PubMed:20973483 / 418-855
Annnotations
LitCoin-entities
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 8201 | 23-53 | ChemicalEntity | denotes | A(2A)/A(1) receptor antagonist | MESH:D058915 |
| 8202 | 198-217 | DiseaseOrPhenotypicFeature | denotes | Parkinson's disease | MESH:D010300 |
| 8203 | 228-233 | OrganismTaxon | denotes | mouse | NCBITaxon:10090 |
| 8204 | 238-241 | OrganismTaxon | denotes | rat | NCBITaxon:10116 |
| 8205 | 252-263 | ChemicalEntity | denotes | haloperidol | MESH:D006220 |
| 8206 | 272-281 | DiseaseOrPhenotypicFeature | denotes | catalepsy | MESH:D002375 |
| 8207 | 283-288 | OrganismTaxon | denotes | mouse | NCBITaxon:10090 |
| 8208 | 298-307 | ChemicalEntity | denotes | reserpine | MESH:D012110 |
| 8209 | 316-324 | DiseaseOrPhenotypicFeature | denotes | akinesia | MESH:D004409 |
| 8210 | 326-329 | OrganismTaxon | denotes | rat | NCBITaxon:10116 |
| 8211 | 330-347 | ChemicalEntity | denotes | 6-hydroxydopamine | MESH:D016627 |
| 8212 | 349-355 | ChemicalEntity | denotes | 6-OHDA | MESH:D016627 |
| 8213 | 400-404 | ChemicalEntity | denotes | MPTP | MESH:D015632 |
| 8214 | 417-422 | OrganismTaxon | denotes | human | NCBITaxon:9606 |
LitCoin-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 0-437 | Sentence | denotes | Compound 1 is a potent A(2A)/A(1) receptor antagonist in vitro (A(2A) K(i) = 4.1 nM; A(1) K(i) = 17.0 nM) that has excellent activity, after oral administration, across a number of animal models of Parkinson's disease including mouse and rat models of haloperidol-induced catalepsy, mouse model of reserpine-induced akinesia, rat 6-hydroxydopamine (6-OHDA) lesion model of drug-induced rotation, and MPTP-treated non-human primate model. |
LitCoin-entities-OrganismTaxon-PD
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 228-233 | OrganismTaxon | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
| T3 | 238-241 | OrganismTaxon | denotes | rat | NCBItxid:10116|NCBItxid:10114 |
| T5 | 283-288 | OrganismTaxon | denotes | mouse | NCBItxid:10090|NCBItxid:10088 |
| T7 | 326-329 | OrganismTaxon | denotes | rat | NCBItxid:10116|NCBItxid:10114 |
| T9 | 417-422 | OrganismTaxon | denotes | human | NCBItxid:9606 |
| T10 | 423-430 | OrganismTaxon | denotes | primate | NCBItxid:9443 |
LitCoin_Mondo
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T3 | 198-217 | DiseaseOrPhenotypicFeature | denotes | Parkinson's disease | 0005180 |
LitCoin-GeneOrGeneProduct-v0
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T9 | 23-30 | GeneOrGeneProduct | denotes | A(2A)/A |
| T10 | 34-42 | GeneOrGeneProduct | denotes | receptor |
| T11 | 43-53 | GeneOrGeneProduct | denotes | antagonist |
| T12 | 81-89 | GeneOrGeneProduct | denotes | nM; A(1) |
| T13 | 125-133 | GeneOrGeneProduct | denotes | activity |
| T14 | 264-271 | GeneOrGeneProduct | denotes | induced |
| T15 | 308-315 | GeneOrGeneProduct | denotes | induced |
| T16 | 357-363 | GeneOrGeneProduct | denotes | lesion |
| T17 | 378-385 | GeneOrGeneProduct | denotes | induced |
| T18 | 400-404 | GeneOrGeneProduct | denotes | MPTP |
LitCoin-GeneOrGeneProduct-v2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T3 | 34-42 | GeneOrGeneProduct | denotes | receptor |
| T4 | 400-404 | GeneOrGeneProduct | denotes | MPTP |
LitCoin-Disease-MeSH
| Id | Subject | Object | Predicate | Lexical cue | originalLabel |
|---|---|---|---|---|---|
| T3 | 198-217 | DiseaseOrPhenotypicFeature | denotes | Parkinson's disease | D010300 |
| T4 | 272-281 | DiseaseOrPhenotypicFeature | denotes | catalepsy | D002375 |
LitCoin-GeneOrGeneProduct-v3
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 400-404 | GeneOrGeneProduct | denotes | MPTP |
LitCoin_Mondo_095
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T3 | 198-217 | DiseaseOrPhenotypicFeature | denotes | Parkinson's disease | 0005180 |
LitCoin-MeSH-Disease-2
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T3 | 198-217 | DiseaseOrPhenotypicFeature | denotes | Parkinson's disease | D010300 |
| T4 | 272-281 | DiseaseOrPhenotypicFeature | denotes | catalepsy | D002375 |
| T5 | 316-324 | DiseaseOrPhenotypicFeature | denotes | akinesia | DISEASE |
LitCoin-NCBITaxon-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 228-233 | OrganismTaxon | denotes | mouse |
| T2 | 238-241 | OrganismTaxon | denotes | rat |
| T3 | 283-288 | OrganismTaxon | denotes | mouse |
| T4 | 326-329 | OrganismTaxon | denotes | rat |
| T5 | 417-422 | OrganismTaxon | denotes | human |
| T6 | 423-430 | OrganismTaxon | denotes | primate |
LitCoin-MONDO_bioort2019
| Id | Subject | Object | Predicate | Lexical cue | #label |
|---|---|---|---|---|---|
| T3 | 198-217 | DiseaseOrPhenotypicFeature | denotes | Parkinson's disease | D010300 |
| T4 | 272-281 | DiseaseOrPhenotypicFeature | denotes | catalepsy | D002375 |
| T5 | 316-324 | DiseaseOrPhenotypicFeature | denotes | akinesia | DISEASE |
LitCoin-Chemical-MeSH-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | ID: |
|---|---|---|---|---|---|
| T3 | 252-263 | ChemicalEntity | denotes | haloperidol | D006220|http://purl.obolibrary.org/obo/CHEBI_5613 |
| T5 | 298-307 | ChemicalEntity | denotes | reserpine | D012110|http://purl.obolibrary.org/obo/CHEBI_28487 |
| T7 | 330-347 | ChemicalEntity | denotes | 6-hydroxydopamine | D016627|http://purl.obolibrary.org/obo/CHEBI_78741 |
| T9 | 349-355 | ChemicalEntity | denotes | 6-OHDA | D016627|http://purl.obolibrary.org/obo/CHEBI_78741 |
| T11 | 400-404 | ChemicalEntity | denotes | MPTP | D015632|http://purl.obolibrary.org/obo/CHEBI_17963 |
LitCoin-training-merged
| Id | Subject | Object | Predicate | Lexical cue | #label | ID: |
|---|---|---|---|---|---|---|
| T11 | 400-404 | ChemicalEntity | denotes | MPTP | http://purl.obolibrary.org/obo/CHEBI_17963|D015632 | |
| T9 | 349-355 | ChemicalEntity | denotes | 6-OHDA | http://purl.obolibrary.org/obo/CHEBI_78741|D016627 | |
| T7 | 330-347 | ChemicalEntity | denotes | 6-hydroxydopamine | http://purl.obolibrary.org/obo/CHEBI_78741|D016627 | |
| T5 | 298-307 | ChemicalEntity | denotes | reserpine | http://purl.obolibrary.org/obo/CHEBI_28487|D012110 | |
| T3 | 252-263 | ChemicalEntity | denotes | haloperidol | http://purl.obolibrary.org/obo/CHEBI_5613|D006220 | |
| T94575 | 400-404 | GeneOrGeneProduct | denotes | MPTP | ||
| T72561 | 316-324 | DiseaseOrPhenotypicFeature | denotes | akinesia | DISEASE | |
| T4 | 272-281 | DiseaseOrPhenotypicFeature | denotes | catalepsy | D002375 | |
| T39398 | 198-217 | DiseaseOrPhenotypicFeature | denotes | Parkinson's disease | D010300 | |
| T6 | 423-430 | OrganismTaxon | denotes | primate | ||
| T2268 | 417-422 | OrganismTaxon | denotes | human | ||
| T91669 | 326-329 | OrganismTaxon | denotes | rat | ||
| T99223 | 283-288 | OrganismTaxon | denotes | mouse | ||
| T36597 | 238-241 | OrganismTaxon | denotes | rat | ||
| T99238 | 228-233 | OrganismTaxon | denotes | mouse |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2 | 198-207 | HP_0001300 | denotes | Parkinson |
| T3 | 316-324 | HP_0002304 | denotes | akinesia |