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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 170-296 DRI_Background denotes Blood-brain barrier (BBB) breakdown after stroke is linked to the up-regulation of metalloproteinases (MMPs) and inflammation.
T2 297-485 DRI_Approach denotes This study examines the effects of progesterone (PROG) and its neuroactive metabolite allopregnanolone (ALLO) on BBB integrity following permanent middle cerebral artery occlusion (pMCAO).
T3 486-821 DRI_Background denotes Rats underwent pMCAO by electro-coagulation and received intraperitoneal injections of PROG (8 mg/kg), ALLO (8 mg/kg) or vehicle at 1 h post-occlusion and then subcutaneous injections (8 mg/kg) at 6, 24, and 48 h. MMP activation and expression were analyzed by Western blot, immunohistochemistry and gelatin zymography 72 h post-pMCAO.
T4 957-1083 DRI_Background denotes BBB permeability was measured by Evans blue extravasation and infarct size was evaluated by cresyl violet at 72 h after pMCAO.
T5 1084-1230 DRI_Approach denotes Ischemic injury significantly (p<0.05) increased the expression of MMP-9, MMP-2, TNF-α and IL-6, and reduced the levels of occludin1 and claudin5.
T6 1231-1391 DRI_Approach denotes These changes were followed by increased infarct size (% contralateral hemisphere) and Evans blue extravasation into the brain indicating compromise of the BBB.
T7 1392-1572 DRI_Approach denotes PROG and ALLO attenuated BBB disruption and infarct size following pMCAO by reducing MMPs and the inflammatory response and by preventing the degradation of occludin1 and claudin5.
T8 1573-1655 DRI_Approach denotes We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO.

c_corpus

Id Subject Object Predicate Lexical cue
T2 0-12 8727 denotes Progesterone
T1 0-12 D011374 denotes Progesterone
T3 0-12 CHEBI:17026 denotes Progesterone
T4 0-12 D011374 denotes Progesterone
T5 17-33 CHEBI:50169 denotes allopregnanolone
T6 17-33 D011280 denotes allopregnanolone
T7 17-33 D011280 denotes allopregnanolone
T8 44-63 UBERON:0000120 denotes blood-brain barrier
T11 102-110 D007511 denotes ischemia
T12 102-110 D007511 denotes ischemia
T13 143-149 UBERON:0027368 denotes matrix
T14 143-168 D020782 denotes matrix metalloproteinases
T16 176-181 UBERON:6110636 denotes brain
T17 176-181 UBERON:0000955 denotes brain
T18 191-194 UBERON:0000120 denotes BBB
T19 196-205 GO:0009056 denotes breakdown
T20 239-249 GO:0065007 denotes regulation
T21 253-271 D045726 denotes metalloproteinases
T22 273-277 D020782 denotes MMPs
T23 283-295 GO:0006954 denotes inflammation
T24 283-295 D007249 denotes inflammation
T25 283-295 D007249 denotes inflammation
T27 332-344 8727 denotes progesterone
T26 332-344 D011374 denotes progesterone
T28 332-344 CHEBI:17026 denotes progesterone
T29 332-344 D011374 denotes progesterone
T30 346-350 Q07162 denotes PROG
T31 372-382 CHEBI:25212 denotes metabolite
T32 383-399 CHEBI:50169 denotes allopregnanolone
T33 383-399 D011280 denotes allopregnanolone
T34 383-399 D011280 denotes allopregnanolone
T35 410-413 UBERON:0000120 denotes BBB
T36 444-466 UBERON:0001627 denotes middle cerebral artery
T37 444-476 D020244 denotes middle cerebral artery occlusion
T38 444-476 D020244 denotes middle cerebral artery occlusion
