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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 588-599 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-79 Sentence denotes DNA methylation and histone H3-K9 modifications contribute to MUC17 expression.
TextSentencer_T2 80-178 Sentence denotes MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract.
TextSentencer_T3 179-312 Sentence denotes It has been suggested that MUC17 expression is correlated with the malignancy potential of pancreatic ductal adenocarcinomas (PDACs).
TextSentencer_T4 313-506 Sentence denotes In the present study, we provided the first report of the MUC17 gene expression through epigenetic regulation such as promoter methylation, histone modification and microRNA (miRNA) expression.
TextSentencer_T5 507-688 Sentence denotes Near the transcriptional start site, the DNA methylation level of MUC17-negative cancer cell lines (e.g. PANC1) was high, whereas that of MUC17-positive cells (e.g. AsPC-1) was low.
TextSentencer_T6 689-776 Sentence denotes Histone H3-K9 (H3-K9) modification status was also closely related to MUC17 expression.
TextSentencer_T7 777-917 Sentence denotes Our results indicate that DNA methylation and histone H3-K9 modification in the 5' flanking region play a critical role in MUC17 expression.
TextSentencer_T8 918-993 Sentence denotes Furthermore, the hypomethylation status was observed in patients with PDAC.
TextSentencer_T9 994-1124 Sentence denotes This indicates that the hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of PDAC.
TextSentencer_T10 1125-1230 Sentence denotes In addition, the result of miRNA microarray analysis showed that five potential miRNA candidates existed.
TextSentencer_T11 1231-1369 Sentence denotes It is also possible that the MUC17 might be post-transcriptionally regulated by miRNA targeting to the 3'-untranslated region of its mRNA.
TextSentencer_T12 1370-1537 Sentence denotes These understandings of the epigenetic changes of MUC17 may be of importance for the diagnosis of carcinogenic risk and the prediction of outcomes for cancer patients.
T1 0-79 Sentence denotes DNA methylation and histone H3-K9 modifications contribute to MUC17 expression.
T2 80-178 Sentence denotes MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract.
T3 179-312 Sentence denotes It has been suggested that MUC17 expression is correlated with the malignancy potential of pancreatic ductal adenocarcinomas (PDACs).
T4 313-506 Sentence denotes In the present study, we provided the first report of the MUC17 gene expression through epigenetic regulation such as promoter methylation, histone modification and microRNA (miRNA) expression.
T5 507-688 Sentence denotes Near the transcriptional start site, the DNA methylation level of MUC17-negative cancer cell lines (e.g. PANC1) was high, whereas that of MUC17-positive cells (e.g. AsPC-1) was low.
T6 689-776 Sentence denotes Histone H3-K9 (H3-K9) modification status was also closely related to MUC17 expression.
T7 777-917 Sentence denotes Our results indicate that DNA methylation and histone H3-K9 modification in the 5' flanking region play a critical role in MUC17 expression.
T8 918-993 Sentence denotes Furthermore, the hypomethylation status was observed in patients with PDAC.
T9 994-1124 Sentence denotes This indicates that the hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of PDAC.
T10 1125-1230 Sentence denotes In addition, the result of miRNA microarray analysis showed that five potential miRNA candidates existed.
T11 1231-1369 Sentence denotes It is also possible that the MUC17 might be post-transcriptionally regulated by miRNA targeting to the 3'-untranslated region of its mRNA.
T12 1370-1537 Sentence denotes These understandings of the epigenetic changes of MUC17 may be of importance for the diagnosis of carcinogenic risk and the prediction of outcomes for cancer patients.
T1 0-79 Sentence denotes DNA methylation and histone H3-K9 modifications contribute to MUC17 expression.
T2 80-178 Sentence denotes MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract.
T3 179-312 Sentence denotes It has been suggested that MUC17 expression is correlated with the malignancy potential of pancreatic ductal adenocarcinomas (PDACs).
T4 313-506 Sentence denotes In the present study, we provided the first report of the MUC17 gene expression through epigenetic regulation such as promoter methylation, histone modification and microRNA (miRNA) expression.
T5 507-688 Sentence denotes Near the transcriptional start site, the DNA methylation level of MUC17-negative cancer cell lines (e.g. PANC1) was high, whereas that of MUC17-positive cells (e.g. AsPC-1) was low.
T6 689-776 Sentence denotes Histone H3-K9 (H3-K9) modification status was also closely related to MUC17 expression.
T7 777-917 Sentence denotes Our results indicate that DNA methylation and histone H3-K9 modification in the 5' flanking region play a critical role in MUC17 expression.
T8 918-993 Sentence denotes Furthermore, the hypomethylation status was observed in patients with PDAC.
T9 994-1124 Sentence denotes This indicates that the hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of PDAC.
T10 1125-1230 Sentence denotes In addition, the result of miRNA microarray analysis showed that five potential miRNA candidates existed.
T11 1231-1369 Sentence denotes It is also possible that the MUC17 might be post-transcriptionally regulated by miRNA targeting to the 3'-untranslated region of its mRNA.
T12 1370-1537 Sentence denotes These understandings of the epigenetic changes of MUC17 may be of importance for the diagnosis of carcinogenic risk and the prediction of outcomes for cancer patients.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 206-211 gene:140453 denotes MUC17
T1 246-256 disease:C1306459 denotes malignancy
T2 206-211 gene:140453 denotes MUC17
T3 246-256 disease:C0006826 denotes malignancy
T4 573-578 gene:140453 denotes MUC17
T5 588-594 disease:C1306459 denotes cancer
T6 573-578 gene:140453 denotes MUC17
T7 588-594 disease:C0006826 denotes cancer
R1 T0 T1 associated_with MUC17,malignancy
R2 T2 T3 associated_with MUC17,malignancy
R3 T4 T5 associated_with MUC17,cancer
R4 T6 T7 associated_with MUC17,cancer

