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PubMed:20801104 JSONTXT

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LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-119 Sentence denotes Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction.
T2 120-323 Sentence denotes This study investigated the possible association between three functional polymorphisms in the promoter region of the dopamine D4 receptor (DRD4) gene and schizophrenia, depression, and heroin addiction.
T3 324-532 Sentence denotes Genomic DNA was isolated from the venous blood leukocytes of 322 unrelated patients with schizophrenia, 156 patients with depression, 300 patients with heroin addiction, and 300 healthy unrelated individuals.
T5 695-754 Sentence denotes Genotype and allele were analyzed using SPSS 11.5 software.
T4 533-694 Sentence denotes Polymorphisms in the promoter region of DRD4 (-120 bp duplication, -616C/G, and -521C/T) were genotyped using allele-specific polymerase chain reaction analysis.
T6 755-965 Sentence denotes Results of this analysis indicated that there is a strong finding of -120 bp duplication allele frequencies with schizophrenia (p=0.008) and weak finding with -1240 L/S and for paranoid schizophrenia (p=0.022).
T7 966-1076 Sentence denotes Interestingly, there is a stronger finding with -521 C/T allele frequencies with heroin dependence (p=0.0002).
T8 1077-1267 Sentence denotes These observations strongly suggest that the -120-bp duplication polymorphism of DRD4 is associated with schizophrenia and that the -521 C/T polymorphism is associated with heroin addiction.

LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
7956 61-65 GeneOrGeneProduct denotes DRD4 NCBIGene:1815
7957 71-84 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
7958 86-96 DiseaseOrPhenotypicFeature denotes depression MESH:D003866
7959 102-118 DiseaseOrPhenotypicFeature denotes heroin addiction MESH:D006556
7960 238-258 GeneOrGeneProduct denotes dopamine D4 receptor NCBIGene:1815
7961 260-264 GeneOrGeneProduct denotes DRD4 NCBIGene:1815
7962 275-288 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
7963 290-300 DiseaseOrPhenotypicFeature denotes depression MESH:D003866
7964 306-322 DiseaseOrPhenotypicFeature denotes heroin addiction MESH:D006556
7965 399-407 OrganismTaxon denotes patients NCBITaxon:9606
7966 413-426 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
7967 432-440 OrganismTaxon denotes patients NCBITaxon:9606
7968 446-456 DiseaseOrPhenotypicFeature denotes depression MESH:D003866
7969 462-470 OrganismTaxon denotes patients NCBITaxon:9606
7970 476-492 DiseaseOrPhenotypicFeature denotes heroin addiction MESH:D006556
7971 573-577 GeneOrGeneProduct denotes DRD4 NCBIGene:1815
7972 579-598 SequenceVariant denotes -120 bp duplication c|DUP|-120||
7973 600-607 SequenceVariant denotes -616C/G DBSNP:rs747302
7974 613-620 SequenceVariant denotes -521C/T DBSNP:rs1800955
7975 824-843 SequenceVariant denotes -120 bp duplication c|DUP|-120||
7976 868-881 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
7977 914-923 SequenceVariant denotes -1240 L/S p|SUB|L|-1240|S
7978 932-954 DiseaseOrPhenotypicFeature denotes paranoid schizophrenia MESH:D012563
7979 1014-1022 SequenceVariant denotes -521 C/T DBSNP:rs1800955
7980 1047-1064 DiseaseOrPhenotypicFeature denotes heroin dependence MESH:D006556
7981 1122-1141 SequenceVariant denotes -120-bp duplication c|DUP|-120||
7982 1158-1162 GeneOrGeneProduct denotes DRD4 NCBIGene:1815
7983 1182-1195 DiseaseOrPhenotypicFeature denotes schizophrenia MESH:D012559
7984 1209-1217 SequenceVariant denotes -521 C/T DBSNP:rs1800955
7985 1250-1266 DiseaseOrPhenotypicFeature denotes heroin addiction MESH:D006556

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 71-84 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T2 275-288 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T3 413-426 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T4 868-881 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T5 932-954 DiseaseOrPhenotypicFeature denotes paranoid schizophrenia 0001484
T6 941-954 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T7 1047-1064 DiseaseOrPhenotypicFeature denotes heroin dependence 0005367
T8 1182-1195 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090

LitCoin-SeqVar

Id Subject Object Predicate Lexical cue
T1 601-605 SequenceVariant denotes 616C
T2 614-618 SequenceVariant denotes 521C