T43 486-490 10118 denotes Rats
T44 486-490 10116 denotes Rats
T45 486-490 D051381 denotes Rats
T46 518-529 GO:0050817 denotes coagulation
T47 573-577 Q07162 denotes PROG
T79 700-703 PR:O04529 denotes MMP
T77 700-703 CHEBI:340824 denotes MMP
T80 700-703 CHEBI:59761 denotes MMP
T78 700-703 GO:0004235 denotes MMP
T81 786-793 4716 denotes gelatin
T82 786-793 D005780 denotes gelatin
T83 786-793 CHEBI:5291 denotes gelatin
T85 822-830 Q91049 denotes Occludin
T86 822-830 Q6P6T5 denotes Occludin
T87 822-830 Q9PUN1 denotes Occludin
T88 822-830 Q16625 denotes Occludin
T89 822-830 PR:000002207 denotes Occludin
T90 822-830 Q61146 denotes Occludin
T91 822-830 Q28269 denotes Occludin
T92 822-830 Q28793 denotes Occludin
T93 822-830 Q5RFS5 denotes Occludin
T84 822-830 D062793 denotes Occludin
T94 833-841 Q9JKD6 denotes claudin5
T95 833-841 O00501 denotes claudin5
T96 833-841 PR:000005553 denotes claudin5
T97 833-841 Q2HJ22 denotes claudin5
T99 833-841 O54942 denotes claudin5
T98 833-841 D062507 denotes claudin5
T100 843-848 D009369 denotes tumor
T101 843-848 D009369 denotes tumor
T133 843-864 GO:0005164 denotes tumor necrosis factor
T143 843-870 PR:000000134 denotes tumor necrosis factor-alpha
T142 843-870 D014409 denotes tumor necrosis factor-alpha
T144 843-870 D014409 denotes tumor necrosis factor-alpha
T145 849-857 GO:0019835 denotes necrosis
T146 849-857 GO:0008219 denotes necrosis
T149 849-857 GO:0008220 denotes necrosis
T150 849-857 GO:0001906 denotes necrosis
T151 849-857 GO:0070265 denotes necrosis
T147 849-857 D009336 denotes necrosis
T148 849-857 D009336 denotes necrosis
T153 872-875 PR:P01375 denotes TNF
T154 872-875 PR:P06804 denotes TNF
T155 872-875 PR:000000134 denotes TNF
T156 872-875 PR:P16599 denotes TNF
T159 883-896 P05231 denotes Interleukin-6
T160 883-896 B6CKP4 denotes Interleukin-6
T161 883-896 Q95181 denotes Interleukin-6
T162 883-896 Q28319 denotes Interleukin-6
T164 883-896 P41323 denotes Interleukin-6
T165 883-896 Q6V919 denotes Interleukin-6
T166 883-896 A3FBE9 denotes Interleukin-6
T167 883-896 P46650 denotes Interleukin-6
T168 883-896 Q28747 denotes Interleukin-6
T169 883-896 Q25BC2 denotes Interleukin-6
T170 883-896 Q5I6E3 denotes Interleukin-6
T171 883-896 Q6L6X6 denotes Interleukin-6
T172 883-896 P08505 denotes Interleukin-6
T173 883-896 Q9XT80 denotes Interleukin-6
T174 883-896 A0S0B0 denotes Interleukin-6
T175 883-896 Q865W7 denotes Interleukin-6
T176 883-896 Q9MZR1 denotes Interleukin-6
T177 883-896 Q865X6 denotes Interleukin-6
T178 883-896 P20607 denotes Interleukin-6
T179 883-896 P41693 denotes Interleukin-6
T180 883-896 PR:000001393 denotes Interleukin-6
T181 883-896 Q0GGL7 denotes Interleukin-6
T182 883-896 P51494 denotes Interleukin-6
T183 883-896 P26893 denotes Interleukin-6
T184 883-896 Q2MH06 denotes Interleukin-6
T185 883-896 O35736 denotes Interleukin-6
T186 883-896 P79341 denotes Interleukin-6
T188 883-896 P29455 denotes Interleukin-6
T189 883-896 Q28819 denotes Interleukin-6
T190 883-896 P41683 denotes Interleukin-6
T191 883-896 Q90YI0 denotes Interleukin-6
T192 883-896 Q8MKH0 denotes Interleukin-6
T193 883-896 P26892 denotes Interleukin-6
T163 883-896 D015850 denotes Interleukin-6
T187 883-896 D015850 denotes Interleukin-6
T194 898-902 P05231 denotes IL-6
T195 898-902 B6CKP4 denotes IL-6
