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PubMed:20974637 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-109 Sentence denotes Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.
TextSentencer_T2 110-216 Sentence denotes Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion.
TextSentencer_T3 217-370 Sentence denotes Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways.
TextSentencer_T4 371-564 Sentence denotes The ubiquitous calcium-binding proteins, calmodulin and calmodulin-dependent protein kinase II (CaMKII), have well-established roles in regulated exocytosis in neurons and neuroendocrine cells.
TextSentencer_T5 565-643 Sentence denotes However, their roles in parathyroid cells and PTH secretion are still unclear.
TextSentencer_T6 644-828 Sentence denotes Using reverse transcription-PCR and western blot analysis, we have demonstrated the expression of calmodulin and CaMKII in human normal parathyroid and parathyroid chief cell adenomas.
TextSentencer_T7 829-1033 Sentence denotes Blocking of calmodulin and CaMKII activity by the specific antagonists calmidazolium and KN-62 respectively caused a rise in PTH secretion from parathyroid adenoma cells in spite of increased [Ca(2+)](i).
TextSentencer_T8 1034-1213 Sentence denotes The inhibitory effect of Ca(2+) calmodulin on PTH secretion may be due to the absence of synaptotagmin 1 protein in parathyroid adenomas, as demonstrated by western blot analysis.
TextSentencer_T9 1214-1407 Sentence denotes An increased extracellular calcium level acutely lowered the amount of active phosphorylated CaMKII (pCaMKII) in adenoma cells in vitro, indicating the physiological importance of this pathway.
TextSentencer_T10 1408-1571 Sentence denotes Moreover, a negative correlation between the levels of pCaMKII in parathyroid adenomas and serum calcium was found in 20 patients with primary hyperparathyroidism.
TextSentencer_T11 1572-1745 Sentence denotes Taken together, these results show that calmodulin negatively contributes to the regulation of PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway.
T1 0-109 Sentence denotes Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma.
T2 110-216 Sentence denotes Intracellular calcium ([Ca(2+)](i)) is the most relevant modulator of parathyroid hormone (PTH) secretion.
T3 217-370 Sentence denotes Uniquely, an increase in [Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways.
T4 371-564 Sentence denotes The ubiquitous calcium-binding proteins, calmodulin and calmodulin-dependent protein kinase II (CaMKII), have well-established roles in regulated exocytosis in neurons and neuroendocrine cells.
T5 565-643 Sentence denotes However, their roles in parathyroid cells and PTH secretion are still unclear.
T6 644-828 Sentence denotes Using reverse transcription-PCR and western blot analysis, we have demonstrated the expression of calmodulin and CaMKII in human normal parathyroid and parathyroid chief cell adenomas.
T7 829-1033 Sentence denotes Blocking of calmodulin and CaMKII activity by the specific antagonists calmidazolium and KN-62 respectively caused a rise in PTH secretion from parathyroid adenoma cells in spite of increased [Ca(2+)](i).
T8 1034-1213 Sentence denotes The inhibitory effect of Ca(2+) calmodulin on PTH secretion may be due to the absence of synaptotagmin 1 protein in parathyroid adenomas, as demonstrated by western blot analysis.
T9 1214-1407 Sentence denotes An increased extracellular calcium level acutely lowered the amount of active phosphorylated CaMKII (pCaMKII) in adenoma cells in vitro, indicating the physiological importance of this pathway.
T10 1408-1571 Sentence denotes Moreover, a negative correlation between the levels of pCaMKII in parathyroid adenomas and serum calcium was found in 20 patients with primary hyperparathyroidism.
T11 1572-1745 Sentence denotes Taken together, these results show that calmodulin negatively contributes to the regulation of PTH secretion in parathyroid adenoma, at least partially via a CaMKII pathway.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1612-1622 gene:801 denotes calmodulin
T1 1684-1703 disease:C0262587 denotes parathyroid adenoma
T2 1612-1622 gene:808 denotes calmodulin
T3 1684-1703 disease:C0262587 denotes parathyroid adenoma
T4 1612-1622 gene:805 denotes calmodulin
T5 1684-1703 disease:C0262587 denotes parathyroid adenoma
T6 1667-1670 gene:5741 denotes PTH
T7 1684-1703 disease:C0262587 denotes parathyroid adenoma
R1 T0 T1 associated_with calmodulin,parathyroid adenoma
R2 T2 T3 associated_with calmodulin,parathyroid adenoma
R3 T4 T5 associated_with calmodulin,parathyroid adenoma
R4 T6 T7 associated_with PTH,parathyroid adenoma

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 973-992 HP_0002897 denotes parathyroid adenoma
T2 1150-1170 HP_0002897 denotes parathyroid adenomas
T3 1474-1494 HP_0002897 denotes parathyroid adenomas
T4 1543-1570 HP_0008200 denotes primary hyperparathyroidism
T5 1551-1570 HP_0000843 denotes hyperparathyroidism
T6 1684-1703 HP_0002897 denotes parathyroid adenoma