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 61-65 GeneOrGeneProduct denotes DRD4
T2 86-96 GeneOrGeneProduct denotes depression
T3 238-258 GeneOrGeneProduct denotes dopamine D4 receptor
T4 260-264 GeneOrGeneProduct denotes DRD4
T5 290-300 GeneOrGeneProduct denotes depression
T6 446-456 GeneOrGeneProduct denotes depression
T7 573-577 GeneOrGeneProduct denotes DRD4
T8 587-598 GeneOrGeneProduct denotes duplication
T9 659-669 GeneOrGeneProduct denotes polymerase
T10 670-675 GeneOrGeneProduct denotes chain
T11 813-820 GeneOrGeneProduct denotes finding
T12 832-843 GeneOrGeneProduct denotes duplication
T13 851-862 GeneOrGeneProduct denotes frequencies
T14 896-900 GeneOrGeneProduct denotes weak
T15 901-908 GeneOrGeneProduct denotes finding
T16 1001-1008 GeneOrGeneProduct denotes finding
T17 1030-1041 GeneOrGeneProduct denotes frequencies
T18 1130-1141 GeneOrGeneProduct denotes duplication
T19 1158-1162 GeneOrGeneProduct denotes DRD4

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 61-65 GeneOrGeneProduct denotes DRD4
T2 238-258 GeneOrGeneProduct denotes dopamine D4 receptor
T3 260-264 GeneOrGeneProduct denotes DRD4
T4 573-577 GeneOrGeneProduct denotes DRD4
T5 659-669 GeneOrGeneProduct denotes polymerase
T6 670-675 GeneOrGeneProduct denotes chain
T7 896-900 GeneOrGeneProduct denotes weak
T8 1158-1162 GeneOrGeneProduct denotes DRD4

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 71-84 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 86-96 DiseaseOrPhenotypicFeature denotes depression DISEASE
T3 102-118 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T4 275-288 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T5 290-300 DiseaseOrPhenotypicFeature denotes depression DISEASE
T6 306-322 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T7 413-426 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T8 446-456 DiseaseOrPhenotypicFeature denotes depression DISEASE
T9 476-492 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T10 868-881 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T11 932-954 DiseaseOrPhenotypicFeature denotes paranoid schizophrenia D012563
T12 1047-1064 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T13 1182-1195 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T14 1250-1266 DiseaseOrPhenotypicFeature denotes heroin addiction D006556

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 61-65 GeneOrGeneProduct denotes DRD4
T2 238-258 GeneOrGeneProduct denotes dopamine D4 receptor
T3 260-264 GeneOrGeneProduct denotes DRD4
T4 573-577 GeneOrGeneProduct denotes DRD4
T5 1158-1162 GeneOrGeneProduct denotes DRD4

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 71-84 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T2 86-96 DiseaseOrPhenotypicFeature denotes depression 0002050
T3 102-118 DiseaseOrPhenotypicFeature denotes heroin addiction 0005367
T4 275-288 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T5 290-300 DiseaseOrPhenotypicFeature denotes depression 0002050
T6 306-322 DiseaseOrPhenotypicFeature denotes heroin addiction 0005367
T7 413-426 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T8 446-456 DiseaseOrPhenotypicFeature denotes depression 0002050
T9 476-492 DiseaseOrPhenotypicFeature denotes heroin addiction 0005367
T10 868-881 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T11 932-954 DiseaseOrPhenotypicFeature denotes paranoid schizophrenia 0001484
T12 1047-1064 DiseaseOrPhenotypicFeature denotes heroin dependence 0005367
T13 1182-1195 DiseaseOrPhenotypicFeature denotes schizophrenia 0005090
T14 1250-1266 DiseaseOrPhenotypicFeature denotes heroin addiction 0005367

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 71-84 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 86-96 DiseaseOrPhenotypicFeature denotes depression DISEASE
T3 102-118 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T4 275-288 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T5 290-300 DiseaseOrPhenotypicFeature denotes depression DISEASE
T6 306-322 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T7 413-426 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T8 446-456 DiseaseOrPhenotypicFeature denotes depression DISEASE
T9 476-492 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T10 868-881 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T11 932-954 DiseaseOrPhenotypicFeature denotes paranoid schizophrenia D012563
T12 1047-1064 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T13 1182-1195 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T14 1250-1266 DiseaseOrPhenotypicFeature denotes heroin addiction D006556

