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PubMed:20973483 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
8197 35-71 ChemicalEntity denotes adenosine A2A/A1 receptor antagonist MESH:D058915
8198 92-111 DiseaseOrPhenotypicFeature denotes Parkinson's disease MESH:D010300
8199 152-192 ChemicalEntity denotes adenosine A(2A)/A(1) receptor antagonist MESH:D058915
8200 221-240 DiseaseOrPhenotypicFeature denotes Parkinson's disease MESH:D010300
8201 441-471 ChemicalEntity denotes A(2A)/A(1) receptor antagonist MESH:D058915
8202 616-635 DiseaseOrPhenotypicFeature denotes Parkinson's disease MESH:D010300
8203 646-651 OrganismTaxon denotes mouse NCBITaxon:10090
8204 656-659 OrganismTaxon denotes rat NCBITaxon:10116
8205 670-681 ChemicalEntity denotes haloperidol MESH:D006220
8206 690-699 DiseaseOrPhenotypicFeature denotes catalepsy MESH:D002375
8207 701-706 OrganismTaxon denotes mouse NCBITaxon:10090
8208 716-725 ChemicalEntity denotes reserpine MESH:D012110
8209 734-742 DiseaseOrPhenotypicFeature denotes akinesia MESH:D004409
8210 744-747 OrganismTaxon denotes rat NCBITaxon:10116
8211 748-765 ChemicalEntity denotes 6-hydroxydopamine MESH:D016627
8212 767-773 ChemicalEntity denotes 6-OHDA MESH:D016627
8213 818-822 ChemicalEntity denotes MPTP MESH:D015632
8214 835-840 OrganismTaxon denotes human NCBITaxon:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-112 Sentence denotes In vivo characterization of a dual adenosine A2A/A1 receptor antagonist in animal models of Parkinson's disease.
T2 113-254 Sentence denotes The in vivo characterization of a dual adenosine A(2A)/A(1) receptor antagonist in several animal models of Parkinson's disease is described.
T3 255-417 Sentence denotes Discovery and scale-up syntheses of compound 1 are described in detail, highlighting optimization steps that increased the overall yield of 1 from 10.0% to 30.5%.
T4 418-855 Sentence denotes Compound 1 is a potent A(2A)/A(1) receptor antagonist in vitro (A(2A) K(i) = 4.1 nM; A(1) K(i) = 17.0 nM) that has excellent activity, after oral administration, across a number of animal models of Parkinson's disease including mouse and rat models of haloperidol-induced catalepsy, mouse model of reserpine-induced akinesia, rat 6-hydroxydopamine (6-OHDA) lesion model of drug-induced rotation, and MPTP-treated non-human primate model.

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 646-651 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T3 656-659 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T5 701-706 OrganismTaxon denotes mouse NCBItxid:10090|NCBItxid:10088
T7 744-747 OrganismTaxon denotes rat NCBItxid:10116|NCBItxid:10114
T9 835-840 OrganismTaxon denotes human NCBItxid:9606
T10 841-848 OrganismTaxon denotes primate NCBItxid:9443

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 92-111 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T2 221-240 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T3 616-635 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 45-48 SequenceVariant denotes A2A

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 49-51 GeneOrGeneProduct denotes A1
T2 52-60 GeneOrGeneProduct denotes receptor
T3 61-71 GeneOrGeneProduct denotes antagonist
T4 162-169 GeneOrGeneProduct denotes A(2A)/A
T5 173-181 GeneOrGeneProduct denotes receptor
T6 182-192 GeneOrGeneProduct denotes antagonist
T7 353-358 GeneOrGeneProduct denotes steps
T8 386-391 GeneOrGeneProduct denotes yield
T9 441-448 GeneOrGeneProduct denotes A(2A)/A
T10 452-460 GeneOrGeneProduct denotes receptor
T11 461-471 GeneOrGeneProduct denotes antagonist
T12 499-507 GeneOrGeneProduct denotes nM; A(1)
T13 543-551 GeneOrGeneProduct denotes activity
T14 682-689 GeneOrGeneProduct denotes induced
T15 726-733 GeneOrGeneProduct denotes induced
T16 775-781 GeneOrGeneProduct denotes lesion
T17 796-803 GeneOrGeneProduct denotes induced
T18 818-822 GeneOrGeneProduct denotes MPTP

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 52-60 GeneOrGeneProduct denotes receptor
T2 173-181 GeneOrGeneProduct denotes receptor
T3 452-460 GeneOrGeneProduct denotes receptor
T4 818-822 GeneOrGeneProduct denotes MPTP