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 588-594 HP_0002664 denotes cancer
T2 1521-1527 HP_0002664 denotes cancer

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 20-27 FMAID:176874 denotes histone
_T2 20-27 FMAID:74413 denotes histone
_T3 20-30 FMAID:198092 denotes histone H3
_T4 20-30 FMAID:84131 denotes histone H3
_T5 28-30 FMAID:198093 denotes H3
_T6 86-98 FMAID:167256 denotes glycoprotein
_T7 86-98 FMAID:62925 denotes glycoprotein
_T8 172-177 FMAID:76739 denotes tract
_T9 172-177 FMAID:183893 denotes tract
_T10 270-287 FMAID:212183 denotes pancreatic ductal
_T11 270-287 FMAID:98476 denotes pancreatic ductal
_T12 270-287 FMAID:207180 denotes pancreatic ductal
_T13 270-287 FMAID:167489 denotes pancreatic ductal
_T14 270-287 FMAID:10419 denotes pancreatic ductal
_T15 270-287 FMAID:167471 denotes pancreatic ductal
_T16 270-287 FMAID:63099 denotes pancreatic ductal
_T17 377-381 FMAID:198663 denotes gene
_T18 453-460 FMAID:74413 denotes histone
_T19 453-460 FMAID:176874 denotes histone
_T20 660-665 FMAID:68646 denotes cells
_T21 660-665 FMAID:169002 denotes cells
_T22 689-696 FMAID:74413 denotes Histone
_T23 689-696 FMAID:176874 denotes Histone
_T24 689-699 FMAID:84131 denotes Histone H3
_T25 689-699 FMAID:198092 denotes Histone H3
_T26 697-699 FMAID:198093 denotes H3
_T27 704-706 FMAID:198093 denotes H3
_T28 823-830 FMAID:74413 denotes histone
_T29 823-830 FMAID:176874 denotes histone
_T30 823-833 FMAID:198092 denotes histone H3
_T31 823-833 FMAID:84131 denotes histone H3
_T32 831-833 FMAID:198093 denotes H3
_T33 860-868 FMAID:104341 denotes flanking

