PubMed:20943793 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/20943793","sourcedb":"PubMed","sourceid":"20943793","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/20943793","text":"Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations.\nBACKGROUND: Taste is an important determinant of food consumption, and genetic variations in the sweet taste receptor subunit TAS1R2 may contribute to interindividual variations in sugar consumption.\nOBJECTIVE: We determined whether Ser9Cys and Ile191Val variations in TAS1R2 were associated with differences in the consumption of sugars in 2 populations.\nDESIGN: Population 1 included 1037 diabetes-free young adults in whom we assessed dietary intake by using a 1-mo, 196-item food-frequency questionnaire. Population 2 consisted of 100 individuals with type 2 diabetes with dietary intakes assessed by using 2 sets of 3-d food records administered 2 wk apart. Dietary counseling was provided between food records 1 and 2. Dietary intakes between genotypes were compared by using analysis of covariance adjusted for potential confounders.\nRESULTS: In population 1, a significant Ile191Val × body mass index (BMI; in kg/m²) interaction was detected for the consumption of sugars, and the effect of genotype was significant only in individuals with a BMI ≥ 25 (n = 205). In comparison with individuals homozygous for the Ile allele, Val carriers consumed fewer sugars (122 ± 6 compared with 103 ± 6 g sugar/d, respectively; P = 0.01). Regression estimates that associated BMI with total sugar consumption by Ile/Ile and Val-carrier genotype intersected at a BMI of 23.5. In population 2, Val carriers also consumed less sugar than did individuals with the Ile/Ile genotype (99 ± 6 compared with 83 ± 6 g sugar/d, respectively; P = 0.04) on food record 2, and sugar was the only macronutrient that decreased significantly (-9 ± 4 g sugar/d, P = 0.02) in Val carriers who received dietary counseling.\nCONCLUSION: Our findings show that a genetic variation in TAS1R2 affects habitual consumption of sugars and may contribute to interindividual differences in changing behaviors in response to dietary counseling.","tracks":[{"project":"Allie","denotations":[{"id":"SS1_20943793_11_0","span":{"begin":1037,"end":1052},"obj":"expanded"},{"id":"SS2_20943793_11_0","span":{"begin":1054,"end":1057},"obj":"abbr"}],"relations":[{"id":"AE1_20943793_11_0","pred":"abbreviatedTo","subj":"SS1_20943793_11_0","obj":"SS2_20943793_11_0"}],"attributes":[{"subj":"SS1_20943793_11_0","pred":"source","obj":"Allie"},{"subj":"SS2_20943793_11_0","pred":"source","obj":"Allie"}]},{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":21,"end":27},"obj":"gene:80834"},{"id":"T1","span":{"begin":84,"end":94},"obj":"disease:C0497406"},{"id":"T2","span":{"begin":21,"end":27},"obj":"gene:80834"},{"id":"T3","span":{"begin":99,"end":104},"obj":"disease:C0028754"},{"id":"T4","span":{"begin":29,"end":38},"obj":"gene:80834"},{"id":"T5","span":{"begin":84,"end":94},"obj":"disease:C0497406"},{"id":"T6","span":{"begin":29,"end":38},"obj":"gene:80834"},{"id":"T7","span":{"begin":99,"end":104},"obj":"disease:C0028754"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"attributes":[{"subj":"T0","pred":"source","obj":"DisGeNET"},{"subj":"T1","pred":"source","obj":"DisGeNET"},{"subj":"T2","pred":"source","obj":"DisGeNET"},{"subj":"T3","pred":"source","obj":"DisGeNET"},{"subj":"T4","pred":"source","obj":"DisGeNET"},{"subj":"T5","pred":"source","obj":"DisGeNET"},{"subj":"T6","pred":"source","obj":"DisGeNET"},{"subj":"T7","pred":"source","obj":"DisGeNET"}]},{"project":"DisGeNET5_variant_disease","denotations":[{"id":"20943793-0#29#38#geners35874116","span":{"begin":29,"end":38},"obj":"geners35874116"},{"id":"20943793-0#84#94#diseaseC0497406","span":{"begin":84,"end":94},"obj":"diseaseC0497406"},{"id":"20943793-0#99#104#diseaseC0028754","span":{"begin":99,"end":104},"obj":"diseaseC0028754"}],"relations":[{"id":"29#38#geners3587411684#94#diseaseC0497406","pred":"associated_with","subj":"20943793-0#29#38#geners35874116","obj":"20943793-0#84#94#diseaseC0497406"},{"id":"29#38#geners3587411699#104#diseaseC0028754","pred":"associated_with","subj":"20943793-0#29#38#geners35874116","obj":"20943793-0#99#104#diseaseC0028754"}],"attributes":[{"subj":"20943793-0#29#38#geners35874116","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"20943793-0#84#94#diseaseC0497406","pred":"source","obj":"DisGeNET5_variant_disease"},{"subj":"20943793-0#99#104#diseaseC0028754","pred":"source","obj":"DisGeNET5_variant_disease"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"20943793-0#21#27#gene80834","span":{"begin":21,"end":27},"obj":"gene80834"},{"id":"20943793-0#29#38#gene80834","span":{"begin":29,"end":38},"obj":"gene80834"},{"id":"20943793-0#84#94#diseaseC0497406","span":{"begin":84,"end":94},"obj":"diseaseC0497406"},{"id":"20943793-0#99#104#diseaseC0028754","span":{"begin":99,"end":104},"obj":"diseaseC0028754"},{"id":"20943793-0#84#94#diseaseC0497406","span":{"begin":84,"end":94},"obj":"diseaseC0497406"},{"id":"20943793-0#99#104#diseaseC0028754","span":{"begin":99,"end":104},"obj":"diseaseC0028754"}],"relations":[{"id":"21#27#gene8083484#94#diseaseC0497406","pred":"associated_with","subj":"20943793-0#21#27#gene80834","obj":"20943793-0#84#94#diseaseC0497406"},{"id":"21#27#gene8083499#104#diseaseC0028754","pred":"associated_with","subj":"20943793-0#21#27#gene80834","obj":"20943793-0#99#104#diseaseC0028754"},{"id":"21#27#gene8083484#94#diseaseC0497406","pred":"associated_with","subj":"20943793-0#21#27#gene80834","obj":"20943793-0#84#94#diseaseC0497406"},{"id":"21#27#gene8083499#104#diseaseC0028754","pred":"associated_with","subj":"20943793-0#21#27#gene80834","obj":"20943793-0#99#104#diseaseC0028754"},{"id":"29#38#gene8083484#94#diseaseC0497406","pred":"associated_with","subj":"20943793-0#29#38#gene80834","obj":"20943793-0#84#94#diseaseC0497406"},{"id":"29#38#gene8083499#104#diseaseC0028754","pred":"associated_with","subj":"20943793-0#29#38#gene80834","obj":"20943793-0#99#104#diseaseC0028754"},{"id":"29#38#gene8083484#94#diseaseC0497406","pred":"associated_with","subj":"20943793-0#29#38#gene80834","obj":"20943793-0#84#94#diseaseC0497406"},{"id":"29#38#gene8083499#104#diseaseC0028754","pred":"associated_with","subj":"20943793-0#29#38#gene80834","obj":"20943793-0#99#104#diseaseC0028754"}],"attributes":[{"subj":"20943793-0#21#27#gene80834","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20943793-0#29#38#gene80834","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20943793-0#84#94#diseaseC0497406","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20943793-0#99#104#diseaseC0028754","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20943793-0#84#94#diseaseC0497406","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"20943793-0#99#104#diseaseC0028754","pred":"source","obj":"DisGeNET5_gene_disease"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"Allie","color":"#93d3ec","default":true},{"id":"DisGeNET","color":"#ecea93"},{"id":"DisGeNET5_variant_disease","color":"#d093ec"},{"id":"DisGeNET5_gene_disease","color":"#93ecb6"}]}]}}