PubMed:20864568
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| TextSentencer_T1 | 0-88 | Sentence | denotes | Galectin multimerization and lattice formation are regulated by linker region structure. |
| TextSentencer_T2 | 89-195 | Sentence | denotes | Galectins regulate cellular functions by binding to glycan ligands on cell surface glycoprotein receptors. |
| TextSentencer_T3 | 196-431 | Sentence | denotes | Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical CRDs connected by a linker domain. |
| TextSentencer_T4 | 432-613 | Sentence | denotes | Dimerization of prototype galectins, or both CRDs in tandem-repeat galectins, is typically required for the crosslinking of glycoprotein receptors and subsequent cellular signaling. |
| TextSentencer_T5 | 614-767 | Sentence | denotes | Several studies have found that tandem-repeat galectins are more potent than prototype galectins in triggering many cell responses, including cell death. |
| TextSentencer_T6 | 768-884 | Sentence | denotes | These differences could be due to CRD specificity, the presence or absence of a linker domain between CRDs, or both. |
| TextSentencer_T7 | 885-1264 | Sentence | denotes | To interrogate the basis for the increased potency of tandem-repeat galectins compared with prototype galectins in triggering cell death, we created three tandem-repeat galectin constructs with different linker regions joining identical galectin-1 CRDs, so that any differences we observed would be due to the contribution of the linker region rather than due to CRD specificity. |
| TextSentencer_T8 | 1265-1650 | Sentence | denotes | We found that random-coil or rigid α-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker. |
| TextSentencer_T9 | 1651-1953 | Sentence | denotes | Thus, the increased potency of tandem-repeat galectins compared with prototype galectins is likely due to the ability of the linker domain to permit intermolecular CRD interactions, resulting in the formation of higher-order multimers with increased valency, rather than differences in CRD specificity. |
| T1 | 0-88 | Sentence | denotes | Galectin multimerization and lattice formation are regulated by linker region structure. |
| T2 | 89-195 | Sentence | denotes | Galectins regulate cellular functions by binding to glycan ligands on cell surface glycoprotein receptors. |
| T3 | 196-431 | Sentence | denotes | Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical CRDs connected by a linker domain. |
| T4 | 432-613 | Sentence | denotes | Dimerization of prototype galectins, or both CRDs in tandem-repeat galectins, is typically required for the crosslinking of glycoprotein receptors and subsequent cellular signaling. |
| T5 | 614-767 | Sentence | denotes | Several studies have found that tandem-repeat galectins are more potent than prototype galectins in triggering many cell responses, including cell death. |
| T6 | 768-884 | Sentence | denotes | These differences could be due to CRD specificity, the presence or absence of a linker domain between CRDs, or both. |
| T7 | 885-1264 | Sentence | denotes | To interrogate the basis for the increased potency of tandem-repeat galectins compared with prototype galectins in triggering cell death, we created three tandem-repeat galectin constructs with different linker regions joining identical galectin-1 CRDs, so that any differences we observed would be due to the contribution of the linker region rather than due to CRD specificity. |
| T8 | 1265-1650 | Sentence | denotes | We found that random-coil or rigid α-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker. |
| T9 | 1651-1953 | Sentence | denotes | Thus, the increased potency of tandem-repeat galectins compared with prototype galectins is likely due to the ability of the linker domain to permit intermolecular CRD interactions, resulting in the formation of higher-order multimers with increased valency, rather than differences in CRD specificity. |
| T1 | 0-88 | Sentence | denotes | Galectin multimerization and lattice formation are regulated by linker region structure. |
| T2 | 89-195 | Sentence | denotes | Galectins regulate cellular functions by binding to glycan ligands on cell surface glycoprotein receptors. |
| T3 | 196-431 | Sentence | denotes | Prototype galectins, such as galectin-1, are one carbohydrate recognition domain (CRD) monomers that noncovalently dimerize, whereas tandem-repeat galectins, such as galectin-9, have two non-identical CRDs connected by a linker domain. |
| T4 | 432-613 | Sentence | denotes | Dimerization of prototype galectins, or both CRDs in tandem-repeat galectins, is typically required for the crosslinking of glycoprotein receptors and subsequent cellular signaling. |
| T5 | 614-767 | Sentence | denotes | Several studies have found that tandem-repeat galectins are more potent than prototype galectins in triggering many cell responses, including cell death. |
| T6 | 768-884 | Sentence | denotes | These differences could be due to CRD specificity, the presence or absence of a linker domain between CRDs, or both. |
| T7 | 885-1264 | Sentence | denotes | To interrogate the basis for the increased potency of tandem-repeat galectins compared with prototype galectins in triggering cell death, we created three tandem-repeat galectin constructs with different linker regions joining identical galectin-1 CRDs, so that any differences we observed would be due to the contribution of the linker region rather than due to CRD specificity. |
| T8 | 1265-1650 | Sentence | denotes | We found that random-coil or rigid α-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker. |
| T9 | 1651-1953 | Sentence | denotes | Thus, the increased potency of tandem-repeat galectins compared with prototype galectins is likely due to the ability of the linker domain to permit intermolecular CRD interactions, resulting in the formation of higher-order multimers with increased valency, rather than differences in CRD specificity. |
GlycoBiology-FMA
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| _T1 | 159-171 | FMAID:212684 | denotes | cell surface |
| _T2 | 159-171 | FMAID:200942 | denotes | cell surface |
| _T3 | 164-171 | FMAID:146300 | denotes | surface |
| _T4 | 164-171 | FMAID:50594 | denotes | surface |
| _T5 | 172-184 | FMAID:167256 | denotes | glycoprotein |
| _T6 | 172-184 | FMAID:62925 | denotes | glycoprotein |
| _T7 | 245-257 | FMAID:82737 | denotes | carbohydrate |
| _T8 | 245-257 | FMAID:197276 | denotes | carbohydrate |
| _T9 | 556-568 | FMAID:167256 | denotes | glycoprotein |
| _T10 | 556-568 | FMAID:62925 | denotes | glycoprotein |
| _T11 | 1504-1516 | FMAID:200942 | denotes | cell surface |
| _T12 | 1504-1516 | FMAID:212684 | denotes | cell surface |
| _T13 | 1509-1516 | FMAID:146300 | denotes | surface |
| _T14 | 1509-1516 | FMAID:50594 | denotes | surface |
| _T15 | 1517-1529 | FMAID:167256 | denotes | glycoprotein |
| _T16 | 1517-1529 | FMAID:62925 | denotes | glycoprotein |
| _T17 | 1800-1818 | FMAID:85706 | denotes | intermolecular CRD |
| _T18 | 1800-1818 | FMAID:202234 | denotes | intermolecular CRD |
uniprot-human
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 225-235 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
| T2 | 1122-1132 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
| T3 | 1352-1362 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
| T4 | 1598-1608 | http://www.uniprot.org/uniprot/P09382 | denotes | galectin-1 |
| T5 | 362-372 | http://www.uniprot.org/uniprot/Q9NQ58 | denotes | galectin-9 |
uniprot-mouse
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 225-235 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
| T2 | 1122-1132 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
| T3 | 1352-1362 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
| T4 | 1598-1608 | http://www.uniprot.org/uniprot/P16045 | denotes | galectin-1 |
| T5 | 362-372 | http://www.uniprot.org/uniprot/O08573 | denotes | galectin-9 |
| T6 | 1286-1290 | http://www.uniprot.org/uniprot/Q5SU73 | denotes | coil |
GlycoBiology-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 108-126 | http://purl.bioontology.org/ontology/STY/T043 | denotes | cellular functions |
| T2 | 185-194 | http://purl.bioontology.org/ontology/STY/T192 | denotes | receptors |
| T3 | 383-386 | http://purl.bioontology.org/ontology/NCBITAXON/604139 | denotes | non |
| T4 | 569-578 | http://purl.bioontology.org/ontology/STY/T192 | denotes | receptors |
| T5 | 725-729 | http://purl.bioontology.org/ontology/NCBITAXON/9973 | denotes | many |
| T6 | 1302-1309 | http://purl.bioontology.org/ontology/NCBITAXON/53324 | denotes | helical |
| T7 | 1530-1539 | http://purl.bioontology.org/ontology/STY/T192 | denotes | receptors |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 37-46 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T2 | 1384-1393 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T3 | 1850-1859 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T4 | 37-60 | http://purl.obolibrary.org/obo/GO_0009889 | denotes | formation are regulated |
| T5 | 51-60 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulated |
| T6 | 99-107 | http://purl.obolibrary.org/obo/GO_0065007 | denotes | regulate |
| T7 | 108-116 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T8 | 594-602 | http://purl.obolibrary.org/obo/GO_0007349 | denotes | cellular |
| T9 | 603-612 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T10 | 756-766 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T11 | 1011-1021 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T12 | 1565-1575 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
| T13 | 761-766 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
| T14 | 1016-1021 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
| T15 | 1570-1575 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 130-137 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T2 | 1474-1481 | http://purl.obolibrary.org/obo/GO_0070026 | denotes | binding |
| T3 | 130-137 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T4 | 1474-1481 | http://purl.obolibrary.org/obo/GO_0003680 | denotes | binding |
| T5 | 130-137 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T6 | 1474-1481 | http://purl.obolibrary.org/obo/GO_0017091 | denotes | binding |
| T7 | 130-137 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
| T8 | 1474-1481 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | binding |
| T9 | 148-155 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
| T10 | 1492-1499 | http://purl.obolibrary.org/obo/GO_0005488 | denotes | ligands |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 159-163 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T2 | 730-734 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T3 | 756-760 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T4 | 1011-1015 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T5 | 1504-1508 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T6 | 1565-1569 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T7 | 159-171 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
| T8 | 1504-1516 | http://purl.obolibrary.org/obo/GO_0009986 | denotes | cell surface |
Allie
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| SS1_20864568_2_0 | 245-276 | expanded | denotes | carbohydrate recognition domain |
| SS2_20864568_2_0 | 278-281 | abbr | denotes | CRD |
| AE1_20864568_2_0 | SS1_20864568_2_0 | SS2_20864568_2_0 | abbreviatedTo | carbohydrate recognition domain,CRD |
EDAM-topics
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 245-257 | http://edamontology.org/topic_0152 | denotes | carbohydrate |
| T2 | 622-629 | http://edamontology.org/topic_3678 | denotes | studies |
| T3 | 1800-1831 | http://edamontology.org/topic_0602 | denotes | intermolecular CRD interactions |
| T4 | 1819-1831 | http://edamontology.org/topic_0602 | denotes | interactions |
EDAM-DFO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 37-46 | http://edamontology.org/format_1915 | denotes | formation |
| T2 | 37-46 | http://edamontology.org/operation_0335 | denotes | formation |
| T3 | 78-87 | http://edamontology.org/data_0883 | denotes | structure |
| T4 | 117-126 | http://edamontology.org/operation_0004 | denotes | functions |
| T5 | 258-269 | http://edamontology.org/operation_2423 | denotes | recognition |
| T6 | 1063-1073 | http://edamontology.org/operation_3429 | denotes | constructs |
| T7 | 1384-1393 | http://edamontology.org/format_1915 | denotes | formation |
| T8 | 1384-1393 | http://edamontology.org/operation_0335 | denotes | formation |
| T9 | 1614-1623 | http://edamontology.org/operation_3429 | denotes | construct |
| T10 | 1850-1859 | http://edamontology.org/format_1915 | denotes | formation |
| T11 | 1850-1859 | http://edamontology.org/operation_0335 | denotes | formation |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1294-1299 | HP_0002063 | denotes | rigid |
| T2 | 1637-1642 | HP_0002063 | denotes | rigid |
GlyTouCan-IUPAC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| GlycanIUPAC_T1 | 383-386 | "http://rdf.glycoinfo.org/glycan/G02780QX" | denotes | non |
| GlycanIUPAC_T2 | 383-386 | "http://rdf.glycoinfo.org/glycan/G18425DX" | denotes | non |
| GlycanIUPAC_T3 | 383-386 | "http://rdf.glycoinfo.org/glycan/G18630JE" | denotes | non |
| GlycanIUPAC_T4 | 383-386 | "http://rdf.glycoinfo.org/glycan/G01004IT" | denotes | non |
| GlycanIUPAC_T5 | 383-386 | "http://rdf.glycoinfo.org/glycan/G87301QZ" | denotes | non |
| GlycanIUPAC_T6 | 383-386 | "http://rdf.glycoinfo.org/glycan/G39790GW" | denotes | non |
| GlycanIUPAC_T7 | 383-386 | "http://rdf.glycoinfo.org/glycan/G42928BB" | denotes | non |
| GlycanIUPAC_T8 | 383-386 | "http://rdf.glycoinfo.org/glycan/G51134HC" | denotes | non |
| GlycanIUPAC_T9 | 383-386 | "http://rdf.glycoinfo.org/glycan/G68183GR" | denotes | non |
| GlycanIUPAC_T10 | 383-386 | "http://rdf.glycoinfo.org/glycan/G46883FA" | denotes | non |
| GlycanIUPAC_T11 | 383-386 | "http://rdf.glycoinfo.org/glycan/G54702VY" | denotes | non |
Lectin
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| Lectin_T1 | 0-8 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | Galectin |
| Lectin_T2 | 225-235 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
| Lectin_T3 | 1122-1132 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
| Lectin_T4 | 1352-1362 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
| Lectin_T5 | 1598-1608 | https://acgg.asia/db/lfdb/LfDB0270 | denotes | galectin-1 |
| Lectin_T6 | 225-235 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
| Lectin_T7 | 1122-1132 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
| Lectin_T8 | 1352-1362 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
| Lectin_T9 | 1598-1608 | https://acgg.asia/db/lfdb/LfDB0057 | denotes | galectin-1 |
| Lectin_T10 | 0-8 | https://acgg.asia/db/lfdb/LfDB0272 | denotes | Galectin |
| Lectin_T11 | 0-8 | https://acgg.asia/db/lfdb/LfDB0274 | denotes | Galectin |
| Lectin_T12 | 362-372 | https://acgg.asia/db/lfdb/LfDB0274 | denotes | galectin-9 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 1563-1569 | Body_part | denotes | T cell | http://purl.obolibrary.org/obo/CL_0000084 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1563-1569 | Cell | denotes | T cell | http://purl.obolibrary.org/obo/CL:0000084 |