T196 898-902 Q95181 denotes IL-6
T197 898-902 Q28319 denotes IL-6
T199 898-902 P41323 denotes IL-6
T200 898-902 Q6V919 denotes IL-6
T201 898-902 A3FBE9 denotes IL-6
T202 898-902 PR:Q90YI0 denotes IL-6
T203 898-902 P46650 denotes IL-6
T204 898-902 Q28747 denotes IL-6
T205 898-902 Q25BC2 denotes IL-6
T206 898-902 Q5I6E3 denotes IL-6
T207 898-902 Q6L6X6 denotes IL-6
T208 898-902 P08505 denotes IL-6
T209 898-902 Q9XT80 denotes IL-6
T210 898-902 A0S0B0 denotes IL-6
T211 898-902 Q865W7 denotes IL-6
T212 898-902 Q9MZR1 denotes IL-6
T213 898-902 PR:P20607 denotes IL-6
T214 898-902 Q865X6 denotes IL-6
T215 898-902 PR:P08505 denotes IL-6
T216 898-902 P20607 denotes IL-6
T217 898-902 P41693 denotes IL-6
T218 898-902 PR:000001393 denotes IL-6
T219 898-902 Q0GGL7 denotes IL-6
T220 898-902 P51494 denotes IL-6
T221 898-902 PR:P05231 denotes IL-6
T222 898-902 P26893 denotes IL-6
T223 898-902 Q2MH06 denotes IL-6
T224 898-902 O35736 denotes IL-6
T225 898-902 P79341 denotes IL-6
T227 898-902 P29455 denotes IL-6
T228 898-902 Q28819 denotes IL-6
T229 898-902 Q90YI0 denotes IL-6
T230 898-902 P41683 denotes IL-6
T232 898-902 Q8MKH0 denotes IL-6
T233 898-902 P26892 denotes IL-6
T198 898-902 D015850 denotes IL-6
T231 898-902 D015850 denotes IL-6
T226 898-902 GO:0005138 denotes IL-6
T234 957-960 UBERON:0000120 denotes BBB
T235 990-1000 D005070 denotes Evans blue
T236 990-1000 D005070 denotes Evans blue
T237 990-1000 CHEBI:82467 denotes Evans blue
T238 1019-1026 D007238 denotes infarct
T239 1019-1026 D007238 denotes infarct
T240 1049-1062 C028911 denotes cresyl violet
T241 1049-1062 C028911 denotes cresyl violet
T242 1049-1062 CHEBI:52815 denotes cresyl violet
T243 1056-1062 D032413 denotes violet
T244 1151-1154 CHEBI:340824 denotes MMP
T247 1151-1154 CHEBI:59761 denotes MMP
T248 1151-1156 PR:P50282 denotes MMP-9
T249 1151-1156 PR:P14780 denotes MMP-9
T250 1151-1156 P14780 denotes MMP-9
T251 1151-1156 PR:P41245 denotes MMP-9
T252 1151-1156 P41246 denotes MMP-9
T253 1151-1156 P41245 denotes MMP-9
T254 1151-1156 PR:P52176 denotes MMP-9
T255 1151-1156 P50282 denotes MMP-9
T257 1151-1156 PR:000010491 denotes MMP-9
T258 1151-1156 P52176 denotes MMP-9
T259 1151-1156 O18733 denotes MMP-9
T256 1151-1156 GO:0004229 denotes MMP-9
T260 1158-1161 CHEBI:340824 denotes MMP
T263 1158-1161 CHEBI:59761 denotes MMP
T264 1158-1163 PR:P08253 denotes MMP-2
T265 1158-1163 Q9GLE5 denotes MMP-2
T266 1158-1163 P08253 denotes MMP-2
T267 1158-1163 Q90611 denotes MMP-2
T269 1158-1163 PR:Q8MPP3 denotes MMP-2
T270 1158-1163 P33436 denotes MMP-2
T271 1158-1163 PR:Q90611 denotes MMP-2
T272 1158-1163 PR:P33436 denotes MMP-2
T273 1158-1163 PR:000010479 denotes MMP-2
T274 1158-1163 PR:P33434 denotes MMP-2
T275 1158-1163 P33434 denotes MMP-2
T276 1158-1163 P50757 denotes MMP-2
T268 1158-1163 GO:0004228 denotes MMP-2
T277 1165-1168 PR:P01375 denotes TNF
T278 1165-1168 PR:P06804 denotes TNF
T279 1165-1168 PR:000000134 denotes TNF
T280 1165-1168 PR:P16599 denotes TNF
T281 1175-1179 P05231 denotes IL-6
T282 1175-1179 B6CKP4 denotes IL-6
T283 1175-1179 Q95181 denotes IL-6
T284 1175-1179 Q28319 denotes IL-6
T286 1175-1179 P41323 denotes IL-6
T287 1175-1179 Q6V919 denotes IL-6
T288 1175-1179 A3FBE9 denotes IL-6
T289 1175-1179 PR:Q90YI0 denotes IL-6