Allie

Id Subject Object Predicate Lexical cue
SS1_20974637_1_0 180-199 expanded denotes parathyroid hormone
SS2_20974637_1_0 201-204 abbr denotes PTH
SS1_20974637_3_0 427-465 expanded denotes calmodulin-dependent protein kinase II
SS2_20974637_3_0 467-473 abbr denotes CaMKII
SS1_20974637_8_0 1292-1313 expanded denotes phosphorylated CaMKII
SS2_20974637_8_0 1315-1322 abbr denotes pCaMKII
AE1_20974637_1_0 SS1_20974637_1_0 SS2_20974637_1_0 abbreviatedTo parathyroid hormone,PTH
AE1_20974637_3_0 SS1_20974637_3_0 SS2_20974637_3_0 abbreviatedTo calmodulin-dependent protein kinase II,CaMKII
AE1_20974637_8_0 SS1_20974637_8_0 SS2_20974637_8_0 abbreviatedTo phosphorylated CaMKII,pCaMKII

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20974637-0#0#10#gene801 243-422 gene801 denotes Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin
20974637-0#0#10#gene805 243-422 gene805 denotes Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin
20974637-0#0#10#gene808 243-422 gene808 denotes Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin
20974637-0#15#25#gene801 427-437 gene801 denotes calmodulin
20974637-0#15#25#gene805 427-437 gene805 denotes calmodulin
20974637-0#15#25#gene808 427-437 gene808 denotes calmodulin
20974637-0#89#108#diseaseC0262587 1127-1169 diseaseC0262587 denotes ptotagmin 1 protein in parathyroid adenoma
20974637-10#95#98#gene5741 1667-1670 gene5741 denotes PTH
20974637-10#112#131#diseaseC0262587 1684-1703 diseaseC0262587 denotes parathyroid adenoma
20974637-5#98#108#gene801 742-752 gene801 denotes calmodulin
20974637-5#98#108#gene805 742-752 gene805 denotes calmodulin
20974637-5#98#108#gene808 742-752 gene808 denotes calmodulin
20974637-5#175#183#diseaseC0001430 819-827 diseaseC0001430 denotes adenomas
20974637-7#89#104#gene6857 1123-1138 gene6857 denotes synaptotagmin 1
20974637-7#116#136#diseaseC0262587 1150-1170 diseaseC0262587 denotes parathyroid adenomas
0#10#gene80189#108#diseaseC0262587 20974637-0#0#10#gene801 20974637-0#89#108#diseaseC0262587 associated_with "Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin",ptotagmin 1 protein in parathyroid adenoma
0#10#gene80589#108#diseaseC0262587 20974637-0#0#10#gene805 20974637-0#89#108#diseaseC0262587 associated_with "Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin",ptotagmin 1 protein in parathyroid adenoma
0#10#gene80889#108#diseaseC0262587 20974637-0#0#10#gene808 20974637-0#89#108#diseaseC0262587 associated_with "Ca(2+)](i) results in an inhibition of PTH secretion, and it probably exerts its function via calcium-binding protein pathways. The ubiquitous calcium-binding proteins, calmodulin",ptotagmin 1 protein in parathyroid adenoma
15#25#gene80189#108#diseaseC0262587 20974637-0#15#25#gene801 20974637-0#89#108#diseaseC0262587 associated_with calmodulin,ptotagmin 1 protein in parathyroid adenoma
15#25#gene80589#108#diseaseC0262587 20974637-0#15#25#gene805 20974637-0#89#108#diseaseC0262587 associated_with calmodulin,ptotagmin 1 protein in parathyroid adenoma
15#25#gene80889#108#diseaseC0262587 20974637-0#15#25#gene808 20974637-0#89#108#diseaseC0262587 associated_with calmodulin,ptotagmin 1 protein in parathyroid adenoma
95#98#gene5741112#131#diseaseC0262587 20974637-10#95#98#gene5741 20974637-10#112#131#diseaseC0262587 associated_with PTH,parathyroid adenoma
98#108#gene801175#183#diseaseC0001430 20974637-5#98#108#gene801 20974637-5#175#183#diseaseC0001430 associated_with calmodulin,adenomas
98#108#gene805175#183#diseaseC0001430 20974637-5#98#108#gene805 20974637-5#175#183#diseaseC0001430 associated_with calmodulin,adenomas
98#108#gene808175#183#diseaseC0001430 20974637-5#98#108#gene808 20974637-5#175#183#diseaseC0001430 associated_with calmodulin,adenomas
89#104#gene6857116#136#diseaseC0262587 20974637-7#89#104#gene6857 20974637-7#116#136#diseaseC0262587 associated_with synaptotagmin 1,parathyroid adenomas

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1076 0-10 gene:801 denotes Calmodulin
T1077 89-108 disease:C0262587 denotes parathyroid adenoma
T1078 15-25 gene:801 denotes calmodulin
T1079 742-752 gene:801 denotes calmodulin
T1080 819-827 disease:C0001430 denotes adenomas
R1 T1076 T1077 associated_with Calmodulin,parathyroid adenoma
R2 T1076 T1077 associated_with Calmodulin,parathyroid adenoma
R3 T1076 T1077 associated_with Calmodulin,parathyroid adenoma
R4 T1078 T1077 associated_with calmodulin,parathyroid adenoma
R5 T1078 T1077 associated_with calmodulin,parathyroid adenoma
R6 T1078 T1077 associated_with calmodulin,parathyroid adenoma
R7 T1079 T1080 associated_with calmodulin,adenomas
R8 T1079 T1080 associated_with calmodulin,adenomas
R9 T1079 T1080 associated_with calmodulin,adenomas

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1499-1504 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1499-1504 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 531-538 http://purl.obolibrary.org/obo/UBERON_2000602 denotes neurons