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 71-84 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2 86-96 DiseaseOrPhenotypicFeature denotes depression DISEASE
T3 102-118 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T4 275-288 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T5 290-300 DiseaseOrPhenotypicFeature denotes depression DISEASE
T6 306-322 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T7 413-426 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T8 446-456 DiseaseOrPhenotypicFeature denotes depression DISEASE
T9 476-492 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T10 868-881 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T11 932-954 DiseaseOrPhenotypicFeature denotes paranoid schizophrenia D012563
T12 1047-1064 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T13 1182-1195 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T14 1250-1266 DiseaseOrPhenotypicFeature denotes heroin addiction D006556

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 399-407 OrganismTaxon denotes patients
T2 432-440 OrganismTaxon denotes patients
T3 462-470 OrganismTaxon denotes patients

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 102-108 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T3 238-246 ChemicalEntity denotes dopamine D004298|http://purl.obolibrary.org/obo/CHEBI_59905|http://purl.obolibrary.org/obo/CHEBI_18243
T6 306-312 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T8 476-482 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T10 1047-1053 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808
T12 1250-1256 ChemicalEntity denotes heroin D003932|http://purl.obolibrary.org/obo/CHEBI_27808

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID:
T12 1250-1256 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T10 1047-1053 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T8 476-482 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T6 306-312 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T3 238-246 ChemicalEntity denotes dopamine http://purl.obolibrary.org/obo/CHEBI_18243|http://purl.obolibrary.org/obo/CHEBI_59905|D004298
T1 102-108 ChemicalEntity denotes heroin http://purl.obolibrary.org/obo/CHEBI_27808|D003932
T5 1158-1162 GeneOrGeneProduct denotes DRD4
T4 573-577 GeneOrGeneProduct denotes DRD4
T35391 260-264 GeneOrGeneProduct denotes DRD4
T2 238-258 GeneOrGeneProduct denotes dopamine D4 receptor
T93078 61-65 GeneOrGeneProduct denotes DRD4
T14 1250-1266 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T13 1182-1195 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T78342 1047-1064 DiseaseOrPhenotypicFeature denotes heroin dependence D006556
T11 932-954 DiseaseOrPhenotypicFeature denotes paranoid schizophrenia D012563
T97197 868-881 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T9 476-492 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T16811 446-456 DiseaseOrPhenotypicFeature denotes depression DISEASE
T7 413-426 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T2159 306-322 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T48858 290-300 DiseaseOrPhenotypicFeature denotes depression DISEASE
T78168 275-288 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T70861 102-118 DiseaseOrPhenotypicFeature denotes heroin addiction D006556
T9153 86-96 DiseaseOrPhenotypicFeature denotes depression DISEASE
T28992 71-84 DiseaseOrPhenotypicFeature denotes schizophrenia D012559
T34679 462-470 OrganismTaxon denotes patients
T59117 432-440 OrganismTaxon denotes patients
T43407 399-407 OrganismTaxon denotes patients
T86089 614-618 SequenceVariant denotes 521C
T51999 601-605 SequenceVariant denotes 616C

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 275-288 HP_0100753 denotes schizophrenia
T2 290-300 HP_0000716 denotes depression
T3 413-426 HP_0100753 denotes schizophrenia
T4 446-456 HP_0000716 denotes depression
T5 587-598 HP_0009609 denotes duplication
T6 832-843 HP_0009609 denotes duplication
T7 868-881 HP_0100753 denotes schizophrenia
T8 932-940 HP_0011999 denotes paranoid
T9 941-954 HP_0100753 denotes schizophrenia
T10 1130-1141 HP_0009609 denotes duplication
T11 1182-1195 HP_0100753 denotes schizophrenia

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
20801104-0#61#65#gene1815 61-65 gene1815 denotes DRD4
20801104-0#71#84#diseaseC0036341 71-84 diseaseC0036341 denotes schizophrenia
20801104-0#102#118#diseaseC0019337 102-118 diseaseC0019337 denotes heroin addiction
61#65#gene181571#84#diseaseC0036341 20801104-0#61#65#gene1815 20801104-0#71#84#diseaseC0036341 associated_with DRD4,schizophrenia
61#65#gene1815102#118#diseaseC0019337 20801104-0#61#65#gene1815 20801104-0#102#118#diseaseC0019337 associated_with DRD4,heroin addiction

tmVarCorpus

Id Subject Object Predicate Lexical cue
T1 600-607 DNAMutation:c|SUB|C|-616|G denotes -616C/G
T2 613-620 DNAMutation:c|SUB|C|-521|T denotes -521C/T
T3 914-923 ProteinMutation:p|SUB|L|-1240|S denotes -1240 L/S
T4 1014-1022 DNAMutation:c|SUB|C|-521|T denotes -521 C/T
T5 1209-1217 DNAMutation:c|SUB|C|-521|T denotes -521 C/T