T290 1175-1179 P46650 denotes IL-6
T291 1175-1179 Q28747 denotes IL-6
T292 1175-1179 Q25BC2 denotes IL-6
T293 1175-1179 Q5I6E3 denotes IL-6
T294 1175-1179 Q6L6X6 denotes IL-6
T295 1175-1179 P08505 denotes IL-6
T296 1175-1179 Q9XT80 denotes IL-6
T297 1175-1179 A0S0B0 denotes IL-6
T298 1175-1179 Q865W7 denotes IL-6
T299 1175-1179 Q9MZR1 denotes IL-6
T300 1175-1179 PR:P20607 denotes IL-6
T301 1175-1179 Q865X6 denotes IL-6
T302 1175-1179 PR:P08505 denotes IL-6
T303 1175-1179 P20607 denotes IL-6
T304 1175-1179 P41693 denotes IL-6
T305 1175-1179 PR:000001393 denotes IL-6
T306 1175-1179 Q0GGL7 denotes IL-6
T307 1175-1179 P51494 denotes IL-6
T308 1175-1179 PR:P05231 denotes IL-6
T309 1175-1179 P26893 denotes IL-6
T310 1175-1179 Q2MH06 denotes IL-6
T311 1175-1179 O35736 denotes IL-6
T312 1175-1179 P79341 denotes IL-6
T314 1175-1179 P29455 denotes IL-6
T315 1175-1179 Q28819 denotes IL-6
T316 1175-1179 Q90YI0 denotes IL-6
T317 1175-1179 P41683 denotes IL-6
T319 1175-1179 Q8MKH0 denotes IL-6
T320 1175-1179 P26892 denotes IL-6
T285 1175-1179 D015850 denotes IL-6
T318 1175-1179 D015850 denotes IL-6
T313 1175-1179 GO:0005138 denotes IL-6
T322 1207-1215 Q91049 denotes occludin
T323 1207-1215 Q6P6T5 denotes occludin
T324 1207-1215 Q9PUN1 denotes occludin
T325 1207-1215 Q16625 denotes occludin
T326 1207-1215 PR:000002207 denotes occludin
T327 1207-1215 Q61146 denotes occludin
T328 1207-1215 Q28269 denotes occludin
T329 1207-1215 Q28793 denotes occludin
T330 1207-1215 Q5RFS5 denotes occludin
T321 1207-1215 D062793 denotes occludin
T331 1221-1229 Q9JKD6 denotes claudin5
T332 1221-1229 O00501 denotes claudin5
T333 1221-1229 PR:000005553 denotes claudin5
T334 1221-1229 Q2HJ22 denotes claudin5
T336 1221-1229 O54942 denotes claudin5
T335 1221-1229 D062507 denotes claudin5
T337 1272-1279 D007238 denotes infarct
T338 1272-1279 D007238 denotes infarct
T339 1302-1312 UBERON:0001869 denotes hemisphere
T340 1318-1328 D005070 denotes Evans blue
T341 1318-1328 D005070 denotes Evans blue
T342 1318-1328 CHEBI:82467 denotes Evans blue
T343 1348-1357 UBERON:0000955 denotes the brain
T346 1387-1390 UBERON:0000120 denotes BBB
T347 1392-1396 Q07162 denotes PROG
T348 1417-1420 UBERON:0000120 denotes BBB
T349 1436-1443 D007238 denotes infarct
T350 1436-1443 D007238 denotes infarct
T351 1477-1481 D020782 denotes MMPs
T352 1490-1511 GO:0006954 denotes inflammatory response
T353 1534-1545 GO:0009056 denotes degradation
T355 1549-1557 Q91049 denotes occludin
T356 1549-1557 Q6P6T5 denotes occludin
T357 1549-1557 Q9PUN1 denotes occludin
T358 1549-1557 Q16625 denotes occludin
T359 1549-1557 PR:000002207 denotes occludin
T360 1549-1557 Q61146 denotes occludin
T361 1549-1557 Q28269 denotes occludin
T362 1549-1557 Q28793 denotes occludin
T363 1549-1557 Q5RFS5 denotes occludin
T354 1549-1557 D062793 denotes occludin
T364 1563-1571 Q9JKD6 denotes claudin5
T365 1563-1571 O00501 denotes claudin5
T366 1563-1571 PR:000005553 denotes claudin5
T367 1563-1571 Q2HJ22 denotes claudin5
T369 1563-1571 O54942 denotes claudin5
T368 1563-1571 D062507 denotes claudin5
T370 1590-1594 Q07162 denotes PROG
T371 1624-1627 UBERON:0000120 denotes BBB

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-169 Sentence denotes Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases.
