291 http://purl.obolibrary.org/obo/GO_0016265 denotes death

GO-MF

Id Subject Object Predicate Lexical cue
T1 10-25 http://purl.obolibrary.org/obo/GO_0005537 denotes mannose-binding
T2 109-124 http://purl.obolibrary.org/obo/GO_0005537 denotes Mannose-binding
T3 10-32 http://purl.obolibrary.org/obo/GO_0005537 denotes mannose-binding lectin
T4 109-131 http://purl.obolibrary.org/obo/GO_0005537 denotes Mannose-binding lectin
T5 18-25 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 117-124 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 193-198 http://purl.obolibrary.org/obo/GO_0070026 denotes binds
T8 18-25 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 117-124 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 193-198 http://purl.obolibrary.org/obo/GO_0003680 denotes binds
T11 18-25 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T12 117-124 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T13 193-198 http://purl.obolibrary.org/obo/GO_0017091 denotes binds
T14 18-25 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T15 117-124 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16 193-198 http://purl.obolibrary.org/obo/GO_0005488 denotes binds

GO-CC

Id Subject Object Predicate Lexical cue
T1 724-737 http://purl.obolibrary.org/obo/GO_0016021 denotes transmembrane
T2 724-737 http://purl.obolibrary.org/obo/GO_0044214 denotes transmembrane

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 182-187 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T2 418-427 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organisms
T3 472-477 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T4 509-513 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T5 773-777 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T6 1311-1315 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T7 1464-1468 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung

Allie

Id Subject Object Predicate Lexical cue
SS1_21045008_1_0 109-131 expanded denotes Mannose-binding lectin
SS2_21045008_1_0 133-136 abbr denotes MBL
SS1_21045008_6_0 630-645 expanded denotes Cystic fibrosis
SS2_21045008_6_0 647-649 abbr denotes CF
SS1_21045008_6_1 721-747 expanded denotes CF transmembrane regulator
SS2_21045008_6_1 749-753 abbr denotes CFTR
AE1_21045008_1_0 SS1_21045008_1_0 SS2_21045008_1_0 abbreviatedTo Mannose-binding lectin,MBL
AE1_21045008_6_0 SS1_21045008_6_0 SS2_21045008_6_0 abbreviatedTo Cystic fibrosis,CF
AE1_21045008_6_1 SS1_21045008_6_1 SS2_21045008_6_1 abbreviatedTo CF transmembrane regulator,CFTR

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 151-165 http://edamontology.org/topic_2830 denotes immune protein
T2 158-165 http://edamontology.org/topic_0078 denotes protein
T3 316-323 http://edamontology.org/topic_0781 denotes viruses
T4 328-333 http://edamontology.org/topic_0782 denotes fungi
T5 375-382 http://edamontology.org/topic_0602 denotes pathway
T6 478-485 http://edamontology.org/topic_0078 denotes protein
T7 668-675 http://edamontology.org/topic_0634 denotes disease
T8 686-695 http://edamontology.org/topic_0199 denotes mutations
T9 724-747 http://edamontology.org/topic_0736 denotes transmembrane regulator
T10 778-785 http://edamontology.org/topic_0634 denotes disease
T11 841-849 http://edamontology.org/topic_0625 denotes genotype
T12 1045-1054 http://edamontology.org/topic_0625 denotes genotypes
T13 1316-1331 http://edamontology.org/topic_3421 denotes transplantation
T14 1469-1476 http://edamontology.org/topic_0634 denotes disease

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 99-107 http://edamontology.org/operation_2945 denotes analysis
T2 158-165 http://edamontology.org/data_1467 denotes protein
T3 158-165 http://edamontology.org/format_1208 denotes protein
T4 375-382 http://edamontology.org/data_2600 denotes pathway
T5 478-485 http://edamontology.org/data_1467 denotes protein
T6 478-485 http://edamontology.org/format_1208 denotes protein
T7 841-849 http://edamontology.org/operation_3196 denotes genotype
T8 1016-1024 http://edamontology.org/operation_2945 denotes analysis
T9 1045-1054 http://edamontology.org/operation_3196 denotes genotypes

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21045008-0#10#32#gene4153 10-32 gene4153 denotes mannose-binding lectin
21045008-0#64#79#diseaseC0010674 64-79 diseaseC0010674 denotes cystic fibrosis
21045008-10#47#50#gene4153 1408-1411 gene4153 denotes MBL
21045008-10#103#115#diseaseC0024115 1464-1476 diseaseC0024115 denotes lung disease
21045008-8#0#3#gene50639 918-921 gene50639 denotes MBL
21045008-8#70#72#diseaseC0010674 988-990 diseaseC0010674 denotes CF
10#32#gene415364#79#diseaseC0010674 21045008-0#10#32#gene4153 21045008-0#64#79#diseaseC0010674 associated_with mannose-binding lectin,cystic fibrosis
47#50#gene4153103#115#diseaseC0024115 21045008-10#47#50#gene4153 21045008-10#103#115#diseaseC0024115 associated_with MBL,lung disease
0#3#gene5063970#72#diseaseC0010674 21045008-8#0#3#gene50639 21045008-8#70#72#diseaseC0010674 associated_with MBL,CF

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 182-187 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver
T2 509-513 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T3 773-777 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T4 1311-1315 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung
T5 1464-1468 http://purl.obolibrary.org/obo/MAT_0000135 denotes lung

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 472-477 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 182-187 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 509-513 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T4 773-777 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T5 1311-1315 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T6 1464-1468 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T7 418-427 http://purl.obolibrary.org/obo/UBERON_0000062 denotes organisms

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 773-785 Phenotype denotes lung disease HP:0002088
T2 1464-1476 Phenotype denotes lung disease HP:0002088

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 64-79 Disease denotes cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T2 527-539 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166
T3 608-618 Disease denotes infectious http://purl.obolibrary.org/obo/MONDO_0005550
T4 630-645 Disease denotes Cystic fibrosis http://purl.obolibrary.org/obo/MONDO_0009061
T5 647-649 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T6 721-723 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T7 770-772 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T8 773-785 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275
T9 988-990 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T10 1461-1463 Disease denotes CF http://purl.obolibrary.org/obo/MONDO_0009061
T11 1464-1476 Disease denotes lung disease http://purl.obolibrary.org/obo/MONDO_0005275

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-108 Sentence denotes Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: A review and meta-analysis.
T2 109-188 Sentence denotes Mannose-binding lectin (MBL) is an innate immune protein produced by the liver.
T3 189-334 Sentence denotes MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi.
T4 335-452 Sentence denotes Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis.
T5 453-540 Sentence denotes MBL is primarily a serum protein but accumulates in the lung during acute inflammation.
T6 541-629 Sentence denotes Recent evidence suggests an important role for MBL in a variety of infectious disorders.
T7 630-755 Sentence denotes Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR).
T8 756-917 Sentence denotes The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis.
T9 918-991 Sentence denotes MBL has been proposed as a possible modulator of clinical severity in CF.
T10 992-1360 Sentence denotes In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P < 0.0001), reduced pulmonary function among adult patients (P < 0.0001 for forced expiratory volume), and an increased rate of death or requirement for lung transplantation (odds ratio 3.69; P = 0.02).
T11 1361-1477 Sentence denotes The available evidence therefore suggests that MBL insufficiency is associated with the severity of CF lung disease.
T12 1478-1570 Sentence denotes The possible future prophylactic or therapeutic application of MBL replacement is discussed.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 306-314 OrganismTaxon denotes bacteria 2|629395
T3 328-333 OrganismTaxon denotes fungi 4751
T4 1133-1155 OrganismTaxon denotes Pseudomonas aeruginosa 287

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 182-187 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097
T2 509-513 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T3 773-777 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T4 1311-1315 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135
T5 1464-1468 Body_part denotes lung http://purl.obolibrary.org/obo/MAT_0000135

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 182-187 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T2 418-427 Body_part denotes organisms http://purl.obolibrary.org/obo/UBERON_0000468
T3 509-513 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T4 724-737 Body_part denotes transmembrane http://purl.obolibrary.org/obo/GO_0016020
T5 773-777 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T6 1311-1315 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048
T7 1464-1468 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048