uniprot-human

Id Subject Object Predicate Lexical cue
T1 20-30 http://www.uniprot.org/uniprot/Q6NWP9 denotes histone H3
T2 823-833 http://www.uniprot.org/uniprot/Q6NWP9 denotes histone H3
T3 31-33 http://www.uniprot.org/uniprot/P35527 denotes K9
T4 700-702 http://www.uniprot.org/uniprot/P35527 denotes K9
T5 707-709 http://www.uniprot.org/uniprot/P35527 denotes K9
T6 834-836 http://www.uniprot.org/uniprot/P35527 denotes K9
T7 62-67 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T8 80-85 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T9 206-211 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T10 371-376 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T11 573-578 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T12 645-650 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T13 759-764 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T14 900-905 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T15 1048-1053 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T16 1260-1265 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17
T17 1420-1425 http://www.uniprot.org/uniprot/Q685J3 denotes MUC17

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 31-33 http://www.uniprot.org/uniprot/Q6RHW0 denotes K9
T2 700-702 http://www.uniprot.org/uniprot/Q6RHW0 denotes K9
T3 707-709 http://www.uniprot.org/uniprot/Q6RHW0 denotes K9
T4 834-836 http://www.uniprot.org/uniprot/Q6RHW0 denotes K9

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 588-594 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer
T2 660-665 http://purl.bioontology.org/ontology/STY/T025 denotes cells
T3 748-755 http://purl.bioontology.org/ontology/NCBITAXON/353209 denotes related
T4 1521-1527 http://purl.bioontology.org/ontology/NCBITAXON/6754 denotes cancer

