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PubMed:20857420 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-140 Sentence denotes Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells.
TextSentencer_T2 141-227 Sentence denotes Deep vein thrombosis associated with advanced cancer is known as Trousseau's syndrome.
TextSentencer_T3 228-353 Sentence denotes We hypothesized that thrombin, an activator of protease-activated receptor (PAR)-1 and PAR-4 contributes to tumor metastasis.
TextSentencer_T4 354-647 Sentence denotes In this study, we demonstrated that thrombin and the PAR-1 activating peptide (AP) SFLLRN, but not the PAR-4 AP GYPGKF, induced HIF-1α activities, protein expression, and cell motility in colorectal cancer cells, and these actions were significantly inhibited by the PAR-1 antagonist SCH79797.
TextSentencer_T5 648-826 Sentence denotes Moreover, thrombin-induced HIF-1α activity and cell motility were blocked by inhibiting important mediators of signaling transduction, including the ERK, PI3K, and mTOR pathways.
TextSentencer_T6 827-961 Sentence denotes These results showed that thrombin induced HIF-1α protein expression through PAR-1 and HIF-1α translational de novo protein synthesis.
TextSentencer_T7 962-1051 Sentence denotes Twist can regulate epithelial-mesenchymal transition (EMT) and increase tumor metastasis.
TextSentencer_T8 1052-1233 Sentence denotes However, we observed that thrombin-induced HIF-1α increased Twist mRNA and its protein level was mediated by the modulation of PAR-1 activation and the HIF-1α translational pathway.
TextSentencer_T9 1234-1326 Sentence denotes In addition, Twist could increase N-cadherin but not E-cadherin to promote tumor metastasis.
TextSentencer_T10 1327-1443 Sentence denotes Overexpression of dominant-negative HIF-1α reversed thrombin-mediated Twist and Twist-induced N-cadherin expression.
TextSentencer_T11 1444-1532 Sentence denotes Moreover, siTwist inhibited Twist-induced N-cadherin and Thrombin-induced cell motility.
TextSentencer_T12 1533-1666 Sentence denotes In conclusion, our study showed that thrombin-induced HIF-1α upregulated Twist at the transcriptional level to enhance cell motility.
TextSentencer_T13 1667-1841 Sentence denotes These findings show that thrombin upregulates Twist via HIF-1α to make tumor cells malignant and also establish a link between the coagulation disorder and cancer metastasis.
T1 0-140 Sentence denotes Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells.
T2 141-227 Sentence denotes Deep vein thrombosis associated with advanced cancer is known as Trousseau's syndrome.
T3 228-353 Sentence denotes We hypothesized that thrombin, an activator of protease-activated receptor (PAR)-1 and PAR-4 contributes to tumor metastasis.
T4 354-647 Sentence denotes In this study, we demonstrated that thrombin and the PAR-1 activating peptide (AP) SFLLRN, but not the PAR-4 AP GYPGKF, induced HIF-1α activities, protein expression, and cell motility in colorectal cancer cells, and these actions were significantly inhibited by the PAR-1 antagonist SCH79797.
T5 648-826 Sentence denotes Moreover, thrombin-induced HIF-1α activity and cell motility were blocked by inhibiting important mediators of signaling transduction, including the ERK, PI3K, and mTOR pathways.
T6 827-961 Sentence denotes These results showed that thrombin induced HIF-1α protein expression through PAR-1 and HIF-1α translational de novo protein synthesis.
T7 962-1051 Sentence denotes Twist can regulate epithelial-mesenchymal transition (EMT) and increase tumor metastasis.
T8 1052-1233 Sentence denotes However, we observed that thrombin-induced HIF-1α increased Twist mRNA and its protein level was mediated by the modulation of PAR-1 activation and the HIF-1α translational pathway.
T9 1234-1326 Sentence denotes In addition, Twist could increase N-cadherin but not E-cadherin to promote tumor metastasis.
T10 1327-1443 Sentence denotes Overexpression of dominant-negative HIF-1α reversed thrombin-mediated Twist and Twist-induced N-cadherin expression.
T11 1444-1532 Sentence denotes Moreover, siTwist inhibited Twist-induced N-cadherin and Thrombin-induced cell motility.
T12 1533-1666 Sentence denotes In conclusion, our study showed that thrombin-induced HIF-1α upregulated Twist at the transcriptional level to enhance cell motility.
T13 1667-1841 Sentence denotes These findings show that thrombin upregulates Twist via HIF-1α to make tumor cells malignant and also establish a link between the coagulation disorder and cancer metastasis.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1723-1729 gene:3091 denotes HIF-1α
T1 1798-1818 disease:C0005779 denotes coagulation disorder
T2 1723-1729 gene:3091 denotes HIF-1α
T3 1823-1829 disease:C0006826 denotes cancer
T4 1723-1729 gene:3091 denotes HIF-1α
T5 1823-1829 disease:C1306459 denotes cancer
T6 1723-1729 gene:3091 denotes HIF-1α
T7 1830-1840 disease:C0027627 denotes metastasis
T8 1723-1729 gene:3091 denotes HIF-1α
T9 1830-1840 disease:C2939420 denotes metastasis
R1 T0 T1 associated_with HIF-1α,coagulation disorder
R2 T2 T3 associated_with HIF-1α,cancer
R3 T4 T5 associated_with HIF-1α,cancer
R4 T6 T7 associated_with HIF-1α,metastasis
R5 T8 T9 associated_with HIF-1α,metastasis

