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PubMed:21042587 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
8215 9-32 GeneOrGeneProduct denotes glucocorticoid receptor NCBIGene:2908
8216 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia MESH:D000312
8217 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess MESH:C537422
8218 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance MESH:C564221
8219 180-191 DiseaseOrPhenotypicFeature denotes OMIM 138040 OMIM:138040
8220 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease MESH:D030342
8221 273-287 ChemicalEntity denotes glucocorticoid MESH:D005938
8222 330-353 GeneOrGeneProduct denotes glucocorticoid receptor NCBIGene:2908
8223 355-357 GeneOrGeneProduct denotes GR NCBIGene:2908
8224 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas MESH:C538238
8225 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance MESH:C535280
8226 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia MESH:D000312
8227 560-572 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
8228 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia MESH:D007008
8229 687-698 SequenceVariant denotes p.R469[R,X] p|SUB|R|469|X
8230 724-726 GeneOrGeneProduct denotes GR NCBIGene:2908
8231 741-789 SequenceVariant denotes arginine (CGA) by a stop (TGA) at amino-acid 469 p|SUB|R|469|X
8232 911-913 GeneOrGeneProduct denotes GR NCBIGene:2908
8233 1183-1185 GeneOrGeneProduct denotes GR NCBIGene:2908
8234 1239-1241 GeneOrGeneProduct denotes GR NCBIGene:2908
8235 1279-1281 GeneOrGeneProduct denotes GR NCBIGene:2908
8236 1344-1358 ChemicalEntity denotes glucocorticoid MESH:D005938
8237 1381-1386 GeneOrGeneProduct denotes FKBP5 NCBIGene:2289
8238 1452-1466 ChemicalEntity denotes glucocorticoid MESH:D005938
8239 1498-1500 GeneOrGeneProduct denotes GR NCBIGene:2908
8240 1568-1570 GeneOrGeneProduct denotes GR NCBIGene:2908
8241 1658-1665 ChemicalEntity denotes emetine MESH:D004640
8242 1699-1701 GeneOrGeneProduct denotes GR NCBIGene:2908
8243 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973
8244 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor NCBIGene:4306
8245 1817-1825 ChemicalEntity denotes cortisol MESH:D006854
8246 1851-1868 ChemicalEntity denotes mineralocorticoid MESH:D008901
8247 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance MESH:C564221
8248 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess MESH:C537422
8249 2011-2030 ChemicalEntity denotes tetrahydrocortisone MESH:D013761
8250 2031-2049 ChemicalEntity denotes tetrahydrocortisol MESH:D013760
8251 2068-2076 OrganismTaxon denotes patients NCBITaxon:9606
8252 2096-2110 ChemicalEntity denotes glucocorticoid MESH:D005938
8253 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2 NCBIGene:3291
8254 2191-2193 GeneOrGeneProduct denotes GR NCBIGene:2908
8255 2231-2233 GeneOrGeneProduct denotes GR NCBIGene:2908
8256 2265-2279 ChemicalEntity denotes glucocorticoid MESH:D005938
8257 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism MESH:D003480
8258 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia MESH:D000312
8259 2421-2438 ChemicalEntity denotes mineralocorticoid MESH:D008901
8260 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension MESH:D006973

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-144 Sentence denotes Familial glucocorticoid receptor haploinsufficiency by non-sense mediated mRNA decay, adrenal hyperplasia and apparent mineralocorticoid excess.
T2 145-359 Sentence denotes Primary glucocorticoid resistance (OMIM 138040) is a rare hereditary disease that causes a generalized partial insensitivity to glucocorticoid action, due to genetic alterations of the glucocorticoid receptor (GR).
T3 360-589 Sentence denotes Investigation of adrenal incidentalomas led to the discovery of a family (eight affected individuals spanning three generations), prone to cortisol resistance, bilateral adrenal hyperplasia, arterial hypertension and hypokalemia.
T4 590-858 Sentence denotes This phenotype exacerbated over time, cosegregates with the first heterozygous nonsense mutation p.R469[R,X] reported to date for the GR, replacing an arginine (CGA) by a stop (TGA) at amino-acid 469 in the second zinc finger of the DNA-binding domain of the receptor.
T5 859-1037 Sentence denotes In vitro, this mutation leads to a truncated 50-kDa GR lacking hormone and DNA binding capacity, devoid of hormone-dependent nuclear translocation and transactivation properties.
T6 1038-1148 Sentence denotes In the proband's fibroblasts, we provided evidence for the lack of expression of the defective allele in vivo.
T7 1149-1265 Sentence denotes The absence of detectable mutated GR mRNA was accompanied by a 50% reduction in wild type GR transcript and protein.
T8 1266-1402 Sentence denotes This reduced GR expression leads to a significantly below-normal induction of glucocorticoid-induced target genes, FKBP5 in fibroblasts.
T9 1403-1698 Sentence denotes We demonstrated that the molecular mechanisms of glucocorticoid signaling dysfunction involved GR haploinsufficiency due to the selective degradation of the mutated GR transcript through a nonsense-mediated mRNA Decay that was experimentally validated on emetine-treated propositus' fibroblasts.
T10 1699-1926 Sentence denotes GR haploinsufficiency leads to hypertension due to illicit occupation of renal mineralocorticoid receptor by elevated cortisol rather than to increased mineralocorticoid production reported in primary glucocorticoid resistance.
T11 1927-2209 Sentence denotes Indeed, apparent mineralocorticoid excess was demonstrated by a decrease in urinary tetrahydrocortisone-tetrahydrocortisol ratio in affected patients, revealing reduced glucocorticoid degradation by renal activity of the 11β-hydroxysteroid dehydrogenase type 2, a GR regulated gene.
T12 2210-2464 Sentence denotes We propose thus that GR haploinsufficiency compromises glucocorticoid sensitivity and may represent a novel genetic cause of subclinical hypercortisolism, incidentally revealed bilateral adrenal hyperplasia and mineralocorticoid-independent hypertension.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 94-105 DiseaseOrPhenotypicFeature denotes hyperplasia 0005043
T2 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess 0009025
T3 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance 0014421
T4 198-202 DiseaseOrPhenotypicFeature denotes rare 0021136
T5 538-549 DiseaseOrPhenotypicFeature denotes hyperplasia 0005043
T6 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance 0014421
T7 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess 0009025
T8 2405-2416 DiseaseOrPhenotypicFeature denotes hyperplasia 0005043

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 687-693 SequenceVariant denotes p.R469

