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PubMed:2083253 JSONTXT

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jnlpba-st-training

Id Subject Object Predicate Lexical cue
T1 16-27 protein denotes TCF-1 alpha
T2 31-67 protein denotes T-cell-specific transcription factor
T3 87-124 DNA denotes T-cell receptor C alpha gene enhancer
T4 179-186 cell_type denotes T cells
T5 416-438 protein denotes T-cell-specific factor
T6 440-451 protein denotes TCF-1 alpha
T7 533-554 protein denotes human T-cell receptor
T8 556-559 protein denotes TCR
T9 562-573 protein denotes TCF-1 alpha
T10 643-657 DNA denotes HIV-1 promoter
T11 684-702 DNA denotes TCR alpha enhancer
T12 710-719 DNA denotes promoters
T13 732-737 DNA denotes genes
T14 811-825 DNA denotes TCR alpha gene
T15 833-839 DNA denotes p56lck
T16 844-853 DNA denotes CD3 delta
T17 881-906 DNA denotes TCF-1 alpha binding motif
T18 950-965 DNA denotes human TCR delta
T19 980-988 DNA denotes TCR beta
T20 990-999 DNA denotes enhancers
T21 1104-1115 protein denotes TCF-1 alpha
T22 1153-1174 protein denotes 57- to 53-kD proteins
T23 1208-1240 cell_line denotes mature and immature T-cell lines
T24 1242-1248 cell_line denotes Jurkat
T25 1250-1258 cell_line denotes CCRF-CEM
T26 1271-1285 cell_line denotes mature B cells
T27 1287-1289 cell_line denotes JY
T28 1291-1298 cell_line denotes Namalwa
T29 1303-1332 cell_line denotes nonlymphoid (HeLa) cell lines
T30 1364-1388 DNA denotes TCR alpha control region
T31 1407-1431 DNA denotes TCF-1 alpha binding site
T32 1453-1474 DNA denotes cAMP-response element
T33 1480-1483 DNA denotes CRE
T34 1487-1502 DNA denotes T alpha 1 motif
T35 1512-1524 DNA denotes binding site
T36 1540-1565 protein denotes lymphoid-specific protein
T37 1567-1578 protein denotes TCF-2 alpha
T38 1600-1624 DNA denotes T-cell-specific enhancer
T39 1695-1723 cell_line denotes mature (Jurkat) T-cell lines
T40 1757-1789 cell_line denotes immature (CCRF-CEM) T-cell lines
T41 1807-1831 DNA denotes TCF-1 alpha binding site
T42 1914-1937 DNA denotes tandem enhancer repeats
T43 1943-1967 DNA denotes TCF-1 alpha binding site
T44 1990-1993 protein denotes TCR
T45 2060-2066 cell_line denotes Jurkat
T46 2075-2085 cell_line denotes HeLa cells
T47 2103-2114 protein denotes TCF-1 alpha
T48 2120-2156 protein denotes T-cell-specific transcription factor
T49 2173-2184 protein denotes TCF-1 alpha
T50 2272-2290 DNA denotes TCR alpha enhancer
T51 2342-2363 DNA denotes heterologous promoter
T52 2403-2414 protein denotes TCF-1 alpha
T53 2440-2451 protein denotes TCF-2 alpha
T54 2456-2465 protein denotes T alpha 1
T55 2467-2471 protein denotes CREB
T56 2473-2494 protein denotes transcription factors
T57 2542-2560 DNA denotes TCR alpha enhancer

pubmed-sentences-benchmark

Id Subject Object Predicate Lexical cue
S1 0-155 Sentence denotes Purification of TCF-1 alpha, a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner.
S2 156-392 Sentence denotes The differentiation of T cells into functionally diverse subpopulations is controlled in part, by transcriptional activation and silencing; however, little is known in detail about the proteins that influence this developmental process.
S3 393-561 Sentence denotes We have purified a new T-cell-specific factor, TCF-1 alpha, that is implicated in the activation of genes encoding a major component of the human T-cell receptor (TCR).
S4 562-855 Sentence denotes TCF-1 alpha, originally identified and purified through its binding sites on the HIV-1 promoter, was found to bind to the TCR alpha enhancer and to promoters for several genes expressed at significantly earlier stages of T-cell development than the TCR alpha gene (e.g., p56lck and CD3 delta).
S5 856-1000 Sentence denotes Sequences related to the TCF-1 alpha binding motif (5'-GGCACCCTTTGA-3') are also found in the human TCR delta (and possibly TCR beta) enhancers.
S6 1001-1333 Sentence denotes Southwestern and gel renaturation experiments with the use of purified protein fractions revealed that TCF-1 alpha activity is derived from a family of 57- to 53-kD proteins that are abundantly expressed in mature and immature T-cell lines (Jurkat, CCRF-CEM) and not in mature B cells (JY, Namalwa) or nonlymphoid (HeLa) cell lines.
S7 1334-1633 Sentence denotes A small 95-bp fragment of the TCR alpha control region that contains the TCF-1 alpha binding site juxtaposed between a cAMP-response element (the CRE or T alpha 1 motif) and the binding site for a distinct lymphoid-specific protein (TCF-2 alpha) behaved as a potent T-cell-specific enhancer in vivo.
S8 1634-1790 Sentence denotes Tandem copies of this enhancer functioned synergistically in mature (Jurkat) T-cell lines as well as resting and activated immature (CCRF-CEM) T-cell lines.
S9 1791-1938 Sentence denotes Mutation of the TCF-1 alpha binding site diminished enhancer activity and disrupted the synergism observed in vivo between tandem enhancer repeats.
S10 1939-2157 Sentence denotes The TCF-1 alpha binding site was also required for TCR alpha enhancer activity in transcriptionally active extracts from Jurkat but not HeLa cells, confirming that TCF-1 alpha is a T-cell-specific transcription factor.
S11 2158-2364 Sentence denotes Curiously, the TCF-1 alpha binding element was inactive in vivo when removed from its neighboring elements on the TCR alpha enhancer and positioned in one or more copies upstream of a heterologous promoter.
S12 2365-2561 Sentence denotes Thus, the transcriptional activity of TCF-1 alpha appears to depend on the TCF-2 alpha and T alpha 1 (CREB) transcription factors and the context of its binding site within the TCR alpha enhancer.

genia-medco-coref

Id Subject Object Predicate Lexical cue
C1 16-27 NP denotes TCF-1 alpha
C3 29-67 NP denotes a T-cell-specific transcription factor
C4 68-72 NP denotes that
C5 83-124 NP denotes the T-cell receptor C alpha gene enhancer
C2 29-154 NP denotes a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner
C6 337-349 NP denotes the proteins
C7 350-354 NP denotes that
C8 410-438 NP denotes a new T-cell-specific factor
C9 440-451 NP denotes TCF-1 alpha
C10 453-457 NP denotes that
C11 562-573 NP denotes TCF-1 alpha
C13 618-621 NP denotes its
C12 618-635 NP denotes its binding sites
C14 680-702 NP denotes the TCR alpha enhancer
C15 1141-1174 NP denotes a family of 57- to 53-kD proteins
C16 1175-1179 NP denotes that
C17 1334-1388 NP denotes A small 95-bp fragment of the TCR alpha control region
C18 1389-1393 NP denotes that
C19 1403-1431 NP denotes the TCF-1 alpha binding site
C20 1529-1579 NP denotes a distinct lymphoid-specific protein (TCF-2 alpha)
C21 1591-1624 NP denotes a potent T-cell-specific enhancer
C22 1651-1664 NP denotes this enhancer
C23 1803-1831 NP denotes the TCF-1 alpha binding site
C24 1939-1967 NP denotes The TCF-1 alpha binding site
C25 2103-2114 NP denotes TCF-1 alpha
C26 2118-2156 NP denotes a T-cell-specific transcription factor
C27 2169-2200 NP denotes the TCF-1 alpha binding element
C28 2240-2243 NP denotes its
C29 2268-2290 NP denotes the TCR alpha enhancer
C30 2403-2414 NP denotes TCF-1 alpha
C31 2436-2451 NP denotes the TCF-2 alpha
C33 2514-2517 NP denotes its
C32 2514-2530 NP denotes its binding site
C34 2538-2560 NP denotes the TCR alpha enhancer
R1 C4 C3 coref-relat that,a T-cell-specific transcription factor
R2 C2 C1 coref-appos a T-cell-specific transcription factor that activates the T-cell receptor C alpha gene enhancer in a context-dependent manner,TCF-1 alpha
R3 C7 C6 coref-relat that,the proteins
R4 C8 C3 coref-ident a new T-cell-specific factor,a T-cell-specific transcription factor
R5 C9 C8 coref-appos TCF-1 alpha,a new T-cell-specific factor
R6 C10 C9 coref-relat that,TCF-1 alpha
R7 C11 C9 coref-ident TCF-1 alpha,TCF-1 alpha
R8 C13 C11 coref-pron its,TCF-1 alpha
R9 C14 C5 coref-ident the TCR alpha enhancer,the T-cell receptor C alpha gene enhancer
R10 C16 C15 coref-relat that,a family of 57- to 53-kD proteins
R11 C18 C17 coref-relat that,A small 95-bp fragment of the TCR alpha control region
R12 C19 C12 coref-ident the TCF-1 alpha binding site,its binding sites
R13 C22 C21 coref-ident this enhancer,a potent T-cell-specific enhancer
R14 C23 C19 coref-ident the TCF-1 alpha binding site,the TCF-1 alpha binding site
R15 C24 C23 coref-ident The TCF-1 alpha binding site,the TCF-1 alpha binding site
R16 C25 C11 coref-ident TCF-1 alpha,TCF-1 alpha
R17 C26 C8 coref-ident a T-cell-specific transcription factor,a new T-cell-specific factor
R18 C28 C27 coref-pron its,the TCF-1 alpha binding element
R19 C29 C14 coref-ident the TCR alpha enhancer,the TCR alpha enhancer
R20 C30 C25 coref-ident TCF-1 alpha,TCF-1 alpha
R21 C31 C20 coref-ident the TCF-2 alpha,a distinct lymphoid-specific protein (TCF-2 alpha)
R22 C33 C24 coref-ident its,The TCF-1 alpha binding site
R23 C32 C30 coref-pron its binding site,TCF-1 alpha
R24 C34 C29 coref-ident the TCR alpha enhancer,the TCR alpha enhancer