GO-BP

Id Subject Object Predicate Lexical cue
T1 4-15 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T2 440-451 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T3 552-563 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T4 807-818 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T5 4-27 http://purl.obolibrary.org/obo/GO_0016571 denotes methylation and histone
T6 440-460 http://purl.obolibrary.org/obo/GO_0016571 denotes methylation, histone
T7 4-30 http://purl.obolibrary.org/obo/GO_0034729 denotes methylation and histone H3
T8 807-833 http://purl.obolibrary.org/obo/GO_0034729 denotes methylation and histone H3
T9 4-30 http://purl.obolibrary.org/obo/GO_0034972 denotes methylation and histone H3
T10 807-833 http://purl.obolibrary.org/obo/GO_0034972 denotes methylation and histone H3
T11 4-30 http://purl.obolibrary.org/obo/GO_0070734 denotes methylation and histone H3
T12 807-833 http://purl.obolibrary.org/obo/GO_0070734 denotes methylation and histone H3
T13 4-30 http://purl.obolibrary.org/obo/GO_0034971 denotes methylation and histone H3
T14 807-833 http://purl.obolibrary.org/obo/GO_0034971 denotes methylation and histone H3
T15 4-30 http://purl.obolibrary.org/obo/GO_0010452 denotes methylation and histone H3
T16 807-833 http://purl.obolibrary.org/obo/GO_0010452 denotes methylation and histone H3
T17 4-30 http://purl.obolibrary.org/obo/GO_0034970 denotes methylation and histone H3
T18 807-833 http://purl.obolibrary.org/obo/GO_0034970 denotes methylation and histone H3
T19 4-30 http://purl.obolibrary.org/obo/GO_0051568 denotes methylation and histone H3
T20 807-833 http://purl.obolibrary.org/obo/GO_0051568 denotes methylation and histone H3
T21 4-33 http://purl.obolibrary.org/obo/GO_0051567 denotes methylation and histone H3-K9
T22 807-836 http://purl.obolibrary.org/obo/GO_0051567 denotes methylation and histone H3-K9
T23 4-33 http://purl.obolibrary.org/obo/GO_0051570 denotes methylation and histone H3-K9
T24 807-836 http://purl.obolibrary.org/obo/GO_0051570 denotes methylation and histone H3-K9
T25 4-33 http://purl.obolibrary.org/obo/GO_0051573 denotes methylation and histone H3-K9
T26 807-836 http://purl.obolibrary.org/obo/GO_0051573 denotes methylation and histone H3-K9
T27 4-33 http://purl.obolibrary.org/obo/GO_0051574 denotes methylation and histone H3-K9
T28 807-836 http://purl.obolibrary.org/obo/GO_0051574 denotes methylation and histone H3-K9
T29 20-33 http://purl.obolibrary.org/obo/GO_0033169 denotes histone H3-K9
T30 689-702 http://purl.obolibrary.org/obo/GO_0033169 denotes Histone H3-K9
T31 20-33 http://purl.obolibrary.org/obo/GO_1990619 denotes histone H3-K9
T32 689-702 http://purl.obolibrary.org/obo/GO_1990619 denotes Histone H3-K9
T33 20-33 http://purl.obolibrary.org/obo/GO_0036123 denotes histone H3-K9
T34 689-702 http://purl.obolibrary.org/obo/GO_0036123 denotes Histone H3-K9
T35 20-33 http://purl.obolibrary.org/obo/GO_0043970 denotes histone H3-K9
T36 689-702 http://purl.obolibrary.org/obo/GO_0043970 denotes Histone H3-K9
T37 20-33 http://purl.obolibrary.org/obo/GO_0036124 denotes histone H3-K9
T38 689-702 http://purl.obolibrary.org/obo/GO_0036124 denotes Histone H3-K9
T39 20-33 http://purl.obolibrary.org/obo/GO_0061647 denotes histone H3-K9
T40 20-47 http://purl.obolibrary.org/obo/GO_0061647 denotes histone H3-K9 modifications
T41 689-702 http://purl.obolibrary.org/obo/GO_0061647 denotes Histone H3-K9
T42 704-723 http://purl.obolibrary.org/obo/GO_0061647 denotes H3-K9) modification
T43 823-849 http://purl.obolibrary.org/obo/GO_0061647 denotes histone H3-K9 modification
T44 162-171 http://purl.obolibrary.org/obo/GO_0007586 denotes digestive
T45 377-392 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T46 412-422 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T47 1298-1307 http://purl.obolibrary.org/obo/GO_0065007 denotes regulated
T48 453-473 http://purl.obolibrary.org/obo/GO_0016570 denotes histone modification
T49 516-531 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T50 1280-1297 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptionally

GO-CC

Id Subject Object Predicate Lexical cue
T1 104-112 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T2 595-599 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3 660-665 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 162-177 http://purl.obolibrary.org/obo/UBERON_0001555 denotes digestive tract

Allie

Id Subject Object Predicate Lexical cue
SS1_20926598_2_0 270-303 expanded denotes pancreatic ductal adenocarcinomas
SS2_20926598_2_0 305-310 abbr denotes PDACs
SS1_20926598_3_0 478-486 expanded denotes microRNA
SS2_20926598_3_0 488-493 abbr denotes miRNA
AE1_20926598_2_0 SS1_20926598_2_0 SS2_20926598_2_0 abbreviatedTo pancreatic ductal adenocarcinomas,PDACs
AE1_20926598_3_0 SS1_20926598_3_0 SS2_20926598_3_0 abbreviatedTo microRNA,miRNA