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 141-161 HP_0002625 denotes Deep vein thrombosis
T2 187-193 HP_0002664 denotes cancer
T3 336-341 HP_0002664 denotes tumor
T4 553-559 HP_0002664 denotes cancer
T5 1034-1039 HP_0002664 denotes tumor
T6 1309-1314 HP_0002664 denotes tumor
T7 1738-1743 HP_0002664 denotes tumor
T8 1798-1818 HP_0001928 denotes coagulation disorder
T9 1823-1829 HP_0002664 denotes cancer

Allie

Id Subject Object Predicate Lexical cue
SS1_20857420_2_0 275-302 expanded denotes protease-activated receptor
SS2_20857420_2_0 304-307 abbr denotes PAR
SS1_20857420_3_0 413-431 expanded denotes activating peptide
SS2_20857420_3_0 433-435 abbr denotes AP
SS1_20857420_6_0 981-1014 expanded denotes epithelial-mesenchymal transition
SS2_20857420_6_0 1016-1019 abbr denotes EMT
AE1_20857420_2_0 SS1_20857420_2_0 SS2_20857420_2_0 abbreviatedTo protease-activated receptor,PAR
AE1_20857420_3_0 SS1_20857420_3_0 SS2_20857420_3_0 abbreviatedTo activating peptide,AP
AE1_20857420_6_0 SS1_20857420_6_0 SS2_20857420_6_0 abbreviatedTo epithelial-mesenchymal transition,EMT