GENIAcorpus

Id Subject Object Predicate Lexical cue
T1 16-27 protein_molecule denotes TCF-1 alpha
T2 31-67 protein_family_or_group denotes T-cell-specific transcription factor
T3 87-124 DNA_domain_or_region denotes T-cell receptor C alpha gene enhancer
T4 179-186 cell_type denotes T cells
T5 254-280 other_name denotes transcriptional activation
T6 285-294 other_name denotes silencing
T7 370-391 other_name denotes developmental process
T8 416-438 protein_family_or_group denotes T-cell-specific factor
T9 440-451 protein_molecule denotes TCF-1 alpha
T10 533-554 protein_family_or_group denotes human T-cell receptor
T11 556-559 protein_family_or_group denotes TCR
T12 562-573 protein_molecule denotes TCF-1 alpha
T13 643-657 DNA_domain_or_region denotes HIV-1 promoter
T14 684-687 protein_family_or_group denotes TCR
T15 710-719 DNA_domain_or_region denotes promoters
T16 732-737 DNA_family_or_group denotes genes
T17 783-801 other_name denotes T-cell development
T18 811-814 protein_family_or_group denotes TCR
T19 833-839 DNA_domain_or_region denotes p56lck
T20 844-853 DNA_domain_or_region denotes CD3 delta
T21 881-892 protein_molecule denotes TCF-1 alpha
T22 908-926 polynucleotide denotes 5'-GGCACCCTTTGA-3'
T23 950-955 DNA_domain_or_region denotes human
T24 956-959 protein_family_or_group denotes TCR
T25 980-983 protein_family_or_group denotes TCR
T26 990-999 DNA_family_or_group denotes enhancers
T27 1001-1013 other_name denotes Southwestern
T28 1018-1046 other_name denotes gel renaturation experiments
T29 1063-1089 other_name denotes purified protein fractions
T30 1104-1115 protein_molecule denotes TCF-1 alpha
T31 1153-1174 protein_family_or_group denotes 57- to 53-kD proteins
T32 1242-1248 cell_line denotes Jurkat
T33 1250-1258 cell_line denotes CCRF-CEM
T34 1271-1285 cell_line denotes mature B cells
T35 1287-1289 cell_line denotes JY
T36 1291-1298 cell_line denotes Namalwa
T37 1303-1332 cell_line denotes nonlymphoid (HeLa) cell lines
T38 1342-1356 polynucleotide denotes 95-bp fragment
T39 1364-1367 protein_family_or_group denotes TCR
T40 1407-1418 protein_molecule denotes TCF-1 alpha
T41 1453-1474 DNA_domain_or_region denotes cAMP-response element
T42 1480-1483 DNA_domain_or_region denotes CRE
T43 1487-1502 DNA_domain_or_region denotes T alpha 1 motif
T44 1512-1524 DNA_domain_or_region denotes binding site
T45 1540-1565 protein_family_or_group denotes lymphoid-specific protein
T46 1567-1578 protein_molecule denotes TCF-2 alpha
T47 1600-1624 DNA_domain_or_region denotes T-cell-specific enhancer
T48 1695-1723 cell_line denotes mature (Jurkat) T-cell lines
T49 1757-1789 cell_line denotes immature (CCRF-CEM) T-cell lines
T50 1807-1818 protein_molecule denotes TCF-1 alpha
T51 1843-1860 other_name denotes enhancer activity
T52 1914-1937 DNA_domain_or_region denotes tandem enhancer repeats
T53 1943-1954 protein_molecule denotes TCF-1 alpha
T54 1990-1993 protein_family_or_group denotes TCR
T55 2021-2054 other_name denotes transcriptionally active extracts
T56 2060-2066 cell_line denotes Jurkat
T57 2075-2085 cell_line denotes HeLa cells
T58 2103-2114 protein_molecule denotes TCF-1 alpha
T59 2120-2156 protein_family_or_group denotes T-cell-specific transcription factor
T60 2173-2184 protein_molecule denotes TCF-1 alpha
T61 2272-2275 protein_family_or_group denotes TCR
T62 2342-2363 DNA_family_or_group denotes heterologous promoter
T63 2403-2414 protein_molecule denotes TCF-1 alpha
T64 2440-2451 protein_molecule denotes TCF-2 alpha
T65 2456-2465 protein_molecule denotes T alpha 1
T66 2467-2471 protein_molecule denotes CREB
T67 2473-2494 protein_family_or_group denotes transcription factors
T68 2542-2545 protein_family_or_group denotes TCR