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 59-64 GeneOrGeneProduct denotes sense
T3 74-78 GeneOrGeneProduct denotes mRNA
T4 79-84 GeneOrGeneProduct denotes decay
T5 198-202 GeneOrGeneProduct denotes rare
T6 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T7 355-357 GeneOrGeneProduct denotes GR
T8 560-572 GeneOrGeneProduct denotes hypertension
T9 724-726 GeneOrGeneProduct denotes GR
T10 761-765 GeneOrGeneProduct denotes stop
T11 781-785 GeneOrGeneProduct denotes acid
T12 804-815 GeneOrGeneProduct denotes zinc finger
T13 823-841 GeneOrGeneProduct denotes DNA-binding domain
T14 849-857 GeneOrGeneProduct denotes receptor
T15 894-903 GeneOrGeneProduct denotes truncated
T16 904-910 GeneOrGeneProduct denotes 50-kDa
T17 911-913 GeneOrGeneProduct denotes GR
T18 922-929 GeneOrGeneProduct denotes hormone
T19 934-945 GeneOrGeneProduct denotes DNA binding
T20 966-973 GeneOrGeneProduct denotes hormone
T21 992-1005 GeneOrGeneProduct denotes translocation
T22 1097-1101 GeneOrGeneProduct denotes lack
T23 1123-1132 GeneOrGeneProduct denotes defective
T24 1183-1185 GeneOrGeneProduct denotes GR
T25 1186-1190 GeneOrGeneProduct denotes mRNA
T26 1239-1241 GeneOrGeneProduct denotes GR
T27 1242-1252 GeneOrGeneProduct denotes transcript
T28 1257-1264 GeneOrGeneProduct denotes protein
T29 1271-1278 GeneOrGeneProduct denotes reduced
T30 1279-1281 GeneOrGeneProduct denotes GR
T31 1381-1386 GeneOrGeneProduct denotes FKBP5
T32 1498-1500 GeneOrGeneProduct denotes GR
T33 1568-1570 GeneOrGeneProduct denotes GR
T34 1571-1581 GeneOrGeneProduct denotes transcript
T35 1610-1614 GeneOrGeneProduct denotes mRNA
T36 1615-1620 GeneOrGeneProduct denotes Decay
T37 1699-1701 GeneOrGeneProduct denotes GR
T38 1730-1742 GeneOrGeneProduct denotes hypertension
T39 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T40 2088-2095 GeneOrGeneProduct denotes reduced
T41 2152-2180 GeneOrGeneProduct denotes hydroxysteroid dehydrogenase
T42 2181-2187 GeneOrGeneProduct denotes type 2
T43 2191-2193 GeneOrGeneProduct denotes GR
T44 2231-2233 GeneOrGeneProduct denotes GR
T45 2312-2317 GeneOrGeneProduct denotes novel
T46 2451-2463 GeneOrGeneProduct denotes hypertension

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T32 1010-1025 GeneOrGeneProduct denotes transactivation
T33 1097-1101 GeneOrGeneProduct denotes lack
T34 1123-1132 GeneOrGeneProduct denotes defective
T35 1175-1182 GeneOrGeneProduct denotes mutated
T36 1183-1185 GeneOrGeneProduct denotes GR
T37 1186-1190 GeneOrGeneProduct denotes mRNA
T38 1239-1241 GeneOrGeneProduct denotes GR
T39 1242-1252 GeneOrGeneProduct denotes transcript
T40 1257-1264 GeneOrGeneProduct denotes protein
T41 1271-1278 GeneOrGeneProduct denotes reduced
T42 1279-1281 GeneOrGeneProduct denotes GR
T43 1359-1366 GeneOrGeneProduct denotes induced
T44 1381-1386 GeneOrGeneProduct denotes FKBP5
T45 1498-1500 GeneOrGeneProduct denotes GR
T46 1501-1519 GeneOrGeneProduct denotes haploinsufficiency
T47 1560-1567 GeneOrGeneProduct denotes mutated
T48 1568-1570 GeneOrGeneProduct denotes GR
T49 1571-1581 GeneOrGeneProduct denotes transcript
T50 1601-1609 GeneOrGeneProduct denotes mediated
T51 1610-1614 GeneOrGeneProduct denotes mRNA
T52 1615-1620 GeneOrGeneProduct denotes Decay
T53 1699-1701 GeneOrGeneProduct denotes GR
T54 1702-1720 GeneOrGeneProduct denotes haploinsufficiency
T55 1730-1742 GeneOrGeneProduct denotes hypertension
T56 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T57 1869-1879 GeneOrGeneProduct denotes production
T58 1962-1968 GeneOrGeneProduct denotes excess
T59 2088-2095 GeneOrGeneProduct denotes reduced
T60 2132-2140 GeneOrGeneProduct denotes activity
T61 2152-2180 GeneOrGeneProduct denotes hydroxysteroid dehydrogenase
T62 2181-2187 GeneOrGeneProduct denotes type 2
T63 2191-2193 GeneOrGeneProduct denotes GR
T64 2194-2203 GeneOrGeneProduct denotes regulated
T65 2231-2233 GeneOrGeneProduct denotes GR
T66 2234-2252 GeneOrGeneProduct denotes haploinsufficiency
T67 2312-2317 GeneOrGeneProduct denotes novel
T68 2451-2463 GeneOrGeneProduct denotes hypertension
T28 922-929 GeneOrGeneProduct denotes hormone
T29 934-945 GeneOrGeneProduct denotes DNA binding
T30 966-973 GeneOrGeneProduct denotes hormone
T31 992-1005 GeneOrGeneProduct denotes translocation
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 33-51 GeneOrGeneProduct denotes haploinsufficiency
T3 59-64 GeneOrGeneProduct denotes sense
T4 65-73 GeneOrGeneProduct denotes mediated
T5 74-78 GeneOrGeneProduct denotes mRNA
T6 79-84 GeneOrGeneProduct denotes decay
T7 137-143 GeneOrGeneProduct denotes excess
T8 198-202 GeneOrGeneProduct denotes rare
T9 256-269 GeneOrGeneProduct denotes insensitivity
T10 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T11 355-357 GeneOrGeneProduct denotes GR
T12 461-469 GeneOrGeneProduct denotes spanning
T13 560-572 GeneOrGeneProduct denotes hypertension
T14 622-626 GeneOrGeneProduct denotes time
T15 678-686 GeneOrGeneProduct denotes mutation
T16 724-726 GeneOrGeneProduct denotes GR
T17 750-760 GeneOrGeneProduct denotes (CGA) by a
T18 761-765 GeneOrGeneProduct denotes stop
T19 781-785 GeneOrGeneProduct denotes acid
T20 804-815 GeneOrGeneProduct denotes zinc finger
T21 823-841 GeneOrGeneProduct denotes DNA-binding domain
T22 849-857 GeneOrGeneProduct denotes receptor
T23 874-882 GeneOrGeneProduct denotes mutation
T24 894-903 GeneOrGeneProduct denotes truncated
T25 904-910 GeneOrGeneProduct denotes 50-kDa
T26 911-913 GeneOrGeneProduct denotes GR
T27 914-921 GeneOrGeneProduct denotes lacking

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 94-105 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T2 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T3 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T4 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease D030342
T5 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas C538238
T6 538-549 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T7 560-572 DiseaseOrPhenotypicFeature denotes hypertension D006973
T8 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T9 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T11 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T12 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism D003480
T13 2405-2416 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T14 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension D006973

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 59-64 GeneOrGeneProduct denotes sense
T3 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T4 355-357 GeneOrGeneProduct denotes GR
T5 724-726 GeneOrGeneProduct denotes GR
T6 804-815 GeneOrGeneProduct denotes zinc finger
T7 904-910 GeneOrGeneProduct denotes 50-kDa
T8 911-913 GeneOrGeneProduct denotes GR
T9 1183-1185 GeneOrGeneProduct denotes GR
T10 1239-1241 GeneOrGeneProduct denotes GR
T11 1242-1264 GeneOrGeneProduct denotes transcript and protein
T12 1279-1281 GeneOrGeneProduct denotes GR
T13 1381-1386 GeneOrGeneProduct denotes FKBP5
T14 1498-1500 GeneOrGeneProduct denotes GR
T15 1568-1570 GeneOrGeneProduct denotes GR
T16 1699-1701 GeneOrGeneProduct denotes GR
T17 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T18 2152-2180 GeneOrGeneProduct denotes hydroxysteroid dehydrogenase
T19 2191-2193 GeneOrGeneProduct denotes GR
T20 2231-2233 GeneOrGeneProduct denotes GR

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia 0018479
T2 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess 0009025
T3 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance 0014421
T4 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease 0003847
T5 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas 0003924
T6 530-549 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia 0018479
T7 560-572 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T8 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia 0003019
T9 767-770 DiseaseOrPhenotypicFeature denotes TGA 0000153
T10 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension 0005044
T11 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance 0014421
T12 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess 0009025
T13 2280-2291 DiseaseOrPhenotypicFeature denotes sensitivity 0000605
T14 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism 0018912|0006640
T16 2397-2416 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia 0018479
T17 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension 0005044

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 94-105 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T2 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T3 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T4 180-191 DiseaseOrPhenotypicFeature denotes OMIM 138040 DISEASE
T5 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease D030342
T6 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas C538238
T7 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance DISEASE
T8 538-549 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T9 560-572 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T11 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension D006973
T12 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T13 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T14 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism D003480
T15 2405-2416 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T16 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension D006973

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 94-105 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T2 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T3 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T4 180-191 DiseaseOrPhenotypicFeature denotes OMIM 138040 DISEASE
T5 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease D030342
T6 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas C538238
T7 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance DISEASE
T8 538-549 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T9 560-572 DiseaseOrPhenotypicFeature denotes hypertension D006973
T10 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T11 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension D006973
T12 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T13 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T14 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism D003480
T15 2405-2416 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T16 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension D006973

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 9-23 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T2 119-136 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T3 153-167 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T4 273-287 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T5 330-344 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T6 499-507 ChemicalEntity denotes cortisol D006854|http://purl.obolibrary.org/obo/CHEBI_17650
T8 741-749 ChemicalEntity denotes arginine http://purl.obolibrary.org/obo/CHEBI_32696|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_16467
T11 804-808 ChemicalEntity denotes zinc D015032|http://purl.obolibrary.org/obo/CHEBI_30185|http://purl.obolibrary.org/obo/CHEBI_27363
T14 1344-1358 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T15 1452-1466 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T16 1658-1665 ChemicalEntity denotes emetine D004640|http://purl.obolibrary.org/obo/CHEBI_4781
T18 1778-1795 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T19 1817-1825 ChemicalEntity denotes cortisol D006854|http://purl.obolibrary.org/obo/CHEBI_17650
T21 1851-1868 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T22 1900-1914 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T23 1944-1961 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T24 2011-2030 ChemicalEntity denotes tetrahydrocortisone D013761
T25 2031-2049 ChemicalEntity denotes tetrahydrocortisol D013760|http://purl.obolibrary.org/obo/CHEBI_28320
T27 2096-2110 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T28 2152-2180 ChemicalEntity denotes hydroxysteroid dehydrogenase D006913
T29 2265-2279 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T30 2421-2438 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 2068-2076 OrganismTaxon denotes patients

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T30 2421-2438 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T29 2265-2279 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T28 2152-2180 ChemicalEntity denotes hydroxysteroid dehydrogenase D006913
T27 2096-2110 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T25 2031-2049 ChemicalEntity denotes tetrahydrocortisol http://purl.obolibrary.org/obo/CHEBI_28320|D013760
T24 2011-2030 ChemicalEntity denotes tetrahydrocortisone D013761
T23 1944-1961 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T22 1900-1914 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T21 1851-1868 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T19 1817-1825 ChemicalEntity denotes cortisol http://purl.obolibrary.org/obo/CHEBI_17650|D006854
T18 1778-1795 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T16 1658-1665 ChemicalEntity denotes emetine http://purl.obolibrary.org/obo/CHEBI_4781|D004640
T15 1452-1466 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T14 1344-1358 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T11 804-808 ChemicalEntity denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185|D015032
T8 741-749 ChemicalEntity denotes arginine http://purl.obolibrary.org/obo/CHEBI_16467|http://purl.obolibrary.org/obo/CHEBI_29016|http://purl.obolibrary.org/obo/CHEBI_32696
T6 499-507 ChemicalEntity denotes cortisol http://purl.obolibrary.org/obo/CHEBI_17650|D006854
T5 330-344 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T4 273-287 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T3 153-167 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T2 119-136 ChemicalEntity denotes mineralocorticoid http://purl.obolibrary.org/obo/CHEBI_25354
T1 9-23 ChemicalEntity denotes glucocorticoid http://purl.obolibrary.org/obo/CHEBI_24261
T20 2231-2233 GeneOrGeneProduct denotes GR
T99978 2191-2193 GeneOrGeneProduct denotes GR
T73547 2152-2180 GeneOrGeneProduct denotes hydroxysteroid dehydrogenase
T17 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T29645 1699-1701 GeneOrGeneProduct denotes GR
T76236 1568-1570 GeneOrGeneProduct denotes GR
T58348 1498-1500 GeneOrGeneProduct denotes GR
T13 1381-1386 GeneOrGeneProduct denotes FKBP5
T12 1279-1281 GeneOrGeneProduct denotes GR
T98245 1242-1264 GeneOrGeneProduct denotes transcript and protein
T10 1239-1241 GeneOrGeneProduct denotes GR
T9 1183-1185 GeneOrGeneProduct denotes GR
T27095 911-913 GeneOrGeneProduct denotes GR
T7 904-910 GeneOrGeneProduct denotes 50-kDa
T63528 804-815 GeneOrGeneProduct denotes zinc finger
T30736 724-726 GeneOrGeneProduct denotes GR
T97848 355-357 GeneOrGeneProduct denotes GR
T14530 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T1120 59-64 GeneOrGeneProduct denotes sense
T66518 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T41382 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension D006973
T72536 2405-2416 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T76274 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism D003480
T23037 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T28764 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T27644 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension D006973
T29133 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia D007008
T47769 560-572 DiseaseOrPhenotypicFeature denotes hypertension D006973
T64906 538-549 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T95198 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance DISEASE
T28090 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas C538238
T20121 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease D030342
T56817 180-191 DiseaseOrPhenotypicFeature denotes OMIM 138040 DISEASE
T16260 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance C564221
T10037 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess C537422
T99512 94-105 DiseaseOrPhenotypicFeature denotes hyperplasia D006965
T57818 2068-2076 OrganismTaxon denotes patients
T68074 687-693 SequenceVariant denotes p.R469

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1778-1804 gene:4306 denotes mineralocorticoid receptor
T1 1730-1742 disease:C0020538 denotes hypertension
T2 1778-1804 gene:4306 denotes mineralocorticoid receptor
T3 1900-1925 disease:C1841972 denotes glucocorticoid resistance
R1 T0 T1 associated_with mineralocorticoid receptor,hypertension
R2 T2 T3 associated_with mineralocorticoid receptor,glucocorticoid resistance

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 530-549 HP_0008221 denotes adrenal hyperplasia
T2 560-572 HP_0000822 denotes hypertension
T3 577-588 HP_0002900 denotes hypokalemia
T4 1730-1742 HP_0000822 denotes hypertension
T5 1944-1968 HP_0000859 denotes mineralocorticoid excess
T6 2347-2363 HP_0001578 denotes hypercortisolism
T7 2397-2416 HP_0008221 denotes adrenal hyperplasia
T8 2451-2463 HP_0000822 denotes hypertension

Allie

Id Subject Object Predicate Lexical cue
SS1_21042587_1_0 330-353 expanded denotes glucocorticoid receptor
SS2_21042587_1_0 355-357 abbr denotes GR
AE1_21042587_1_0 SS1_21042587_1_0 SS2_21042587_1_0 abbreviatedTo glucocorticoid receptor,GR

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
21042587-0#9#32#gene2908 9-32 gene2908 denotes glucocorticoid receptor
21042587-0#110#143#diseaseC3887949 110-143 diseaseC3887949 denotes apparent mineralocorticoid excess
21042587-1#185#208#gene2908 330-353 gene2908 denotes glucocorticoid receptor
21042587-1#210#212#gene2908 355-357 gene2908 denotes GR
21042587-1#8#33#diseaseC1841972 153-178 diseaseC1841972 denotes glucocorticoid resistance
21042587-11#21#23#gene2908 2231-2233 gene2908 denotes GR
21042587-11#137#153#diseaseC0001622 2347-2363 diseaseC0001622 denotes hypercortisolism
21042587-11#137#153#diseaseC0010481 2347-2363 diseaseC0010481 denotes hypercortisolism
21042587-11#241#253#diseaseC0020538 2451-2463 diseaseC0020538 denotes hypertension
21042587-8#95#97#gene2908 1498-1500 gene2908 denotes GR
21042587-8#165#167#gene2908 1568-1570 gene2908 denotes GR
21042587-8#74#85#diseaseC3887505 1477-1488 diseaseC3887505 denotes dysfunction
21042587-9#79#105#gene4306 1778-1804 gene4306 denotes mineralocorticoid receptor
21042587-9#31#43#diseaseC0020538 1730-1742 diseaseC0020538 denotes hypertension
21042587-9#201#226#diseaseC1841972 1900-1925 diseaseC1841972 denotes glucocorticoid resistance
9#32#gene2908110#143#diseaseC3887949 21042587-0#9#32#gene2908 21042587-0#110#143#diseaseC3887949 associated_with glucocorticoid receptor,apparent mineralocorticoid excess
185#208#gene29088#33#diseaseC1841972 21042587-1#185#208#gene2908 21042587-1#8#33#diseaseC1841972 associated_with glucocorticoid receptor,glucocorticoid resistance
210#212#gene29088#33#diseaseC1841972 21042587-1#210#212#gene2908 21042587-1#8#33#diseaseC1841972 associated_with GR,glucocorticoid resistance
21#23#gene2908137#153#diseaseC0001622 21042587-11#21#23#gene2908 21042587-11#137#153#diseaseC0001622 associated_with GR,hypercortisolism
21#23#gene2908137#153#diseaseC0010481 21042587-11#21#23#gene2908 21042587-11#137#153#diseaseC0010481 associated_with GR,hypercortisolism
21#23#gene2908241#253#diseaseC0020538 21042587-11#21#23#gene2908 21042587-11#241#253#diseaseC0020538 associated_with GR,hypertension
95#97#gene290874#85#diseaseC3887505 21042587-8#95#97#gene2908 21042587-8#74#85#diseaseC3887505 associated_with GR,dysfunction
165#167#gene290874#85#diseaseC3887505 21042587-8#165#167#gene2908 21042587-8#74#85#diseaseC3887505 associated_with GR,dysfunction
79#105#gene430631#43#diseaseC0020538 21042587-9#79#105#gene4306 21042587-9#31#43#diseaseC0020538 associated_with mineralocorticoid receptor,hypertension
79#105#gene4306201#226#diseaseC1841972 21042587-9#79#105#gene4306 21042587-9#201#226#diseaseC1841972 associated_with mineralocorticoid receptor,glucocorticoid resistance