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20857420-0#63#90#gene3091 63-90 gene3091 denotes hypoxia-inducible factor-1α
20857420-0#116#133#diseaseC0009402 116-133 diseaseC0009402 denotes colorectal cancer
20857420-0#116#133#diseaseC1527249 116-133 diseaseC1527249 denotes colorectal cancer
20857420-12#56#62#gene3091 1723-1729 gene3091 denotes HIF-1α
20857420-12#163#173#diseaseC0027627 1830-1840 diseaseC0027627 denotes metastasis
20857420-12#131#151#diseaseC0005779 1798-1818 diseaseC0005779 denotes coagulation disorder
20857420-2#87#92#gene9002 315-320 gene9002 denotes PAR-4
20857420-2#87#92#gene5074 315-320 gene5074 denotes PAR-4
20857420-2#87#92#gene347745 315-320 gene347745 denotes PAR-4
20857420-2#108#124#diseaseC0027627 336-352 diseaseC0027627 denotes tumor metastasis
20857420-3#53#58#gene2149 407-412 gene2149 denotes PAR-1
20857420-3#53#58#gene2011 407-412 gene2011 denotes PAR-1
20857420-3#53#58#gene8856 407-412 gene8856 denotes PAR-1
20857420-3#53#58#gene145624 407-412 gene145624 denotes PAR-1
20857420-3#53#58#gene79581 407-412 gene79581 denotes PAR-1
20857420-3#188#205#diseaseC0009402 542-559 diseaseC0009402 denotes colorectal cancer
20857420-3#188#205#diseaseC1527249 542-559 diseaseC1527249 denotes colorectal cancer
20857420-3#188#205#diseaseC0009402 542-559 diseaseC0009402 denotes colorectal cancer
20857420-3#188#205#diseaseC1527249 542-559 diseaseC1527249 denotes colorectal cancer
20857420-3#188#205#diseaseC0009402 542-559 diseaseC0009402 denotes colorectal cancer
20857420-3#188#205#diseaseC1527249 542-559 diseaseC1527249 denotes colorectal cancer
20857420-3#188#205#diseaseC0009402 542-559 diseaseC0009402 denotes colorectal cancer
20857420-3#188#205#diseaseC1527249 542-559 diseaseC1527249 denotes colorectal cancer
20857420-3#188#205#diseaseC0009402 542-559 diseaseC0009402 denotes colorectal cancer
20857420-3#188#205#diseaseC1527249 542-559 diseaseC1527249 denotes colorectal cancer
63#90#gene3091116#133#diseaseC0009402 20857420-0#63#90#gene3091 20857420-0#116#133#diseaseC0009402 associated_with hypoxia-inducible factor-1α,colorectal cancer
63#90#gene3091116#133#diseaseC1527249 20857420-0#63#90#gene3091 20857420-0#116#133#diseaseC1527249 associated_with hypoxia-inducible factor-1α,colorectal cancer
56#62#gene3091163#173#diseaseC0027627 20857420-12#56#62#gene3091 20857420-12#163#173#diseaseC0027627 associated_with HIF-1α,metastasis
56#62#gene3091131#151#diseaseC0005779 20857420-12#56#62#gene3091 20857420-12#131#151#diseaseC0005779 associated_with HIF-1α,coagulation disorder
87#92#gene9002108#124#diseaseC0027627 20857420-2#87#92#gene9002 20857420-2#108#124#diseaseC0027627 associated_with PAR-4,tumor metastasis
87#92#gene5074108#124#diseaseC0027627 20857420-2#87#92#gene5074 20857420-2#108#124#diseaseC0027627 associated_with PAR-4,tumor metastasis
87#92#gene347745108#124#diseaseC0027627 20857420-2#87#92#gene347745 20857420-2#108#124#diseaseC0027627 associated_with PAR-4,tumor metastasis
53#58#gene2149188#205#diseaseC0009402 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC1527249 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC0009402 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC1527249 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC0009402 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC1527249 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC0009402 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC1527249 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC0009402 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2149188#205#diseaseC1527249 20857420-3#53#58#gene2149 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC0009402 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC1527249 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC0009402 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC1527249 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC0009402 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC1527249 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC0009402 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC1527249 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC0009402 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene2011188#205#diseaseC1527249 20857420-3#53#58#gene2011 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC0009402 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC1527249 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC0009402 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC1527249 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC0009402 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC1527249 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC0009402 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC1527249 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC0009402 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene8856188#205#diseaseC1527249 20857420-3#53#58#gene8856 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC0009402 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC1527249 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC0009402 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC1527249 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC0009402 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC1527249 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC0009402 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC1527249 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC0009402 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene145624188#205#diseaseC1527249 20857420-3#53#58#gene145624 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC0009402 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC1527249 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC0009402 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC1527249 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC0009402 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC1527249 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC0009402 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC1527249 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC0009402 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC0009402 associated_with PAR-1,colorectal cancer
53#58#gene79581188#205#diseaseC1527249 20857420-3#53#58#gene79581 20857420-3#188#205#diseaseC1527249 associated_with PAR-1,colorectal cancer

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2330 63-90 gene:3091 denotes hypoxia-inducible factor-1α
T2331 116-133 disease:C0009402 denotes colorectal cancer
T2332 315-320 gene:9002 denotes PAR-4
T2333 336-352 disease:C0027627 denotes tumor metastasis
T2334 407-412 gene:2149 denotes PAR-1
T2335 542-559 disease:C0009402 denotes colorectal cancer
R1 T2330 T2331 associated_with hypoxia-inducible factor-1α,colorectal cancer
R2 T2330 T2331 associated_with hypoxia-inducible factor-1α,colorectal cancer
R3 T2332 T2333 associated_with PAR-4,tumor metastasis
R4 T2332 T2333 associated_with PAR-4,tumor metastasis
R5 T2332 T2333 associated_with PAR-4,tumor metastasis
R6 T2334 T2335 associated_with PAR-1,colorectal cancer
R7 T2334 T2335 associated_with PAR-1,colorectal cancer
R8 T2334 T2335 associated_with PAR-1,colorectal cancer
R9 T2334 T2335 associated_with PAR-1,colorectal cancer
R10 T2334 T2335 associated_with PAR-1,colorectal cancer
R11 T2334 T2335 associated_with PAR-1,colorectal cancer
R12 T2334 T2335 associated_with PAR-1,colorectal cancer
R13 T2334 T2335 associated_with PAR-1,colorectal cancer
R14 T2334 T2335 associated_with PAR-1,colorectal cancer
R15 T2334 T2335 associated_with PAR-1,colorectal cancer

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 146-150 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
PD-UBERON-AE-B_T2 992-1003 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 141-150 http://purl.obolibrary.org/obo/UBERON_0035552 denotes Deep vein
PD-UBERON-AE-B_T2 146-150 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
PD-UBERON-AE-B_T3 992-1003 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal