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PubMed:20829347 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-170 Sentence denotes Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.
T2 171-258 Sentence denotes Endoplasmic reticulum (ER) stress is a causative factor of inflammatory bowel diseases.
T3 259-440 Sentence denotes ER stress mediators, including CCAAT enhancer-binding protein (C/EBP) homologous protein (CHOP), are elevated in intestinal epithelia from patients with inflammatory bowel diseases.
T4 441-615 Sentence denotes The present study arose from the question of how chemical ER stress and CHOP protein were associated with nuclear factor-κB (NF-κB)-mediated epithelial inflammatory response.
T5 616-801 Sentence denotes In a human intestinal epithelial cell culture model, chemical ER stresses induced proinflammatory cytokine interleukin-8 (IL-8) expression and the nuclear translocation of CHOP protein.
T6 802-965 Sentence denotes CHOP was positively involved in ER-activated IL-8 production and was negatively associated with expression of peroxisome proliferator-activated receptor γ (PPARγ).
T7 966-1072 Sentence denotes ER stress-induced IL-8 production was enhanced by NF-κB activation that was negatively regulated by PPARγ.
T8 1073-1233 Sentence denotes Mechanistically, ER stress-induced CHOP suppressed PPARγ transcription by sequestering C/EBPβ and limiting availability of C/EBPβ binding to the PPARγ promoter.
T9 1234-1430 Sentence denotes Due to the CHOP-mediated regulation of PPARγ action, ER stress can enhance proinflammatory NF-κB activation and maintain an increased level of IL-8 production in human intestinal epithelial cells.
T10 1431-1549 Sentence denotes In contrast, PPARγ was a counteracting regulator of gut inflammatory response through attenuation of NF-κB activation.
T11 1550-1796 Sentence denotes The collective results support the view that balances between CHOP and PPARγ are crucial for epithelial homeostasis, and disruption of these balances in mucosal ER stress can etiologically affect the progress of human inflammatory bowel diseases.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 372-382 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T2 627-637 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T3 1402-1412 http://purl.obolibrary.org/obo/MAT_0000043 denotes intestinal
T4 1483-1486 http://purl.obolibrary.org/obo/MAT_0000043 denotes gut

Allie

Id Subject Object Predicate Lexical cue
SS1_20829347_1_0 324-624 expanded denotes EBP) homologous protein (CHOP), are elevated in intestinal epithelia from patients with inflammatory bowel diseases. The present study arose from the question of how chemical ER stress and CHOP protein were associated with nuclear factor-κB (NF-κB)-mediated epithelial inflammatory response. In a hum
SS2_20829347_1_0 834-836 abbr denotes ER
SS1_20829347_2_0 290-320 expanded denotes CCAAT enhancer-binding protein
SS2_20829347_2_0 322-327 abbr denotes C/EBP
SS1_20829347_3_0 547-564 expanded denotes nuclear factor-κB
SS2_20829347_3_0 566-571 abbr denotes NF-κB
SS1_20829347_4_0 723-736 expanded denotes interleukin-8
SS2_20829347_4_0 738-742 abbr denotes IL-8
SS1_20829347_5_0 912-956 expanded denotes peroxisome proliferator-activated receptor γ
SS2_20829347_5_0 958-963 abbr denotes PPARγ
AE1_20829347_1_0 SS1_20829347_1_0 SS2_20829347_1_0 abbreviatedTo "EBP) homologous protein (CHOP), are elevated in intestinal epithelia from patients with inflammatory bowel diseases. The present study arose from the question of how chemical ER stress and CHOP protein were associated with nuclear factor-κB (NF-κB)-mediated epithelial inflammatory response. In a hum",ER
AE1_20829347_2_0 SS1_20829347_2_0 SS2_20829347_2_0 abbreviatedTo CCAAT enhancer-binding protein,C/EBP
AE1_20829347_3_0 SS1_20829347_3_0 SS2_20829347_3_0 abbreviatedTo nuclear factor-κB,NF-κB
AE1_20829347_4_0 SS1_20829347_4_0 SS2_20829347_4_0 abbreviatedTo interleukin-8,IL-8
AE1_20829347_5_0 SS1_20829347_5_0 SS2_20829347_5_0 abbreviatedTo peroxisome proliferator-activated receptor γ,PPARγ

LocText

Id Subject Object Predicate Lexical cue
T1 0-21 go:GO:0005783 denotes Endoplasmic reticulum
T2 73-80 go:GO:0005634 denotes nuclear
T3 121-169 uniprot:P37231 denotes peroxisome proliferator-activated receptor gamma
T4 171-192 go:GO:0005783 denotes Endoplasmic reticulum
T5 194-196 go:GO:0005783 denotes ER
T6 259-261 go:GO:0005783 denotes ER
T7 349-353 uniprot:P35638 denotes CHOP
T8 499-501 go:GO:0005783 denotes ER
T9 513-517 uniprot:P35638 denotes CHOP
T10 547-554 go:GO:0005634 denotes nuclear
T11 621-626 taxonomy:9606 denotes human
T12 678-680 go:GO:0005783 denotes ER
T13 723-736 uniprot:P10145 denotes interleukin-8
T14 738-742 uniprot:P10145 denotes IL-8
T15 763-770 go:GO:0005634 denotes nuclear
T16 788-792 uniprot:P35638 denotes CHOP
T17 802-806 uniprot:P35638 denotes CHOP
T18 834-836 go:GO:0005783 denotes ER
T19 847-851 uniprot:P10145 denotes IL-8
T20 912-956 uniprot:P37231 denotes peroxisome proliferator-activated receptor γ
T21 958-963 uniprot:P37231 denotes PPARγ
T22 966-968 go:GO:0005783 denotes ER
T23 984-988 uniprot:P10145 denotes IL-8
T24 1066-1071 uniprot:P37231 denotes PPARγ
T25 1090-1092 go:GO:0005783 denotes ER
T26 1108-1112 uniprot:P35638 denotes CHOP
T27 1124-1129 uniprot:P37231 denotes PPARγ
T28 1160-1166 uniprot:P17676 denotes C/EBPβ
T29 1196-1202 uniprot:P17676 denotes C/EBPβ
T30 1218-1223 uniprot:P37231 denotes PPARγ
T31 1245-1249 uniprot:P35638 denotes CHOP
T32 1273-1278 uniprot:P37231 denotes PPARγ
T33 1287-1289 go:GO:0005783 denotes ER
T34 1377-1381 uniprot:P10145 denotes IL-8
T35 1396-1401 taxonomy:9606 denotes human
T36 1444-1449 uniprot:P37231 denotes PPARγ
T37 1612-1616 uniprot:P35638 denotes CHOP
T38 1621-1626 uniprot:P37231 denotes PPARγ
T39 1711-1713 go:GO:0005783 denotes ER
T40 1762-1767 taxonomy:9606 denotes human
R1 T16 T15 localizeTo CHOP,nuclear
R2 T28 T15 localizeTo C/EBPβ,nuclear

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 230-257 Phenotype denotes inflammatory bowel diseases HP:0002037
T2 412-439 Phenotype denotes inflammatory bowel diseases HP:0002037
T3 1768-1795 Phenotype denotes inflammatory bowel diseases HP:0002037

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 230-257 Disease denotes inflammatory bowel diseases http://purl.obolibrary.org/obo/MONDO_0005265
T2 412-439 Disease denotes inflammatory bowel diseases http://purl.obolibrary.org/obo/MONDO_0005265
T3 1768-1795 Disease denotes inflammatory bowel diseases http://purl.obolibrary.org/obo/MONDO_0005265

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 621-626 OrganismTaxon denotes human 9606
T2 1396-1401 OrganismTaxon denotes human 9606
T3 1762-1767 OrganismTaxon denotes human 9606

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 372-382 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T2 627-637 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T3 1402-1412 Body_part denotes intestinal http://purl.obolibrary.org/obo/MAT_0000043
T4 1483-1486 Body_part denotes gut http://purl.obolibrary.org/obo/MAT_0000043

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 12-21 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T2 183-192 Body_part denotes reticulum http://purl.obolibrary.org/obo/UBERON_0007361
T3 243-248 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T4 425-430 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160
T5 627-653 Body_part denotes intestinal epithelial cell http://purl.obolibrary.org/obo/CL_0002563
T6 1402-1429 Body_part denotes intestinal epithelial cells http://purl.obolibrary.org/obo/CL_0002563
T7 1483-1486 Body_part denotes gut http://purl.obolibrary.org/obo/UBERON_0001007|http://purl.obolibrary.org/obo/UBERON_0001555|http://purl.obolibrary.org/obo/UBERON_0004907
T10 1781-1786 Body_part denotes bowel http://purl.obolibrary.org/obo/UBERON_0000160

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 627-653 Cell denotes intestinal epithelial cell http://purl.obolibrary.org/obo/CL:0002563
T2 638-653 Cell denotes epithelial cell http://purl.obolibrary.org/obo/CL:0000066
T3 1402-1429 Cell denotes intestinal epithelial cells http://purl.obolibrary.org/obo/CL:0002563