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 0-15 http://edamontology.org/topic_3295 denotes DNA methylation
T2 0-15 http://edamontology.org/topic_3171 denotes DNA methylation
T3 20-47 http://edamontology.org/topic_3295 denotes histone H3-K9 modifications
T4 328-333 http://edamontology.org/topic_3678 denotes study
T5 377-392 http://edamontology.org/topic_0203 denotes gene expression
T6 401-411 http://edamontology.org/topic_3295 denotes epigenetic
T7 431-439 http://edamontology.org/topic_0749 denotes promoter
T8 431-439 http://edamontology.org/topic_1312 denotes promoter
T9 431-439 http://edamontology.org/topic_0111 denotes promoter
T10 453-473 http://edamontology.org/topic_3295 denotes histone modification
T11 478-486 http://edamontology.org/topic_0659 denotes microRNA
T12 488-493 http://edamontology.org/topic_0659 denotes miRNA
T13 516-531 http://edamontology.org/topic_0110 denotes transcriptional
T14 516-531 http://edamontology.org/topic_0203 denotes transcriptional
T15 516-531 http://edamontology.org/topic_3308 denotes transcriptional
T16 516-531 http://edamontology.org/topic_3512 denotes transcriptional
T17 548-563 http://edamontology.org/topic_3171 denotes DNA methylation
T18 548-563 http://edamontology.org/topic_3295 denotes DNA methylation
T19 588-594 http://edamontology.org/topic_2640 denotes cancer
T20 803-818 http://edamontology.org/topic_3295 denotes DNA methylation
T21 803-818 http://edamontology.org/topic_3171 denotes DNA methylation
T22 823-849 http://edamontology.org/topic_3295 denotes histone H3-K9 modification
T23 1054-1062 http://edamontology.org/topic_0749 denotes promoter
T24 1054-1062 http://edamontology.org/topic_1312 denotes promoter
T25 1054-1062 http://edamontology.org/topic_0111 denotes promoter
T26 1080-1090 http://edamontology.org/topic_3295 denotes epigenetic
T27 1152-1157 http://edamontology.org/topic_0659 denotes miRNA
T28 1152-1168 http://edamontology.org/topic_3518 denotes miRNA microarray
T29 1152-1168 http://edamontology.org/topic_0200 denotes miRNA microarray
T30 1152-1168 http://edamontology.org/topic_0203 denotes miRNA microarray
T31 1158-1168 http://edamontology.org/topic_3518 denotes microarray
T32 1158-1168 http://edamontology.org/topic_0200 denotes microarray
T33 1205-1210 http://edamontology.org/topic_0659 denotes miRNA
T34 1311-1316 http://edamontology.org/topic_0659 denotes miRNA
T35 1317-1326 http://edamontology.org/topic_0154 denotes targeting
T36 1398-1408 http://edamontology.org/topic_3295 denotes epigenetic
T37 1521-1527 http://edamontology.org/topic_2640 denotes cancer

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 226-236 http://edamontology.org/operation_3465 denotes correlated
T2 357-363 http://edamontology.org/data_2048 denotes report
T3 1158-1177 http://edamontology.org/operation_2500 denotes microarray analysis
T4 1169-1177 http://edamontology.org/operation_2945 denotes analysis
T5 1494-1504 http://edamontology.org/operation_2423 denotes prediction

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 162-177 http://purl.obolibrary.org/obo/UBERON_0001555 denotes digestive tract
PD-UBERON-AE-B_T2 270-287 http://purl.obolibrary.org/obo/UBERON_0007329 denotes pancreatic ductal

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 270-303 Phenotype denotes pancreatic ductal adenocarcinomas HP:0006725
T2 305-310 Phenotype denotes PDACs HP:0006725
T3 588-594 Phenotype denotes cancer HP:0002664
T4 1521-1527 Phenotype denotes cancer HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 270-303 Disease denotes pancreatic ductal adenocarcinomas http://purl.obolibrary.org/obo/MONDO_0005184
T2 305-310 Disease denotes PDACs http://purl.obolibrary.org/obo/MONDO_0005184
T3 588-594 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T4 1521-1527 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 104-112 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 162-177 Body_part denotes digestive tract http://purl.obolibrary.org/obo/UBERON_0001555