T2 170-296 Sentence denotes Blood-brain barrier (BBB) breakdown after stroke is linked to the up-regulation of metalloproteinases (MMPs) and inflammation.
T3 297-485 Sentence denotes This study examines the effects of progesterone (PROG) and its neuroactive metabolite allopregnanolone (ALLO) on BBB integrity following permanent middle cerebral artery occlusion (pMCAO).
T4 486-699 Sentence denotes Rats underwent pMCAO by electro-coagulation and received intraperitoneal injections of PROG (8 mg/kg), ALLO (8 mg/kg) or vehicle at 1 h post-occlusion and then subcutaneous injections (8 mg/kg) at 6, 24, and 48 h.
T5 700-821 Sentence denotes MMP activation and expression were analyzed by Western blot, immunohistochemistry and gelatin zymography 72 h post-pMCAO.
T6 822-956 Sentence denotes Occludin1, claudin5, tumor necrosis factor-alpha (TNF-α) and Interleukin-6 (IL-6) were analyzed at 72 h post-pMCAO with Western blots.
T7 957-1083 Sentence denotes BBB permeability was measured by Evans blue extravasation and infarct size was evaluated by cresyl violet at 72 h after pMCAO.
T8 1084-1230 Sentence denotes Ischemic injury significantly (p<0.05) increased the expression of MMP-9, MMP-2, TNF-α and IL-6, and reduced the levels of occludin1 and claudin5.
T9 1231-1391 Sentence denotes These changes were followed by increased infarct size (% contralateral hemisphere) and Evans blue extravasation into the brain indicating compromise of the BBB.
T10 1392-1572 Sentence denotes PROG and ALLO attenuated BBB disruption and infarct size following pMCAO by reducing MMPs and the inflammatory response and by preventing the degradation of occludin1 and claudin5.
T11 1573-1655 Sentence denotes We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO.
T1 0-169 Sentence denotes Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases.
T2 170-296 Sentence denotes Blood-brain barrier (BBB) breakdown after stroke is linked to the up-regulation of metalloproteinases (MMPs) and inflammation.
T3 297-485 Sentence denotes This study examines the effects of progesterone (PROG) and its neuroactive metabolite allopregnanolone (ALLO) on BBB integrity following permanent middle cerebral artery occlusion (pMCAO).
T4 486-699 Sentence denotes Rats underwent pMCAO by electro-coagulation and received intraperitoneal injections of PROG (8 mg/kg), ALLO (8 mg/kg) or vehicle at 1 h post-occlusion and then subcutaneous injections (8 mg/kg) at 6, 24, and 48 h.
T5 700-821 Sentence denotes MMP activation and expression were analyzed by Western blot, immunohistochemistry and gelatin zymography 72 h post-pMCAO.
T6 822-956 Sentence denotes Occludin1, claudin5, tumor necrosis factor-alpha (TNF-α) and Interleukin-6 (IL-6) were analyzed at 72 h post-pMCAO with Western blots.
T7 957-1083 Sentence denotes BBB permeability was measured by Evans blue extravasation and infarct size was evaluated by cresyl violet at 72 h after pMCAO.
T8 1084-1230 Sentence denotes Ischemic injury significantly (p<0.05) increased the expression of MMP-9, MMP-2, TNF-α and IL-6, and reduced the levels of occludin1 and claudin5.