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 92-111 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T2 221-240 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T3 616-635 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T4 690-699 DiseaseOrPhenotypicFeature denotes catalepsy D002375

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 818-822 GeneOrGeneProduct denotes MPTP

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 92-111 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T2 221-240 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180
T3 616-635 DiseaseOrPhenotypicFeature denotes Parkinson's disease 0005180

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 92-111 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T2 221-240 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T3 616-635 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T4 690-699 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 734-742 DiseaseOrPhenotypicFeature denotes akinesia DISEASE

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 646-651 OrganismTaxon denotes mouse
T2 656-659 OrganismTaxon denotes rat
T3 701-706 OrganismTaxon denotes mouse
T4 744-747 OrganismTaxon denotes rat
T5 835-840 OrganismTaxon denotes human
T6 841-848 OrganismTaxon denotes primate

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 92-111 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T2 221-240 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T3 616-635 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T4 690-699 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T5 734-742 DiseaseOrPhenotypicFeature denotes akinesia DISEASE

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 35-71 ChemicalEntity denotes adenosine A2A/A1 receptor antagonist ChemicalEntity
T2 152-161 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T3 670-681 ChemicalEntity denotes haloperidol D006220|http://purl.obolibrary.org/obo/CHEBI_5613
T5 716-725 ChemicalEntity denotes reserpine D012110|http://purl.obolibrary.org/obo/CHEBI_28487
T7 748-765 ChemicalEntity denotes 6-hydroxydopamine D016627|http://purl.obolibrary.org/obo/CHEBI_78741
T9 767-773 ChemicalEntity denotes 6-OHDA D016627|http://purl.obolibrary.org/obo/CHEBI_78741
T11 818-822 ChemicalEntity denotes MPTP D015632|http://purl.obolibrary.org/obo/CHEBI_17963

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T11 818-822 ChemicalEntity denotes MPTP http://purl.obolibrary.org/obo/CHEBI_17963|D015632
T9 767-773 ChemicalEntity denotes 6-OHDA http://purl.obolibrary.org/obo/CHEBI_78741|D016627
T7 748-765 ChemicalEntity denotes 6-hydroxydopamine http://purl.obolibrary.org/obo/CHEBI_78741|D016627
T5 716-725 ChemicalEntity denotes reserpine http://purl.obolibrary.org/obo/CHEBI_28487|D012110
T3 670-681 ChemicalEntity denotes haloperidol http://purl.obolibrary.org/obo/CHEBI_5613|D006220
T2 152-161 ChemicalEntity denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T1 35-71 ChemicalEntity denotes adenosine A2A/A1 receptor antagonist ChemicalEntity
T94575 818-822 GeneOrGeneProduct denotes MPTP
T72561 734-742 DiseaseOrPhenotypicFeature denotes akinesia DISEASE
T4 690-699 DiseaseOrPhenotypicFeature denotes catalepsy D002375
T39398 616-635 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T74617 221-240 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T76672 92-111 DiseaseOrPhenotypicFeature denotes Parkinson's disease D010300
T6 841-848 OrganismTaxon denotes primate
T2268 835-840 OrganismTaxon denotes human
T91669 744-747 OrganismTaxon denotes rat
T99223 701-706 OrganismTaxon denotes mouse
T36597 656-659 OrganismTaxon denotes rat
T99238 646-651 OrganismTaxon denotes mouse
T62420 45-48 SequenceVariant denotes A2A

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 221-230 HP_0001300 denotes Parkinson
T2 616-625 HP_0001300 denotes Parkinson
T3 734-742 HP_0002304 denotes akinesia

bc5cdr-valid-experiment

Id Subject Object Predicate Lexical cue
T1 35-71 Chemical denotes adenosine A2A/A1 receptor antagonist
T2 92-111 Disease denotes Parkinson's disease
T3 152-192 Chemical denotes adenosine A(2A)/A(1) receptor antagonist
T4 221-240 Disease denotes Parkinson's disease
T5 616-635 Disease denotes Parkinson's disease
T6 670-681 Chemical denotes haloperidol
T7 690-699 Disease denotes catalepsy
T8 716-725 Chemical denotes reserpine
T9 734-742 Disease denotes akinesia
T10 748-765 Chemical denotes 6-hydroxydopamine
T11 767-773 Chemical denotes 6-OHDA
T12 818-822 Chemical denotes MPTP