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 687-698 ProteinMutation:p|SUB|R|469|X denotes p.R469[R,X]

biored-valid

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 153-178 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance
T5 180-191 DiseaseOrPhenotypicFeature denotes OMIM 138040
T6 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease
T7 273-287 ChemicalEntity denotes glucocorticoid
T8 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T9 355-357 GeneOrGeneProduct denotes GR
T10 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T11 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T12 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T13 560-572 DiseaseOrPhenotypicFeature denotes hypertension
T14 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T15 687-698 SequenceVariant denotes p.R469[R,X]
T16 724-726 GeneOrGeneProduct denotes GR
T17 741-789 SequenceVariant denotes arginine (CGA) by a stop (TGA) at amino-acid 469
T18 911-913 GeneOrGeneProduct denotes GR
T19 1183-1185 GeneOrGeneProduct denotes GR
T20 1239-1241 GeneOrGeneProduct denotes GR
T21 1279-1281 GeneOrGeneProduct denotes GR
T22 1344-1358 ChemicalEntity denotes glucocorticoid
T23 1381-1386 GeneOrGeneProduct denotes FKBP5
T24 1452-1466 ChemicalEntity denotes glucocorticoid
T25 1498-1500 GeneOrGeneProduct denotes GR
T26 1568-1570 GeneOrGeneProduct denotes GR
T27 1658-1665 ChemicalEntity denotes emetine
T28 1699-1701 GeneOrGeneProduct denotes GR
T29 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T30 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T31 1817-1825 ChemicalEntity denotes cortisol
T32 1851-1868 ChemicalEntity denotes mineralocorticoid
T33 1900-1925 DiseaseOrPhenotypicFeature denotes glucocorticoid resistance
T34 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T35 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T36 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T37 2068-2076 OrganismTaxon denotes patients
T38 2096-2110 ChemicalEntity denotes glucocorticoid
T39 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T40 2191-2193 GeneOrGeneProduct denotes GR
T41 2231-2233 GeneOrGeneProduct denotes GR
T42 2265-2279 ChemicalEntity denotes glucocorticoid
T43 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism
T44 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T45 2421-2438 ChemicalEntity denotes mineralocorticoid
T46 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension

biored-valid-deepseek-nr-ng

Id Subject Object Predicate Lexical cue
T1 0-8 DiseaseOrPhenotypicFeature denotes Familial
T2 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T3 33-51 DiseaseOrPhenotypicFeature denotes haploinsufficiency
T4 55-84 DiseaseOrPhenotypicFeature denotes non-sense mediated mRNA decay
T5 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T6 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T7 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T8 180-191 DiseaseOrPhenotypicFeature denotes OMIM 138040
T9 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T10 355-357 GeneOrGeneProduct denotes GR
T11 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T12 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T13 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T14 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T15 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T16 656-686 SequenceVariant denotes heterozygous nonsense mutation
T17 687-698 SequenceVariant denotes p.R469[R,X]
T18 724-726 GeneOrGeneProduct denotes GR
T19 741-749 ChemicalEntity denotes arginine
T20 751-754 SequenceVariant denotes CGA
T21 761-765 SequenceVariant denotes stop
T22 767-770 SequenceVariant denotes TGA
T23 823-841 GeneOrGeneProduct denotes DNA-binding domain
T24 849-857 GeneOrGeneProduct denotes receptor
T25 894-903 SequenceVariant denotes truncated
T26 904-913 GeneOrGeneProduct denotes 50-kDa GR
T27 934-954 GeneOrGeneProduct denotes DNA binding capacity
T28 966-1005 DiseaseOrPhenotypicFeature denotes hormone-dependent nuclear translocation
T29 1010-1036 DiseaseOrPhenotypicFeature denotes transactivation properties
T30 1045-1066 CellLine denotes proband's fibroblasts
T31 1123-1139 SequenceVariant denotes defective allele
T32 1175-1190 GeneOrGeneProduct denotes mutated GR mRNA
T33 1229-1252 GeneOrGeneProduct denotes wild type GR transcript
T34 1257-1264 ChemicalEntity denotes protein
T35 1279-1292 GeneOrGeneProduct denotes GR expression
T36 1344-1379 GeneOrGeneProduct denotes glucocorticoid-induced target genes
T37 1381-1386 GeneOrGeneProduct denotes FKBP5
T38 1452-1488 DiseaseOrPhenotypicFeature denotes glucocorticoid signaling dysfunction
T39 1498-1519 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T40 1560-1581 GeneOrGeneProduct denotes mutated GR transcript
T41 1592-1620 DiseaseOrPhenotypicFeature denotes nonsense-mediated mRNA Decay
T42 1674-1697 CellLine denotes propositus' fibroblasts
T43 1699-1701 GeneOrGeneProduct denotes GR
T44 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T45 1772-1804 GeneOrGeneProduct denotes renal mineralocorticoid receptor
T46 1817-1825 ChemicalEntity denotes cortisol
T47 1851-1879 DiseaseOrPhenotypicFeature denotes mineralocorticoid production
T48 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T49 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T50 2003-2055 ChemicalEntity denotes urinary tetrahydrocortisone-tetrahydrocortisol ratio
T51 2088-2122 DiseaseOrPhenotypicFeature denotes reduced glucocorticoid degradation
T52 2126-2187 GeneOrGeneProduct denotes renal activity of the 11β-hydroxysteroid dehydrogenase type 2
T53 2265-2291 DiseaseOrPhenotypicFeature denotes glucocorticoid sensitivity
T54 2312-2363 DiseaseOrPhenotypicFeature denotes novel genetic cause of subclinical hypercortisolism
T55 2365-2416 DiseaseOrPhenotypicFeature denotes incidentally revealed bilateral adrenal hyperplasia
T56 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-deepseek-nr-g

Id Subject Object Predicate Lexical cue
T1 0-51 DiseaseOrPhenotypicFeature denotes Familial glucocorticoid receptor haploinsufficiency
T2 55-84 DiseaseOrPhenotypicFeature denotes non-sense mediated mRNA decay
T3 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T4 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T5 145-192 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance (OMIM 138040)
T6 203-221 DiseaseOrPhenotypicFeature denotes hereditary disease
T7 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T8 355-357 GeneOrGeneProduct denotes GR
T9 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T10 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T11 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T12 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T13 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T14 595-604 DiseaseOrPhenotypicFeature denotes phenotype
T15 656-686 SequenceVariant denotes heterozygous nonsense mutation
T16 687-698 SequenceVariant denotes p.R469[R,X]
T17 724-726 GeneOrGeneProduct denotes GR
T18 741-749 ChemicalEntity denotes arginine
T19 751-754 ChemicalEntity denotes CGA
T20 767-770 ChemicalEntity denotes TGA
T21 775-785 ChemicalEntity denotes amino-acid
T22 823-841 GeneOrGeneProduct denotes DNA-binding domain
T23 904-910 GeneOrGeneProduct denotes 50-kDa
T24 911-913 GeneOrGeneProduct denotes GR
T25 922-929 ChemicalEntity denotes hormone
T26 1183-1185 GeneOrGeneProduct denotes GR
T27 1374-1378 GeneOrGeneProduct denotes gene
T28 1381-1386 GeneOrGeneProduct denotes FKBP5
T29 1498-1500 GeneOrGeneProduct denotes GR
T30 1592-1620 DiseaseOrPhenotypicFeature denotes nonsense-mediated mRNA Decay
T31 1772-1804 GeneOrGeneProduct denotes renal mineralocorticoid receptor
T32 1817-1825 ChemicalEntity denotes cortisol
T33 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T34 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T35 2003-2030 ChemicalEntity denotes urinary tetrahydrocortisone
T36 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T37 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T38 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T39 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T40 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-deepseek-r-ng

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T5 355-357 GeneOrGeneProduct denotes GR
T6 499-507 ChemicalEntity denotes cortisol
T7 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T8 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T9 687-698 SequenceVariant denotes p.R469[R,X]
T10 1055-1066 CellLine denotes fibroblasts
T11 1381-1386 GeneOrGeneProduct denotes FKBP5
T12 1658-1665 ChemicalEntity denotes emetine
T13 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T14 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T15 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T16 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism

biored-valid-deepseek-r-g

Id Subject Object Predicate Lexical cue
T1 0-51 DiseaseOrPhenotypicFeature denotes Familial glucocorticoid receptor haploinsufficiency
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T5 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T6 355-357 GeneOrGeneProduct denotes GR
T7 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T8 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T9 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T10 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T11 687-698 SequenceVariant denotes p.R469[R,X]
T12 1175-1190 GeneOrGeneProduct denotes mutated GR mRNA
T13 1229-1252 GeneOrGeneProduct denotes wild type GR transcript
T14 1381-1386 GeneOrGeneProduct denotes FKBP5
T15 1498-1519 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T16 1658-1665 ChemicalEntity denotes emetine
T17 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T18 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T19 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T20 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T21 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gemini-nr-ng

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 33-51 DiseaseOrPhenotypicFeature denotes haploinsufficiency
T3 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T4 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T5 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T6 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T7 355-357 GeneOrGeneProduct denotes GR
T8 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T9 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T10 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T11 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T12 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T13 687-698 SequenceVariant denotes p.R469[R,X]
T14 724-726 GeneOrGeneProduct denotes GR
T15 741-749 ChemicalEntity denotes arginine
T16 751-754 ChemicalEntity denotes CGA
T17 767-770 ChemicalEntity denotes TGA
T18 911-913 GeneOrGeneProduct denotes GR
T19 1055-1066 CellLine denotes fibroblasts
T20 1183-1185 GeneOrGeneProduct denotes GR
T21 1239-1241 GeneOrGeneProduct denotes GR
T22 1381-1386 GeneOrGeneProduct denotes FKBP5
T23 1390-1401 CellLine denotes fibroblasts
T24 1501-1519 DiseaseOrPhenotypicFeature denotes haploinsufficiency
T25 1658-1665 ChemicalEntity denotes emetine
T26 1699-1701 GeneOrGeneProduct denotes GR
T27 1702-1720 DiseaseOrPhenotypicFeature denotes haploinsufficiency
T28 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T29 1772-1804 GeneOrGeneProduct denotes renal mineralocorticoid receptor
T30 1817-1825 ChemicalEntity denotes cortisol
T31 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T32 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T33 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T34 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T35 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T36 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism
T37 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T38 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gemini-r-g

Id Subject Object Predicate Lexical cue
T1 9-51 DiseaseOrPhenotypicFeature denotes glucocorticoid receptor haploinsufficiency
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T5 256-294 DiseaseOrPhenotypicFeature denotes insensitivity to glucocorticoid action
T6 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T7 355-357 GeneOrGeneProduct denotes GR
T8 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T9 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T10 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T11 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T12 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T13 669-686 SequenceVariant denotes nonsense mutation
T14 687-698 SequenceVariant denotes p.R469[R,X]
T15 724-726 GeneOrGeneProduct denotes GR
T16 751-754 ChemicalEntity denotes CGA
T17 767-770 ChemicalEntity denotes TGA
T18 911-913 GeneOrGeneProduct denotes GR
T19 1055-1066 CellLine denotes fibroblasts
T20 1183-1190 GeneOrGeneProduct denotes GR mRNA
T21 1239-1252 GeneOrGeneProduct denotes GR transcript
T22 1344-1358 ChemicalEntity denotes glucocorticoid
T23 1381-1386 GeneOrGeneProduct denotes FKBP5
T24 1390-1401 CellLine denotes fibroblasts
T25 1498-1519 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T26 1568-1581 GeneOrGeneProduct denotes GR transcript
T27 1658-1665 ChemicalEntity denotes emetine
T28 1686-1697 CellLine denotes fibroblasts
T29 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T30 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T31 1817-1825 ChemicalEntity denotes cortisol
T32 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T33 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T34 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T35 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T36 2096-2110 ChemicalEntity denotes glucocorticoid
T37 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T38 2191-2193 GeneOrGeneProduct denotes GR
T39 2231-2252 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T40 2347-2363 DiseaseOrPhenotypicFeature denotes hypercortisolism
T41 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T42 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gemini-r-ng

Id Subject Object Predicate Lexical cue
T1 9-51 DiseaseOrPhenotypicFeature denotes glucocorticoid receptor haploinsufficiency
T2 74-78 ChemicalEntity denotes mRNA
T3 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T4 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T5 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T6 236-294 DiseaseOrPhenotypicFeature denotes generalized partial insensitivity to glucocorticoid action
T7 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T8 355-357 GeneOrGeneProduct denotes GR
T9 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T10 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T11 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T12 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T13 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T14 656-698 SequenceVariant denotes heterozygous nonsense mutation p.R469[R,X]
T15 724-726 GeneOrGeneProduct denotes GR
T16 741-749 ChemicalEntity denotes arginine
T17 823-826 ChemicalEntity denotes DNA
T18 849-857 GeneOrGeneProduct denotes receptor
T19 911-913 GeneOrGeneProduct denotes GR
T20 922-929 ChemicalEntity denotes hormone
T21 1055-1066 CellLine denotes fibroblasts
T22 1183-1185 GeneOrGeneProduct denotes GR
T23 1186-1190 ChemicalEntity denotes mRNA
T24 1257-1264 GeneOrGeneProduct denotes protein
T25 1279-1281 GeneOrGeneProduct denotes GR
T26 1344-1358 ChemicalEntity denotes glucocorticoid
T27 1381-1386 GeneOrGeneProduct denotes FKBP5
T28 1390-1401 CellLine denotes fibroblasts
T29 1452-1488 DiseaseOrPhenotypicFeature denotes glucocorticoid signaling dysfunction
T30 1498-1519 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T31 1610-1614 ChemicalEntity denotes mRNA
T32 1658-1665 ChemicalEntity denotes emetine
T33 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T34 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T35 1817-1825 ChemicalEntity denotes cortisol
T36 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T37 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T38 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T39 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T40 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T41 2191-2193 GeneOrGeneProduct denotes GR
T42 2231-2252 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T43 2265-2291 DiseaseOrPhenotypicFeature denotes glucocorticoid sensitivity
T44 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T45 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T46 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gpt-nr-ng

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance

biored-valid-gpt-nr-g

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T5 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T6 355-357 GeneOrGeneProduct denotes GR
T7 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T8 499-507 ChemicalEntity denotes cortisol
T9 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T10 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T11 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T12 687-698 SequenceVariant denotes p.R469[R,X]
T13 724-726 GeneOrGeneProduct denotes GR
T14 911-913 GeneOrGeneProduct denotes GR
T15 1183-1185 GeneOrGeneProduct denotes GR
T16 1239-1241 GeneOrGeneProduct denotes GR
T17 1381-1386 GeneOrGeneProduct denotes FKBP5
T18 1498-1500 GeneOrGeneProduct denotes GR
T19 1568-1570 GeneOrGeneProduct denotes GR
T20 1658-1665 ChemicalEntity denotes emetine
T21 1699-1701 GeneOrGeneProduct denotes GR
T22 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T23 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T24 1817-1825 ChemicalEntity denotes cortisol
T25 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T26 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T27 2011-2049 ChemicalEntity denotes tetrahydrocortisone-tetrahydrocortisol
T28 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T29 2191-2193 GeneOrGeneProduct denotes GR
T30 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T31 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T32 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gpt-r-g

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T5 273-287 ChemicalEntity denotes glucocorticoid
T6 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T7 355-357 GeneOrGeneProduct denotes GR
T8 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T9 499-507 ChemicalEntity denotes cortisol
T10 530-549 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T11 560-572 DiseaseOrPhenotypicFeature denotes hypertension
T12 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T13 687-698 SequenceVariant denotes p.R469[R,X]
T14 724-726 GeneOrGeneProduct denotes GR
T15 911-913 GeneOrGeneProduct denotes GR
T16 1183-1190 GeneOrGeneProduct denotes GR mRNA
T17 1239-1241 GeneOrGeneProduct denotes GR
T18 1344-1358 ChemicalEntity denotes glucocorticoid
T19 1381-1386 GeneOrGeneProduct denotes FKBP5
T20 1452-1466 ChemicalEntity denotes glucocorticoid
T21 1498-1500 GeneOrGeneProduct denotes GR
T22 1568-1570 GeneOrGeneProduct denotes GR
T23 1658-1665 ChemicalEntity denotes emetine
T24 1699-1701 GeneOrGeneProduct denotes GR
T25 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T26 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T27 1817-1825 ChemicalEntity denotes cortisol
T28 1851-1868 ChemicalEntity denotes mineralocorticoid
T29 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T30 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T31 2011-2049 ChemicalEntity denotes tetrahydrocortisone-tetrahydrocortisol
T32 2096-2110 ChemicalEntity denotes glucocorticoid
T33 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T34 2191-2193 GeneOrGeneProduct denotes GR
T35 2231-2252 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T36 2265-2279 ChemicalEntity denotes glucocorticoid
T37 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T38 2397-2416 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T39 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gpt-r-ng

Id Subject Object Predicate Lexical cue
T1 0-51 DiseaseOrPhenotypicFeature denotes Familial glucocorticoid receptor haploinsufficiency
T2 74-78 ChemicalEntity denotes mRNA
T3 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T4 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T5 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T6 273-287 ChemicalEntity denotes glucocorticoid
T7 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T8 355-357 GeneOrGeneProduct denotes GR
T9 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T10 499-507 ChemicalEntity denotes cortisol
T11 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T12 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T13 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T14 687-698 SequenceVariant denotes p.R469[R,X]
T15 724-726 GeneOrGeneProduct denotes GR
T16 741-749 ChemicalEntity denotes arginine
T17 804-808 ChemicalEntity denotes zinc
T18 823-826 ChemicalEntity denotes DNA
T19 911-913 GeneOrGeneProduct denotes GR
T20 934-937 ChemicalEntity denotes DNA
T21 1183-1185 GeneOrGeneProduct denotes GR
T22 1186-1190 ChemicalEntity denotes mRNA
T23 1239-1241 GeneOrGeneProduct denotes GR
T24 1344-1358 ChemicalEntity denotes glucocorticoid
T25 1381-1386 GeneOrGeneProduct denotes FKBP5
T26 1452-1466 ChemicalEntity denotes glucocorticoid
T27 1498-1500 GeneOrGeneProduct denotes GR
T28 1568-1570 GeneOrGeneProduct denotes GR
T29 1610-1614 ChemicalEntity denotes mRNA
T30 1658-1665 ChemicalEntity denotes emetine
T31 1699-1701 GeneOrGeneProduct denotes GR
T32 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T33 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T34 1817-1825 ChemicalEntity denotes cortisol
T35 1851-1868 ChemicalEntity denotes mineralocorticoid
T36 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T37 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T38 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T39 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T40 2096-2110 ChemicalEntity denotes glucocorticoid
T41 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T42 2191-2193 GeneOrGeneProduct denotes GR
T43 2265-2279 ChemicalEntity denotes glucocorticoid
T44 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T45 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T46 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gemini-nr-g

Id Subject Object Predicate Lexical cue
T1 9-32 GeneOrGeneProduct denotes glucocorticoid receptor
T2 33-51 DiseaseOrPhenotypicFeature denotes haploinsufficiency
T3 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T4 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T5 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T6 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T7 355-357 GeneOrGeneProduct denotes GR
T8 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T9 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T10 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T11 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T12 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T13 687-698 SequenceVariant denotes p.R469[R,X]
T14 724-726 GeneOrGeneProduct denotes GR
T15 741-749 ChemicalEntity denotes arginine
T16 751-754 ChemicalEntity denotes CGA
T17 767-770 ChemicalEntity denotes TGA
T18 911-913 GeneOrGeneProduct denotes GR
T19 1183-1185 GeneOrGeneProduct denotes GR
T20 1239-1241 GeneOrGeneProduct denotes GR
T21 1279-1281 GeneOrGeneProduct denotes GR
T22 1381-1386 GeneOrGeneProduct denotes FKBP5
T23 1501-1519 DiseaseOrPhenotypicFeature denotes haploinsufficiency
T24 1658-1665 ChemicalEntity denotes emetine
T25 1699-1701 GeneOrGeneProduct denotes GR
T26 1702-1720 DiseaseOrPhenotypicFeature denotes haploinsufficiency
T27 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T28 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T29 1817-1825 ChemicalEntity denotes cortisol
T30 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T31 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T32 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T33 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T34 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T35 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T36 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T37 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-gpt-r-m

Id Subject Object Predicate Lexical cue
T1 9-23 ChemicalEntity denotes glucocorticoid
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T5 273-287 ChemicalEntity denotes glucocorticoid
T6 330-344 ChemicalEntity denotes glucocorticoid
T7 355-357 GeneOrGeneProduct denotes GR
T8 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T9 449-460 OrganismTaxon denotes individuals
T10 499-507 ChemicalEntity denotes cortisol
T11 530-549 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T12 560-572 DiseaseOrPhenotypicFeature denotes hypertension
T13 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T14 687-698 SequenceVariant denotes p.R469[R,X]
T15 724-726 GeneOrGeneProduct denotes GR
T16 911-913 GeneOrGeneProduct denotes GR
T17 1045-1054 OrganismTaxon denotes proband's
T18 1183-1185 GeneOrGeneProduct denotes GR
T19 1239-1241 GeneOrGeneProduct denotes GR
T20 1344-1358 ChemicalEntity denotes glucocorticoid
T21 1381-1386 GeneOrGeneProduct denotes FKBP5
T22 1452-1466 ChemicalEntity denotes glucocorticoid
T23 1498-1500 GeneOrGeneProduct denotes GR
T24 1568-1570 GeneOrGeneProduct denotes GR
T25 1658-1665 ChemicalEntity denotes emetine
T26 1674-1685 OrganismTaxon denotes propositus'
T27 1699-1701 GeneOrGeneProduct denotes GR
T28 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T29 1778-1795 ChemicalEntity denotes mineralocorticoid
T30 1817-1825 ChemicalEntity denotes cortisol
T31 1851-1868 ChemicalEntity denotes mineralocorticoid
T32 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T33 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T34 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T35 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T36 2068-2076 OrganismTaxon denotes patients
T37 2096-2110 ChemicalEntity denotes glucocorticoid
T38 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T39 2191-2193 GeneOrGeneProduct denotes GR
T40 2231-2252 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T41 2265-2279 ChemicalEntity denotes glucocorticoid
T42 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T43 2397-2416 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T44 2421-2438 ChemicalEntity denotes mineralocorticoid
T45 2451-2463 DiseaseOrPhenotypicFeature denotes hypertension

biored-valid-gemini-r-m

Id Subject Object Predicate Lexical cue
T1 0-51 DiseaseOrPhenotypicFeature denotes Familial glucocorticoid receptor haploinsufficiency
T2 74-78 GeneOrGeneProduct denotes mRNA
T3 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T4 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T5 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T6 273-287 ChemicalEntity denotes glucocorticoid
T7 330-353 GeneOrGeneProduct denotes glucocorticoid receptor
T8 355-357 GeneOrGeneProduct denotes GR
T9 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T10 449-460 OrganismTaxon denotes individuals
T11 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T12 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T13 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T14 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T15 669-686 SequenceVariant denotes nonsense mutation
T16 687-698 SequenceVariant denotes p.R469[R,X]
T17 724-726 GeneOrGeneProduct denotes GR
T18 911-913 GeneOrGeneProduct denotes GR
T19 1055-1066 CellLine denotes fibroblasts
T20 1183-1185 GeneOrGeneProduct denotes GR
T21 1186-1190 GeneOrGeneProduct denotes mRNA
T22 1344-1358 ChemicalEntity denotes glucocorticoid
T23 1381-1386 GeneOrGeneProduct denotes FKBP5
T24 1390-1401 CellLine denotes fibroblasts
T25 1498-1519 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T26 1610-1614 GeneOrGeneProduct denotes mRNA
T27 1658-1665 ChemicalEntity denotes emetine
T28 1730-1742 DiseaseOrPhenotypicFeature denotes hypertension
T29 1778-1804 GeneOrGeneProduct denotes mineralocorticoid receptor
T30 1817-1825 ChemicalEntity denotes cortisol
T31 1892-1925 DiseaseOrPhenotypicFeature denotes primary glucocorticoid resistance
T32 1935-1968 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T33 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T34 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T35 2068-2076 OrganismTaxon denotes patients
T36 2096-2110 ChemicalEntity denotes glucocorticoid
T37 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T38 2191-2193 GeneOrGeneProduct denotes GR
T39 2231-2252 DiseaseOrPhenotypicFeature denotes GR haploinsufficiency
T40 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T41 2387-2416 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T42 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension

biored-valid-deepseek-r-m

Id Subject Object Predicate Lexical cue
T1 0-51 DiseaseOrPhenotypicFeature denotes Familial glucocorticoid receptor haploinsufficiency
T2 86-105 DiseaseOrPhenotypicFeature denotes adrenal hyperplasia
T3 110-143 DiseaseOrPhenotypicFeature denotes apparent mineralocorticoid excess
T4 145-178 DiseaseOrPhenotypicFeature denotes Primary glucocorticoid resistance
T5 355-357 GeneOrGeneProduct denotes GR
T6 377-399 DiseaseOrPhenotypicFeature denotes adrenal incidentalomas
T7 499-518 DiseaseOrPhenotypicFeature denotes cortisol resistance
T8 520-549 DiseaseOrPhenotypicFeature denotes bilateral adrenal hyperplasia
T9 551-572 DiseaseOrPhenotypicFeature denotes arterial hypertension
T10 577-588 DiseaseOrPhenotypicFeature denotes hypokalemia
T11 687-698 SequenceVariant denotes p.R469[R,X]
T12 724-726 GeneOrGeneProduct denotes GR
T13 911-913 GeneOrGeneProduct denotes GR
T14 1055-1066 CellLine denotes fibroblasts
T15 1183-1185 GeneOrGeneProduct denotes GR
T16 1381-1386 GeneOrGeneProduct denotes FKBP5
T17 1658-1665 ChemicalEntity denotes emetine
T18 2011-2030 ChemicalEntity denotes tetrahydrocortisone
T19 2031-2049 ChemicalEntity denotes tetrahydrocortisol
T20 2148-2187 GeneOrGeneProduct denotes 11β-hydroxysteroid dehydrogenase type 2
T21 2335-2363 DiseaseOrPhenotypicFeature denotes subclinical hypercortisolism
T22 2421-2463 DiseaseOrPhenotypicFeature denotes mineralocorticoid-independent hypertension