T9 1231-1391 Sentence denotes These changes were followed by increased infarct size (% contralateral hemisphere) and Evans blue extravasation into the brain indicating compromise of the BBB.
T10 1392-1572 Sentence denotes PROG and ALLO attenuated BBB disruption and infarct size following pMCAO by reducing MMPs and the inflammatory response and by preventing the degradation of occludin1 and claudin5.
T11 1573-1655 Sentence denotes We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 212-218 HP_0001297 denotes stroke
T2 843-848 HP_0002664 denotes tumor

Allie

Id Subject Object Predicate Lexical cue
SS1_20816826_1_0 170-189 expanded denotes Blood-brain barrier
SS2_20816826_1_0 191-194 abbr denotes BBB
SS1_20816826_2_0 332-344 expanded denotes progesterone
SS2_20816826_2_0 346-350 abbr denotes PROG
SS1_20816826_2_1 383-399 expanded denotes allopregnanolone
SS2_20816826_2_1 401-405 abbr denotes ALLO
SS1_20816826_2_2 434-476 expanded denotes permanent middle cerebral artery occlusion
SS2_20816826_2_2 478-483 abbr denotes pMCAO
SS1_20816826_5_0 843-870 expanded denotes tumor necrosis factor-alpha
SS2_20816826_5_0 872-877 abbr denotes TNF-α
SS1_20816826_5_1 883-896 expanded denotes Interleukin-6
SS2_20816826_5_1 898-902 abbr denotes IL-6
AE1_20816826_1_0 SS1_20816826_1_0 SS2_20816826_1_0 abbreviatedTo Blood-brain barrier,BBB
AE1_20816826_2_0 SS1_20816826_2_0 SS2_20816826_2_0 abbreviatedTo progesterone,PROG
AE1_20816826_2_1 SS1_20816826_2_1 SS2_20816826_2_1 abbreviatedTo allopregnanolone,ALLO
AE1_20816826_2_2 SS1_20816826_2_2 SS2_20816826_2_2 abbreviatedTo permanent middle cerebral artery occlusion,pMCAO
AE1_20816826_5_0 SS1_20816826_5_0 SS2_20816826_5_0 abbreviatedTo tumor necrosis factor-alpha,TNF-α
AE1_20816826_5_1 SS1_20816826_5_1 SS2_20816826_5_1 abbreviatedTo Interleukin-6,IL-6

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-169 DRI_Approach denotes Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases.
T2 170-296 DRI_Background denotes Blood-brain barrier (BBB) breakdown after stroke is linked to the up-regulation of metalloproteinases (MMPs) and inflammation.
T3 297-485 DRI_Approach denotes This study examines the effects of progesterone (PROG) and its neuroactive metabolite allopregnanolone (ALLO) on BBB integrity following permanent middle cerebral artery occlusion (pMCAO).
T4 486-821 DRI_Background denotes Rats underwent pMCAO by electro-coagulation and received intraperitoneal injections of PROG (8 mg/kg), ALLO (8 mg/kg) or vehicle at 1 h post-occlusion and then subcutaneous injections (8 mg/kg) at 6, 24, and 48 h. MMP activation and expression were analyzed by Western blot, immunohistochemistry and gelatin zymography 72 h post-pMCAO.
T5 822-956 DRI_Unspecified denotes Occludin1, claudin5, tumor necrosis factor-alpha (TNF-α) and Interleukin-6 (IL-6) were analyzed at 72 h post-pMCAO with Western blots.
T6 957-1083 DRI_Background denotes BBB permeability was measured by Evans blue extravasation and infarct size was evaluated by cresyl violet at 72 h after pMCAO.
T7 1084-1230 DRI_Outcome denotes Ischemic injury significantly (p<0.05) increased the expression of MMP-9, MMP-2, TNF-α and IL-6, and reduced the levels of occludin1 and claudin5.
T8 1231-1391 DRI_Approach denotes These changes were followed by increased infarct size (% contralateral hemisphere) and Evans blue extravasation into the brain indicating compromise of the BBB.
T9 1392-1572 DRI_Approach denotes PROG and ALLO attenuated BBB disruption and infarct size following pMCAO by reducing MMPs and the inflammatory response and by preventing the degradation of occludin1 and claudin5.
T10 1573-1655 DRI_Approach denotes We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO.